Biological Robustness

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Robustness and Evolvability in Living Systems

Author : Andreas Wagner
Publisher : Princeton University Press
ISBN 13 : 0691134049
Total Pages : 383 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Robustness and Evolvability in Living Systems by : Andreas Wagner

Download or read book Robustness and Evolvability in Living Systems written by Andreas Wagner and published by Princeton University Press. This book was released on 2007-07-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.

Ancestral Sequence Reconstruction

Author : David A Liberles
Publisher : Oxford University Press
ISBN 13 : 0199299188
Total Pages : 267 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Ancestral Sequence Reconstruction by : David A Liberles

Download or read book Ancestral Sequence Reconstruction written by David A Liberles and published by Oxford University Press. This book was released on 2007-05-31 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including wholeproteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized toprovide insights and inform future research.This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.

A New Biology for the 21st Century

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309147867
Total Pages : 113 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A New Biology for the 21st Century by : National Research Council

Download or read book A New Biology for the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2009-11-20 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.

Biological Robustness

Author : Marta Bertolaso
Publisher : Springer
ISBN 13 : 3030011984
Total Pages : 263 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Biological Robustness by : Marta Bertolaso

Download or read book Biological Robustness written by Marta Bertolaso and published by Springer. This book was released on 2019-01-04 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews examples and notions of robustness at several levels of biological organization. It tackles many philosophical and conceptual issues and casts an outlook on the future challenges of robustness studies in the context of a practice-oriented philosophy of science. The focus of discussion is on concrete case studies. These highlight the necessity of a level-dependent description of robust biological behaviors.Experts from the neurosciences, biochemistry, ecology, biology, and the history and the philosophy of life sciences provide a multiplex perspective on the topic. Contributions span from protein folding, to cell-level robustness, to organismal and developmental robustness, to sensorimotor systems, up to the robustness of ecological systems.Several chapters detail neurobiological case-studies. The brain, the poster child of plasticity in biology, offers multiple examples of robustness. Neurobiology explores the importance of temporal organization and multiscalarity in making this robustness-with-plasticity possible. The discussion also includes structures well beyond the brain, such as muscles and the complex feedback loops involved in the peculiar robustness of music perception. Overall, the volume grounds general reflections upon concrete case studies, opening to all the life sciences but also to non-biological and bio-inspired fields such as post-modern engineering. It will appeal to researchers, students, as well as non-expert readers.

Bioinspired Legged Locomotion

Author : Maziar Ahmad Sharbafi
Publisher : Butterworth-Heinemann
ISBN 13 : 0128037741
Total Pages : 698 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Bioinspired Legged Locomotion by : Maziar Ahmad Sharbafi

Download or read book Bioinspired Legged Locomotion written by Maziar Ahmad Sharbafi and published by Butterworth-Heinemann. This book was released on 2017-11-21 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinspired Legged Locomotion: Models, Concepts, Control and Applications explores the universe of legged robots, bringing in perspectives from engineering, biology, motion science, and medicine to provide a comprehensive overview of the field. With comprehensive coverage, each chapter brings outlines, and an abstract, introduction, new developments, and a summary. Beginning with bio-inspired locomotion concepts, the book's editors present a thorough review of current literature that is followed by a more detailed view of bouncing, swinging, and balancing, the three fundamental sub functions of locomotion. This part is closed with a presentation of conceptual models for locomotion. Next, the book explores bio-inspired body design, discussing the concepts of motion control, stability, efficiency, and robustness. The morphology of legged robots follows this discussion, including biped and quadruped designs. Finally, a section on high-level control and applications discusses neuromuscular models, closing the book with examples of applications and discussions of performance, efficiency, and robustness. At the end, the editors share their perspective on the future directions of each area, presenting state-of-the-art knowledge on the subject using a structured and consistent approach that will help researchers in both academia and industry formulate a better understanding of bioinspired legged robotic locomotion and quickly apply the concepts in research or products. - Presents state-of-the-art control approaches with biological relevance - Provides a thorough understanding of the principles of organization of biological locomotion - Teaches the organization of complex systems based on low-dimensional motion concepts/control - Acts as a guideline reference for future robots/assistive devices with legged architecture - Includes a selective bibliography on the most relevant published articles

Robust Design

Author : Erica Jen
Publisher : Oxford University Press
ISBN 13 : 0195165330
Total Pages : 306 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Robust Design by : Erica Jen

Download or read book Robust Design written by Erica Jen and published by Oxford University Press. This book was released on 2005 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Robust Design' brings together an eminent group of authors in a wide range of fields presenting aspects of robustness in biological, ecological and computational systems.

An Introduction to Systems Biology

Author : Uri Alon
Publisher : CRC Press
ISBN 13 : 1584886420
Total Pages : 324 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis An Introduction to Systems Biology by : Uri Alon

Download or read book An Introduction to Systems Biology written by Uri Alon and published by CRC Press. This book was released on 2006-07-07 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Adaptation in Natural and Artificial Systems

Author : John H. Holland
Publisher : MIT Press
ISBN 13 : 9780262581110
Total Pages : 236 pages
Book Rating : 4.5/5 (811 download)

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Book Synopsis Adaptation in Natural and Artificial Systems by : John H. Holland

Download or read book Adaptation in Natural and Artificial Systems written by John H. Holland and published by MIT Press. This book was released on 1992-04-29 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic algorithms are playing an increasingly important role in studies of complex adaptive systems, ranging from adaptive agents in economic theory to the use of machine learning techniques in the design of complex devices such as aircraft turbines and integrated circuits. Adaptation in Natural and Artificial Systems is the book that initiated this field of study, presenting the theoretical foundations and exploring applications. In its most familiar form, adaptation is a biological process, whereby organisms evolve by rearranging genetic material to survive in environments confronting them. In this now classic work, Holland presents a mathematical model that allows for the nonlinearity of such complex interactions. He demonstrates the model's universality by applying it to economics, physiological psychology, game theory, and artificial intelligence and then outlines the way in which this approach modifies the traditional views of mathematical genetics. Initially applying his concepts to simply defined artificial systems with limited numbers of parameters, Holland goes on to explore their use in the study of a wide range of complex, naturally occuring processes, concentrating on systems having multiple factors that interact in nonlinear ways. Along the way he accounts for major effects of coadaptation and coevolution: the emergence of building blocks, or schemata, that are recombined and passed on to succeeding generations to provide, innovations and improvements.

Nanocomputers and Swarm Intelligence

Author : Jean-Baptiste Waldner
Publisher : John Wiley & Sons
ISBN 13 : 1118624157
Total Pages : 321 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Nanocomputers and Swarm Intelligence by : Jean-Baptiste Waldner

Download or read book Nanocomputers and Swarm Intelligence written by Jean-Baptiste Waldner and published by John Wiley & Sons. This book was released on 2013-03-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the last 50 years, the power of integrated circuits has continued to grow. However, this performance will end up reaching its physical limit. What new ways will then be available to develop even more powerful and up-to-date systems? This book introduces the principles of quantic computing, the use of nano-tubes in molecular transistors and ADN computing. It suggests new fabrication methods for the 21st century and introduces new architecture models, ranging from the most conventional to the most radical. Using a chronological theme, it explains our unavoidable entry in the nano-device world: from the 1948 transistor to the microchip. It concludes by anticipating the changes in daily living: investments, impact on coding activities, nanocomputing systems implementation and IT job mutation.

How to Build a Brain

Author : Chris Eliasmith
Publisher : Oxford University Press
ISBN 13 : 0199794693
Total Pages : 475 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis How to Build a Brain by : Chris Eliasmith

Download or read book How to Build a Brain written by Chris Eliasmith and published by Oxford University Press. This book was released on 2013-04-16 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to Build a Brain provides a detailed exploration of a new cognitive architecture - the Semantic Pointer Architecture - that takes biological detail seriously, while addressing cognitive phenomena. Topics ranging from semantics and syntax, to neural coding and spike-timing-dependent plasticity are integrated to develop the world's largest functional brain model.

Evolutionary Systems Biology

Author : Orkun S. Soyer
Publisher : Springer Science & Business Media
ISBN 13 : 1461435676
Total Pages : 459 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Evolutionary Systems Biology by : Orkun S. Soyer

Download or read book Evolutionary Systems Biology written by Orkun S. Soyer and published by Springer Science & Business Media. This book was released on 2012-07-23 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

Quantum Effects in Biology

Author : Masoud Mohseni
Publisher : Cambridge University Press
ISBN 13 : 1107010802
Total Pages : 421 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Quantum Effects in Biology by : Masoud Mohseni

Download or read book Quantum Effects in Biology written by Masoud Mohseni and published by Cambridge University Press. This book was released on 2014-08-07 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the role of quantum mechanics in biology for advanced undergraduate and graduate students in physics, biology and chemistry.

Biological Variation

Author : Callum G. Fraser
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883492
Total Pages : 172 pages
Book Rating : 4.8/5 (834 download)

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Book Synopsis Biological Variation by : Callum G. Fraser

Download or read book Biological Variation written by Callum G. Fraser and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2001 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain and Human Body Modeling 2020

Author : Sergey N. Makarov
Publisher : Springer Nature
ISBN 13 : 3030456234
Total Pages : 395 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Brain and Human Body Modeling 2020 by : Sergey N. Makarov

Download or read book Brain and Human Body Modeling 2020 written by Sergey N. Makarov and published by Springer Nature. This book was released on 2021 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.

Plasticity, Robustness, Development and Evolution

Author : Patrick Bateson
Publisher : Cambridge University Press
ISBN 13 : 9780521516297
Total Pages : 166 pages
Book Rating : 4.5/5 (162 download)

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Book Synopsis Plasticity, Robustness, Development and Evolution by : Patrick Bateson

Download or read book Plasticity, Robustness, Development and Evolution written by Patrick Bateson and published by Cambridge University Press. This book was released on 2011-06-30 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we understand and explain the apparent dichotomy between plasticity and robustness in the context of development? Can we identify these complex processes without resorting to 'either/or' solutions? Written by two leaders in the field, this is the first book to fully unravel the complexity of the subject, explaining that the epigenetic processes generating plasticity and robustness are in fact deeply intertwined. It identifies the different mechanisms that generate robustness and the various forms of plasticity, before considering the functional significance of the integrated mechanisms and how the component processes might have evolved. Finally, it highlights the ways in which epigenetic mechanisms could be instrumental in driving evolutionary change. Essential reading for biologists and psychologists interested in epigenetics and evolution, this book is also a valuable resource for biological anthropologists, sociobiologists, child psychologists and paediatricians.

Introduction to Biological Networks

Author : Alpan Raval
Publisher : CRC Press
ISBN 13 : 1420010360
Total Pages : 329 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Introduction to Biological Networks by : Alpan Raval

Download or read book Introduction to Biological Networks written by Alpan Raval and published by CRC Press. This book was released on 2016-04-19 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network bi

The Logic of Chance

Author : Eugene V. Koonin
Publisher : FT Press
ISBN 13 : 013262317X
Total Pages : 530 pages
Book Rating : 4.1/5 (326 download)

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Book Synopsis The Logic of Chance by : Eugene V. Koonin

Download or read book The Logic of Chance written by Eugene V. Koonin and published by FT Press. This book was released on 2011-06-23 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept; the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes. "Koonin's account of viral and pre-eukaryotic evolution is undoubtedly up-to-date. His "mega views" of evolution (given what was said above) and his cosmological musings, on the other hand, are interesting reading." Summing Up: Recommended Reprinted with permission from CHOICE, copyright by the American Library Association.