Bk Channels Integrators Of Cellular Signals In Health And Disease

Download Bk Channels Integrators Of Cellular Signals In Health And Disease full books in PDF, epub, and Kindle. Read online Bk Channels Integrators Of Cellular Signals In Health And Disease ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

BK Channels: Integrators of Cellular Signals in Health and Disease

Author : Thomas M. Weiger
Publisher : Frontiers Media SA
ISBN 13 : 2889452913
Total Pages : 185 pages
Book Rating : 4.8/5 (894 download)

DOWNLOAD NOW!

Book Synopsis BK Channels: Integrators of Cellular Signals in Health and Disease by : Thomas M. Weiger

Download or read book BK Channels: Integrators of Cellular Signals in Health and Disease written by Thomas M. Weiger and published by Frontiers Media SA. This book was released on 2017-11-10 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease.

Cellular Signaling in Health and Disease

Author : Martin Beckerman
Publisher : Springer Science & Business Media
ISBN 13 : 038798173X
Total Pages : 477 pages
Book Rating : 4.3/5 (879 download)

DOWNLOAD NOW!

Book Synopsis Cellular Signaling in Health and Disease by : Martin Beckerman

Download or read book Cellular Signaling in Health and Disease written by Martin Beckerman and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Signal Transduction and Smooth Muscle

Author : Mohamed Trebak
Publisher : CRC Press
ISBN 13 : 1498774237
Total Pages : 433 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!

Book Synopsis Signal Transduction and Smooth Muscle by : Mohamed Trebak

Download or read book Signal Transduction and Smooth Muscle written by Mohamed Trebak and published by CRC Press. This book was released on 2018-08-06 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle Chapter 9 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.

Mitochondria in Renal Health and Disease

Author : Egor Plotnikov
Publisher : Frontiers Media SA
ISBN 13 : 2889714047
Total Pages : 129 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!

Book Synopsis Mitochondria in Renal Health and Disease by : Egor Plotnikov

Download or read book Mitochondria in Renal Health and Disease written by Egor Plotnikov and published by Frontiers Media SA. This book was released on 2021-09-29 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ion Channels and Transporters of Epithelia in Health and Disease

Author : Kirk L. Hamilton
Publisher : Springer
ISBN 13 : 1493933663
Total Pages : 1019 pages
Book Rating : 4.4/5 (939 download)

DOWNLOAD NOW!

Book Synopsis Ion Channels and Transporters of Epithelia in Health and Disease by : Kirk L. Hamilton

Download or read book Ion Channels and Transporters of Epithelia in Health and Disease written by Kirk L. Hamilton and published by Springer. This book was released on 2015-12-14 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Mechanobiology Handbook

Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 1420091220
Total Pages : 564 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Mechanobiology Handbook by : Jiro Nagatomi

Download or read book Mechanobiology Handbook written by Jiro Nagatomi and published by CRC Press. This book was released on 2011-03-15 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology-the study of the effects of mechanical environments on the biological processes of cells-has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanob

Mechanobiology Handbook, Second Edition

Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 0429816731
Total Pages : 960 pages
Book Rating : 4.4/5 (298 download)

DOWNLOAD NOW!

Book Synopsis Mechanobiology Handbook, Second Edition by : Jiro Nagatomi

Download or read book Mechanobiology Handbook, Second Edition written by Jiro Nagatomi and published by CRC Press. This book was released on 2018-12-07 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Molecular Components of Store-Operated Calcium Entry in Health and Disease

Author : Joanna Gruszczynska-Biegala
Publisher : Frontiers Media SA
ISBN 13 : 2889717569
Total Pages : 199 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!

Book Synopsis Molecular Components of Store-Operated Calcium Entry in Health and Disease by : Joanna Gruszczynska-Biegala

Download or read book Molecular Components of Store-Operated Calcium Entry in Health and Disease written by Joanna Gruszczynska-Biegala and published by Frontiers Media SA. This book was released on 2021-12-01 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Membrane Transporters and Channels as Targets for Drugs

Author : Graça Soveral
Publisher : Frontiers Media SA
ISBN 13 : 2889633578
Total Pages : 333 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!

Book Synopsis Membrane Transporters and Channels as Targets for Drugs by : Graça Soveral

Download or read book Membrane Transporters and Channels as Targets for Drugs written by Graça Soveral and published by Frontiers Media SA. This book was released on 2020-01-03 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.

Neurobiology of Mental Illness

Author : Dennis S. Charney
Publisher : Oxford University Press
ISBN 13 : 0199934959
Total Pages : 1259 pages
Book Rating : 4.1/5 (999 download)

DOWNLOAD NOW!

Book Synopsis Neurobiology of Mental Illness by : Dennis S. Charney

Download or read book Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press. This book was released on 2013-07-04 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1930 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Medical Microbiology E-Book

Author : Patrick R. Murray
Publisher : Elsevier Health Sciences
ISBN 13 : 0323359523
Total Pages : 888 pages
Book Rating : 4.3/5 (233 download)

DOWNLOAD NOW!

Book Synopsis Medical Microbiology E-Book by : Patrick R. Murray

Download or read book Medical Microbiology E-Book written by Patrick R. Murray and published by Elsevier Health Sciences. This book was released on 2015-09-15 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Turn to Medical Microbiology, 8th Edition for a thorough, clinically relevant understanding of microbes and their diseases. This succinct, easy-to-use text presents the fundamentals of microbiology and immunology in a clearly written, engaging manner—effectively preparing you for your courses, exams, and beyond. Coverage of basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology help you master the essentials. Review questions at the end of each chapter correlate basic science with clinical practice to help you understand the clinical relevance of the organisms examined. Clinical cases illustrate the epidemiology, diagnosis, and treatment of infectious diseases, reinforcing a clinical approach to learning. Full-color clinical photographs, images, and illustrations help you visualize the clinical presentations of infections. Summary tables and text boxes emphasizing essential concepts and learning issues optimize exam review. Additional images, 200 self-assessment questions, NEW animations, and more. Thoroughly updated chapters include the latest information on the human microbiome and probiotics/prebiotics; including a new chapter on Human Microbiome In Health and Disease NEW chapter summaries introduce each microbe chapter, including trigger words and links to the relevant chapter text (on e-book version on Student Consult), providing a concise introduction or convenient review for each topic. Full-color clinical photographs, images, and illustrations help you visualize the clinical presentations of infections. Additional images, 200 self-assessment questions, NEW animations, and more.

Integration of IoT with Cloud Computing for Smart Applications

Author : Rohit Anand
Publisher : CRC Press
ISBN 13 : 1000906094
Total Pages : 267 pages
Book Rating : 4.0/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Integration of IoT with Cloud Computing for Smart Applications by : Rohit Anand

Download or read book Integration of IoT with Cloud Computing for Smart Applications written by Rohit Anand and published by CRC Press. This book was released on 2023-07-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integration of IoT with Cloud Computing for Smart Applications provides an integrative overview of the Internet of Things (IoT) and cloud computing to be used for the various futuristic and intelligent applications. The aim of this book is to integrate IoT and cloud computing to translate ordinary resources into smart things. Discussions in this book include a broad and integrated perspective on the collaboration, security, growth of cloud infrastructure, and real-time data monitoring. Features: Presents an integrated approach to solve the problems related to security, reliability, and energy consumption. Explains a unique approach to discuss the research challenges and opportunities in the field of IoT and cloud computing. Discusses a novel approach for smart agriculture, smart healthcare systems, smart cities and many other modern systems based on machine learning, artificial intelligence, and big data, etc. Information presented in a simplified way for students, researchers, academicians and scientists, business innovators and entrepreneurs, management professionals and practitioners. This book can be great reference for graduate and postgraduate students, researchers, and academicians working in the field of computer science, cloud computing, artificial intelligence, etc.

Dynamics of cyclic nucleotide signaling in neurons

Author : Pierre Vincent
Publisher : Frontiers Media SA
ISBN 13 : 2889196461
Total Pages : 94 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!

Book Synopsis Dynamics of cyclic nucleotide signaling in neurons by : Pierre Vincent

Download or read book Dynamics of cyclic nucleotide signaling in neurons written by Pierre Vincent and published by Frontiers Media SA. This book was released on 2015-09-16 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons.

Braunwald's Heart Disease E-Book

Author : Robert O. Bonow
Publisher : Elsevier Health Sciences
ISBN 13 : 1437727700
Total Pages : 2049 pages
Book Rating : 4.4/5 (377 download)

DOWNLOAD NOW!

Book Synopsis Braunwald's Heart Disease E-Book by : Robert O. Bonow

Download or read book Braunwald's Heart Disease E-Book written by Robert O. Bonow and published by Elsevier Health Sciences. This book was released on 2011-02-25 with total page 2049 pages. Available in PDF, EPUB and Kindle. Book excerpt: Braunwald’s Heart Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, and Peter Libby, this dynamic, multimedia reference helps you apply the most recent knowledge in molecular biology and genetics, imaging, pharmacology, interventional cardiology, electrophysiology, and much more. Weekly updates online, personally selected by Dr. Braunwald, continuously keep you current on the most important new developments affecting your practice. Enhanced premium online content includes new dynamic cardiac imaging videos, heart sound recordings, and podcasts. With sweeping updates throughout, and contributions from a "who’s who" of global cardiology, Braunwald’s is the cornerstone of effective practice. Continuously access the most important new developments affecting your practice with weekly updates personally selected by Dr. Braunwald, including focused reviews, "hot off the press" commentaries, and late-breaking clinical trials. Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Search the complete contents online at www.expertconsult.com. Stay on top of the latest advances in molecular imaging, intravascular ultrasound, cardiovascular regeneration and tissue engineering, device therapy for advanced heart failure, atrial fibrillation management, structural heart disease, Chagasic heart disease, ethics in cardiovascular medicine, the design and conduct of clinical trials, and many other timely topics. Hone your clinical skills with new dynamic cardiac imaging videos, heart sound recordings, and podcasts at www.expertconsult.com.

Hurst's the Heart, 14th Edition: Two Volume Set

Author : Valentin Fuster
Publisher : McGraw Hill Professional
ISBN 13 : 0071842438
Total Pages : 2613 pages
Book Rating : 4.0/5 (718 download)

DOWNLOAD NOW!

Book Synopsis Hurst's the Heart, 14th Edition: Two Volume Set by : Valentin Fuster

Download or read book Hurst's the Heart, 14th Edition: Two Volume Set written by Valentin Fuster and published by McGraw Hill Professional. This book was released on 2017-03-22 with total page 2613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiology’s cornerstone text – thoroughly updated to reflect the latest clinical perspectives and cutting-edge topics Hailed for its authority, currency, and ability to translate the latest technical and clinical advances into clinical application, Hurst’s The Heart is the field’s landmark text and cardiology’s longest continuously published reference text. A previous edition of this trusted classic was described by Doody’s as “an outstanding choice for those who strive for a firm foundation in cardiovascular medicine, as well as an up-to-date and user-friendly source that addresses every discipline in the field.” Readers will find succinct, visually appealing summaries of all the major new trials, and guidelines, along with tips for optimizing outcomes and health quality. The Fourteenth Edition has been completely updated to reflect the latest technical, therapeutic, and clinical advances, while still maintaining a strong focus on patient care. Other enhancements include the addition of textual features such as Practice Points, Common Clinical Questions, and an increased number of the acclaimed Hurst’s diagrams. • NEW TO THIS EDITION: Section on Metabolic Disorders and Cardiovascular Disease, Cigarette Smoking and Cardiovascular Disease • Enhanced by more than 1,500 full-color illustrations and more than 500 tables • Brand new chapters include: Arrythmogenic Cardiomyopathy, Ischemic Mitral Regurgitation, Degenerative Mitral Valve Disease, Left Ventricular Noncompaction, Evaluation and Management of Acute Heart Failure, Carotid Artery Stenting, Race, Ethnicity, and Cardiovascular disease • The only comprehensive cardiology reference to publish every 2.5 years to allow for reporting of the latest trials and guidelines

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

DOWNLOAD NOW!

Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References