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Association Between Individuals Genomic Ancestry And Variation In Disease Susceptibility
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Book Synopsis Association Between Individuals’ Genomic Ancestry and Variation in Disease Susceptibility by : Ranajit Das
Download or read book Association Between Individuals’ Genomic Ancestry and Variation in Disease Susceptibility written by Ranajit Das and published by Frontiers Media SA. This book was released on 2022-03-03 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Ranajit Das is the Founder Director of Genome Mapster and Infygene Genomic Healthcare. Topic Editor Tatiana Tatarinova holds patents related to the Research Topic subject. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Book Synopsis Measuring and Using Genetic Ancestry Information in Genome-wide Admixture Mapping and Association Mapping of Complex Diseases by : Chao Tian
Download or read book Measuring and Using Genetic Ancestry Information in Genome-wide Admixture Mapping and Association Mapping of Complex Diseases written by Chao Tian and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: There exists much variation in genetic ancestry within and between ethnic groups, which causes substantial population stratification to be present not only in recently admixed populations like African Americans but also in generally assumed homogeneous populations like European Americans. In Chapter One I reviewed the recent studies of measuring and using genetic ancestry in human complex disease studies. Genetics variations constitute an important basis for Admixture Mapping. Many complex diseases show population specific prevalence that could be due to the differences of particular disease-susceptible genes among founding populations of different ancestry. Statistical methods can be applied to infer the locus ancestry along the chromosome in admixed individuals and tests for the association of the locus ancestry with the disease in admixed population, so called admixture mapping. Admixture mapping requires a genome-wide panel of relatively evenly spaced markers that can distinguish the locus ancestral origins in admixed individuals. In Chapter Two and Chapter Three I introduced our defined genome-wide Single-Nucleotide-Polymorphism panels that can extract ancestry information mostly with the least markers for African American and Mexican American admixed populations. On the other hand, a consequence of population stratification is the potential for false allelic associations and thus the inconsistent reports across genome-wide association studies. Statistical methods can be applied to discern and correct for the individual ancestry differences using Genome-wide association panel. In Chapter Four I introduced our findings of the European substructures, which have significant genetic variation along the north to south and west to east geographic axis. One of our recent report showed that after accounting for genetic ancestry difference, some locus are no long associated to Rheumatoid Arthritis but they appeared as very strong candidates without accounting for the substructure. In Chapter Five I introduced our findings of the East Asian substructures. Our analysis showed that there exist genetic variations both between different East Asian groups and within the Han Chinese population. In Chapter Six I reviewed the current available methods and importance of accounting for ancestry in genome-wide association studies. In Chapter Seven, I discussed some implications and future research directions.
Book Synopsis Understanding Racial and Ethnic Differences in Health in Late Life by : National Research Council
Download or read book Understanding Racial and Ethnic Differences in Health in Late Life written by National Research Council and published by National Academies Press. This book was released on 2004-09-08 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the population of older Americans grows, it is becoming more racially and ethnically diverse. Differences in health by racial and ethnic status could be increasingly consequential for health policy and programs. Such differences are not simply a matter of education or ability to pay for health care. For instance, Asian Americans and Hispanics appear to be in better health, on a number of indicators, than White Americans, despite, on average, lower socioeconomic status. The reasons are complex, including possible roles for such factors as selective migration, risk behaviors, exposure to various stressors, patient attitudes, and geographic variation in health care. This volume, produced by a multidisciplinary panel, considers such possible explanations for racial and ethnic health differentials within an integrated framework. It provides a concise summary of available research and lays out a research agenda to address the many uncertainties in current knowledge. It recommends, for instance, looking at health differentials across the life course and deciphering the links between factors presumably producing differentials and biopsychosocial mechanisms that lead to impaired health.
Book Synopsis Genes, Behavior, and the Social Environment by : Institute of Medicine
Download or read book Genes, Behavior, and the Social Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-12-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
Book Synopsis Bioinformatics of Genome Regulation, Volume I, 2nd Edition by : Yuriy L. Orlov
Download or read book Bioinformatics of Genome Regulation, Volume I, 2nd Edition written by Yuriy L. Orlov and published by Frontiers Media SA. This book was released on with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher’s note: In this 2nd edition, the following article has been updated: Orlov YL, Tatarinova TV, Oparina NY, Galieva ER and Baranova AV (2021) Editorial: Bioinformatics of Genome Regulation, Volume I. Front. Genet. 12:803273. doi: 10.3389/fgene.2021.803273
Book Synopsis Assessing Genetic Risks by : Institute of Medicine
Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Book Synopsis High-throughput Sequencing-based Investigation of Chronic Disease Markers and Mechanisms. by : Hua Li
Download or read book High-throughput Sequencing-based Investigation of Chronic Disease Markers and Mechanisms. written by Hua Li and published by Frontiers Media SA. This book was released on 2022-07-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Graduate Program in Molecular & Cell Biology by :
Download or read book Graduate Program in Molecular & Cell Biology written by and published by . This book was released on 1998 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress and Challenges in Precision Medicine by : Mukesh Verma
Download or read book Progress and Challenges in Precision Medicine written by Mukesh Verma and published by Academic Press. This book was released on 2016-12-22 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development
Book Synopsis Mathematical Population Genetics 1 by : Warren J. Ewens
Download or read book Mathematical Population Genetics 1 written by Warren J. Ewens and published by Springer Science & Business Media. This book was released on 2004-01-09 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of a planned two-volume work discussing the mathematical aspects of population genetics with an emphasis on evolutionary theory. This volume draws heavily from the author’s 1979 classic, but it has been revised and expanded to include recent topics which follow naturally from the treatment in the earlier edition, such as the theory of molecular population genetics.
Book Synopsis Critical Perspectives on Racial and Ethnic Differences in Health in Late Life by : National Research Council
Download or read book Critical Perspectives on Racial and Ethnic Differences in Health in Late Life written by National Research Council and published by National Academies Press. This book was released on 2004-10-16 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: In their later years, Americans of different racial and ethnic backgrounds are not in equally good-or equally poor-health. There is wide variation, but on average older Whites are healthier than older Blacks and tend to outlive them. But Whites tend to be in poorer health than Hispanics and Asian Americans. This volume documents the differentials and considers possible explanations. Selection processes play a role: selective migration, for instance, or selective survival to advanced ages. Health differentials originate early in life, possibly even before birth, and are affected by events and experiences throughout the life course. Differences in socioeconomic status, risk behavior, social relations, and health care all play a role. Separate chapters consider the contribution of such factors and the biopsychosocial mechanisms that link them to health. This volume provides the empirical evidence for the research agenda provided in the separate report of the Panel on Race, Ethnicity, and Health in Later Life.
Book Synopsis Biobanking in the 21st Century by : Feridoun Karimi-Busheri
Download or read book Biobanking in the 21st Century written by Feridoun Karimi-Busheri and published by Springer. This book was released on 2015-09-29 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biobanking, an emerging field supported by academia, industry and health administrators alike, is distinctly different today from the practice that once defined it. The science of Biobanking, which initially involved simply storing blood or tissue samples in a freezer, is now a highly sophisticated field of research, and expected to grow exponentially over the next decade or two. This book aims to serve the purpose of further enriching the available literature on Biobanking, by offering unique and more useful collection of ideas for the future. The book outlines the experiences of developing modern Biobanking repositories in different countries, whilst covering specific topics regarding the many aspects of Biobanking. This book will be of interest to a wide range of readers including: academics, students, volunteers and advocates of patients’ rights.
Book Synopsis Immunopharmacogenomics by : Yusuke Nakamura
Download or read book Immunopharmacogenomics written by Yusuke Nakamura and published by Springer. This book was released on 2015-09-18 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.
Book Synopsis Genetic Dissection of Complex Traits by : D.C. Rao
Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Book Synopsis Molecular Epidemiology by : Paul A. Schulte
Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Book Synopsis Genomic Disorders by : James R. Lupski
Download or read book Genomic Disorders written by James R. Lupski and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Book Synopsis Obesity and Cardiovascular Disease by : Malcolm K Robinson
Download or read book Obesity and Cardiovascular Disease written by Malcolm K Robinson and published by CRC Press. This book was released on 2006-03-07 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe
