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Author : Karin Frischknecht
Publisher :
ISBN 13 :
Total Pages : 81 pages
Book Rating : 4.:/5 (853 download)
Download or read book Biology of Vascular Smooth Muscle Cells from Coronary Artery Bypass Vessels written by Karin Frischknecht and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sabine Ursina Weiss
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (428 download)
Download or read book Different Migration of Vascular Smooth Muscle Cells from Human Coronary Artery Bypass Vessels written by Sabine Ursina Weiss and published by . This book was released on 2007 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0080543502
Total Pages : 427 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Vascular Smooth Muscle Cell written by and published by Elsevier. This book was released on 1995-10-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also examines the proliferation and replication of SMC and its role in pharmacology and vascular disease. A must for cell, developmental, and molecular biologists, this book also will appeal to cardiologists, pathologists, and biomedical researchers interested in smooth muscle cells. Presents a molecular, genetic, and developmental perspective of the vas smooth muscle cell Overview sections highlight key points of chapters, including the clinical relevance of the research and expectations for future study Appeals to both the basic biologist and to the biomedical researcher of vascular disease
Author : M.F. III Crass
Publisher : Elsevier
ISBN 13 : 0323159877
Total Pages : 220 pages
Book Rating : 4.3/5 (231 download)
Download or read book Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms written by M.F. III Crass and published by Elsevier. This book was released on 2012-12-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic disease. This book is organized into six chapters and begins with an introduction to the complexities of energy metabolism and how metabolic events can be correlated with a simultaneous quantitative assessment of smooth muscle mechanics and the contractile machinery at the molecular level. The next two chapters offer the reader a view of smooth muscle membrane properties in terms of the distribution, transport, and metabolic control of electrolytes and specific aspects of ion conductance and electrical activity. This text also explains how smooth muscle cells regulate their contractile activity through regulation of calcium ion fluxes and the interaction, at the molecular level, of calcium ions with regulatory proteins associated with the contractile apparatus. Reference is made to the relation of possible anomalies in cellular or subcellular smooth muscle metabolic and/or ionic events to the bases of certain types of vascular disease. A chapter that examines the events leading to vascular pathology in the form of atherogenesis concludes the book. This book is intended for researchers and clinicians engaged in the study of smooth muscle and related areas.
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Ping Song
Publisher : Frontiers Media SA
ISBN 13 : 2832500706
Total Pages : 172 pages
Book Rating : 4.8/5 (325 download)
Download or read book Vascular Smooth Muscle Cell fate and Vascular Remodeling: Mechanisms, Therapeutic Targets, and Drugs, Volume I written by Ping Song and published by Frontiers Media SA. This book was released on 2022-09-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Katharina Sophia Volz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (919 download)
Download or read book Pericytes are Progenitors for Coronary Artery Smooth Muscle written by Katharina Sophia Volz and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The vasculature is a network of endothelial-lined tubes covered with mural cells where pericytes associate with small vessels and smooth muscle surrounds larger arteries and veins. Because these cells exist in close proximity, vascular biologists have long wondered whether pericytes and smooth muscle cells interconvert. However, direct evidence has been restricted by limited experimental tools and a lack of knowledge about when and where such differentiation events might occur. Knowing whether pericytes and smooth muscle differentiate into each other, and the mechanisms that stimulate this process, has the potential to impact clinical treatments for cardiovascular disease. Thus, the central aim of this PhD thesis has been to study the lineage relationship between pericytes and smooth muscle and the molecular signals regulating their interactions. I found that, in the heart during embryonic development, pericytes are the progenitors of coronary artery smooth muscle, and that Notch signaling stimulates the pericyte to smooth muscle transition. My studies also provide evidence that smooth muscle cells can revert to a pericyte phenotype during remodeling of the vasculature. Together, these studies answer the long outstanding question of how pericytes and smooth muscle relate and reveal a progenitor cell population and molecular pathway that could be manipulated for coronary artery regeneration. Because understanding coronary artery biology could identify clinical treatments for coronary artery disease, I focused my studies on coronary artery smooth muscle development, which remains a poorly understood process. The first step was to characterize how coronary artery smooth muscle cells form during embryonic development in the intact, three dimensional heart, which had not previously been performed yet at high cellular resolution. My data showed for the first time that, in mice, coronary artery smooth muscle cells differentiate deep within the myocardium around vessels that have just begun to remodel into coronary arteries. Because epicardial cells at the surface of the heart are known to give rise to coronary artery smooth muscle, we took a clonal analysis approach to trace the differentiation events between the epicardium and smooth muscle. Clonal analysis and direct lineage tracing experiments led us to discover that pericytes are the epicardial-derived progenitors for coronary artery smooth muscle cells. Additional clonal analysis revealed that smooth muscle related pericytes are also maintained in the adult heart. As for the molecular regulators, we show evidence that the pericyte to smooth muscle cell transition is stimulated by blood flow induced Jagged and Notch signaling (Chapter 2). This work is the first to show a direct ontogenic relationship between pericytes and smooth muscle and identifies a pathway that could be used to influence smooth muscle differentiation during cardiovascular regeneration. The discovery of a pericyte to smooth muscle differentiation pathway led me to ask whether smooth muscle could be transformed into pericytes. To address this question, I lineage traced mature smooth muscle cells. These experiments resulted in lineage labeled pericytes specifically at the ends of coronary arteries suggesting that mature smooth muscle dedifferentiates during developmental vascular remodeling (Chapter 3). Current methods of coronary artery regeneration fail to produce meaningful repair following cardiovascular injury, which is likely due to our lack of knowledge on progenitor cell populations and the signaling pathways that activate their differentiation. Our discovery that pericytes are epicardial derived coronary artery smooth muscle progenitors could have implications for regenerative medicine as this knowledge could reveal new progenitor cells and targetable pathways for coronary disease.
Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author : Kunihiro Sakuma
Publisher : BoD – Books on Demand
ISBN 13 : 1789840058
Total Pages : 372 pages
Book Rating : 4.7/5 (898 download)
Download or read book Muscle Cell and Tissue written by Kunihiro Sakuma and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.
Author : Michael Mark Gritzuk
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (177 download)
Download or read book Angiotension II-induced Apoptosis in Vascular Smooth Muscle Cells written by Michael Mark Gritzuk and published by . This book was released on 2006 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the likelihood for developing restenosis following coronary artery bypass grafting surgery remains a viable threat, assessing the physiological differences of conduit bypass vessels has become a crucial topic for vascular research. With much recognition of the challenges in addressing the differential properties of bypass conduit vessels, the current research demonstrates a differential response to in vitro angiotensin II-induced apoptosis between SV and IMA VSMCs.
Author : Wolfgang Schaper
Publisher : Springer Science & Business Media
ISBN 13 : 140208126X
Total Pages : 371 pages
Book Rating : 4.4/5 (2 download)
Download or read book Arteriogenesis written by Wolfgang Schaper and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the research activities of Germany’s Nauheim Institute of the Max Planck Society and its group of investigators both past and present, in the field of collateral artery growth. Incorporates a multidisciplinary in vivo approach to the study of arteriogenesis that includes molecular approaches with classical physiology and immunohistochemistry. Full color throughout and well illustrated.
Author : Guo-Wei He
Publisher : Springer
ISBN 13 :
Total Pages : 480 pages
Book Rating : 4.3/5 (91 download)
Download or read book Arterial Grafts for Coronary Bypass Surgery written by Guo-Wei He and published by Springer. This book was released on 1999 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides updated knowledge about the biological characteristics and clinical use of arterial grafts for coronary artery bypass surgery. The book is written by world-renowned cardiac surgeons and cardiovascular research scientists working in this area. This work offers first-hand information for arterial grafts with regard to their biological characteristics, clinical uses, results, and future development.
Author : HyungSeok Kim
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Download or read book IN SITU VASCULAR SMOOTH MUSCLE GENE EXPRESSION BETWEEN HUMAN MIDDLE CEREBRAL AND CORONARY ARTERY written by HyungSeok Kim and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background and AimsHuman cerebral arteries smooth muscle cell layer has unique embryologic, histologic, physiologic and pathologic characteristics compared to coronary arteries, and it is presumed that there are different mechanisms for the fatal outcome, such as atherosclerosis. However, there are no study about the difference in gene expression between the cerebral artery and the coronary artery muscle cell layer.MethodsIn this study, vascular smooth muscle layer of the middle cerebral artery and left anterior descending coronary artery obtained from the same individual were extracted by autopsy (n=10), and gene expression was compared by cDNA microarray (n=3).Results The total gene expression in the two blood vessels showed 341 different expression levels. Of the 341 genes expressed relatively differently in the cerebral artery, 256 were increased and 85 were decreased. Vascular muscle cells of the cerebral artery were found to be rich in the expression of genes involved in angiogenesis, extracellular matrix, cell migration, neurogenesis, and inflammatory response as compared to coronary arteries. Ingenuity PathwayAnalysis(IPA) revealed top pathways associated with atherosclerosis signaling in cardiovascular system. In this study, it was confirmed that the vascular muscle cells of human middle cerebral artery and coronary artery showed different gene expression.ConclusionsThe discovery of some genes involved in atherosclerosis, which is characteristically highly expressed in middle cerebral artery, can be interpreted as an understanding of the differentiation of arterial function regulation and susceptibility to vascular diseases such as atherosclerosis and diabetes.KeywordAtherosclerosis, Vascular smooth muscle cell, Middle cerebral artery, Coronary artery, Gene expression.
Author : International Society for Applied Cardiovascular Biology. Meeting
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (54 download)
Download or read book Applied Cardiovascular Biology, 1990-91 written by International Society for Applied Cardiovascular Biology. Meeting and published by . This book was released on 1992 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Guo-Wei He
Publisher : Springer Science & Business Media
ISBN 13 : 3540300848
Total Pages : 349 pages
Book Rating : 4.5/5 (43 download)
Download or read book Arterial Grafting for Coronary Artery Bypass Surgery written by Guo-Wei He and published by Springer Science & Business Media. This book was released on 2006-08-25 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition examines the biological characteristics and clinical use of arterial grafts for coronary artery bypass surgery. It contains first-hand information on arterial grafts, as well as vein grafts with regard to biological characteristics, clinical use including off-pump coronary bypass grafting surgery, results, and future developments. The book is a practical guide and as a stimulus for further improvement of arterial grafting techniques.
Author : Thomas Luescher
Publisher : Springer Science & Business Media
ISBN 13 : 3642786375
Total Pages : 399 pages
Book Rating : 4.6/5 (427 download)
Download or read book Coronary Artery Graft Disease written by Thomas Luescher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: In patients with coronary artery disease, surgical revascu- larization with arterial or venous bypass grafts not only relieves symptoms, but also prolongs life. The result of such interventions, however, is frequently impaired by graft dysfunction and occlusion. This monograph highlights the clinical importance of coronary artery bypass graft disease and, in particular, the use of modern diagnostic techniques to assess graft structure and function. The molecular and cellular mechanisms of coronary bypass graft disease are ex- tensively discussed with several chapters devoted to prophy- lactic medical therapy. The indication, technique and results of reinterventions with balloon angioplasty, reope- ration or transplantation in patients with graft failure are also reviewed.
Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
