Blood Perfusion and Microenvironment of Human Tumors

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Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood Perfusion and Microenvironment of Human Tumors by : Michael Molls

Download or read book Blood Perfusion and Microenvironment of Human Tumors written by Michael Molls and published by . This book was released on 1998 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.

Blood Perfusion and Microenvironment of Human Tumors

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Publisher : Springer
ISBN 13 : 9783642588136
Total Pages : 0 pages
Book Rating : 4.5/5 (881 download)

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Book Synopsis Blood Perfusion and Microenvironment of Human Tumors by : M. Molls

Download or read book Blood Perfusion and Microenvironment of Human Tumors written by M. Molls and published by Springer. This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.

Tumor Blood Circulation

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Publisher : CRC Press
ISBN 13 : 1000083551
Total Pages : 320 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Tumor Blood Circulation by : Hans-Inge Peterson

Download or read book Tumor Blood Circulation written by Hans-Inge Peterson and published by CRC Press. This book was released on 2020-04-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1979, this book offers a full, insight into the relationship between malignant tumors and blood flow. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Systems Biology of Tumor Microenvironment

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Publisher : Springer
ISBN 13 : 3319420232
Total Pages : 264 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Systems Biology of Tumor Microenvironment by : Katarzyna A. Rejniak

Download or read book Systems Biology of Tumor Microenvironment written by Katarzyna A. Rejniak and published by Springer. This book was released on 2016-10-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

Tumor Microenvironment

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Publisher : John Wiley & Sons
ISBN 13 : 1119956927
Total Pages : 407 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Tumor Microenvironment by : Dietmar W. Siemann

Download or read book Tumor Microenvironment written by Dietmar W. Siemann and published by John Wiley & Sons. This book was released on 2011-06-24 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.

Cancer Microenvironment and Therapeutic Implications

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Publisher : Springer Science & Business Media
ISBN 13 : 1402095767
Total Pages : 247 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cancer Microenvironment and Therapeutic Implications by : Gianfranco Baronzio

Download or read book Cancer Microenvironment and Therapeutic Implications written by Gianfranco Baronzio and published by Springer Science & Business Media. This book was released on 2009-04-10 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

Tumor Microenvironment Regulation of Tumor Expansion

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Publisher : Academic Press
ISBN 13 : 0128228040
Total Pages : 174 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Tumor Microenvironment Regulation of Tumor Expansion by : Domenico Ribatti

Download or read book Tumor Microenvironment Regulation of Tumor Expansion written by Domenico Ribatti and published by Academic Press. This book was released on 2021-04-04 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs. - Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression - Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments - Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

Manipulating the Tumor Microenvironment for Therapeutic Benefit

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Manipulating the Tumor Microenvironment for Therapeutic Benefit by : Kate M. Bailey

Download or read book Manipulating the Tumor Microenvironment for Therapeutic Benefit written by Kate M. Bailey and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The physical tumor microenvironment contributes significantly to carcinogenesis, cancer progression and metastatic dissemination. Two main components of the tumor microenvironment, hypoxia and acidosis, are present in nearly every solid tumor and act as powerful selection forces against the tumor. Hypoxia and acidosis promote tumor heterogeneity and contribute to chemotherapy and radiotherapy resistance. This dissertation interrogates methods to target the tumor microenvironment including two novel studies describing mechanisms of buffer therapy resistance and targeting tumor hypoxia with vasodilators to enhance the efficacy of a hypoxia activated prodrug, TH-302. In the first study, mechanisms of buffer therapy resistance were identified and detailed. Many studies have shown that the acidity of solid tumors contributes to local invasion and metastasis. Oral pH buffers can specifically neutralize the acidic pH of tumors and reduce the incidence of local invasion and metastatic formation in multiple murine models. However, this effect is not universal as we have previously observed that metastasis is not inhibited by buffers in some tumor models, regardless of the buffer used. B16-F10 (murine melanoma), LL/2 (murine lung) and HCT116 (human colon) tumors are resistant to treatment with lysine buffer therapy, whereas metastasis is potently inhibited by lysine buffers in MDA-MB-231 (human breast) and PC3M (human prostate) tumors. In the current work, I confirmed that sensitive cells utilized a pH-dependent mechanism for successful metastasis supported by a highly glycolytic phenotype that acidifies the local tumor microenvironment resulting in morphological changes. In contrast, buffer-resistant cell lines exhibited a pH-independent metastatic mechanism involving constitutive secretion of matrix degrading proteases without elevated glycolysis.

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

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Publisher : Springer Nature
ISBN 13 : 4431568808
Total Pages : 325 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cancer Drug Delivery Systems Based on the Tumor Microenvironment by : Yasuhiro Matsumura

Download or read book Cancer Drug Delivery Systems Based on the Tumor Microenvironment written by Yasuhiro Matsumura and published by Springer Nature. This book was released on 2020-01-07 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

Oxygen Transport to Tissue XXVI

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Publisher : Springer Science & Business Media
ISBN 13 : 0387262067
Total Pages : 390 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Oxygen Transport to Tissue XXVI by : Paul Okunieff

Download or read book Oxygen Transport to Tissue XXVI written by Paul Okunieff and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society of Oxygen Transport to Tissue (ISOTT) was founded in 1973 to provide a forum for bioengineers, basic scientists, physiologists, and physicians to discuss new data, original theories, new interpretations of old data, and new technologies for the measurement of oxygen. At each annual meeting all posters are presented orally along with plenary lectures, and all presentations are given in a general session attended by everyone. Each meeting has had a specific focus, ranging from neonatology to physical chemistry to cancer biology. The Society has helped to build many careers, through opportunities to meet leaders in the field, and through awards made to young physicians and scientists. The Society also, through cross fertilization of ideas and scientific comradery, has inspired many breakthroughs in clinical medicine that now benefit mankind. I find myself president of the society after having been a winner of the Melvin Knisely Award for young scientists, in 1991. The 2003 meeting emphasized the role of oxygen and oxygen measurement in tumor growth, metastasis, physiology, and treatment resistance. Additionally, however, completely novel approaches to measurement of tissue oxygen were presented (notably work by Dr. Takahashi) and molecular methods for estimating tissue oxygen were evaluated. Papers discussing other aspects of oxygen measurement and pathophysiology were presented including in vivo ESR spectroscopy (notably including Dr. Swartz and colleagues), exercise physiology, organ transplant outcome (discussed by Dr. Cicco, our 2004 president), circulatory physiology, and cerebral oxygenation (notably including Dr. Chance).

Holland-Frei Cancer Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Tumor Blood Supply and Metabolic Microenvironment

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Publisher :
ISBN 13 : 9783437306754
Total Pages : 340 pages
Book Rating : 4.3/5 (67 download)

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Book Synopsis Tumor Blood Supply and Metabolic Microenvironment by : Peter Vaupel

Download or read book Tumor Blood Supply and Metabolic Microenvironment written by Peter Vaupel and published by . This book was released on 1991 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Vascularization

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Publisher : Academic Press
ISBN 13 : 0128194944
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Tumor Vascularization by : Domenico Ribatti

Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

The Heterogeneity of Cancer Metabolism

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Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

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Publisher : Springer Science & Business Media
ISBN 13 : 3540743863
Total Pages : 363 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies by : Michael Molls

Download or read book The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies written by Michael Molls and published by Springer Science & Business Media. This book was released on 2009-03-25 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.

Advances in Radiation Therapy

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318063622
Total Pages : 146 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Advances in Radiation Therapy by : M. Guckenberger

Download or read book Advances in Radiation Therapy written by M. Guckenberger and published by Karger Medical and Scientific Publishers. This book was released on 2018-04-12 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.

Tumor Blood Supply and Metabolic Microenvironment

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Publisher : Vch Pub
ISBN 13 : 9781560813286
Total Pages : 340 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Tumor Blood Supply and Metabolic Microenvironment by : P. Vaupel

Download or read book Tumor Blood Supply and Metabolic Microenvironment written by P. Vaupel and published by Vch Pub. This book was released on 1991-08-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: