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Assessing Chemical Mutagens The Risk To Humans Volume 1
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Book Synopsis ASSESSING CHEMICAL MUTAGENS, THE RISK TO HUMANS (VOLUME 1). by : S ABRAHAMSON (Ed)
Download or read book ASSESSING CHEMICAL MUTAGENS, THE RISK TO HUMANS (VOLUME 1). written by S ABRAHAMSON (Ed) and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 MUTATION AND DISEASE IN HUMANS. 2 STRENGTHS AND WEAKNESSES OF TESTS FOR MUTAGENESIS. 3 BACTERIAL MUTAGENICITY TESTING: SOME PRACTICAL CONSIDERATIONS. 4 THEORY AND DESIGN OF SHORT TERM BACTERIAL TESTS FOR MUTAGENESIS. 5 DNA REPAIR. 6 CYTOGENETIC STUDIES AND RISK ASSESSMENT FOR CHEMICALS AND IONIZING RADIATION. 7 RADIATION INDUCED CANCER. 8 LOW DOSE AND SPECIES TO SPECIES EXTRAPOLATION FOR CHEMICALLY INDUCED CARCINOGENESIS. 9 ESTIMATING RADIATION INDUCED CARCINOGENESIS. 10 RISK ASSESSMENT OF ETHYLENE OXIDE AND OTHER COMPOUNDS. 11 DOSIMETRY OF ALKYLATING AGENTS. 12 ARE BENZENE EFFECTS LIMITED TO THE CHROMOSOMAL LEVEL?. 13 GENERAL ASPECTS OF COMPARATIVE MUTAGENESIS.
Book Synopsis Assessing Chemical Mutagens by : Victor K. McElheny
Download or read book Assessing Chemical Mutagens written by Victor K. McElheny and published by Cold Spring Harbor Laboratory Press. This book was released on 1979 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Assessing chemical mutagens written by and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mutagenic Impurities by : Andrew Teasdale
Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Book Synopsis Mutagenicity: Assays and Applications by : Ashutosh Kumar
Download or read book Mutagenicity: Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Book Synopsis Science and Decisions by : National Research Council
Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
Author :IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Publisher : ISBN 13 : Total Pages :332 pages Book Rating :4.3/5 (91 download)
Book Synopsis Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Download or read book Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by . This book was released on 1999 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Publisher :IARC ISBN 13 :9789283212850 Total Pages :354 pages Book Rating :4.2/5 (128 download)
Book Synopsis Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Download or read book Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis
Book Synopsis Toxic Substances and Human Risk by : Robert G. Tardiff
Download or read book Toxic Substances and Human Risk written by Robert G. Tardiff and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: As society has become increasingly aware of the potential threats to human health due to exposures to toxic chemicals in the environment and the workplace and in consumer products, it has placed increased demands upon the still-fledgling science of toxicology. As is often the case when science is called upon to supply firm answers when pertinent information and fundamental knowledge are lack ing, both the scientific and the social issues become confused and new tensions develop. One of the major purposes of this book is to focus on those aspects of the science of toxicology that pertain most to social issues-namely, analysis of risk for purposes of human health protection. Although it is apparent that the discipline of toxicology is not yet prepared to provide firm answers to many questions concerning human risk, it is important that the rigorously derived information be used in the most objective and logical way to yield the closest approximation to the truth. This book is designed to sup ply as much guidance for such tasks as is permitted by the current state of our knowledge. Its emphasis is thus placed on interpretation of toxicity data (broadly defined) for assessing risks to human health. In this way, it differs from other basic toxicology texts, most of which emphasize methods for performing studies or describe various toxicological endpoints and classes of toxic agents.
Book Synopsis Second International Conference on Environmental Mutagens in Human Populations by :
Download or read book Second International Conference on Environmental Mutagens in Human Populations written by and published by . This book was released on 1996 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Publisher :World Health Organization ISBN 13 : Total Pages :350 pages Book Rating :4.3/5 (91 download)
Book Synopsis Tobacco Habits Other Than Smoking, Betel-quid and Areca-nut Chewing, and Some Related Nitrosamines by : IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
Download or read book Tobacco Habits Other Than Smoking, Betel-quid and Areca-nut Chewing, and Some Related Nitrosamines written by IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans and published by World Health Organization. This book was released on 1985 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicological Profile for Chlordane by :
Download or read book Toxicological Profile for Chlordane written by and published by . This book was released on 1994 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning
Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Book Synopsis Molecular Biology of Mutagens and Carcinogens by : Beatrice Singer
Download or read book Molecular Biology of Mutagens and Carcinogens written by Beatrice Singer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.
Book Synopsis Chemical Mutagenesis, Human Population Monitoring, and Genetic Risk Assessment by : K. C. Bora
Download or read book Chemical Mutagenesis, Human Population Monitoring, and Genetic Risk Assessment written by K. C. Bora and published by Amsterdam : Elsevier Biomedical Press. This book was released on 1982 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
