Arthritis and Autoimmune Disease

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Publisher :
ISBN 13 : 9781469949239
Total Pages : 448 pages
Book Rating : 4.9/5 (492 download)

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Book Synopsis Arthritis and Autoimmune Disease by : Katherine Margaret Poehlmann

Download or read book Arthritis and Autoimmune Disease written by Katherine Margaret Poehlmann and published by . This book was released on 2012 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Arthritis and Autoimmune Disease: the Infection Connection

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Publisher :
ISBN 13 : 9781469949239
Total Pages : 498 pages
Book Rating : 4.9/5 (492 download)

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Book Synopsis Arthritis and Autoimmune Disease: the Infection Connection by : Katherine Margaret Poehlmann

Download or read book Arthritis and Autoimmune Disease: the Infection Connection written by Katherine Margaret Poehlmann and published by . This book was released on 2012-02-07 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: ARTHRITIS and AUTOIMMUNE DISEASE: THE INFECTION CONNECTION Finding and Treating the Many Causes of Chronic Fatigue and Inflammation Third Updated, Revised, and Expanded Edition of "Rheumatoid Arthritis: The Infection Connection" Appendix: Physician's Protocol for Treating Rheumatic Disease by Dr. Joseph Mercola, D.O. (mercola.com) Appendix: Treatment for Chronic Illnesses and Autoimmune Diseases by Dr. Garth Nicolson (immed.org) 2013 Eric Hoffer Award finalist: health category. A professional health researcher, scientist, systems engineer, and former Rheumatoid Arthritis (RA) sufferer presents proven benign treatments for symptoms associated with autoimmune conditions. In This Book You Will Discover: » How microorganisms cause autoimmune diseases like RA: bacteria, mycoplasmas, viruses, molds, spirochetes, fungi, and more; » Their role in other illnesses characterized by Inflammation and Chronic Fatigue such as Arthritis, MS, Lyme Disease, Diabetes, Autism, COPD, and gut disorders; » How slow-growing persistent infections lead to premature aging and Alzheimer's; » Ways to suppress these pathogens and destroy the toxins they produce; » How to control allergies that trigger histamine reactions; » Ways suggested by clinicians to strengthen the immune system using diet and other natural, non-toxic methods; » Pointers to our ongoing medical research on our website and to other Internet sites for resources, support groups, and study citations. » Persistent infections caused by microbes that invade epithelial and immune cells, causing or exacerbating many rheumatic and so-called autoimmune conditions and diseases. In 2002 there were 59 recognized autoimmune diseases. A decade later the list numbered 109, with Autism Spectrum Disorders (ASD) and COPD recently added. The list is growing. Inflammatory autoimmune diseases are caused and/or complicated by persistent, shape-changing microbes, toxins, vaccines, and inadequate nutrition. A few examples are: Allergies (food and environmental); ALS (Lou Gherig's Disease); Alzheimer's; Autoimmune and rheumatic conditions; Autism/ASD; Arthritis (all forms-rheumatoid, osteoarthritis, psoriatic, reactive, septic, Ankylosing Spondylitis, juvenile RA, gout, and many more): Carpal Tunnel; Bursitis (and tendonitis); CFS/CFIDS (Chronic Fatigue Syndrome); Fibromyalgia (including backache and muscle pain); Gastroesophageal Reflux Disease (GERD); Gulf War Illness; Gut imbalance (many forms-diabetes, diverticulitis, dysbiosis, IBS, colitis, leaky gut, Crohn's disease, ulcers); Heart and circulatory conditions (atherosclerosis); Hepatitis; Lupus; Lyme Disease; Malaria; Meningitis; Multiple Sclerosis; Psychiatric disorders (bipolar, schizophrenia, depression, dementia); encephalitis; Respiratory Tract (asthma, bronchitis, COPD); Sarcoidosis; Scleroderma; sleep disorders; thyroid diseases; Metabolic Syndrome; Tuberculosis; Urinary Tract illness (cystitis, prostatitis). Nutrition, antibiotics, probiotics, and immune system-managing drugs can be used in combination to control allergies and inflammation. » Dr Mercola's nutrition-based regimen and Dr. Brown's low-dose, long-term tetracycline antibiotic protocol is described in detail, with updates since the prior edition. » Web pointers are provided to descriptions of other successful, multi-antibiotic, and nutritional protocols. » This book provides the latest information on alternative medical treatments that supplement conventional treatments for controlling and eliminating chronic infections. Extensive references and citations in endnotes for each chapter are found at our website, www.RA-Infection-Connection.com, with active Internet hot links to many of the source documents. The best health research and resource websites are listed in tables. They are also found on our website with active hot links to each site.

The Autoimmune Connection

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 0071425519
Total Pages : 427 pages
Book Rating : 4.0/5 (714 download)

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Book Synopsis The Autoimmune Connection by : Rita Baron-Faust

Download or read book The Autoimmune Connection written by Rita Baron-Faust and published by McGraw Hill Professional. This book was released on 2003-04-22 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empowers women to make informed decisions about autoimmune disorders More than 50 million Americans, most of them women, suffer from a constellation of mysterious, often misdiagnosed diseases that can result in disability, disfigurement, and death. Called "autoimmune diseases," they arise when the immune system attacks healthy tissues in almost any area of the body, and include lupus rheumatoid arthritis, Crohn's disease, scleroderma, and Graves' disease. Now Jill Buyon, a doctor working on the cutting edge of research into these diseases, and Rita Baron-Faust, an award-winning medical journalist, arm women with the knowledge they need to obtain accurate diagnoses and the best possible treatments. In The Autoimmune Connection readers learn about the recent groundbreaking discovery of the links between the different autoimmune diseases and why women are more likely to develop them. The authors offer the most up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease.

Rheumatoid Arthritis

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Publisher :
ISBN 13 : 9780961726867
Total Pages : 0 pages
Book Rating : 4.7/5 (268 download)

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Book Synopsis Rheumatoid Arthritis by : Katherine M. Poehlmann

Download or read book Rheumatoid Arthritis written by Katherine M. Poehlmann and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-documented study asserts that rheumatoid arthritis (RA) and other chronic illnesses are caused by a microbial infection. When the infection triggers allergic reactions, it appears that the body's immune system has turned on itself. Once the cause of the infection and allergies are identified and removed, arthritis symptoms will decrease and likely disappear as long as the body's collective systems remain in balance.

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

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Publisher : Elsevier
ISBN 13 : 0080534430
Total Pages : 557 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Idiotypes in Medicine: Autoimmunity, Infection and Cancer by : R.C. Kennedy

Download or read book Idiotypes in Medicine: Autoimmunity, Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Infection and Autoimmunity

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Publisher : Elsevier
ISBN 13 : 0080534651
Total Pages : 769 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Infection and Autoimmunity by : Yehuda Shoenfeld

Download or read book Infection and Autoimmunity written by Yehuda Shoenfeld and published by Elsevier. This book was released on 2004-09-18 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity. The only book directed at the interactions between infectious agents and autoimmunity Describes the prevalence and incidence of the global issues and current therapeutic approaches Presents the measures for infection control Completely updated, with new chapters One-stop reference with easy access to topics

Infections in Systemic Autoimmune Diseases: Risk Factors and Management

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Publisher : Elsevier
ISBN 13 : 044464217X
Total Pages : 228 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Infections in Systemic Autoimmune Diseases: Risk Factors and Management by :

Download or read book Infections in Systemic Autoimmune Diseases: Risk Factors and Management written by and published by Elsevier. This book was released on 2020-03-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field. Written by leading international clinical/surgical and scientific experts on Infection problems in systemic autoimmune diseases Provides a practical guide to the safer treatment of infections in patients with autoimmune diseases Includes a number of problems and recommendation that cannot be found in other books Designed as a 'guide to clinical practice' for management and risk interventions required by patients with SAD's

The Autoimmune Connection: Essential Information for Women on Diagnosis, Treatment, and Getting On With Your Life

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Publisher : McGraw-Hill Education
ISBN 13 : 9780071841221
Total Pages : 0 pages
Book Rating : 4.8/5 (412 download)

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Book Synopsis The Autoimmune Connection: Essential Information for Women on Diagnosis, Treatment, and Getting On With Your Life by : Jill P. Buyon

Download or read book The Autoimmune Connection: Essential Information for Women on Diagnosis, Treatment, and Getting On With Your Life written by Jill P. Buyon and published by McGraw-Hill Education. This book was released on 2016-04-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most up-to-date book on the subject gives women all the essential information on diagnosis and treatment of autoimmune medical conditions The Autoimmune Connection explains the links between autoimmune diseases and offers up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease, such as lupus, rheumatoid arthritis, or Crohn's disease. You will learn how to sort out vague and seemingly unrelated early signs and symptoms; which diagnostic tests they may need and what the results can mean; how autoimmune diseases and treatments can affect you at different stages of life; what new treatments and therapies are on the horizon; and where to find the proper specialist and how to navigate the health-care system NEW: Major breakthroughs in the treatment of rheumatoid arthritis, thyroid disease, diabetes, Celiac, multiple sclerosis NEW: Potential environmental triggers for autoimmunity, such as cigarette smoke, crystalline silica, asbestos, mercury, lead, viruses and other microbes, pesticides, pollutants, solvents, and petroleum byproducts NEW: Current drugs on the market and recently discovered side effects and long-term complications connected to existing drug therapies NEW: Healthcare law reform provisions and key changes to Medicare and Medicaid

Infection and Autoimmunity Handbook

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Author :
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (826 download)

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Book Synopsis Infection and Autoimmunity Handbook by : Robert Ben, MD

Download or read book Infection and Autoimmunity Handbook written by Robert Ben, MD and published by Independently Published. This book was released on 2024-02-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the groundbreaking connection between infections and autoimmune diseases in this riveting guide to optimal health. From the depths of molecular mimicry to the frontline defenses of immune responses, delve into the intricate dance between infections and autoimmune disorders. Unravel the mysteries behind conditions like rheumatoid arthritis, lupus, and multiple sclerosis as you explore cutting-edge research and real-life case studies. With expert insights and actionable advice, learn to decode the signals your body sends and forge a path to vibrant wellness. Whether you're a healthcare professional seeking breakthrough treatments or a patient determined to take control of your health, this book is your roadmap to understanding and conquering autoimmune challenges. Embrace the power of prevention, harness the latest treatments, and embark on a journey toward vitality. Join the movement toward autoimmune resilience and unlock a future of boundless possibilities. Your health journey starts now.

Infections and the Rheumatic Diseases

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Publisher : Springer Nature
ISBN 13 : 3030233111
Total Pages : 460 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Infections and the Rheumatic Diseases by : Luis R. Espinoza

Download or read book Infections and the Rheumatic Diseases written by Luis R. Espinoza and published by Springer Nature. This book was released on 2019-09-26 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of the basic and clinical aspects of infections and infectious processes that trigger or aggravate a variety of autoimmune and inflammatory musculoskeletal disorders. It delivers a timely update on the interactions between infection and rheumatic diseases in order to provide clinicians with the tools they need for proper diagnosis and treatment. The book is divided into five main sections. The first examines the basic aspects of bacterial infections with a discussion of molecular biology, the microbiome, various types of bacteria that cause infection, and recent advances in biologic therapy. The next section focuses on different forms of viral arthritis including hepatitis arthritis, arthritis associated with alpha viruses, and parvovirus-related arthritis. Subsequent chapters then discuss arthritis caused by mycobacteria, fungi, spirochete, and other miscellaneous arthritides. Following this are various analyzations on reactive arthritis and infection-related rheumatic diseases such as Whipple’s Disease, SAPHO Syndrome, rheumatic fever, and HIV-associated rheumatic manifestations. Finally, the book closes with three chapters on external impacts on infectious diseases such as climate change, vaccinations and systemic lupus erythematosus. Infections and the Rheumatic Diseases is an essential resource for physicians and related professionals, residents, fellows, graduate students, and nurses in rheumatology, clinical immunology, and internal medicine.

The Autoimmune Diseases

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Publisher : Academic Press
ISBN 13 : 0123849306
Total Pages : 1302 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Autoimmune Diseases by : M. Eric Gershwin

Download or read book The Autoimmune Diseases written by M. Eric Gershwin and published by Academic Press. This book was released on 2013-12-03 with total page 1302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors. Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant

Veterans and Agent Orange

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Publisher : National Academies Press
ISBN 13 : 0309477166
Total Pages : 739 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Veterans and Agent Orange by : National Academies of Sciences, Engineering, and Medicine

Download or read book Veterans and Agent Orange written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-20 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database.

Periprosthetic Joint Infection: Practical Management Guide

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Publisher : JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.
ISBN 13 : 9350908255
Total Pages : 432 pages
Book Rating : 4.3/5 (59 download)

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Book Synopsis Periprosthetic Joint Infection: Practical Management Guide by : Parvizi Javad

Download or read book Periprosthetic Joint Infection: Practical Management Guide written by Parvizi Javad and published by JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.. This book was released on 2013-12-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book Periprosthetic Joint Infection is a portable guide to the practical management of surgical site infections following orthopedic procedures. It designed to help answer clinician's questions regarding the prevention and treatment of periprosthetic infections. It organized for rapid review, featuring evidence reviews, pitfalls, Rothman Institute Current Practices and Controversies. The guide is being included in the course materials for the 29th Annual Current Concepts in Joint Replacement® (CCJR) meeting thanks to a generous educational grant from 3M Health Care.

Skills in Rheumatology

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Publisher : Springer Nature
ISBN 13 : 9811583234
Total Pages : 562 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Skills in Rheumatology by : Hani Almoallim

Download or read book Skills in Rheumatology written by Hani Almoallim and published by Springer Nature. This book was released on 2021-01-05 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

Polymyositis and Dermatomyositis

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Publisher : Butterworth-Heinemann
ISBN 13 : 1483163040
Total Pages : 362 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Polymyositis and Dermatomyositis by : Marinos C. Dalakas

Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Mosaic of Autoimmunity

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Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mosaic of Autoimmunity by : Carlo Perricone

Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Rheumatoid Arthritis

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642761895
Total Pages : 387 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Rheumatoid Arthritis by : Josef S. Smolen

Download or read book Rheumatoid Arthritis written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.