Biological Response Modifiers Interferons Double Stranded Rna And 25 Oligoadenylates

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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

Author : W.E.G. Müller
Publisher : Springer Science & Business Media
ISBN 13 : 3642785492
Total Pages : 290 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates by : W.E.G. Müller

Download or read book Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates written by W.E.G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

Biology of Aging

Author : Alvaro Macieira-Coelho
Publisher : Springer Science & Business Media
ISBN 13 : 3642189946
Total Pages : 198 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Biology of Aging by : Alvaro Macieira-Coelho

Download or read book Biology of Aging written by Alvaro Macieira-Coelho and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.

Epigenetics and Chromatin

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 9783540852360
Total Pages : 284 pages
Book Rating : 4.8/5 (523 download)

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Book Synopsis Epigenetics and Chromatin by : Philippe Jeanteur

Download or read book Epigenetics and Chromatin written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2008-09-10 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.

RNA Trafficking and Nuclear Structure Dynamics

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 9783540404514
Total Pages : 168 pages
Book Rating : 4.4/5 (45 download)

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Book Synopsis RNA Trafficking and Nuclear Structure Dynamics by : Philippe Jeanteur

Download or read book RNA Trafficking and Nuclear Structure Dynamics written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2004-01-14 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores nuclear structure and trafficking involving or relevant to RNA and RNPs. Topics include advances and current problems in the structural organization of different subnuclear compartments, Cajal bodies and gems, speckles containing splicing factors, and PML bodies characteristic of ProMyelocytic leukemia. The book also describes the dynamic aspects of RNA trafficking and the latest technologies for live cell imaging of mRNA.

Regulation of Alternative Splicing

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 3662097281
Total Pages : 254 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Regulation of Alternative Splicing by : Philippe Jeanteur

Download or read book Regulation of Alternative Splicing written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Guidance Cues in the Developing Brain

Author : Ivica Kostovic
Publisher : Springer Science & Business Media
ISBN 13 : 3642555578
Total Pages : 174 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Guidance Cues in the Developing Brain by : Ivica Kostovic

Download or read book Guidance Cues in the Developing Brain written by Ivica Kostovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.

Invertebrate Cytokines and the Phylogeny of Immunity

Author : Alain Beschin
Publisher : Springer Science & Business Media
ISBN 13 : 364218670X
Total Pages : 192 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Invertebrate Cytokines and the Phylogeny of Immunity by : Alain Beschin

Download or read book Invertebrate Cytokines and the Phylogeny of Immunity written by Alain Beschin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.

Silicon Biomineralization

Author : Werner E. G. Müller
Publisher : Springer Science & Business Media
ISBN 13 : 3642554865
Total Pages : 342 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Silicon Biomineralization by : Werner E. G. Müller

Download or read book Silicon Biomineralization written by Werner E. G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: During evolution silica deposition has been used in Protozoa, Metazoa and in plants as skeletal elements. It appears that the mechanisms for the formation of biogenic silica have evolved independently in these three taxa. In Protozoa and plants biosilicification appears to be primarily driven by non-enzymatic processes and procedes on organic matrices. In contrast, in sponges (phylum Porifera) this process is mediated by enzymes; the initiation of this process is likewise dependent on organic matrices. In this monograph the role of biosilica as stabilizing structures in different organisms is reviewed and their role for morphogenetic processes is outlined. It provides an up-to-date summary of the mechanisms by which polymeric biosilica is formed. The volume is intended for biologists, biochemists and molecular biologists, involved in the understanding of structure formation in living organisms and will also be very useful for scientists working in the field of applied Nanotechnology and Nanobiotechnology.

Viruses and Apoptosis

Author : Covadonga Alonso
Publisher : Springer Science & Business Media
ISBN 13 : 9783540202288
Total Pages : 370 pages
Book Rating : 4.2/5 (22 download)

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Book Synopsis Viruses and Apoptosis by : Covadonga Alonso

Download or read book Viruses and Apoptosis written by Covadonga Alonso and published by Springer Science & Business Media. This book was released on 2004-03-24 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1488 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Ageing and Development

Author :
Publisher :
ISBN 13 :
Total Pages : 278 pages
Book Rating : 4.:/5 (49 download)

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Book Synopsis Mechanisms of Ageing and Development by :

Download or read book Mechanisms of Ageing and Development written by and published by . This book was released on 1995 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Medical Microbiology

Author : Patrick R. Murray, PhD
Publisher : Elsevier Health Sciences
ISBN 13 : 0323299563
Total Pages : 977 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Medical Microbiology by : Patrick R. Murray, PhD

Download or read book Medical Microbiology written by Patrick R. Murray, PhD and published by Elsevier Health Sciences. This book was released on 2015-10-28 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: Turn to Medical Microbiology, 8th Edition for a thorough, clinically relevant understanding of microbes and their diseases. This succinct, easy-to-use text presents the fundamentals of microbiology and immunology in a clearly written, engaging manner-effectively preparing you for your courses, exams, and beyond. Coverage of basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology help you master the essentials. Review questions at the end of each chapter correlate basic science with clinical practice to help you understand the clinical relevance of the organisms examined. Clinical cases illustrate the epidemiology, diagnosis, and treatment of infectious diseases, reinforcing a clinical approach to learning. Full-color clinical photographs, images, and illustrations help you visualize the clinical presentations of infections. Summary tables and text boxes emphasizing essential concepts and learning issues optimize exam review. Additional images, 200 self-assessment questions, NEW animations, and more. Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text, videos, images, and references from the book. Thoroughly updated chapters include the latest information on the human microbiome and probiotics/prebiotics; including a new chapter on Human Microbiome In Health and Disease. NEW chapter summaries introduce each microbe chapter, including trigger words and links to the relevant chapter text (on e-book version on Student Consult), providing a concise introduction or convenient review for each topic. Online access to the complete text, additional images, 200 self-assessment questions, NEW animations, and more is available through Student Consult.

Cancer Research

Author :
Publisher :
ISBN 13 :
Total Pages : 558 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Cancer Research by :

Download or read book Cancer Research written by and published by . This book was released on 1992 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oncogene and Cancer

Author : Yahwardiah Siregar
Publisher : Inst za onkologiju i radiol
ISBN 13 : 9535108581
Total Pages : 497 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Oncogene and Cancer by : Yahwardiah Siregar

Download or read book Oncogene and Cancer written by Yahwardiah Siregar and published by Inst za onkologiju i radiol. This book was released on 2013-01-24 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors

Biological Response Modifiers in the Treatment of Hematopoietic Neoplasia

Author : Moshe Talpaz
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biological Response Modifiers in the Treatment of Hematopoietic Neoplasia by : Moshe Talpaz

Download or read book Biological Response Modifiers in the Treatment of Hematopoietic Neoplasia written by Moshe Talpaz and published by Marcel Dekker. This book was released on 1992 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Index to PHS-supported Research

Author :
Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1993 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Viral Pathogenesis

Author : Neal Nathanson
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 970 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Viral Pathogenesis by : Neal Nathanson

Download or read book Viral Pathogenesis written by Neal Nathanson and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 970 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is the most complete reference devoted specifically to viral pathogenesis, describing both the development of viral disease and the host/virus interaction. Presenting contributions from leading authorities in this particularly topical field, this comprehensive text exposits the current knowledge on the pathogenesis of viruses, an understanding of which is critical to treatment and prevention of viral diseases. The book opens with a thorough review of principles, covering in detail the life cycle of viruses, including entry, dissemination, shedding and transmission, and replication; the pathology of viral disease, including disease mechanisms, virus virulence, and viral oncogenesis; immune responses, including immune suppression; and therapeutic applications. The second section focuses on experimental pathogenesis, covering detection and quantification of viral genomes, messages, and proteins in tissues and organs; and examining classical and new methods for animal studies. Chapters in the next section, devoted to classical models of viral pathogenesis, cover ectromelia, poliomyelitis, rabies, lymphocytic choriomeningitis virus, avian and murine retroviruses, lentiviruses, and reoviruses. The final section covers systems pathogenesis, emphasizing viral diseases of humans but also drawing on animal studies that elucidate the pathogenesis of human infections.