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BioWatch PCR Assays

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309367255
Total Pages : 184 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis BioWatch PCR Assays by : National Research Council

Download or read book BioWatch PCR Assays written by National Research Council and published by National Academies Press. This book was released on 2015-06-26 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: BioWatch is an air monitoring system deployed in jurisdictions around the country with the goal of detecting the presence of certain high risk pathogenic microorganisms. It relies on a network of federal and nonfederal collaborative relationships to be successful, and is one part of a larger array of disease surveillance, intelligence-gathering, and biomonitoring activities in support of public safety and health. The assays used in the BioWatch system to detect the presence of pathogens in collected samples rely on the technique of polymerase chain reaction (PCR) to sensitively and specifically amplify target nucleic acid sequences. BioWatch PCR Assays evaluates and provides guidance on appropriate standards for the validation and verification of PCR tests and assays in order to ensure that adequate performance data are available to public health and other key decision makers with a sufficient confidence level to facilitate the public health response to a BioWatch Actionable Response. This report discusses principles of performance standards, reviews information from several existing guidance documents and standards that might be applicable to BioWatch, and discusses assay testing efforts that have occurred or are ongoing. BioWatch PCR Assays provides recommendations on general principles and approaches for a performance standard and validation framework to meet BioWatch's mission. The report also considers how developments in technology, particularly in multiplex PCR and next-generation sequencing, can contribute to the ability of the BioWatch program to meet current and future challenges. This report has been determined to contain information exempt from disclosure under 5 U.S.C. 552(b). Section 15 of the Federal Advisory Committee Act provides that the National Academies shall make its final report available to the public unless the National Academies determines that the report would disclose matters described in one or more of the exemption provisions under the Freedom of Information Act (FOIA). In such case, the National Academies "shall make public an abbreviated version of the report that does not disclose those matters." This unrestricted, abbreviated version of the report represents, in so far as possible, the committee's findings, recommendations, and other substantive material without disclosing materials described in 5 U.S.C. 552(b).

BioWatch and Public Health Surveillance

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030918763X
Total Pages : 252 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis BioWatch and Public Health Surveillance by : National Research Council

Download or read book BioWatch and Public Health Surveillance written by National Research Council and published by National Academies Press. This book was released on 2011-01-25 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the attacks of September 11, 2001 and the anthrax letters, the ability to detect biological threats as quickly as possible became a top priority. In 2003 the Department of Homeland Security (DHS) introduced the BioWatch program-a federal monitoring system intended to speed detection of specific biological agents that could be released in aerosolized form during a biological attack. The present volume evaluates the costs and merits of both the current BioWatch program and the plans for a new generation of BioWatch devices. BioWatch and Public Health Surveillance also examines infectious disease surveillance through hospitals and public health agencies in the United States, and considers whether BioWatch and traditional infectious disease surveillance are redundant or complementary.

Enhancing BioWatch Capabilities Through Technology and Collaboration

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030945168X
Total Pages : 111 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Enhancing BioWatch Capabilities Through Technology and Collaboration by : National Academies of Sciences, Engineering, and Medicine

Download or read book Enhancing BioWatch Capabilities Through Technology and Collaboration written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-29 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Department of Homeland Security's (DHS's) BioWatch program aims to provide an early indication of an aerosolized biological weapon attack. The first generation of BioWatch air samplers were deployed in 2003. The current version of this technology, referred to as Generation 2 (Gen-2), uses daily manual collection and testing of air filters from each monitor, a process that can take 12 to 36 hours to detect the presence of biological pathogens. Until April 2014, DHS pursued a next-generation autonomous detection technology that aimed to shorten the time from sample collection to detection to less than 6 hours, reduce the cost of analysis, and increase the number of detectable biological pathogens. Because of concerns about the cost and effectiveness of the proposed Generation 3 system (Gen-3), DHS cancelled its acquisition plans for the next-generation surveillance system. In response to the cancellation announcement, Congress asked the Government Accountability Office (GAO) to conduct a review of the program and the proposed system enhancements that would have been incorporated in BioWatch Gen-3. However, Mike Walter, BioWatch Program manager, Office of Health Affairs, DHS, said that DHS did not agree with all of GAO's characterizations of the BioWatch program efforts described in this review. In response to this, DHS requested that the National Academies of Sciences, Engineering, and Medicine conduct a workshop to further explore the findings of the 2015 GAO report and discuss the impact these findings may have with regard to the future development of the technical capabilities of the BioWatch program. Workshop participants also discussed existing and possible collaborations between BioWatch, public health laboratories, and other stakeholders that could contribute to the enhancement of biosurveillance capabilities at the federal, state, and local levels. This publication summarizes the presentations and discussions from the workshop.

Biodefense in the Age of Synthetic Biology

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309465184
Total Pages : 189 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Biodefense in the Age of Synthetic Biology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Department of Homeland Security Bioterrorism Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120284
Total Pages : 172 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Department of Homeland Security Bioterrorism Risk Assessment by : National Research Council

Download or read book Department of Homeland Security Bioterrorism Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2009-01-03 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mission of Department of Homeland Security Bioterrorism Risk Assessment: A Call for Change, the book published in December 2008, is to independently and scientifically review the methodology that led to the 2006 Department of Homeland Security report, Bioterrorism Risk Assessment (BTRA) and provide a foundation for future updates. This book identifies a number of fundamental concerns with the BTRA of 2006, ranging from mathematical and statistical mistakes that have corrupted results, to unnecessarily complicated probability models and models with fidelity far exceeding existing data, to more basic questions about how terrorist behavior should be modeled. Rather than merely criticizing what was done in the BTRA of 2006, this new NRC book consults outside experts and collects a number of proposed alternatives that could improve DHS's ability to assess potential terrorist behavior as a key element of risk-informed decision making, and it explains these alternatives in the specific context of the BTRA and the bioterrorism threat.

Microorganisms and Bioterrorism

Author : Burt Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 0387281592
Total Pages : 251 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Microorganisms and Bioterrorism by : Burt Anderson

Download or read book Microorganisms and Bioterrorism written by Burt Anderson and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring together, in a single volume, the most up-to-date information concerning microbes with potential as bioterrorist weapons. The primary audience includes microbiologists, including bacteriologists, virologists and mycologists, in academia, government laboratories and research institutes at the forefront of studies concerning microbes which have potential as bioterrorist weapons, public health physicians and researchers and scientists who must be trained to deal with bioterrorist attacks as well as laboratory investigators who must identify and characterize these microorganisms from the environment and from possibly infected patients.

Tactical Biopolitics

Author : Beatriz Da Costa
Publisher : MIT Press
ISBN 13 : 0262514915
Total Pages : 535 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Tactical Biopolitics by : Beatriz Da Costa

Download or read book Tactical Biopolitics written by Beatriz Da Costa and published by MIT Press. This book was released on 2010-08-13 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists, scholars, and artists consider the political significance of recent advances in the biological sciences. Popular culture in this “biological century” seems to feed on proliferating fears, anxieties, and hopes around the life sciences at a time when such basic concepts as scientific truth, race and gender identity, and the human itself are destabilized in the public eye. Tactical Biopolitics suggests that the political challenges at the intersection of life, science, and art are best addressed through a combination of artistic intervention, critical theorizing, and reflective practices. Transcending disciplinary boundaries, contributions to this volume focus on the political significance of recent advances in the biological sciences and explore the possibility of public participation in scientific discourse, drawing on research and practice in art, biology, critical theory, anthropology, and cultural studies. After framing the subject in terms of both biology and art, Tactical Biopolitics discusses such topics as race and genetics (with contributions from leading biologists Richard Lewontin and Richard Levins); feminist bioscience; the politics of scientific expertise; bioart and the public sphere (with an essay by artist Claire Pentecost); activism and public health (with an essay by Treatment Action Group co-founder Mark Harrington); biosecurity after 9/11 (with essays by artists' collective Critical Art Ensemble and anthropologist Paul Rabinow); and human-animal interaction (with a framing essay by cultural theorist Donna Haraway). Contributors Gaymon Bennett, Larry Carbone, Karen Cardozo, Gary Cass, Beatriz da Costa, Oron Catts, Gabriella Coleman, Critical Art Ensemble, Gwen D'Arcangelis, Troy Duster, Donna Haraway, Mark Harrington, Jens Hauser, Kathy High, Fatimah Jackson, Gwyneth Jones, Jonathan King, Richard Levins, Richard Lewontin, Rachel Mayeri, Sherie McDonald, Claire Pentecost, Kavita Philip, Paul Rabinow, Banu Subramanian, subRosa, Abha Sur, Samir Sur, Jacqueline Stevens, Eugene Thacker, Paul Vanouse, Ionat Zurr

A Framework for Assessing the Health Hazard Posed by Bioaerosols

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309178436
Total Pages : 100 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Framework for Assessing the Health Hazard Posed by Bioaerosols by : National Research Council

Download or read book A Framework for Assessing the Health Hazard Posed by Bioaerosols written by National Research Council and published by National Academies Press. This book was released on 2008-10-30 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological warfare agent (BWA) detectors are designed to provide alerts to military personnel of the presence of dangerous biological agents. Detecting such agents promptly makes it possible to minimize contamination and personnel exposure and initiate early treatment. It is also important, though, that detectors not raise an alarm when the situation does not warrant it. The question considered in this book is whether Agent-Containing Particles per Liter of Air (ACPLA) is an appropriate unit of measure for use in the evaluation of aerosol detectors and whether a better, alternative measure can be developed. The book finds that ACPLA alone cannot determine whether a health threat exists. In order to be useful and comparable across all biological agents and detection systems, measurements must ultimately be related to health hazard. A Framework for Assessing the Health Hazard Posed by Bioaerosols outlines the possibility of a more complex, but more useful measurement framework that makes it possible to evaluate relative hazard by including agent identity and activity, particle size, and infectious dose.

Microbial Forensics

Author : Bruce Budowle
Publisher : Academic Press
ISBN 13 : 0123820073
Total Pages : 753 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Microbial Forensics by : Bruce Budowle

Download or read book Microbial Forensics written by Bruce Budowle and published by Academic Press. This book was released on 2010-10-27 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Forensics is a rapidly evolving scientific discipline. In the last decade, and particularly due to the anthrax letter attacks in the United States, microbial forensics has become more formalized and has played an increasingly greater role in crime investigations. This has brought renewed interest, development and application of new technologies, and new rules of forensic and policy engagement. It has many applications ranging from biodefense, criminal investigations, providing intelligence information, making society more secure, and helping protect precious resources, particularly human life. A combination of diverse areas is investigated, including the major disciplines of biology, microbiology, medicine, chemistry, physics, statistics, population genetics, and computer science. Microbial Forensics, Second Edition is fully revised and updated and serves as a complete reference of the discipline. It describes the advances, as well as the challenges and opportunities ahead, and will be integral in applying science to help solve future biocrimes. - A collection of microbiology, virology, toxicology and mycology as it relates to forensics, in one reference - New and expanded content to include statistical analysis of forensic data and legal admissibility and the standards of evidence, to name a few - Includes research information and application of that research to crime scene analysis, which will allow practitioners to understand and apply the knowledge to their practice with ease

Defense Against Biological Attacks

Author : Sunit K. Singh
Publisher : Springer
ISBN 13 : 3030030539
Total Pages : 332 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Defense Against Biological Attacks by : Sunit K. Singh

Download or read book Defense Against Biological Attacks written by Sunit K. Singh and published by Springer. This book was released on 2019-03-30 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first volume of a two-volume set describes general aspects, such as the historical view on the topic, the role of information distribution and preparedness of health-care systems and preparedness in emergency cases. Part two describes and discusseses in detail the pathogens and toxins that are potentially used for biological attacks. As such, the book is a valuable resource for faculties engaged in molecular biology, genetic engineering, neurology, biodefense, biosafety & biosecurity, virology, and infectious disease programs, as well as professional medical research organizations.

Computational Intelligence Techniques for Combating COVID-19

Author : Sandeep Kautish
Publisher : Springer Nature
ISBN 13 : 3030689360
Total Pages : 392 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Computational Intelligence Techniques for Combating COVID-19 by : Sandeep Kautish

Download or read book Computational Intelligence Techniques for Combating COVID-19 written by Sandeep Kautish and published by Springer Nature. This book was released on 2021 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest cutting edge research, theoretical methods, and novel applications in the field of computational intelligence and computational biological approaches that are aiming to combat COVID-19. The book gives the technological key drivers behind using AI to find drugs that target the virus, shedding light on the structure of COVID-19, detecting the outbreak and spread of new diseases, spotting signs of a COVID-19 infection in medical images, monitoring how the virus and lockdown is affecting mental health, and forecasting how COVID-19 cases and deaths will spread across cities and why. Further, the book helps readers understand computational intelligence techniques combating COVID-19 in a simple and systematic way. Provides a comprehensive reference covering innovations and development of theories, conceptual models and computational algorithms focused on COVID-19; Asserts all relevant research, key themes, complex adaptive systems, metrics and paradigms dedicated towards COVID-19, enabled with evolutionary methods of computational sciences; Explores how AI and computational techniques can help to predict which patients with the virus would go on to develop Acute Respiratory Distress Syndrome (ARDS).

Strategies for Effective Improvements to the BioWatch System

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030947177X
Total Pages : 223 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Strategies for Effective Improvements to the BioWatch System by : National Academies of Sciences, Engineering, and Medicine

Download or read book Strategies for Effective Improvements to the BioWatch System written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-04-17 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: BioWatch is the Department of Homeland Security's (DHS's) system for detecting an aerosolized biological attack using collectors that are positioned strategically across the country to continuously monitor the air for biological threats. As currently deployed, BioWatch collectors draw air through filters that field technicians collect daily and transport to laboratories, where professional technicians analyze the material collected on the filter for evidence of biological threats. As part of the BioWatch program's efforts to enhance its effectiveness and capabilities, particularly with regard to detecting biological threats in challenging indoor environments, DHS requested the National Academies of Sciences, Engineering, and Medicine hold a workshop to explore alternative and effective biodetection systems for aerosolized biological agents that would meet BioWatch's technical and operational requirements, integrate into the existing system architecture and public health infrastructure, and be deployable by 2027. This publication summarizes the presentations and discussions from the workshop.

Returning Individual Research Results to Participants

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309475201
Total Pages : 399 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Returning Individual Research Results to Participants by : National Academies of Sciences, Engineering, and Medicine

Download or read book Returning Individual Research Results to Participants written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-08-23 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: When is it appropriate to return individual research results to participants? The immense interest in this question has been fostered by the growing movement toward greater transparency and participant engagement in the research enterprise. Yet, the risks of returning individual research resultsâ€"such as results with unknown validityâ€"and the associated burdens on the research enterprise are competing considerations. Returning Individual Research Results to Participants reviews the current evidence on the benefits, harms, and costs of returning individual research results, while also considering the ethical, social, operational, and regulatory aspects of the practice. This report includes 12 recommendations directed to various stakeholdersâ€"investigators, sponsors, research institutions, institutional review boards (IRBs), regulators, and participantsâ€"and are designed to help (1) support decision making regarding the return of results on a study-by-study basis, (2) promote high-quality individual research results, (3) foster participant understanding of individual research results, and (4) revise and harmonize current regulations.

Continuing Concerns Over BioWatch and the Surveillance of Bioterrorism

Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Continuing Concerns Over BioWatch and the Surveillance of Bioterrorism by : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations

Download or read book Continuing Concerns Over BioWatch and the Surveillance of Bioterrorism written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations and published by . This book was released on 2014 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Defense Against Bioterror: Detection Technologies, Implementation Strategies and Commercial Opportunities

Author : Dennis Morrison
Publisher : Springer Science & Business Media
ISBN 13 : 9781402033858
Total Pages : 342 pages
Book Rating : 4.0/5 (338 download)

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Book Synopsis Defense Against Bioterror: Detection Technologies, Implementation Strategies and Commercial Opportunities by : Dennis Morrison

Download or read book Defense Against Bioterror: Detection Technologies, Implementation Strategies and Commercial Opportunities written by Dennis Morrison and published by Springer Science & Business Media. This book was released on 2005-12-13 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a critical assessment of breakthrough biosensor technologies that will allow for the rapid identification of biological threat agents in the environment and human population. The book provides a comprehensive overview of the current state of biological weapons threat, and reviews biosensor technologies including detection platforms, networked alarm-type biodetector systems, implementation strategies, electro-optical and electrochemical biosensors.

The Prokaryotes

Author : Edward F. DeLong
Publisher : Springer
ISBN 13 : 9783642389214
Total Pages : 0 pages
Book Rating : 4.3/5 (892 download)

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Book Synopsis The Prokaryotes by : Edward F. DeLong

Download or read book The Prokaryotes written by Edward F. DeLong and published by Springer. This book was released on 2014-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Prokaryotes is a comprehensive, multi-authored, peer reviewed reference work on Bacteria and Achaea. This fourth edition of The Prokaryotes is organized to cover all taxonomic diversity, using the family level to delineate chapters. Different from other resources, this new Springer product includes not only taxonomy, but also prokaryotic biology and technology of taxa in a broad context. Technological aspects highlight the usefulness of prokaryotes in processes and products, including biocontrol agents and as genetics tools. The content of the expanded fourth edition is divided into two parts: Part 1 contains review chapters dealing with the most important general concepts in molecular, applied and general prokaryote biology; Part 2 describes the known properties of specific taxonomic groups. Two completely new sections have been added to Part 1: bacterial communities and human bacteriology. The bacterial communities section reflects the growing realization that studies on pure cultures of bacteria have led to an incomplete picture of the microbial world for two fundamental reasons: the vast majority of bacteria in soil, water and associated with biological tissues are currently not culturable, and that an understanding of microbial ecology requires knowledge on how different bacterial species interact with each other in their natural environment. The new section on human microbiology deals with bacteria associated with healthy humans and bacterial pathogenesis. Each of the major human diseases caused by bacteria is reviewed, from identifying the pathogens by classical clinical and non-culturing techniques to the biochemical mechanisms of the disease process. The 4th edition of The Prokaryotes is the most complete resource on the biology of prokaryotes. The following volumes are published consecutively within the 4th Edition: Prokaryotic Biology and Symbiotic Associations Prokaryotic Communities and Ecophysiology Prokaryotic Physiology and Biochemistry Applied Bacteriology and Biotechnology Human Microbiology Actinobacteria Firmicutes Alphaproteobacteria and Betaproteobacteria Gammaproteobacteria Deltaproteobacteria and Epsilonproteobacteria Other Major Lineages of Bacteria and the Archaea

International Complete Collection of R&D Information about Traditional Chinese Materia Medica and Biotechnology Enterprises

Author : Zhengsong Zhan
Publisher : World Scientific
ISBN 13 : 9814291560
Total Pages : 1006 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis International Complete Collection of R&D Information about Traditional Chinese Materia Medica and Biotechnology Enterprises by : Zhengsong Zhan

Download or read book International Complete Collection of R&D Information about Traditional Chinese Materia Medica and Biotechnology Enterprises written by Zhengsong Zhan and published by World Scientific. This book was released on 2010-04-01 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Complete Collection of R&D Information about Traditional Chinese Materia Medica (TCMM) and Biotechnology (BT) Enterprises is designed as an informative medicinal reference directory listing of up-to-date R&D information about TCMM, medical biotechnology, and related medical equipment companies. The focus of this valuable and practical directory is on providing a comprehensive coverage of the most recent developments in scientific research, patents and major products of about 3,000 companies from 50 countries covering the five continents: Asia, Europe, America, Africa and the Oceania. The resource material and information are relevant and compulsory to practitioners and professionals in the fields of TCMM, medical biotechnology, biochemical industry and related medical instrumentation/equipment, as well as to organizational departments of the medicinal information management, intelligence, logistics and trade. The directory also opens up and serves as an important window through which biotech professionals master product information of their counterparts across the world. The directory will benefit professionals of medical heath, TCMM, biotechnology and related fields, as well as academics and students, executives of research, information media staffs and translators.