Autism Imaging and Devices

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Publisher : CRC Press
ISBN 13 : 1498709826
Total Pages : 572 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Autism Imaging and Devices by : Manuel F. Casanova

Download or read book Autism Imaging and Devices written by Manuel F. Casanova and published by CRC Press. This book was released on 2017-01-06 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers state-of-the-art medical image analysis approaches currently pursued in autism research. Chapters cover recent advances in diagnosis using structural neuroimaging. All aspects of imaging are included, such as electrophysiology (EEG, ERP, QEEG, and MEG), postmortem techniques, and advantages and difficulties of depositing/acquiring images in larger databases. The book incorporates 2D, 3D, and 4D imaging and advances scientific research within the broad field of autism imaging.

Autism Imaging and Devices

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Author :
Publisher : CRC Press
ISBN 13 : 1315354195
Total Pages : 608 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Autism Imaging and Devices by : Manuel F. Casanova

Download or read book Autism Imaging and Devices written by Manuel F. Casanova and published by CRC Press. This book was released on 2017-01-06 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers state-of-the-art medical image analysis approaches currently pursued in autism research. Chapters cover recent advances in diagnosis using structural neuroimaging. All aspects of imaging are included, such as electrophysiology (EEG, ERP, QEEG, and MEG), postmortem techniques, and advantages and difficulties of depositing/acquiring images in larger databases. The book incorporates 2D, 3D, and 4D imaging and advances scientific research within the broad field of autism imaging.

Neural Engineering Techniques for Autism Spectrum Disorder

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Publisher : Academic Press
ISBN 13 : 0128230657
Total Pages : 400 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Neural Engineering Techniques for Autism Spectrum Disorder by : Ayman S. El-Baz

Download or read book Neural Engineering Techniques for Autism Spectrum Disorder written by Ayman S. El-Baz and published by Academic Press. This book was released on 2021-07-16 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Engineering for Autism Spectrum Disorder, Volume One: Imaging and Signal Analysis Techniques presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, social behaviors and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals are presented for detection and estimation of the degree of ASD. Presents applications of Neural Engineering and other Machine Learning techniques for the diagnosis of Autism Spectrum Disorder (ASD) Includes in-depth technical coverage of imaging and signal analysis techniques, including coverage of functional MRI, neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, and neuroanatomy of autism Covers Signal Analysis for the detection and estimation of Autism Spectrum Disorder (ASD), including brain signal analysis, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals for ASD Written to help engineers, computer scientists, researchers and clinicians understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)

Advanced Neuroimaging Methods for Studying Autism Disorder

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889453162
Total Pages : 143 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Advanced Neuroimaging Methods for Studying Autism Disorder by : Alessandro Grecucci

Download or read book Advanced Neuroimaging Methods for Studying Autism Disorder written by Alessandro Grecucci and published by Frontiers Media SA. This book was released on 2017-11-16 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last twenty years, many attempts have been made to provide neurobiological models of autism. Functional, structural and connectivity analyses have highlighted reduced responses in key social areas, such as amygdala, medial prefrontal cortex, cingulate cortex, and superior temporal sulcus. However, these studies present discrepant results and some of them have been questioned for methodological limitations. The aim of this research topic is to present advanced neuroimaging methods able to capture the complexity of the neural deficits displayed in autism. This special issue presents new studies using structural and functional MRI, as well as magnetoencephalography, and novel protocols to analyze data (Analysis of Cluster Variability, Noise Reduction Strategies, Source-based Morphometry, Functional Connectivity Density, Restriction Spectrum Imaging and the others). We believe it is time to integrate data provided by different techniques and methodologies in order to have a better understanding of autism.

Autism Spectrum Disorder

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535120379
Total Pages : 380 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Autism Spectrum Disorder by : Michael Fitzgerald

Download or read book Autism Spectrum Disorder written by Michael Fitzgerald and published by BoD – Books on Demand. This book was released on 2015-04-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Psychoradiology, An Issue of Neuroimaging Clinics of North America, Ebook

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323708870
Total Pages : 145 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Psychoradiology, An Issue of Neuroimaging Clinics of North America, Ebook by : Qiyong Gong

Download or read book Psychoradiology, An Issue of Neuroimaging Clinics of North America, Ebook written by Qiyong Gong and published by Elsevier Health Sciences. This book was released on 2019-12-03 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Neuroimaging Clinics of North America focuses on Psychoradiology, and is edited by Dr. Qiyong Gong. Articles will include: Clinical Strategies and Technical Challenges in Psychoradiology; Resting State Functional MRI for Psychiatry; Magnetic Resonance Spectroscopy for Psychiatry; Psychoradiology of Major Depression; Psychoradiological Biomarkers for Psychopharmaceutical Effects; Implementing Imaging into Clinical Routine Screening for Psychosis; Imaging of Autism; Individual-specific Analysis for Psychoradiology; Interventional Psychoradiology: Imaging Guided Therapeutic Intervention of Neuropsychiatric Disorders; Imaging-based Subtyping for Psychiatric Syndromes; Imaging of Post-Traumatic Stress Disorder; Imaging of Schizophrenia; and more!

Autism

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Author :
Publisher : Taylor & Francis
ISBN 13 : 100083820X
Total Pages : 306 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Autism by : Mary Clasquin-Johnson

Download or read book Autism written by Mary Clasquin-Johnson and published by Taylor & Francis. This book was released on 2023-02-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written at a time of a paradigm shift in the African continent where dependence on western epistemologies and ontologies are giving way to African indigenous knowledge systems. Africa has been an importer of knowledge from the west since time immemorial and this book contributes to the body of knowledge on autism spectrum disorder (ASD) from the African perspective. As a result, decoloniality and Inclusive Education have gained traction within the academic discourse, with University of South Africa (UNISA) hosting decoloniality annual conference and a summer school to stimulate academic discussions and debates with a focus on African indigenous knowledge systems and theoretical lenses as opposed to the western epistemologies. The book also demystifies some of the misconceptions that children with ASD are a curse and punishment from God or gods. Among others, Ubuntu seems to be the dominant theoretical framework underpinning some of the research studies reported in this book.

Understanding and Treating Anxiety in Autism

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Author :
Publisher : Jessica Kingsley Publishers
ISBN 13 : 1787751538
Total Pages : 274 pages
Book Rating : 4.7/5 (877 download)

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Book Synopsis Understanding and Treating Anxiety in Autism by : Stephen M. Edelson

Download or read book Understanding and Treating Anxiety in Autism written by Stephen M. Edelson and published by Jessica Kingsley Publishers. This book was released on 2020-09-21 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anxiety is a prevalent and often debilitating condition for individuals on the autism spectrum. This book promotes a multidisciplinary approach to intervention and treatment of the condition, providing professional understanding of the underlying causes and available treatments. With chapters co-authored by well-known advocates and pioneering researchers, contributors examine factors including sensory processing issues, sleep impairments and the crossover between the autonomic nervous system and immune system. The book expands upon current areas of research, including immune activation and the role of environmental toxicants, dietary and nutritional support, the treatment of gastrointestinal disorders and individualised methods of managing stress and anxiety. Providing an invaluable resource for professionals and academics seeking further insight into anxiety and autism, this book explores contemporary research and sets the groundwork for the most effective methods of treatment for individuals of all ages.

Technology-Supported Teaching and Research Methods for Educators

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Author :
Publisher : IGI Global
ISBN 13 : 1522559167
Total Pages : 348 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Technology-Supported Teaching and Research Methods for Educators by : Makewa, Lazarus Ndiku

Download or read book Technology-Supported Teaching and Research Methods for Educators written by Makewa, Lazarus Ndiku and published by IGI Global. This book was released on 2018-09-28 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technology can be a powerful tool for transforming learning. It can help affirm and advance relationships between educators and students, reinvent approaches to learning and collaboration, shrink long-standing equity and accessibility gaps, and adapt learning experiences to meet the needs of all learners. Technology-Supported Teaching and Research Methods for Educators provides innovative insights into the utilization and maintenance of technology-supported teaching and research methods for educators. The content within this publication represents the work of e-learning, digital technologies, and current issues and trends in the field of teaching and learning in the context of contemporary technologies. It is a vital reference source for school educators, professionals, school administrators, academicians, researchers, and graduate-level students seeking coverage on topics centered on the integration of effective technologies that will support educators and students.

Neuropsychiatry, An Issue of Psychiatric Clinics of North America

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323789528
Total Pages : 217 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Neuropsychiatry, An Issue of Psychiatric Clinics of North America by : Vassilis E Koliatsos

Download or read book Neuropsychiatry, An Issue of Psychiatric Clinics of North America written by Vassilis E Koliatsos and published by Elsevier Health Sciences. This book was released on 2020-05-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Psychiatric Clinics, guest edited by Dr. Vassilis E. Koliatsos will cover Neuropsychiatry. This issue is one of four each year selected by our series consulting editor, Dr. Harsh Trivedi of Sheppard Pratt Health System. Topics in this issue include: The clinical neurobiology of autism spectrum disorders; New developments in impulse control disorders; Schizophrenia as a neurodevelopmental phenotype; Neuropsychiatric Aspects of Epilepsy; New developments in addiction; The clinical neuroscience of acquired brain injury; New developments in frontotemporal dementia; Lewy body degenerations as neuropsychiatric disorders; Neuropsychiatric challenges in Alzheimer’s disease; and New pharmacological approaches in Neuropsychiatry, among others.

Neural Engineering Techniques for Autism Spectrum Disorder, Volume 2

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Author :
Publisher : Academic Press
ISBN 13 : 0128244224
Total Pages : 347 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Neural Engineering Techniques for Autism Spectrum Disorder, Volume 2 by : Jasjit Suri

Download or read book Neural Engineering Techniques for Autism Spectrum Disorder, Volume 2 written by Jasjit Suri and published by Academic Press. This book was released on 2022-10-17 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Engineering for Autism Spectrum Disorder, Volume Two: Diagnosis and Clinical Analysis presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, magnetic resonance spectroscopy, MRI, fMRI, DTI, video analysis of sensory-motor and social behaviors, and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, fuzzy model and temporal fractal analysis of rest state BOLD signals and brain signals are also presented. A clinical guide for general practitioners is provided along with a variety of assessment techniques such as magnetic resonance spectroscopy. The book is presented in two volumes, including Volume One: Imaging and Signal Analysis Techniques comprised of two Parts: Autism and Medical Imaging, and Autism and Signal Analysis. Volume Two: Diagnosis and Treatment includes Autism and Clinical Analysis: Diagnosis, and Autism and Clinical Analysis: Treatment. Presents applications of Neural Engineering techniques for diagnosis of Autism Spectrum Disorder (ASD) Includes in-depth technical coverage of assessment techniques, such as the functional and structural networks underlying visuospatial vs. linguistic reasoning in autism Covers treatment techniques for Autism Spectrum Disorder (ASD), including social skills intervention, behavioral treatment, evidence-based treatments, and technical tools such as Magnetic Resonance Spectroscopy for ASD Written by engineers for engineers, computer scientists, researchers and clinicians who need to understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)

Modern Approaches to Augmentation of Brain Function

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Author :
Publisher : Springer Nature
ISBN 13 : 3030545644
Total Pages : 747 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Modern Approaches to Augmentation of Brain Function by : Ioan Opris

Download or read book Modern Approaches to Augmentation of Brain Function written by Ioan Opris and published by Springer Nature. This book was released on 2021-08-25 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in neural technology that provide for enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits involved in perception, cognition, emotion and action, that represent the building blocks of behavior and cognition. Augmentation of brain function can be achieved by using brain implants for recordings, stimulation, or drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. This volume evaluates existing methods of brain augmentation while discussing the brain circuitry and neuronal mechanisms that make augmentation possible. This volume offers novel insights into brain disorders, and explores new devices for brain repair while also addressing the philosophical and ethical implications of brain augmentation. The information in this book is relevant to researchers in the fields of neuroscience, engineering, and clinical practice. Advance Praise for Modern Approaches to Augmentation of Brain Function: “This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.” Ray Kurzweil, best-selling author, inventor, entrepreneur and a recipient of the National Medal of Technology and Innovation (1999), and the Lemelson-MIT Prize (2001) "This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. " Ioan Dumitrache, Prof. Dr. Eng. Faculty of Computer Science, Polytechnic University of Bucharest, Bucharest, Romania “This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.” György Buzsáki, MD, PhD is the Biggs Professor of Neuroscience, NYU School of Medicine, New York, NY

Brain Connectivity in Autism

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Author :
Publisher : Frontiers E-books
ISBN 13 : 2889192822
Total Pages : 265 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Brain Connectivity in Autism by : Rajesh K. Kana

Download or read book Brain Connectivity in Autism written by Rajesh K. Kana and published by Frontiers E-books. This book was released on 2014-09-23 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.

Medical Image Computing and Computer Assisted Intervention – MICCAI 2018

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Author :
Publisher : Springer
ISBN 13 : 3030009319
Total Pages : 749 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 by : Alejandro F. Frangi

Download or read book Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 written by Alejandro F. Frangi and published by Springer. This book was released on 2018-09-13 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: The four-volume set LNCS 11070, 11071, 11072, and 11073 constitutes the refereed proceedings of the 21st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2018, held in Granada, Spain, in September 2018. The 373 revised full papers presented were carefully reviewed and selected from 1068 submissions in a double-blind review process. The papers have been organized in the following topical sections: Part I: Image Quality and Artefacts; Image Reconstruction Methods; Machine Learning in Medical Imaging; Statistical Analysis for Medical Imaging; Image Registration Methods. Part II: Optical and Histology Applications: Optical Imaging Applications; Histology Applications; Microscopy Applications; Optical Coherence Tomography and Other Optical Imaging Applications. Cardiac, Chest and Abdominal Applications: Cardiac Imaging Applications: Colorectal, Kidney and Liver Imaging Applications; Lung Imaging Applications; Breast Imaging Applications; Other Abdominal Applications. Part III: Diffusion Tensor Imaging and Functional MRI: Diffusion Tensor Imaging; Diffusion Weighted Imaging; Functional MRI; Human Connectome. Neuroimaging and Brain Segmentation Methods: Neuroimaging; Brain Segmentation Methods. Part IV: Computer Assisted Intervention: Image Guided Interventions and Surgery; Surgical Planning, Simulation and Work Flow Analysis; Visualization and Augmented Reality. Image Segmentation Methods: General Image Segmentation Methods, Measures and Applications; Multi-Organ Segmentation; Abdominal Segmentation Methods; Cardiac Segmentation Methods; Chest, Lung and Spine Segmentation; Other Segmentation Applications.

Autism

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Author :
Publisher : The Rosen Publishing Group, Inc
ISBN 13 : 1435848268
Total Pages : 66 pages
Book Rating : 4.4/5 (358 download)

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Book Synopsis Autism by : Jeri Freedman

Download or read book Autism written by Jeri Freedman and published by The Rosen Publishing Group, Inc. This book was released on 2008-08-15 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes a wide spectrum of developmental disorders affecting four times as many boys and girls. The expert-reviewed book takes the reader through the history of the disorder, explaining in detail its symptoms, diagnosis, and treatment. It also lays our the most current explanation of the disorder, as well as the best ways to researchers have found to treat the symptoms. The last chapter is dedicated to explaining how researchers are working to design

Re-Envisioning and Restructuring Blended Learning for Underprivileged Communities

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Author :
Publisher : IGI Global
ISBN 13 : 1799869423
Total Pages : 330 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Re-Envisioning and Restructuring Blended Learning for Underprivileged Communities by : Bosch, Chantelle

Download or read book Re-Envisioning and Restructuring Blended Learning for Underprivileged Communities written by Bosch, Chantelle and published by IGI Global. This book was released on 2021-05-14 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Challenges in the educational arena are not new phenomena. However, with the recent outbreak of the COVID-19 pandemic, researchers and educators have been made even more aware of the need for a paradigm shift in education. Blended learning, as opposed to fully online learning or traditional face-to-face teaching, has been well-researched and has been found to have the potential to provide better educational solutions in challenging contexts. These contexts range from pandemic situations where social distancing is the order of the day to financial and time constraints regarding full-time study, as well as limited physical capacity at institutions. Blended learning solutions are often designed for resourceful institutions and cannot be easily implemented in developing countries and in communities where resources are limited. Typical issues like connectivity, accessibility, lack of suitable devices, and affordability need to be taken into consideration and in cognizance of blended learning interventions. These challenges are often neglected in blended learning research but are critical discussions to be had. Re-Envisioning and Restructuring Blended Learning for Underprivileged Communities shares how institutions in the developing world and less privileged communities have re-imagined and restructured blended education to enhance teaching and learning for underprivileged communities. This book aims to address blended learning solutions across institutional, program, course, and activity levels. The chapters will cover a variety of learning environments, from rural settings to less developed countries and more, and explore the programs and courses designed to improve student success and accessibility in diverse student populations. This book is ideally intended for teachers, administrators, teacher educators, practitioners, stakeholders, researchers, academicians, and students who are interested in blended learning opportunities in less-privileged settings and to underserved and marginalized populations.

Autism Spectrum Disorders: From Genotypes to Phenotypes

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889196801
Total Pages : 95 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Autism Spectrum Disorders: From Genotypes to Phenotypes by : Valsamma Eapen

Download or read book Autism Spectrum Disorders: From Genotypes to Phenotypes written by Valsamma Eapen and published by Frontiers Media SA. This book was released on 2015-12-10 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.