Biocombinatorial Approaches for Drug Finding

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Publisher : Springer Science & Business Media
ISBN 13 : 3540270558
Total Pages : 302 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Biocombinatorial Approaches for Drug Finding by : W. Wohlleben

Download or read book Biocombinatorial Approaches for Drug Finding written by W. Wohlleben and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.

Biocombinatorial Approaches for Drug Finding

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Publisher : Springer
ISBN 13 : 9783540801979
Total Pages : 284 pages
Book Rating : 4.8/5 (19 download)

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Book Synopsis Biocombinatorial Approaches for Drug Finding by : W. Wohlleben

Download or read book Biocombinatorial Approaches for Drug Finding written by W. Wohlleben and published by Springer. This book was released on 2009-09-02 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.

Biocatalysis for the Pharmaceutical Industry

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Publisher : John Wiley & Sons
ISBN 13 : 0470823151
Total Pages : 250 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Biocatalysis for the Pharmaceutical Industry by : Junhua (Alex) Tao

Download or read book Biocatalysis for the Pharmaceutical Industry written by Junhua (Alex) Tao and published by John Wiley & Sons. This book was released on 2009-07-23 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides

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Publisher : Academic Press
ISBN 13 : 0080923356
Total Pages : 703 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides by :

Download or read book Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides written by and published by Academic Press. This book was released on 2009-04-10 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides Provides an extremely useful reference for the experienced research scientist

Appropriate Dose Selection - How to Optimize Clinical Drug Development

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540495290
Total Pages : 224 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Appropriate Dose Selection - How to Optimize Clinical Drug Development by : J. Venitz

Download or read book Appropriate Dose Selection - How to Optimize Clinical Drug Development written by J. Venitz and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.

Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacement Therapy

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Publisher : Springer Science & Business Media
ISBN 13 : 3540378618
Total Pages : 183 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacement Therapy by : M. A. Lewis

Download or read book Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacement Therapy written by M. A. Lewis and published by Springer Science & Business Media. This book was released on 2007-05-24 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) in modern postmenopausal women on the basis of evidence provided by recent epidemiological studies. It addresses all aspects of benefits and risks associated with HRT. It focuses, however, on cancer risk and on risk of breast cancer in particular. The book advocates further epidemiological studies which incorporate pathobiological assessments.

Natural Products via Enzymatic Reactions

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Publisher : Springer Science & Business Media
ISBN 13 : 3642164269
Total Pages : 221 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Natural Products via Enzymatic Reactions by : Jörn Piel

Download or read book Natural Products via Enzymatic Reactions written by Jörn Piel and published by Springer Science & Business Media. This book was released on 2010-10-21 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Building Blocks via Enzyme-Mediated Synthesis, by Thomas Fischer and Jörg Pietruszka * Engineered Biosynthesis of Plant Polyketides: Structure-Based and Precursor-Directed Approach, by Ikuro Abe * Enzymatic and Chemo-Enzymatic Approaches Towards Natural and Non-Natural Alkaloids: Indoles, Isoquinolines, and Others, by Joachim Stöckigt, Zhong Chen, and Martin Ruppert * Chemoenzymatic and Bioenzymatic Synthesis of Carbohydrate Containing Natural Products, by Bohdan Ostash, Xiaohui Yan, Victor Fedorenko, and Andreas Bechthold * Total (Bio)Synthesis: Strategies of Nature and of Chemists, by Alexandra A. Roberts, Katherine S. Ryan, Bradley S. Moore, and Tobias A.M. Gulder

New Mechanisms for Tissue-Selective Estrogen-Free Contraception

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540271473
Total Pages : 273 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis New Mechanisms for Tissue-Selective Estrogen-Free Contraception by : H.B. Croxatto

Download or read book New Mechanisms for Tissue-Selective Estrogen-Free Contraception written by H.B. Croxatto and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.

The Histone Code and Beyond

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Publisher : Springer Science & Business Media
ISBN 13 : 354037633X
Total Pages : 223 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis The Histone Code and Beyond by : Shelley L. Berger

Download or read book The Histone Code and Beyond written by Shelley L. Berger and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

PET Chemistry

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Publisher : Springer Science & Business Media
ISBN 13 : 3540495274
Total Pages : 348 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis PET Chemistry by : P.A. Schubiger

Download or read book PET Chemistry written by P.A. Schubiger and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

The Promises and Challenges of Regenerative Medicine

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540234814
Total Pages : 160 pages
Book Rating : 4.2/5 (348 download)

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Book Synopsis The Promises and Challenges of Regenerative Medicine by : John Morser

Download or read book The Promises and Challenges of Regenerative Medicine written by John Morser and published by Springer Science & Business Media. This book was released on 2005-07-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melanocyte system for studying stem cell niche -- Establishment and maniupulation of monkey and human embryonic stem cell lines for biomedical research -- Human embryonic stem cell derivation -- In search of the elusive epidermal stem cell -- Corneal cells for regeneration -- Polycomb gene product Bmi-l -- Directed differentiation of neural and sensory tissues from embryonic stem cells in vitro -- Stem cell biology for vascular regeneration.

Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 3540376739
Total Pages : 225 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases by : R. Numerof

Download or read book Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases written by R. Numerof and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".

Chronic Viral and Inflammatory Cardiomyopathy

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Publisher : Springer Science & Business Media
ISBN 13 : 3540308229
Total Pages : 369 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Chronic Viral and Inflammatory Cardiomyopathy by : Heinz-Peter Schultheiss

Download or read book Chronic Viral and Inflammatory Cardiomyopathy written by Heinz-Peter Schultheiss and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interconnectedness of genetics and susceptibility to disease, viral and non-viral inflammation, and the role of immunity and the development of autoimmunity is a fascinating and much discussed topic in cardiomyopathy. This publication constitutes the outcome of an ESRF meeting held together with the German Research Foundation. Clinical researchers, immunologists, virologists and molecular biologists provide the latest findings in their fields, advancing our understanding of what causes chronic viral and inflammatory cardiomyopathy, why it affects a subset of individuals while sparing the majority, how we can develop better therapies, and whether the disease can be prevented. Special emphasis is placed on the role of viruses in the aetiology and pathogenesis of cardiomyopathy. The editors are convinced that the broad spectrum covered by this state-of-the-art publication will be of exceptional value to its readers.

Chemical Genomics

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Publisher : Springer Science & Business Media
ISBN 13 : 3540376356
Total Pages : 187 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Chemical Genomics by : Stefan Jaroch

Download or read book Chemical Genomics written by Stefan Jaroch and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

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Publisher : Springer Science & Business Media
ISBN 13 : 3540276262
Total Pages : 200 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Opportunities and Challenges of the Therapies Targeting CNS Regeneration by : H.D. Perez

Download or read book Opportunities and Challenges of the Therapies Targeting CNS Regeneration written by H.D. Perez and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Advances in Applied Microbiology

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Publisher : Elsevier
ISBN 13 : 9780080463285
Total Pages : 272 pages
Book Rating : 4.4/5 (632 download)

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Book Synopsis Advances in Applied Microbiology by :

Download or read book Advances in Applied Microbiology written by and published by Elsevier. This book was released on 2011-07-29 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in Microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics including Archaea and Sick Building Syndrome. Impact factor for 2003: 1.893

American Book Publishing Record

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Publisher :
ISBN 13 :
Total Pages : 760 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis American Book Publishing Record by :

Download or read book American Book Publishing Record written by and published by . This book was released on 2003 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: