Basic Statistics And Pharmaceutical Statistical Applications Second Edition

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Basic Statistics and Pharmaceutical Statistical Applications, Second Edition

Author : James E. De Muth
Publisher : CRC Press
ISBN 13 : 9780849337994
Total Pages : 754 pages
Book Rating : 4.3/5 (379 download)

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Book Synopsis Basic Statistics and Pharmaceutical Statistical Applications, Second Edition by : James E. De Muth

Download or read book Basic Statistics and Pharmaceutical Statistical Applications, Second Edition written by James E. De Muth and published by CRC Press. This book was released on 2006-05-10 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Basic Statistics and Pharmaceutical Statistical Applications successfully provided a practical, easy-to-read, basic statistics book. This second edition not only updates the previous edition, but expands coverage in the area of biostatistics and how it relates to real-world professional practice. Taking you on a roller coaster ride through the world of statistics, Dr. De Muth clearly details the methodology necessary to summarize data and make informed decisions about observed outcomes. What's new or different in the Second Edition? New chapters cover: Measures of association primarily with nominal and ordinal data and and more than 15 tests Survival statistics including actuarial analysis and an introduction to multiple regression with survival data using proportional hazards regression An introduction to the topic of evidence-based practice with discussions of sensitivity and specificity, predictive values, and likelihood ratios Odds ratios and relative risk ratios that provide valuable information for dealing with probability, odds, and risk New sections address Power and sample size determination for two-sample Z-tests of proportions Clinical equivalence and noninferiority studies, process capability, and tolerance limits Methods for assessing repeatability and reproducibility Expanded information includes: Chi square, repeated measures designs, Latin Square designs, nine multiple comparison tests, and outlier testing Inverse prediction with linear regression, handling of multiple data points at different levels of independent variable, and assessment of parallelism of slopes for two samples Additional types of bivariate correlations and various assessments for independence and randomness More nonparametric tests including new information on post hoc comparisons for a significant Kruskal-Wallis test, the Kolmogorov-Smirnov goodness-of-fit test, and the Anderson-Darling test, as well as runs and range tests Eight new tables useful for the interpretation of some of the new inferential statistics De Muth provides concrete examples that enable you to effectively manage information in your day-to-day problem solving and reporting of findings. By avoiding heavy-duty mathematics and theory, even the mathematically challenged can benefit and increase their confidence in using statistics procedures.

Basic Statistics and Pharmaceutical Statistical Applications, Third Edition

Author : James E. De Muth
Publisher : CRC Press
ISBN 13 : 1466596732
Total Pages : 850 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Basic Statistics and Pharmaceutical Statistical Applications, Third Edition by : James E. De Muth

Download or read book Basic Statistics and Pharmaceutical Statistical Applications, Third Edition written by James E. De Muth and published by CRC Press. This book was released on 2014-04-28 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on its best-selling predecessors, Basic Statistics and Pharmaceutical Statistical Applications, Third Edition covers statistical topics most relevant to those in the pharmaceutical industry and pharmacy practice. It focuses on the fundamentals required to understand descriptive and inferential statistics for problem solving. Incorporating new material in virtually every chapter, this third edition now provides information on software applications to assist with evaluating data. New to the Third Edition Use of Excel® and Minitab® for performing statistical analysis Discussions of nonprobability sampling procedures, determining if data is normally distributed, evaluation of covariances, and testing for precision equivalence Expanded sections on regression analysis, chi square tests, tests for trends with ordinal data, and tests related to survival statistics Additional nonparametric procedures, including the one-sided sign test, Wilcoxon signed-ranks test, and Mood’s median test With the help of flow charts and tables, the author dispels some of the anxiety associated with using basic statistical tests in the pharmacy profession and helps readers correctly interpret their results using statistical software. Through the text’s worked-out examples, readers better understand how the mathematics works, the logic behind many of the equations, and the tests’ outcomes.

Basic Statistics and Pharmaceutical Statistical Applications

Author : James E. De Muth
Publisher : CRC Press
ISBN 13 : 9780824719678
Total Pages : 624 pages
Book Rating : 4.7/5 (196 download)

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Book Synopsis Basic Statistics and Pharmaceutical Statistical Applications by : James E. De Muth

Download or read book Basic Statistics and Pharmaceutical Statistical Applications written by James E. De Muth and published by CRC Press. This book was released on 1999-06-18 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extremely pragmatic and accessible reference provides scientists with a basic knowledge of statistics-focusing on the practical applications of statistical methods to research, quality control, and data analysis. Basic Statistics and Pharmaceutical Statistical Applications explores types of variables, random sampling, probability, measures of central tendency, and hypothesis (or significance) testing, discusses regression analysis, nonparametric tests, and power determination, and examines study designs, confidence intervals, dissolution testing, and bioequivalence. The author also describes the interrelation of hypotheses, test statistics, decision rules, computations, and statistical decisions and addresses testing factors such as precision, accuracy, bias, sensitivity, and selectivity Featuring almost 500 equations, tables, drawings, and references, Basic Statistics and Pharmaceutical Statistical Applications is required reading for pharmacists, analytical chemists, clinical trial monitors, medical writers, and upper-level undergraduate and graduate students in these disciplines.

Basic Statistics

Author : Olive Jean Dunn
Publisher : John Wiley & Sons
ISBN 13 : 0470496851
Total Pages : 271 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Basic Statistics by : Olive Jean Dunn

Download or read book Basic Statistics written by Olive Jean Dunn and published by John Wiley & Sons. This book was released on 2009-08-11 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Edition of a Classic Guide to Statistical Applications in the Biomedical Sciences In the last decade, there have been significant changes in the way statistics is incorporated into biostatistical, medical, and public health research. Addressing the need for a modernized treatment of these statistical applications, Basic Statistics, Fourth Edition presents relevant, up-to-date coverage of research methodology using careful explanations of basic statistics and how they are used to address practical problems that arise in the medical and public health settings. Through concise and easy-to-follow presentations, readers will learn to interpret and examine data by applying common statistical tools, such as sampling, random assignment, and survival analysis. Continuing the tradition of its predecessor, this new edition outlines a thorough discussion of different kinds of studies and guides readers through the important, related decision-making processes such as determining what information is needed and planning the collections process. The book equips readers with the knowledge to carry out these practices by explaining the various types of studies that are commonly conducted in the fields of medical and public health, and how the level of evidence varies depending on the area of research. Data screening and data entry into statistical programs is explained and accompanied by illustrations of statistical analyses and graphs. Additional features of the Fourth Edition include: A new chapter on data collection that outlines the initial steps in planning biomedical and public health studies A new chapter on nonparametric statistics that includes a discussion and application of the Sign test, the Wilcoxon Signed Rank test, and the Wilcoxon Rank Sum test and its relationship to the Mann-Whitney U test An updated introduction to survival analysis that includes the Kaplan Meier method for graphing the survival function and a brief introduction to tests for comparing survival functions Incorporation of modern statistical software, such as SAS, Stata, SPSS, and Minitab into the presented discussion of data analysis Updated references at the end of each chapter Basic Statistics, Fourth Edition is an ideal book for courses on biostatistics, medicine, and public health at the upper-undergraduate and graduate levels. It is also appropriate as a reference for researchers and practitioners who would like to refresh their fundamental understanding of statistical techniques.

Pharmaceutical Statistics

Author : Sanford Bolton
Publisher : CRC Press
ISBN 13 : 1420074237
Total Pages : 666 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pharmaceutical Statistics by : Sanford Bolton

Download or read book Pharmaceutical Statistics written by Sanford Bolton and published by CRC Press. This book was released on 2009-12-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through the use of practical examples and solutions, Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition provides the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly in clinical trials and bioequivalence studies.

Multiple Testing Problems in Pharmaceutical Statistics

Author : Alex Dmitrienko
Publisher : CRC Press
ISBN 13 : 1584889853
Total Pages : 323 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Multiple Testing Problems in Pharmaceutical Statistics by : Alex Dmitrienko

Download or read book Multiple Testing Problems in Pharmaceutical Statistics written by Alex Dmitrienko and published by CRC Press. This book was released on 2009-12-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c

Sample Size Calculations in Clinical Research, Second Edition

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 1584889837
Total Pages : 480 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Sample Size Calculations in Clinical Research, Second Edition by : Shein-Chung Chow

Download or read book Sample Size Calculations in Clinical Research, Second Edition written by Shein-Chung Chow and published by CRC Press. This book was released on 2007-08-22 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, noninferiority/superiority, and equivalence. A comprehensive and unified presentation of statistical concepts and practical applications, this book highlights the interactions between clinicians and biostatisticians, includes a well-balanced summary of current and emerging clinical issues, and explores recently developed statistical methodologies for sample size calculation. Whenever possible, each chapter provides a brief history or background, regulatory requirements, statistical designs and methods for data analysis, real-world examples, future research developments, and related references. One of the few books to systematically summarize clinical research procedures, this edition contains new chapters that focus on three key areas of this field. Incorporating the material of this book in your work will help ensure the validity and, ultimately, the success of your clinical studies.

Bayesian Missing Data Problems

Author : Ming T. Tan
Publisher : CRC Press
ISBN 13 : 9781420077506
Total Pages : 344 pages
Book Rating : 4.0/5 (775 download)

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Book Synopsis Bayesian Missing Data Problems by : Ming T. Tan

Download or read book Bayesian Missing Data Problems written by Ming T. Tan and published by CRC Press. This book was released on 2009-08-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Missing Data Problems: EM, Data Augmentation and Noniterative Computation presents solutions to missing data problems through explicit or noniterative sampling calculation of Bayesian posteriors. The methods are based on the inverse Bayes formulae discovered by one of the author in 1995. Applying the Bayesian approach to important real-world problems, the authors focus on exact numerical solutions, a conditional sampling approach via data augmentation, and a noniterative sampling approach via EM-type algorithms. After introducing the missing data problems, Bayesian approach, and posterior computation, the book succinctly describes EM-type algorithms, Monte Carlo simulation, numerical techniques, and optimization methods. It then gives exact posterior solutions for problems, such as nonresponses in surveys and cross-over trials with missing values. It also provides noniterative posterior sampling solutions for problems, such as contingency tables with supplemental margins, aggregated responses in surveys, zero-inflated Poisson, capture-recapture models, mixed effects models, right-censored regression model, and constrained parameter models. The text concludes with a discussion on compatibility, a fundamental issue in Bayesian inference. This book offers a unified treatment of an array of statistical problems that involve missing data and constrained parameters. It shows how Bayesian procedures can be useful in solving these problems.

Data and Safety Monitoring Committees in Clinical Trials

Author : Jay Herson
Publisher : CRC Press
ISBN 13 : 1420070398
Total Pages : 194 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Data and Safety Monitoring Committees in Clinical Trials by : Jay Herson

Download or read book Data and Safety Monitoring Committees in Clinical Trials written by Jay Herson and published by CRC Press. This book was released on 2009-03-13 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical clinical and statistical issues that arise in pharmaceutical industry trials, this book summarizes the author’s experience in serving on many data monitoring committees (DMCs) and in heading up a contract research organization that provided statistical support to nearly seventy-five DMCs. It explains the difference in DMC operations between the pharmaceutical industry and National Institutes of Health (NIH)-sponsored trials. Leading you through the types of reports for adverse events and lab values, the author presents the statistical requirements of data monitoring committees and gives advice on how statisticians can best interact with physician members of these committees. He also shows how physicians think differently about safety data than statisticians, proving that both views are needed.

Frailty Models in Survival Analysis

Author : Andreas Wienke
Publisher : CRC Press
ISBN 13 : 9781420073911
Total Pages : 324 pages
Book Rating : 4.0/5 (739 download)

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Book Synopsis Frailty Models in Survival Analysis by : Andreas Wienke

Download or read book Frailty Models in Survival Analysis written by Andreas Wienke and published by CRC Press. This book was released on 2010-07-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. In its simplest form, frailty is an unobserved random proportionality factor that modifies the hazard function of an individual or a group of related individuals. Frailty Models in Survival Analysis presents a comprehensive overview of the fundamental approaches in the area of frailty models. The book extensively explores how univariate frailty models can represent unobserved heterogeneity. It also emphasizes correlated frailty models as extensions of univariate and shared frailty models. The author analyzes similarities and differences between frailty and copula models; discusses problems related to frailty models, such as tests for homogeneity; and describes parametric and semiparametric models using both frequentist and Bayesian approaches. He also shows how to apply the models to real data using the statistical packages of R, SAS, and Stata. The appendix provides the technical mathematical results used throughout. Written in nontechnical terms accessible to nonspecialists, this book explains the basic ideas in frailty modeling and statistical techniques, with a focus on real-world data application and interpretation of the results. By applying several models to the same data, it allows for the comparison of their advantages and limitations under varying model assumptions. The book also employs simulations to analyze the finite sample size performance of the models.

Monte Carlo Simulation for the Pharmaceutical Industry

Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1439835934
Total Pages : 566 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Monte Carlo Simulation for the Pharmaceutical Industry by : Mark Chang

Download or read book Monte Carlo Simulation for the Pharmaceutical Industry written by Mark Chang and published by CRC Press. This book was released on 2010-09-29 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to commercialization. It presents the theories and metho

Bayesian Adaptive Methods for Clinical Trials

Author : Scott M. Berry
Publisher : CRC Press
ISBN 13 : 1439825513
Total Pages : 316 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bayesian Adaptive Methods for Clinical Trials by : Scott M. Berry

Download or read book Bayesian Adaptive Methods for Clinical Trials written by Scott M. Berry and published by CRC Press. This book was released on 2010-07-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti

Bayesian Modeling in Bioinformatics

Author : Dipak K. Dey
Publisher : CRC Press
ISBN 13 : 1420070185
Total Pages : 466 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Bayesian Modeling in Bioinformatics by : Dipak K. Dey

Download or read book Bayesian Modeling in Bioinformatics written by Dipak K. Dey and published by CRC Press. This book was released on 2010-09-03 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and c

Clinical Trial Methodology

Author : Karl E. Peace
Publisher : CRC Press
ISBN 13 : 1584889187
Total Pages : 422 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Clinical Trial Methodology by : Karl E. Peace

Download or read book Clinical Trial Methodology written by Karl E. Peace and published by CRC Press. This book was released on 2010-07-20 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Drawing from the authors' courses on the subject as well as the first author's more than 30 years wor

A Review of Statistical Methods for Medical and Allied Health Professionals

Author : Antoine Al-Achi
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527588599
Total Pages : 607 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis A Review of Statistical Methods for Medical and Allied Health Professionals by : Antoine Al-Achi

Download or read book A Review of Statistical Methods for Medical and Allied Health Professionals written by Antoine Al-Achi and published by Cambridge Scholars Publishing. This book was released on 2022-10-13 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistics is a subject that benefits many other disciplines in its application and has contributed tremendously to the advancement of medicine. In recognition of the central role of statistics in the health fields, certification agencies have incorporated this science into their requirements for knowledge acquisition by their members. This recognition is also reflected in the board exams, particularly those taken for clinical board specialty certification tests. This book reinforces statistical principles for those who have taken a course in the subject during their years of education. It provides many examples and exercises to allow the reader to review the material discussed. Its concise presentation and the repetition of ideas throughout the text help solidify the reader’s learning and retention of knowledge of the various topics presented.

Translational Medicine

Author : Dennis Cosmatos
Publisher : CRC Press
ISBN 13 : 1584888733
Total Pages : 244 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Translational Medicine by : Dennis Cosmatos

Download or read book Translational Medicine written by Dennis Cosmatos and published by CRC Press. This book was released on 2008-12-17 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines Critical Decisions for Transitioning Lab Science to a Clinical SettingThe development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in

Elementary Bayesian Biostatistics

Author : Lemuel A. Moye
Publisher : CRC Press
ISBN 13 : 1584887257
Total Pages : 400 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Elementary Bayesian Biostatistics by : Lemuel A. Moye

Download or read book Elementary Bayesian Biostatistics written by Lemuel A. Moye and published by CRC Press. This book was released on 2016-04-19 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of noninformative priors as well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian procedures, Elementary Bayesian Biostatistics explo