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Author : Andrea Aquilato
Publisher :
ISBN 13 :
Total Pages : 61 pages
Book Rating : 4.:/5 (814 download)
Download or read book BRAF Mutation as a Target for Treatment of Melanoma written by Andrea Aquilato and published by . This book was released on 2012 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ryan J. Sullivan
Publisher : Springer
ISBN 13 : 1493921436
Total Pages : 206 pages
Book Rating : 4.4/5 (939 download)
Download or read book BRAF Targets in Melanoma written by Ryan J. Sullivan and published by Springer. This book was released on 2014-11-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
Author : Charles M. Balch
Publisher : Springer
ISBN 13 : 9783030050689
Total Pages : 0 pages
Book Rating : 4.0/5 (56 download)
Download or read book Cutaneous Melanoma written by Charles M. Balch and published by Springer. This book was released on 2020-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030462277
Total Pages : 428 pages
Book Rating : 4.0/5 (34 download)
Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Download or read book Cutaneous Melanoma written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Liang Cheng
Publisher : Springer Nature
ISBN 13 : 3031351185
Total Pages : 725 pages
Book Rating : 4.0/5 (313 download)
Download or read book Molecular Surgical Pathology written by Liang Cheng and published by Springer Nature. This book was released on 2023-10-31 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available “quick reference” for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.
Author : Bernardo L. Rapoport
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068187
Total Pages : 109 pages
Book Rating : 4.3/5 (18 download)
Download or read book Fast Facts: Comprehensive Genomic Profiling written by Bernardo L. Rapoport and published by Karger Medical and Scientific Publishers. This book was released on 2020-10-20 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Author : Jihyun Kang
Publisher :
ISBN 13 :
Total Pages : 57 pages
Book Rating : 4.:/5 (87 download)
Download or read book BRAF Mutation in Cutaneous Malignant Melanoma and Targeted Therapy written by Jihyun Kang and published by . This book was released on 2013 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mahamat Babagana
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781976112768
Total Pages : 160 pages
Book Rating : 4.1/5 (127 download)
Download or read book Identifying and Targeting Mechanisms of Resistance to BRAF Inhibitors written by Mahamat Babagana and published by Createspace Independent Publishing Platform. This book was released on 2017-09-04 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous melanoma is the most fatal type of skin cancer. The steady increase in incidence and static mortality rates have intensified the need to improve melanoma therapeutics. Constitutive activation of the growth signaling mitogen activated protein kinase (MAPK) pathway, frequently due to mutations in the proto-oncoprotein BRAF (BRAFV600E), has been found to provide the perpetual mitogenic signal needed for continued proliferation in many cancers, including melanoma. Although direct targeting of BRAF signaling has had some benefit for patients in the treatment of metastatic melanoma, it does not suffice in providing a lasting cure among the majority of responders due to acquired resistance. Additionally, a large subset of patients, who contain mutant BRAF, do not respond to BRAF inhibition due to intrinsic resistance. Because of the high occurrence of activating BRAF mutations in melanoma and other cancers and the limited efficacy of MAPK pathway targeting drugs due to acquired and intrinsic resistance, there is an immense need to identify additional strategies that can be used to safely increase the efficacy of MAPK pathway inhibitors. Here we demonstrate that the serine/threonine p21 activated kinase (PAK1) is a converging point used by several pathways to provide resistance to MAPK pathway inhibitors. Moreover, PAK1 inhibition can revert acquired and intrinsic resistance to MAPK pathway inhibitors. In addition, we show that polo-like kinase 3 (PLK3) can modulate MAPK pathway inhibitor efficacy in vitro and in vivo. Concurrently, there is a significant correlation of increased PLK3 expression in relapsed patient tumors and in many melanoma cell lines that are relatively resistant to MAPK pathway inhibitors. We have also identified that increased stimulation of the serine/threonine kinase, AKT, which itself has be shown to drive cancer progression and resistance to many types of therapy, including BRAF inhibitors, enhances cellular toxicity associated with exposure to increased temperatures. Our results identify patient subgroups who are at high risk for failure to current targeted therapeutics used for the treatment of BRAF mutated cancers. Additionally, we identify novel avenues which could be targeted to increase the efficacy of MAPK pathway inhibitors in melanoma and other BRAF mutated cancers. Our findings also support hyperthermia as a therapeutic approach which could be used to selectivity target a wide range of cancers cells with increased AKT signaling.
Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
ISBN 13 : 1789230942
Total Pages : 214 pages
Book Rating : 4.7/5 (892 download)
Download or read book Human Skin Cancers written by Miroslav Blumenberg and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.
Author : Manmeet Ahluwalia
Publisher : Springer Nature
ISBN 13 : 3030234177
Total Pages : 421 pages
Book Rating : 4.0/5 (32 download)
Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Author : Liang Cheng
Publisher : Springer
ISBN 13 : 9781461447993
Total Pages : 1136 pages
Book Rating : 4.4/5 (479 download)
Download or read book Molecular Genetic Pathology written by Liang Cheng and published by Springer. This book was released on 2013-03-05 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)
Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.
Author : Mandi Murph
Publisher : BoD – Books on Demand
ISBN 13 : 9533072938
Total Pages : 430 pages
Book Rating : 4.5/5 (33 download)
Download or read book Research on Melanoma written by Mandi Murph and published by BoD – Books on Demand. This book was released on 2011-09-12 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.
Author : Carlos A. Torres-Cabala
Publisher : Springer
ISBN 13 : 1493935542
Total Pages : 291 pages
Book Rating : 4.4/5 (939 download)
Download or read book Genetics of Melanoma written by Carlos A. Torres-Cabala and published by Springer. This book was released on 2016-05-11 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.
Author : Sanjiv S. Agarwala
Publisher : CRC Press
ISBN 13 : 1000654613
Total Pages : 225 pages
Book Rating : 4.0/5 (6 download)
Download or read book Melanoma written by Sanjiv S. Agarwala and published by CRC Press. This book was released on 2008-08-08 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily
Author : Larry Nathanson
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)
Download or read book Management of Advanced Melanoma written by Larry Nathanson and published by . This book was released on 1986 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
