Bioreactor Modeling

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Bioreactor Modeling

Author : Jerome Morchain
Publisher : Elsevier
ISBN 13 : 0081011660
Total Pages : 220 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Bioreactor Modeling by : Jerome Morchain

Download or read book Bioreactor Modeling written by Jerome Morchain and published by Elsevier. This book was released on 2017-10-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. - Presents a multiphase description of bioreactor modeling - Includes a combination of concepts issued from different scientific fields to address a practical issue - Provides a detailed description of the population balance concept as applied to biological systems - Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

Bioreaction Engineering

Author : K. Schügerl
Publisher : Springer Science & Business Media
ISBN 13 : 3642597351
Total Pages : 639 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Bioreaction Engineering by : K. Schügerl

Download or read book Bioreaction Engineering written by K. Schügerl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Industrial Biotechnology

Author : Christoph Wittmann
Publisher : John Wiley & Sons
ISBN 13 : 3527341811
Total Pages : 642 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Industrial Biotechnology by : Christoph Wittmann

Download or read book Industrial Biotechnology written by Christoph Wittmann and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.

Bioreactors

Author : Lakhveer Singh
Publisher : Elsevier
ISBN 13 : 0128212640
Total Pages : 336 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Bioreactors by : Lakhveer Singh

Download or read book Bioreactors written by Lakhveer Singh and published by Elsevier. This book was released on 2020-04-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.

Advanced Methods and Mathematical Modeling of Biofilms

Author : Mojtaba Aghajani Delavar
Publisher : Academic Press
ISBN 13 : 0323903746
Total Pages : 266 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advanced Methods and Mathematical Modeling of Biofilms by : Mojtaba Aghajani Delavar

Download or read book Advanced Methods and Mathematical Modeling of Biofilms written by Mojtaba Aghajani Delavar and published by Academic Press. This book was released on 2022-05-14 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Mathematical Modelling of Biofilms and its Applications covers the concepts and fundamentals of biofilms, including sections on numerical discrete and numerical continuum models and different biofilms methods, e.g., the lattice Boltzmann method (LBM) and cellular automata (CA) and integrated LBM and individual-based model (iBM). Other sections focus on design, problem-solving and state-of-the-art modelling methods. Addressing the needs to upgrade and update information and knowledge for students, researchers and engineers on biofilms in health care, medicine, food, aquaculture and industry, this book also covers areas of uncertainty and future needs for advancing the use of biofilm models. Over the past 25-30 years, there have been rapid advances in various areas of computer technologies, applications and methods (e.g. complex programming and algorithms, lattice Boltzmann method, high resolution visualization and high-performance computation). These new and emerging technologies are providing unprecedented opportunities to develop modeling frameworks of biofilms and their applications. - Introduces state-of-the-art methods of biofilm modeling, such as integrated lattice Boltzmann method (LBM) and cellular automata (CA) and integrated LBM and individual-based model (iBM) - Provides recent progress in more powerful tools for a deeper understanding of biofilm complexity by implementing state-of-the art biofilm modeling programs - Compares advantages and disadvantages of different biofilm models and analyzes some specific problems for model selection - Evaluates novel process designs without the cost, time and risk of building a physical prototype of the process to identify the most promising designs for experimental testing

Bioreactor Technology in Food Processing

Author : Rosane F. Schwan
Publisher : CRC Press
ISBN 13 : 0429754396
Total Pages : 649 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Bioreactor Technology in Food Processing by : Rosane F. Schwan

Download or read book Bioreactor Technology in Food Processing written by Rosane F. Schwan and published by CRC Press. This book was released on 2024-11-29 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactor Technology in Food Processing brings peculiarities, specificities, and updates on bioreactors and bioprocesses related to food and beverage production. The 26 chapters of this book are the result of the participation of more than 70 professionals, including professors, researchers, and experts from the industrial sector from different countries around the world. The chapters cover such topics as history, classification, scale-up, analytical tools, and mathematical and kinetic models for the operation of bioreactors in the food industry. In addition, chapters detail the characteristics of bioreactors for the production of food (bread, cheese, and coffee fermentation) and fermented beverages (beer, wine), distilled beverages, and organic compounds such as enzymes, acids, aromas, and pigments (biocolorants), among others. Key Features: Describes the basic and applied aspects of bioreactor in food processing Gathers information on bioreactors that is scattered in different journals and monographs as reviews and research articles Covers various types of bioreactors including stirred tank, airlift, photo-bioreactor, and disposable bioreactors Gives a broad overview of what exactly is involved in designing a bioreactor and optimizing its performance and finally their applications in the food processing industry The broad interdisciplinary approach of this book will certainly make your reading very interesting, and we hope that it can contribute to knowledge and instigate creative thinking to overcome the challenges that food bioprocessing brings us.

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

Author : Enes Kadic
Publisher : John Wiley & Sons
ISBN 13 : 1118869834
Total Pages : 330 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer by : Enes Kadic

Download or read book An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer written by Enes Kadic and published by John Wiley & Sons. This book was released on 2014-03-14 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current process needs Reviews the problems of bioreactor selection globally while considering all bioreactor options rather than concentrating on one specific bioreactor type

Solid-State Fermentation Bioreactors

Author : David A. Mitchell
Publisher : Springer Science & Business Media
ISBN 13 : 3540312862
Total Pages : 481 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Solid-State Fermentation Bioreactors by : David A. Mitchell

Download or read book Solid-State Fermentation Bioreactors written by David A. Mitchell and published by Springer Science & Business Media. This book was released on 2006-08-02 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Predictive Modeling of Pharmaceutical Unit Operations

Author : Preetanshu Pandey
Publisher : Woodhead Publishing
ISBN 13 : 0081001800
Total Pages : 465 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Predictive Modeling of Pharmaceutical Unit Operations by : Preetanshu Pandey

Download or read book Predictive Modeling of Pharmaceutical Unit Operations written by Preetanshu Pandey and published by Woodhead Publishing. This book was released on 2016-09-26 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. - Explains the commonly used modeling and simulation tools - Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing - Practical examples of the application of modeling tools through case studies - Discussion of modeling techniques used for a risk-based approach to regulatory filings - Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points

Computational Modeling in Bioengineering and Bioinformatics

Author : Nenad Filipovic
Publisher : Academic Press
ISBN 13 : 0128195843
Total Pages : 448 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Computational Modeling in Bioengineering and Bioinformatics by : Nenad Filipovic

Download or read book Computational Modeling in Bioengineering and Bioinformatics written by Nenad Filipovic and published by Academic Press. This book was released on 2019-10-09 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering. The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia. - Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research - Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others - Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis

Bioreactors

Author : Carl-Fredrik Mandenius
Publisher : John Wiley & Sons
ISBN 13 : 3527683372
Total Pages : 520 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Bioreactors by : Carl-Fredrik Mandenius

Download or read book Bioreactors written by Carl-Fredrik Mandenius and published by John Wiley & Sons. This book was released on 2016-02-16 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Current Developments in Biotechnology and Bioengineering

Author : Ashok Pandey
Publisher : Elsevier
ISBN 13 : 0323984835
Total Pages : 523 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Current Developments in Biotechnology and Bioengineering by : Ashok Pandey

Download or read book Current Developments in Biotechnology and Bioengineering written by Ashok Pandey and published by Elsevier. This book was released on 2022-08-18 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future. - Covers state-of-the-art, technological advancements in the field of bioprocessing - Includes design and scale-up of bioreactors, monitoring and control systems, advances in upstream and downstream processing - Includes design and development of fermentation processes such as the suitability of experimental design, full factorial, central composite design, Box-Behnken, Plackett-Burman, and more

CFD Modeling of Complex Chemical Processes

Author : Li Xi
Publisher : MDPI
ISBN 13 : 3036512667
Total Pages : 296 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis CFD Modeling of Complex Chemical Processes by : Li Xi

Download or read book CFD Modeling of Complex Chemical Processes written by Li Xi and published by MDPI. This book was released on 2021-09-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development. Complex chemical processes often involve coupling between dynamics at vastly different length and time scales, as well as coupling of different physical models. The multiscale and multiphysics nature of those problems calls for delicate modeling approaches. This book showcases recent contributions in this field, from the development of modeling methodology to its application in supporting the design, development, and optimization of engineering processes.

Bioreactors

Author : Goutam Saha
Publisher : CRC Press
ISBN 13 : 1498736025
Total Pages : 121 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Bioreactors by : Goutam Saha

Download or read book Bioreactors written by Goutam Saha and published by CRC Press. This book was released on 2017-12-01 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Biological Reaction Engineering

Author : Elmar Heinzle
Publisher : John Wiley & Sons
ISBN 13 : 3527325247
Total Pages : 62 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Biological Reaction Engineering by : Elmar Heinzle

Download or read book Biological Reaction Engineering written by Elmar Heinzle and published by John Wiley & Sons. This book was released on 2021-07-06 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical book presents the modeling of dynamic biological engineering processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh computers. Madonna solves models comprising many ordinary differential equations using very simple programming, including arrays. It is so powerful that the model parameters may be defined as "sliders", which allow the effect of their change on the model behavior to be seen almost immediately. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be viewed simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance. The extensive teaching experience of the authors is reflected in this well-balanced presentation, which is suitable for the teacher, student, biochemist or the engineer.

Comprehensive Biotechnology

Author :
Publisher : Elsevier
ISBN 13 : 0444640479
Total Pages : 4876 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Comprehensive Biotechnology by :

Download or read book Comprehensive Biotechnology written by and published by Elsevier. This book was released on 2019-07-17 with total page 4876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science

Hybrid Modeling in Process Industries

Author : Jarka Glassey
Publisher : CRC Press
ISBN 13 : 1351184369
Total Pages : 219 pages
Book Rating : 4.3/5 (511 download)

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Book Synopsis Hybrid Modeling in Process Industries by : Jarka Glassey

Download or read book Hybrid Modeling in Process Industries written by Jarka Glassey and published by CRC Press. This book was released on 2018-02-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title introduces the underlying theory and demonstrates practical applications in different process industries using hybrid modeling. It reviews hybrid modeling approach applicability in wide range of process industries, recommends how to increase hybrid model performance and throw Insights into cost efficient practices in modeling techniques Discusses advance process operation maximizing the benefits of available process knowledge and Includes real-life and practical case studies