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![Download Asymmetric Synthesis of [beta]-lactam Derivatives PDF Online Free](https://books.google.com/books/content/images/frontcover/YzsrOAAACAAJ?fife=w200-h370)
Author : Chun Ma
Publisher :
ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (283 download)
Download or read book Asymmetric Synthesis of [beta]-lactam Derivatives written by Chun Ma and published by . This book was released on 1992 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bimal K. Banik
Publisher : Springer
ISBN 13 : 3319556215
Total Pages : 423 pages
Book Rating : 4.3/5 (195 download)
Download or read book Beta-Lactams written by Bimal K. Banik and published by Springer. This book was released on 2017-05-11 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Author : Caroline Evans
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (824 download)
Download or read book A Novel Methodology for the Asymmetric Synthesis of Beta-lactams and Beta-amino Acids written by Caroline Evans and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first example of an intramolecular ester enolate-imine cyclisation reaction for the asymmetric synthesis of polycyclic ~-Iactams and cyclic ~-amino acid derivatives has been developed. In Chapter 1, the synthesis of monocyclic ~-Iactams using intermolecular ester enolate- imine cyclisation reactions is reviewed. The use of chiral auxiliaries contained within the ester or imino functionality to control the diastereoselectivity of the reaction is discussed, as well as enantioselective approaches. The utilization of this methodology for the synthesis of natural products such as Taxol is described, as well as the use of polymer support protocols to improve the efficiency of this reaction. In Chapter 2, the synthesis of an appropriate cyclisation substrate containing an ester and imino functionality with a chiral auxiliary fragment is reported. Appropriate conditions were established that enabled an intramolecular enolate-imine cyclisation reaction to be used for the synthesis of the tricyclic ~-Iactam benzocispentacin in good yield and excellent de. The formation of ~-amino ester side products was investigated and an explanation for the production of ~-Iactams as major products over their corresponding ~-amino esters is proposed. This protocol was then applied to the asymmetric synthesis of six benzocispentacin derivatives all with good yields and excellent de, with the configuration of one of these derivatives being confirmed by X-ray crystallography. A deprotection methodology was then established to afford their corresponding tricyclic NH-~-Iactams and cis and trans bicyclic ~-amino esters. In Chapter 3, the newly devised methodology was also applied to acyclic substrates for the synthesis of the antifungal cispentacin. The ability to access both cis- and transpentacin in both high yields and excellent de as monomers for foldamer synthesis is reported.
![Download Asymmetric Synthesis of Optically Pure Non-protein Amino Acids and Their Derivatives Through [beta]-Lactam Synthon Method PDF Online Free](https://books.google.com/books/content/images/frontcover/oK6DNwAACAAJ?fife=w200-h370)
Author : Yazhong Pei
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (249 download)
Download or read book Asymmetric Synthesis of Optically Pure Non-protein Amino Acids and Their Derivatives Through [beta]-Lactam Synthon Method written by Yazhong Pei and published by . This book was released on 1990 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eusebio Juaristi
Publisher : John Wiley & Sons
ISBN 13 : 0471698474
Total Pages : 658 pages
Book Rating : 4.4/5 (716 download)
Download or read book Enantioselective Synthesis of Beta-Amino Acids written by Eusebio Juaristi and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.
![Download Asymmetric Synthesis of [beta]-lactams for the Preparation of Bioactive Compounds PDF Online Free](https://books.google.com/books/content/images/frontcover/MTv0NwAACAAJ?fife=w200-h370)
Author : Zhijun Wu
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (342 download)
Download or read book Asymmetric Synthesis of [beta]-lactams for the Preparation of Bioactive Compounds written by Zhijun Wu and published by . This book was released on 1995 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Asymmetric Synthesis of [beta]-lactams and Their Applications to Taxoids and Nonprotein Amino Acids PDF Online Free](https://books.google.com/books/content/images/frontcover/BmTBNwAACAAJ?fife=w200-h370)
Author : Young Hoon Park
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (325 download)
Download or read book Asymmetric Synthesis of [beta]-lactams and Their Applications to Taxoids and Nonprotein Amino Acids written by Young Hoon Park and published by . This book was released on 1994 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download A Novel Methodology for the Asymmetric Synthesis of B[beta]-lactams and B[beta]-amino Acids PDF Online Free](https://books.google.com/books/content/images/frontcover/9wNRyQEACAAJ?fife=w200-h370)
Author : Caroline Diana Evans
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book A Novel Methodology for the Asymmetric Synthesis of B[beta]-lactams and B[beta]-amino Acids written by Caroline Diana Evans and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bimal K. Banik
Publisher : Springer
ISBN 13 : 3642128459
Total Pages : 386 pages
Book Rating : 4.6/5 (421 download)
Download or read book Heterocyclic Scaffolds I written by Bimal K. Banik and published by Springer. This book was released on 2010-06-01 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: B. Alcaide ∙ P. Almendros: Novel Aspects on the Preparation of Spirocyclic and Fused Unsual β-Lactams.- S.S. Bari ∙ A. Bhalla: Spirocyclic β-Lactams: Synthesis and Biological Evaluation of Novel Heterocycles.- L. Troisi ∙ C. Granito ∙ E. Pindinelli: Novel and Recent Synthesis and Applications of β-Lactams.- C. Palomo ∙ M. Oiarbide: β-Lactams Ring Opening: A Useful Entry to Amino Acids and Relevant Nitrogen-Containing Compounds.- B. Mandal ∙ P. Ghosh ∙ B. Basu: Recent Approaches Towards Solid Phase Synthesis of β-Lactams.- A.Arrieta ∙ B. Lecea ∙ F.P. Cossio: Computational Studies on the Synthesis of β-Lactams Via [ 2+2] Thermal Cycloadditions.- B. K. Banik ∙ I. Banik ∙ F. F. Becker: Novel Anticancer β-Lactams
Author : Barry A. Bunin
Publisher : Elsevier
ISBN 13 : 0080542409
Total Pages : 341 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Combinatorial Index written by Barry A. Bunin and published by Elsevier. This book was released on 1998-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. - Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods - Serves as a laboratory manual for bench chemists - Includes a chapter on linkers to assist in choice of linking strategy - Discusses strengths and limitations of the various methods - Contains a structural index showing functional group transformations in solid-phase synthesis
Author : Alle Bruggink
Publisher : Springer Science & Business Media
ISBN 13 : 9401008507
Total Pages : 328 pages
Book Rating : 4.4/5 (1 download)
Download or read book Synthesis of β-Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author : Bimal Krishna Banik
Publisher : CRC Press
ISBN 13 : 1040146627
Total Pages : 474 pages
Book Rating : 4.0/5 (41 download)
Download or read book Chemistry and Biology of Beta-Lactams written by Bimal Krishna Banik and published by CRC Press. This book was released on 2024-11-07 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: • Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams • Microwave, ultrasound, and solid support-mediated preparation of beta-lactams • Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them • Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science • Synthesis and mechanism of formation of polyaromatic beta-lactams
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Author : Xiangming Guan
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (258 download)
Download or read book Asymmetric Synthesis of [alpha]-alkylated [alpha]-amino Acids and Stereoselective Synthesis of [beta]-lactams written by Xiangming Guan and published by . This book was released on 1991 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Asymmetric Synthesis of [alpha]-hydroxyl-4-alkyl-[beta]-lactams PDF Online Free](https://books.google.com/books/content/images/frontcover/NbVrNwAACAAJ?fife=w200-h370)
Author : Chung-Ming Sun
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (351 download)
Download or read book Asymmetric Synthesis of [alpha]-hydroxyl-4-alkyl-[beta]-lactams written by Chung-Ming Sun and published by . This book was released on 1995 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Takahiko Akiyama
Publisher : John Wiley & Sons
ISBN 13 : 1119736412
Total Pages : 798 pages
Book Rating : 4.1/5 (197 download)
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
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Author : Xiaogang Qiu
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (249 download)
Download or read book Synthesis of [alpha]-alkyl [alpha]-amino Acids, Dipeptides and Their Derivatives Through Asymmetric Alkylation of [beta]-lactam Esters written by Xiaogang Qiu and published by . This book was released on 1988 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bimal Krishna Banik
Publisher : CRC Press
ISBN 13 : 1040146619
Total Pages : 410 pages
Book Rating : 4.0/5 (41 download)
Download or read book Chemistry and Biology of Beta-Lactams written by Bimal Krishna Banik and published by CRC Press. This book was released on 2024-11-07 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams Microwave, ultrasound, and solid support-mediated preparation of beta-lactams Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science Synthesis and mechanism of formation of polyaromatic beta-lactams
