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Biomarkers In Cancer Detection And Monitoring Of Therapeutics
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Book Synopsis Biomarkers in Cancer Detection and Monitoring of Therapeutics by : Ranbir Chander Sobti
Download or read book Biomarkers in Cancer Detection and Monitoring of Therapeutics written by Ranbir Chander Sobti and published by Academic Press. This book was released on 2023-11-16 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. Provides up-to-date information on current molecular biomarkers research for cancer Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient’s survivorship Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas
Book Synopsis Biomarkers in Cancer Detection and Monitoring of Therapeutics by : Ranbir Chander Sobti
Download or read book Biomarkers in Cancer Detection and Monitoring of Therapeutics written by Ranbir Chander Sobti and published by Academic Press. This book was released on 2023-11-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine.This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research. Provides up-to-date information on current molecular biomarkers research for cancer Presents basic research aspects and novel technologies applied in the discovery of new biomarkers Discusses several technologies, including artificial intelligence, robotics, data mining, gene editing, omics and their applicability for specific cancer types
Book Synopsis Biomarkers in Cancer Therapy by : Hideaki Shimada
Download or read book Biomarkers in Cancer Therapy written by Hideaki Shimada and published by Springer. This book was released on 2019-05-30 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is focused on proteomics or gene analysis of resected tissue, diagnostic markers have since become significant in terms of gauging the effectiveness of molecularly targeted drugs or the likelihood of a favorable prognosis. In addition, conventional treatment strategy, which draws on archives of resected tissue samples, is now gradually being replaced by monitoring with the use of liquid biopsy, which is poised to become the new mainstream in molecular targeting therapy. The contributing authors discuss in detail biomarkers, molecular targets for treatment, monitoring markers to evaluate treatment responses, prognostic markers, and screening and early diagnosis. Accordingly, this excellent collection of texts will benefit not only oncologists, but also medical and biological researchers and pharmaceutical scientists involved in the latest cancer research.
Book Synopsis Cancer Biomarkers in Diagnosis and Therapeutics by : Adeeb Shehzad
Download or read book Cancer Biomarkers in Diagnosis and Therapeutics written by Adeeb Shehzad and published by Springer Nature. This book was released on 2022-05-27 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
Book Synopsis Molecular Biomarkers for Cancer Diagnosis and Therapy by : Ranbir Chander Sobti
Download or read book Molecular Biomarkers for Cancer Diagnosis and Therapy written by Ranbir Chander Sobti and published by Springer. This book was released on 2023-08-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particular interest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.
Book Synopsis Cancer Biomarkers: Clinical Aspects and Laboratory Determination by : Lakshmi V. Ramanathan
Download or read book Cancer Biomarkers: Clinical Aspects and Laboratory Determination written by Lakshmi V. Ramanathan and published by Elsevier. This book was released on 2022-06-07 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Biomarkers: Clinical Aspects and Laboratory Determination provides a comprehensive overview of current biomarkers for cancer detection, monitoring and recurrence, focusing on emerging technologies, impacts on the field, and selected biomarkers currently used in clinical practice. The content highlights current laboratory tests used in the management of adult and pediatric cancer patients. In addition, it investigates the role of Circulating Tumor Cells and circulating tumor DNA as biomarkers in cancer management as well as cytokines in monitoring response to CAR T therapies. This title is a perfect reference for clinical pathologists, laboratory scientists, medical technologists, physicians specializing in oncology, internal medicine, family practice and transplant medicine, resident physicians, medical students, nurse practitioners and clinical chemists. Provides insights into the overall complexity that the cancer patient presents and how laboratory tests are used in the management of care Discusses current and new technologies applicable to cancer biomarker evaluation, including the use of non-traditional specimens like saliva, fluids and uterine lavage Reviews current trends in liquid biopsy and cancer biomarkers Provides a roadmap for bringing new technologies and markers from the bench to the bedside in the quest for finding the ideal tumor marker
Book Synopsis Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients by : Zohreh Amoozgar
Download or read book Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients written by Zohreh Amoozgar and published by Frontiers Media SA. This book was released on 2023-08-16 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional cancer diagnosis relies on tissue biopsy, blood testing as well as medical imaging. By the detection moment, in most cases the tumor size may reach several millimeters and the risk of distant metastasis is unavoidable. Even, following drug treatment, there is no accurate and timely way to follow up the success of treatment. New reliable tumor-specific biomarkers/tools that allow non-invasive early cancer detection as well as monitoring of anti-cancer therapeutic regime is highly demanded. To tackle limitations of traditional cancer management, liquid biopsy has emerged which screen bodily fluids using ultrasensitive biosensing systems capable of simultaneous capturing and studying horizontal gene transfer (HGT) materials including circulating tumor cells (CTCs), exosomes, cell-free DNA, and apoptotic bodies. These are messengers and/or delivery systems by which tumor cells are communicating as well as transforming/sharing new phenotypes with each other resulting in drug resistance, distant metastatic outbreaks, and cancer recurrence. Acting as next-generation prognostic and therapeutic tools call for understanding the molecular mechanisms by which HGT works to tran
Book Synopsis Advances in Cancer Biomarkers by : Roberto Scatena
Download or read book Advances in Cancer Biomarkers written by Roberto Scatena and published by Springer. This book was released on 2015-11-03 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and “polluted” knowledge may have dramatic consequences for patient. The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology. This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation.
Book Synopsis Role of Biomarkers in Medicine by : Mu Wang
Download or read book Role of Biomarkers in Medicine written by Mu Wang and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.
Book Synopsis Early Detection of Breast Cancer by : S. Brünner
Download or read book Early Detection of Breast Cancer written by S. Brünner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous expansion seen over the last decade in the mammo graphic detection of breast cancer lesions, especially the use of screen ing procedures for the early detection of clinically unsuspected tumors, has made it necessary to summarize the experience made by various centers in the world. The 2nd International Copenhagen Symposium on Detection of Breast Cancer afforded an opportunity of gathering scientists from all over the world to discuss the various problems of early breast cancer detection with special reference to screening procedures. This book forms a synthesis of the information presented by leading scientists from many of the world's mammo graphic centers, particularly those in Sweden and the USA. Hence, the reader will have the opportunity to study the outstanding work carried out by various institutes and centers of breast cancer screening. It is our sincere hope that a study of this volume will encourage other scientists to join in the work on screening procedures. S. Brunner B. Langfeldt P. E. Andersen Contents S. A. Feig: 1 Hypothetical Breast Cancer Risk from Mammography S. A. Feig: Benefits and Risks of Mammography 11 R. L. Egan and M. B. McSweeney: Multicentric Breast Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . 28 M. B. McSweeney and R. L. Egan: Breast Cancer in the Younger Patient: A Preliminary Report 36 M. B. McSweeney and R. L. Egan: Bilateral Breast Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . ' 41 N. Bjurstam: The Radiographic Appearance of Normal and Metastatic Axillary Lymph Nodes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 M. Moskowitz, S. A. Feig, C. Cole-Beuglet, S. H.
Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Book Synopsis Precision Medicine in Oncology by : Bulent Aydogan
Download or read book Precision Medicine in Oncology written by Bulent Aydogan and published by John Wiley & Sons. This book was released on 2020-11-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
Author :National Academy of Engineering Publisher :National Academies Press ISBN 13 :0309487501 Total Pages :125 pages Book Rating :4.3/5 (94 download)
Book Synopsis Frontiers of Engineering by : National Academy of Engineering
Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.
Book Synopsis Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by : Institute of Medicine
Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Book Synopsis Epigenetic Biomarkers and Diagnostics by : José Luis García-Giménez
Download or read book Epigenetic Biomarkers and Diagnostics written by José Luis García-Giménez and published by Academic Press. This book was released on 2015-12-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Book Synopsis Evolution of Translational Omics by : Institute of Medicine
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Exhaled Biomarkers written by I. Horvath and published by European Respiratory Society. This book was released on 2010-09-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.
