Biomarkers Of Environmental Toxicants

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Biomarkers of Environmental Toxicants

Author : Kun Lu
Publisher : Mdpi AG
ISBN 13 : 9783039367368
Total Pages : 292 pages
Book Rating : 4.3/5 (673 download)

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Book Synopsis Biomarkers of Environmental Toxicants by : Kun Lu

Download or read book Biomarkers of Environmental Toxicants written by Kun Lu and published by Mdpi AG. This book was released on 2020-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.

Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants

Author : Curtis C. Travis
Publisher : Springer Science & Business Media
ISBN 13 : 1489920528
Total Pages : 283 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants by : Curtis C. Travis

Download or read book Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants written by Curtis C. Travis and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological markers (biomarkers) are useful tools for understanding the nature and extent of human exposure and risk from environmental toxicants. Biomarkers are classified into three basic categories: exposure, effect, or susceptibility. A marker of exposure is the product of the interaction between a target cell or molecule and a foreign substance (NAS, 1989). These markers can be used to determine the biologically effective dose necessary to elicit a particular physiological change in an organism. A marker of effect is a biochemical or physiological change in an organism that can predict the onset of adverse health effects resulting from a given exposure. Lastly, markers of susceptibility act as indicators of an inherent or acquired tendency of an organism to experience an adverse health effect (NAS, 1989). These markers are already used to detect a variety of diseases and show great promise for developing a better understanding of the mechanicisms of disease. Additionally, biomarkers can be used to establish a more rational basis for quantitative risk extrapolation between species, as weIl as to obtain more precise estimates of the time of critical exposure. These markers can also prove helpful in identifying potentially damaging exposures before the onset of adverse health effects. Biomarkers serve as a valuable exposure assessment tool because they take into account exposure from all routes and integrate exposure from all sources. They have the potential to yield better risk estimates than current monitoring and modeling protocols. In lune 1992, Dr. Travis and Dr.

Human Biomonitoring for Environmental Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309133904
Total Pages : 316 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Biomonitoring for Environmental Chemicals by : National Research Council

Download or read book Human Biomonitoring for Environmental Chemicals written by National Research Council and published by National Academies Press. This book was released on 2006-10-30 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Identification of Candidate Exposure Biomarkers for Toxicants in Complex Environmental Matrices

Author : Natalie Ann Osika
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (794 download)

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Book Synopsis Identification of Candidate Exposure Biomarkers for Toxicants in Complex Environmental Matrices by : Natalie Ann Osika

Download or read book Identification of Candidate Exposure Biomarkers for Toxicants in Complex Environmental Matrices written by Natalie Ann Osika and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term "biomarker" refers to an indicator employed to monitor the interactions between a xenobiotic and an individual, provide information of an individual's biologic state, or refer to an individual's susceptibility to a xenobiotic, condition or disease. They are currently employed to assess exposure to, or effects from, environmental toxicants. It is important to have biomarkers that can accurately and precisely assess complex mixture exposures, since environmental exposures to single substances rarely occur outside the laboratory setting, and complex exposures are often associated with specific occupational or environmental settings. This project employed microarray technology and subsequent bioinformatic analyses to identify candidate biomarkers of ' in vitro' exposure to coal tar extract. Murine pulmonary epithelial cells were exposed to coal tar extract and gene expression was assessed using microarrays. The results showed that expression of genes involved in steroidogenesis, cytokine-cytokine interaction, angiogenesis, as well as several genes that code for secreted proteins, were altered by coal tar exposure. The entire work constitutes the initial stages of a project that will ultimately identify gene expression and secretome profiles that are specific to coal tar exposure.

Bioindicators and Biomarkers of Environmental Pollution and Risk Assessment

Author : Jamil Kaiser
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Bioindicators and Biomarkers of Environmental Pollution and Risk Assessment by : Jamil Kaiser

Download or read book Bioindicators and Biomarkers of Environmental Pollution and Risk Assessment written by Jamil Kaiser and published by . This book was released on 2001 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the reader with an overview of the variety of animal and plants that are available for use as environmental monitors. The author emphasizes that the use of a single species of target bioindicator is not appropriate or scientifically sound for the monitoring of several toxic pollutants.

Perspectives in Environmental Toxicology

Author : Kavindra Kumar Kesari
Publisher : Springer
ISBN 13 : 3319462482
Total Pages : 224 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Perspectives in Environmental Toxicology by : Kavindra Kumar Kesari

Download or read book Perspectives in Environmental Toxicology written by Kavindra Kumar Kesari and published by Springer. This book was released on 2017-03-07 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a valuable contribution to the debate about the harmful effects of environmental toxicants on human health, which is a growing concern in the 21st century. Complementary chapters decipher the phenomena and highlight the latest developments in environmental toxicology, providing readers with a comprehensive overview of environmental toxicology and human health. Since the toxicants in question are not only chemical or biological in nature, but also include man-made electromagnetic fields, the book explores in detail multidisciplinary approaches to environmental toxicology, with a focus on the following five aspects: 1. The effects of man-made electromagnetic fields (RF-EMF) on human health proposed mechanisms and biological effects and measures). 2. An overview of nanotoxicity, nanomedicine and cancer research. 3. A bio-computational approach to the molecular interaction of environmental carcinogens with DNA. 4. The toxicology of environmental pollutants in the air, dust, soil, water and natural toxins in the environment: exposure and health. 5. Social insects as environmental indicators of ecotoxicological effects in different ecosystems. The book analyzes the carcinogenic, mutagenic, genotoxic and neurotoxic effects of both anthropogenic and natural toxins present in water, soil, air and our surroundings in the form of electro-pollution or electro-smog.

Biomarkers of Environmental Contamination

Author : 0 McCarthy
Publisher : CRC Press
ISBN 13 : 1351087169
Total Pages : 485 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Biomarkers of Environmental Contamination by : 0 McCarthy

Download or read book Biomarkers of Environmental Contamination written by 0 McCarthy and published by CRC Press. This book was released on 2018-01-18 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.

Cellular Models for Environmental Toxicant Biomarker Discovery

Author :
Publisher :
ISBN 13 :
Total Pages : 5 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Cellular Models for Environmental Toxicant Biomarker Discovery by :

Download or read book Cellular Models for Environmental Toxicant Biomarker Discovery written by and published by . This book was released on 2006 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: A research and development priority in the area of occupational environmental health surveillance (OEHS) is the development of biomarkers of exposure, effect, and susceptibility. As exposure monitoring using environmental sampling equipment can be impractical and doesn't account for differences in individual responses, new methodologies must be sought. Biomarkers offer the opportunity to quantify toxic exposures and effects in individuals before, during, and after deployments. Therefore, concerted efforts in this area of research are underway at the U.S. Army Center for Environmental Health Research (USACEHR). This report demonstrates the feasibility of using in vitro cellular models as biomarker discovery tools. The combination of these models with state of the art proteomic screening technologies and an enzyme-linked immunosorbent assay (ELISA), provides insight into the effects of trinitrotoluene (TNT), dinitrobenzene (DNB), and the carbamate aldicarb. The results of these toxicant exposures are discussed.

Biomarkers in Toxicology

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0124046495
Total Pages : 1149 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Biomarkers in Toxicology by : Ramesh C Gupta

Download or read book Biomarkers in Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2014-01-25 with total page 1149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

Biomarkers

Author : David B. Peakall
Publisher : Springer Science & Business Media
ISBN 13 : 3642846319
Total Pages : 136 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Biomarkers by : David B. Peakall

Download or read book Biomarkers written by David B. Peakall and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program.

Environmental Toxicants

Author : Morton Lippmann
Publisher : John Wiley & Sons
ISBN 13 : 0470442883
Total Pages : 1189 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Environmental Toxicants by : Morton Lippmann

Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Environmental Toxicology and Risk Assessment

Author : Diane S. Henshel
Publisher : ASTM International
ISBN 13 : 0803120311
Total Pages : 485 pages
Book Rating : 4.8/5 (31 download)

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Book Synopsis Environmental Toxicology and Risk Assessment by : Diane S. Henshel

Download or read book Environmental Toxicology and Risk Assessment written by Diane S. Henshel and published by ASTM International. This book was released on 1996 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Biomarkers of Environmental Contamination

Author : 0 McCarthy
Publisher : CRC Press
ISBN 13 : 1351078712
Total Pages : 467 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Biomarkers of Environmental Contamination by : 0 McCarthy

Download or read book Biomarkers of Environmental Contamination written by 0 McCarthy and published by CRC Press. This book was released on 2018-01-18 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.

Biologic Markers in Reproductive Toxicology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 9780309039796
Total Pages : 198 pages
Book Rating : 4.0/5 (397 download)

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Book Synopsis Biologic Markers in Reproductive Toxicology by : National Research Council

Download or read book Biologic Markers in Reproductive Toxicology written by National Research Council and published by National Academies Press. This book was released on 1989-02-01 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Use of Biomarkers for Environmental Quality Assessment

Author : Jean-Claude Amiard
Publisher : CRC Press
ISBN 13 : 1000448371
Total Pages : 370 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Use of Biomarkers for Environmental Quality Assessment by : Jean-Claude Amiard

Download or read book Use of Biomarkers for Environmental Quality Assessment written by Jean-Claude Amiard and published by CRC Press. This book was released on 2021-05-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is primarily designed for any person or organization in charge of assessment of the quality of natural resources and of pollution prevention.

Encyclopedia of Aquatic Ecotoxicology

Author : Jean-Francois Férard
Publisher : Springer
ISBN 13 : 9789400750401
Total Pages : 0 pages
Book Rating : 4.7/5 (54 download)

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Book Synopsis Encyclopedia of Aquatic Ecotoxicology by : Jean-Francois Férard

Download or read book Encyclopedia of Aquatic Ecotoxicology written by Jean-Francois Férard and published by Springer. This book was released on 2013-06-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its 104 chapters, this Encyclopedia of aquatic ecotoxicology reveals the diversity of issues, problems and challenges that have faced, and are facing today, receiving environments. It also indicates ways by which tools, strategies and future investigations can contribute to correct, minimize, solve and prevent water quality degradation. Structured homogeneously, the chapters convey salient information on historical background, features, characteristics, uses and/or applications of treated topics, often complemented by illustrations and case studies, as well as by conclusions and prospects. This work is most suitable for teaching purposes. Academics, for example, could literally deliver comprehensive lectures to students simply based on chapter outlines and contents. Meet the Authors of the Encyclopedia! Check out 'Meet the Authors' under ADDITIONAL INFORMATION (Right menu).

Stress-Inducible Cellular Responses

Author : U. Feige
Publisher : Springer Science & Business Media
ISBN 13 : 9783764352059
Total Pages : 514 pages
Book Rating : 4.3/5 (52 download)

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Book Synopsis Stress-Inducible Cellular Responses by : U. Feige

Download or read book Stress-Inducible Cellular Responses written by U. Feige and published by Springer Science & Business Media. This book was released on 1996-09-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimental approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins.