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Biodegradable Polymeric Materials For Gene And Drug Delivery
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Book Synopsis Biodegradable Polymers in Clinical Use and Clinical Development by : Abraham J. Domb
Download or read book Biodegradable Polymers in Clinical Use and Clinical Development written by Abraham J. Domb and published by John Wiley & Sons. This book was released on 2011-05-12 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.
Book Synopsis Biodegradable Polymeric Materials for Gene and Drug Delivery by : Chih-Kuang Chen
Download or read book Biodegradable Polymeric Materials for Gene and Drug Delivery written by Chih-Kuang Chen and published by . This book was released on 2013 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, gene therapy has been recognized as a powerful tool in cancer treatment as the genetic links to tumor growth have been identified and studied. For instance, small interfering RNAs (siRNAs) can induce down-regulation and knockdown expression of mutated genes and overexpressed proteins, respectively; as a result, RNA interference (RNAi) using siRNAs as therapeutic gene materials has been developed. Unfortunately, therapeutic genes are poorly internalized and are susceptible to degradation by ubiquitous nucleases, and there is serious biosafety concern on viral vectors. Thus, the development of safe and efficient non-viral gene therapy vectors addressing the aforementioned delivery problems is of high importance. Based on the practical needs of non-viral vectors, well-defined tertiary amine-functionalized cationic polylactides (CPLAs) were synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide (APLA).^They were further utilized for the delivery of interleukin-8 (IL-8) siRNA to prostate cancer cells (PC3 cells), via the formation of CPLA-IL-8 siRNA nanocomplexes by electrostatic interaction. The CPLAs possess high hydrolytic degradability and low cytotoxicity. The CPLA-IL-8 siRNA nanocomplexes are readily taken up by PC3 cells, resulting in statistically significant IL-8 gene silencing. It was determined that the degradability, as well as transfection efficiency of CPLAs, positively correlate with the amine mol% of CPLAs. In addition to siRNA delivery, CPLAs were successfully used to deliver plasmid DNA (pDNA) to two physiological distinct cell lines (macrophage and fibroblast) via the formation of CPLA/pDNA nanocomplexes. Biophysical characterization of charge densities at various CPLA/pDNA weight ratios revealed a positive correlation between surface charge and gene delivery. To be more relevant for clinical applications, well-defined poly(ethylene glycol)-block-cationic polylactides (PEG-b-CPLAs) functionalized with tertiary amine-based cationic groups were synthesized by thiol-ene functionalization of a PEG-b-APLA. Subsequently, the application of PEG-b-CPLAs as biodegradable vectors for the pDNA delivery was investigated. Via the formation of PEG-b-CPLA/pDNA nanocomplexes by spontaneous electrostatic interaction, pDNAs encoding luciferase or enhanced green fluorescent protein were successfully delivered to four physiologically distinct cell lines (including macrophage, fibroblast, epithelial, and stem cell). Biophysical characterization of charge densities of nanocomplexes at various polymer:pDNA weight ratios revealed a positive correlation between surface charge and gene delivery. With PEG shielding layers, these nanocomplexes exhibited much higher serum resistance as compared to positive controls using an in vitro serum gene delivery inhibition assay. Recently, the simultaneous delivery of small molecular drug with gene via a single platform has emerged as a novel strategy to combat cancer diseases. Cross-linked biodegradable CPLA nanocapasules (CPLA NCs) were synthesized by miniemulsion interfacial thiol-ene cross-linking of CPLA. CPLA NCs exhibit high hydrolytic degradability without noticeable cytotoxicity. With size ranging from 20 to 50 nm, these NCs can avoid fast clearance in a mouse model. Multidrug resistance (MDR) by cancer cells remains a major challenge in chemotherapy, in which P-glycoprotein (Pgp) plays a key role by enhanced efflux of anticancer drug. Through the encapusulation by NCs, Doxorubicin (Dox) can successfully bypass Pgp-mediated efflux pump, thereby resulting in increased intracellular drug concentration and enhanced therapeutic efficacy. Relative to free Dox, Dox-loaded CPLA NCs exhibited a significantly enhanced anti-proliferation effect in MCF7/ADR cells (a stable MDR model). Additionally, these NCs can in situ encapsulate Dox with inner cavities and bind IL-8 siRNA with cationic shells, thereby enabling the codelivery of drugs with genes. In vitro studies showed that the NCs loaded with Dox, IL-8 siRNA and both agents can be readily taken up by PC3 prostate cancer cells, resulting in significant chemotherapeutic effect and/or IL-8 gene silencing. In addition to CPLA-based nanocapsules, we are interested in synthesizing chitosan-based NCs due to the low synthetic cost and facile preparation procedures. Well-defined chitosan nanocapsules (CSNCs) with tunable sizes were synthesized through interfacial cross-linking of N-maleoyl-functionalized chitosan (MCS) in miniemulsions, and their application in the delivery of Dox was investigated. Thiol-ene interfacial cross-linking was conducted in oil-in-water miniemulsions at room temperature under UV irradiation for 1 h, using MCS as both surfactant and precursor polymer, 1,4-butanediol bis(3-mercapto-propionate) as cross-linker and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as co-surfactant. With the increase of co-surfactant concentration in the reaction systems, the sizes of the resulting CSNCs decreased steadily. Dox-loaded CSNCs were readily prepared by in situ encapsulation of Dox during miniemulsion cross-linking. With acid-labile β-thiopropionate cross-linkages, the Dox-loaded CSNCs demonstrated faster Dox release rate under acidic conditions. Relative to free Dox, Dox-loaded CSNCs exhibited enhanced cytotoxicity towards MCF-7 breast cancer cells while the empty CSNCs did not show noticeable cytotoxicity. Effective delivery of Dox into the cancer cells via Dox-loaded CSNCs was also observed. Overall, the results suggest promising potential applications of these novel CSNCs as nanoscopic scaffolds for therapeutic delivery.
Book Synopsis Handbook of Biodegradable Polymers by : Abraham J. Domb
Download or read book Handbook of Biodegradable Polymers written by Abraham J. Domb and published by CRC Press. This book was released on 1998-02-04 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biodegradable Polymers, the seventh volume in the Drug Delivery and Targeting book series, provides a source manual for synthetic procedures, properties and applications of bioerodible polymers. The authors describe widely available materials such as polyactides, collagen and gelatin, as well as polymers of emerging importance, such as the genetically-engineered and elastin-based polymers which are either proprietary or in early stages of development. Section I addresses synthetic absorbable polymers, and Section 2 profiles natural, semi-synthetic and biosynthetic polymers. Section 3 discusses the surface characterization of degradable polymers, the modeling of biodegradation and non-medical polymers. This book is ideal for researchers from academia and industry as well as chemists, pharmacists and physicians who deal with biopolymers, drug delivery and targeting, bioengineering and implantable devices.
Book Synopsis Handbook of Biodegradable Polymeric Materials and Their Applications: Applications by : Surya Mallapragada
Download or read book Handbook of Biodegradable Polymeric Materials and Their Applications: Applications written by Surya Mallapragada and published by . This book was released on 2006 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Biodegradable Polymers by : Andreas Lendlein
Download or read book Handbook of Biodegradable Polymers written by Andreas Lendlein and published by John Wiley & Sons. This book was released on 2011-08-15 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.
Book Synopsis Polymers in Drug Delivery by : Ijeoma F. Uchegbu
Download or read book Polymers in Drug Delivery written by Ijeoma F. Uchegbu and published by CRC Press. This book was released on 2006-05-19 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Book Synopsis Polymeric Drug Delivery Systems by : Glen S. Kwon
Download or read book Polymeric Drug Delivery Systems written by Glen S. Kwon and published by CRC Press. This book was released on 2005-04-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Book Synopsis Absorbable and Biodegradable Polymers by : Shalaby W. Shalaby
Download or read book Absorbable and Biodegradable Polymers written by Shalaby W. Shalaby and published by CRC Press. This book was released on 2003-10-27 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in biodegradable and absorbable polymers is growing rapidly in large part because of their biomedical implant and drug delivery applications. This text illustrates creative approaches to custom designing unique, fiber-forming materials for equally unique applications. It includes an example of the development and application of a new absor
Book Synopsis Polymeric Biomaterials, Revised and Expanded by : Severian Dumitriu
Download or read book Polymeric Biomaterials, Revised and Expanded written by Severian Dumitriu and published by CRC Press. This book was released on 2001-11-29 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering nearly 7000 references-3900 more than the first edition-Polymeric Biomaterials, Second Edition is an up-to-the-minute source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised and updated, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.
Book Synopsis Biomedical Polymers by : Mike Jenkins
Download or read book Biomedical Polymers written by Mike Jenkins and published by Elsevier. This book was released on 2007-08-06 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the rapid development and use of biomaterials, it is becoming increasingly important to understand the structure, processing and properties of biomedical polymers and their medical applications. With its distinguished editor and team of international contributors, Biomedical Polymers reviews the latest research on this important group of biomaterials.The book discusses natural, synthetic, biodegradable and non bio-degradable polymers and their applications. Chapters review polymeric scaffolds for tissue engineering and drug delivery systems, the use of polymers in cell encapsulation, their role as replacement materials for heart valves and arteries, and their applications in joint replacement. The book also discusses the use of polymers in biosensor applications.Biomedical polymers is an essential reference for scientists and all those concerned with the development and use of this important group of biomaterials - Reviews the latest research in this important group of biomaterials - Discusses natural, synthetic, biodegradable and non-biodegradable polymers and their applications - Examines the use of biomedical polymers in such areas as drug delivery systems and cell encapsulation
Book Synopsis Handbook of Biodegradable Polymers by : Shakeel Ahmed
Download or read book Handbook of Biodegradable Polymers written by Shakeel Ahmed and published by CRC Press. This book was released on 2024-08-02 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and authoritative review of the recent developments and advances in biodegradable polymers and their biomedical applications. Following an interdisciplinary approach, it combines the medical and pharmaceutical fields in conjunction with biomedical engineering, polymer science, materials science, and pharmacological aspects of biodegradable polymers. The text covers the synthesis, properties, and characterization of biodegradable polymers and systems and their applications in sustained drug delivery, anticancer therapy, vaccine delivery, gene delivery, surgery, wound care, cardiology, dentistry, orthopedics, medical devices, tissue engineering, and cosmeceuticals. It also details the safety aspects, market economy, challenges, and opportunities related to biodegradable polymers, providing an understanding of the commercial and translational aspects of these crucial biomaterials. Edited and authored by renowned scientists working on biodegradable polymers, biocomposites, biodegradable systems, and implants, the book is an important resource for academicians, researchers, students, professionals, and general readers interested in exploring the potential biomedical applications of biodegradable polymers.
Book Synopsis Polymeric Gene Delivery Systems by : Yiyun Cheng
Download or read book Polymeric Gene Delivery Systems written by Yiyun Cheng and published by Springer. This book was released on 2018-09-04 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Biodegradable Polymers in Pharmacy and Medicine. Classification, Chemical Structure, Principles of Biodegradation and Use by : Jan Gajdziok
Download or read book Biodegradable Polymers in Pharmacy and Medicine. Classification, Chemical Structure, Principles of Biodegradation and Use written by Jan Gajdziok and published by GRIN Verlag. This book was released on 2016-09-13 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Document from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , course: Pharmaceutical technology, language: English, abstract: The aim of this book is to provide a brief but comprehensive overview on the issue of biodegradable polymers. The introduction chapter is followed by a description of the general characteristics of biodegradable polymers and pathways of their degradation in the human body. Particular pitfalls and specifics of their various biomedical and pharmaceutical applications, especially in the field of pharmaceutical technology, are described in order to define the ideal carrier polymer system for specific types of therapy. Finally, the work presents the classification of these polymers based on the type of degradation mechanism. This section also includes the chemical structure of particular polymer molecules, their chemical or bio-synthesis and the description of their uses in specific biomedical and pharmaceutical applications. The book could be used as a textbook for students of medical and pharmaceutical sciences as well as by researchers in this field or industrial area. In the past few decades, biodegradable polymers have reached significant importance in fields of biomedical and pharmaceutical applications. They have become preferred candidates for the manufacture of therapeutic forms, for instance, orthopaedics devices, temporary bone screws and spins, three-dimensional scaffolds for tissue engineering or drug delivery systems for sustained and targeted release. Each of these applications requires material with specific physical, biological, and chemical properties, as well as specific degradation profile. These polymers (natural or synthetic) undergo hydrolytic or enzymatic degradation, which both have some advantages and disadvantages. Most widely used polymer materials in biomedical applications are listed, including their structure and degradation pathways.
Book Synopsis Bioresorbable Polymers and their Biomedical Applications by : Declan M Devine
Download or read book Bioresorbable Polymers and their Biomedical Applications written by Declan M Devine and published by Smithers Rapra. This book was released on 2017-04-10 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioresorbable or biodegradable polymers are commonly used in various biomedical applications. The application of bioresorbable polymers in the biomedical sector has been widely exploited by immobilising suturing thread with an analgesic or antibacterial drugs, and the development of bioresorbable vascular scaffolds, wound-healing and intravenous drug-delivery devices. Furthermore, biodegradable polymers have been investigated as a replacement for metallic orthopaedic devices due to their precise control of material composition and microstructure. These polymers are eliminated from the body via dissolution, assimilation and excretion through metabolic pathways. The hydrolysing process breaks down the polymer into smaller units and its degradation products are excreted by means of the citric acid cycle or by direct renal excretion with no residual side effects.Processing of bioresorbable implants can be achieved via conventional polymer processing methods such as extrusion, injection and compressing moulding, solvent spinning or casting. However, special consideration must be given when processing these materials because heat can cause a reduction in molecular weight due to the hydrolysing of bonds. In addition, overheating can depolymerise the polymer and, as a result, monomers can have a plasticising effect on the polymer. Recently, alternative approaches utilising rapid prototyping and micro-/nanofabrication processes have been employed.This book addresses these issues and highlights recent advances in the biomedical field that have being enabled by the use of biodegradable polymers. This book is designed as a reference guide for academic researchers utilising biodegradable polymers in a range of areas from tissue engineering to controlled release of active pharmaceuticals, through to industry-based processors of biodegradable polymers.
Book Synopsis Biopolymers In Drug Delivery: Recent Advances and Challenges by : Michael U. Adikwu
Download or read book Biopolymers In Drug Delivery: Recent Advances and Challenges written by Michael U. Adikwu and published by Bentham Science Publishers. This book was released on 2010-05-13 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This Ebook describes the applicability of diverse natural and synthetic biopolymers and their blends in drugs, vaccines and gene delivery. It would serve as a concise body of information on biopolymers for researchers, industries and students of pharmaceu"
Book Synopsis Biodegradable Polymers as Drug Delivery Systems by : Mark Chasin
Download or read book Biodegradable Polymers as Drug Delivery Systems written by Mark Chasin and published by CRC Press. This book was released on 1990-08-31 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the properties, synthesis, and formulations of a number of well studied polymers increasingly being used in site-specific or systematic administration of pharmaceutical agents. For each of the polymers, discusses the background; chemistry and synthesis; the formulation of microcapsules, solv
Book Synopsis Biodegradable Poly (Lactic Acid) by : Jie Ren
Download or read book Biodegradable Poly (Lactic Acid) written by Jie Ren and published by Springer Science & Business Media. This book was released on 2011-04-05 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Biodegradable Poly (Lactic Acid): Synthesis, Modification, Processing and Applications" describes the preparation, modification, processing, and the research and applications of biodegradable poly (lactic acid), which belong to the biomedical and environment-friendly materials. Highly illustrated, the book introduces systematically the synthesis, physical and chemical modifications, and the latest developments of research and applications of poly (lactic acid) in biomedical materials. The book is intended for researchers and graduate students in the fields of materials science and engineering, polymer science and engineering, biomedicine, chemistry, environmental sciences, textile science and engineering, package materials, and so on. Dr. Jie Ren is a professor at the Institute of Nano and Bio-Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, China.
