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Author :
Publisher :
ISBN 13 :
Total Pages : 166 pages
Book Rating : 4.:/5 (327 download)
Download or read book Boron Compounds Suitable for Neutron Capture Therapy for the Treatment of Cancer written by and published by . This book was released on 1988 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Compounds Suitable for Neutron Capture Therapy for the Treatment of Cancer written by and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 156 pages
Book Rating : 4.:/5 (199 download)
Download or read book Boron Compounds Suitable for Neutron Capture Therapy for the Treatment of Cancer written by and published by . This book was released on 1988 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Narayan S. Hosmane
Publisher : World Scientific
ISBN 13 : 9814338672
Total Pages : 271 pages
Book Rating : 4.8/5 (143 download)
Download or read book Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment written by Narayan S. Hosmane and published by World Scientific. This book was released on 2012 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs have turned the area to be the hottest one and worthy of further investigation with the new clinical trials in the USA and elsewhere.
Author : R. Fairchild
Publisher : Springer Science & Business Media
ISBN 13 : 1468456229
Total Pages : 363 pages
Book Rating : 4.4/5 (684 download)
Download or read book Clinical Aspects of Neutron Capture Therapy written by R. Fairchild and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.
Author : Shinji Kawabata
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Boron Compounds for Neutron Capture Therapy in the Treatment of Brain Tumors written by Shinji Kawabata and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT), which uses the capture reaction between neutrons and boron-10, an isotope of boron, is rapidly gaining interest. The reason for this is the successful development of a compact accelerator-type neutron generator that can be installed in a hospital and launched into the clinical setting. BNCT, which provides selective radiotherapeutic effects at the cellular level, is expected to be effective against invasive cancer. We have been investigating BNCT applications in various types of malignant brain tumors, especially malignant gliomas, as medical applications. Recently, we have conducted clinical trials using the developed accelerator neutron source. Research on pharmaceutical applications of compounds that transport boron to cancer cells is expected to be in even greater need. Currently, the only boron agent used in cancer therapy is BPA (Borofaran 10B), which takes advantage of the demand for essential amino acids, but the research and development of boron agents are an absolutely key technology to further improve the precision of this treatment modality. This chapter summarizes and discusses the results of BNCT in the treatment of brain tumors.
Author : Wolfgang A.G. Sauerwein
Publisher : Springer Science & Business Media
ISBN 13 : 3642313345
Total Pages : 545 pages
Book Rating : 4.6/5 (423 download)
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Author : B.J. Allen
Publisher : Springer Science & Business Media
ISBN 13 : 1461533848
Total Pages : 641 pages
Book Rating : 4.4/5 (615 download)
Download or read book Progress in Neutron Capture Therapy for Cancer written by B.J. Allen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases, failure to achieve local control results in death. First among these cancers are the high grade brain tumours, astrocytoma 3,4 and glioblastoma multiforme. Local control of these tumours should lead to cure. Other cancers melanoma metastatic to the brain, for which a useful palliative therapy is not yet available, and pancreatic cancer for which localised control at an early stage could bring about improved prognosis. Patients with these cancers have little grounds for hope. Our primary objective is to reverse this situation with Neutron Capture Therapy (NCT). The purpose of this fourth symposium is to hasten the day whereby patients with these cancers can reasonably hope for substantial remissions. The first symposium on NCT was held in Boston in 1983, followed by Tokyo in 1985 and Bremen, Germany in 1988.
Author : Evamarie Hey-Hawkins
Publisher : John Wiley & Sons
ISBN 13 : 1119275555
Total Pages : 490 pages
Book Rating : 4.1/5 (192 download)
Download or read book Boron-Based Compounds written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2018-07-23 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Author : Hiroshi Hatanaka
Publisher : Kluwer Academic Pub
ISBN 13 : 9780852006832
Total Pages : 463 pages
Book Rating : 4.0/5 (68 download)
Download or read book Boron-Neutron Capture Therapy for Tumors written by Hiroshi Hatanaka and published by Kluwer Academic Pub. This book was released on 1986-01-01 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gianni Ciofani
Publisher : William Andrew
ISBN 13 : 0323389600
Total Pages : 248 pages
Book Rating : 4.3/5 (233 download)
Download or read book Boron Nitride Nanotubes in Nanomedicine written by Gianni Ciofani and published by William Andrew. This book was released on 2016-04-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron Nitride Nanotubes in Nanomedicine compiles, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine. Boron nitride nanotubes (BNNTs) represent an innovative and extremely intriguing class of nanomaterials. After introducing BNNTs and explaining their preparation and evaluation, the book shows how the physical, chemical, piezoelectric and biocompatibility properties of these nanotubes give rise to their potential uses in biomedicine. Evidence is offered (from both in vitro and in vivo investigations) for how BNNTs can be useful in biomedical and nanomedicine applications such as therapeutic applications, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers. Covers a range of promising biomedical BNNT applications Provides great value not just to academics but also industry researchers in fields such as materials science, molecular biology, pharmacology, biomedical engineering, and biophysical sciences Offers evidence for how BNNTs can be useful in biomedical and nanomedicine applications such as therapy, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers Incorporates, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine
Author :
Publisher :
ISBN 13 :
Total Pages : 21 pages
Book Rating : 4.:/5 (727 download)
Download or read book Synthesis and Evaluation of Boron Compounds for Neutron Capture Therapy of Malignant Brain Tumors written by and published by . This book was released on 1990 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy offers the potentiality for treating brain tumors currently resistant to treatment. The success of this form of therapy is directly dependent upon the delivery of sufficient numbers of thermal-neutrons to tumor cells which possess high concentrations of B-10. The objective of this project is to develop chemical methodology to synthesize boron-containing compounds with the potential for becoming incorporated into rapidly-dividing malignant brain tumor cells and excluded from normal components of the brain and surrounding tissues, to develope biological methods for assessing the potential of the compound by use of cell culture or intratumoral injection, to develop analytical methodology for measuring boron in cells and tissue using direct current plasma atomic emission spectroscopy (DCP-AES) and alpha track autoradiography, to develop biochemical and HPLC procedures for evaluating compound uptake and tissue half-life, and to develop procedures required to assess both in vitro and vivo efficacy of BNCT with selected compounds.
Author : Evamarie Hey-Hawkins
Publisher : John Wiley & Sons
ISBN 13 : 111927558X
Total Pages : 496 pages
Book Rating : 4.1/5 (192 download)
Download or read book Boron-Based Compounds written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2018-04-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Author : Jugal Kaushik Shah
Publisher :
ISBN 13 :
Total Pages : 39 pages
Book Rating : 4.:/5 (31 download)
Download or read book Hypoxia-selective Compounds for Boron Neutron Capture Therapy written by Jugal Kaushik Shah and published by . This book was released on 2008 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon sufficient vascularization within the tumor. To investigate the possibility of delivering boron to hypoxic regions of tumor, a new boronated nitroimidazole delivery agent has been synthesized as a carrier of boron-10 for BNCT. It is expected that this will be used in combination with the existing boron carrier boronophenylalanine-fructose to treat solid tumors. An immunohistochemical protocol to visualize hypoxia was tested and refined to confirm the suitability of two tumor models established in the lab for hypoxia related uptake studies. The immunohistochemical protocol is used to detect pimonidazole, which localizes at hypoxic regions in tissue and is the parent compound for the new hypoxia-selective boron carrier. The protocol was used to test and confirm the suitability of a hypoxic in vivo tumor model. Two tumor lines were tested: SCCVII squamous cell carcinoma and EMT-6 murine mammary carcinoma. Both exhibited hypoxia. Finally, quantitative studies using Inductive Coupled Plasma Atomic Emission Spectrum demonstrated that the synthesized boronated nitroimidazole reaches suitable concentrations in SCCVII and F98 tumor. Future therapeutic studies are required to empirically confirm the effectiveness of this compound.
Author : Bart Verlinden
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)
Download or read book Optimization of Boron Determination with ICP-MS for Boron Neutron Capture Therapy (BNCT) Studies in Vitro written by Bart Verlinden and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT) is a cancer treatment in its research phase. In this type of therapy, a nuclear reaction is employed to kill cancer cells. When boron-10 is irradiated with thermal neutrons, the result are highly reactive alpha particles and lithium-7 nuclei, both with a very short path length. When boron-10 is selectively internalized into malignant cells, the reactive nuclei after neutron irradiation will selectively kill the malignant cells. However, research on boron compounds is still necessary (on selectivity for example), which involves experiments in vitro. The aim of this research is the development of a method for the determination of boron in cells exposed to boron-containing molecules in vitro. For the quantitative determination of boron, inductively coupled plasma mass spectrometry (ICP-MS) was employed. However, when using this device, it is important to first completely dissolve the cells and their content and to remove carbon to minimize matrix effects. In addition, during this sample preparation, complete recovery of boron is envisaged, which is difficult because of the volatility of boron. Because low boron concentrations will be determined also a low background signal of boron, which implicates the prevention of contamination with boron during sample treatment, is important. Sample preparations based on acidic digestion and UV digestion were performed on cell suspensions. These were evaluated with total organic carbon and ICP-MS measurements. From the results of these analyses, it was concluded that the ideal method is a short sealed acidic digestion combined with UV digestion. In this way, low carbon contents, low detection limits and high recoveries of boron can be obtained. Employing this method, it was possible to quantitatively determine associated boron in exposed cells. The result is important for future in vitro BNCT research, but it may also prove its importance for ICP-MS elemental analysis of cells.
Author : Ibrahim Omerhodzic
Publisher : BoD – Books on Demand
ISBN 13 : 1789849535
Total Pages : 260 pages
Book Rating : 4.7/5 (898 download)
Download or read book Glioma written by Ibrahim Omerhodzic and published by BoD – Books on Demand. This book was released on 2019-01-16 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two.
Download or read book Halogenated Sulfidohydroboranes for Nuclear Medicine and Boron Neutron Capture Therapy written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub. 4 B.sub. 12 I.sub. 11 SSB.sub. 12 I.sub. 11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
