Applications Of Liquid Chromatography Mass Spectrometry In Bioassays

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Applications of Liquid Chromatography-Mass Spectrometry in Bioassays

Author : Dhananjay D. Shinde
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783848401116
Total Pages : 224 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Applications of Liquid Chromatography-Mass Spectrometry in Bioassays by : Dhananjay D. Shinde

Download or read book Applications of Liquid Chromatography-Mass Spectrometry in Bioassays written by Dhananjay D. Shinde and published by LAP Lambert Academic Publishing. This book was released on 2012-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery is a complex and interdisciplinary research, often with conflicting goals and a complex large data used for the development of a balanced clinical candidate. Written from the perspective of drug discovery, it is a practical guide for the analyst and ADME scientists and advanced students in this field. Separate chapters discuss each important aspect, covering the fundamental concepts of separation science, mass spectrometry and pharmacokinetic (PK) studies discussed with minimum mathematical equations. The present book provides in-hand solutions for offline and online sample extraction methods, column switching techniques, chiral separations and validation of the optimized methods as per the standard protocol and FDA guidelines. With practical details obtained in analytical laboratory...synthesis of drug metabolites and related substances, their characterization, separation, validation and applications in PK studies, book provides a successful approach to design, planning, execution and interpretation of research studies. This book will serve as a practical reference in regular use for researchers and scientist interested in drug discovery.

Liquid Chromatography/Mass Spectrometry

Author : Alfred L. Yergey
Publisher : Springer Science & Business Media
ISBN 13 : 148993605X
Total Pages : 310 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Liquid Chromatography/Mass Spectrometry by : Alfred L. Yergey

Download or read book Liquid Chromatography/Mass Spectrometry written by Alfred L. Yergey and published by Springer Science & Business Media. This book was released on 2013-12-14 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended both to be an introduction to techniques and applications of liquid chromatography/mass spectrometry and to serve as a reference for future workers. When we undertook its writing, we chose not to cover the field, particularly applications, exhaustively. Rather we wished to produce a book that would be of use to people just beginning to use the technique as well as to more advanced practitioners. In this regard, we have sought to highlight techniques and applications that are of current importance, while not neglecting descriptions of approaches that may be of significance in the future. We hope that we have succeeded in this. At the same time we hope that the bibliography, with indexes classified by author and title, will make this book of value to those who may disagree with our emphasis. ACKNOWLEDGMENTS. One of us (C. G. E. ) wishes to acknowledge the en couragment of Professor J. A. McCloskey in undertaking this project. All four of us are grateful for the continuous and expert assistance of V. A. Edmonds in the preparation of the Bibliography. Alfred L. Y ergey Bethesda, Maryland Charles G. Edmonds Richland, Washington lvor A. S. Lewis London, England Marvin L. Vestal Houston, Texas v Contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . 1 . . . . . . . . . . . 2. Direct Liquid Introduction Interfaces . . . . . . . . . . 5 . . . 2. 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 2. Operating Principles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 3. Specific DLI Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2. 3. 1. Capillary Inlets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2. 3. 2. Diaphragm Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2. 3. 3. Nebulizing Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Ultra Performance Liquid Chromatography Mass Spectrometry

Author : Mu Naushad
Publisher : CRC Press
ISBN 13 : 1466591552
Total Pages : 464 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Ultra Performance Liquid Chromatography Mass Spectrometry by : Mu Naushad

Download or read book Ultra Performance Liquid Chromatography Mass Spectrometry written by Mu Naushad and published by CRC Press. This book was released on 2014-03-18 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a unique collection of up-to-date UPLC-MS/MS (ultra performance liquid chromatography-tandem mass spectrometric) methods for the separation and quantitative determination of pesticides, capsaicinoids, heterocyclic amines, aflatoxin, perfluorochemicals, acrylamide, procyanidins and alkaloids, lactose content, phenolic compounds, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. With contributions by experts in interdisciplinary fields, this reference offers practical information for readers in research and development, production, and routing analysis of foods and food products.

Clinical Applications of Mass Spectrometry in Drug Analysis

Author : Uttam Garg
Publisher : Springer Nature
ISBN 13 : 1071635417
Total Pages : 469 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Clinical Applications of Mass Spectrometry in Drug Analysis by : Uttam Garg

Download or read book Clinical Applications of Mass Spectrometry in Drug Analysis written by Uttam Garg and published by Springer Nature. This book was released on 2023-11-30 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.

Liquid Chromatography-Mass Spectrometry

Author : Wilfried M.A. Niessen
Publisher : CRC Press
ISBN 13 : 1420014544
Total Pages : 629 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Liquid Chromatography-Mass Spectrometry by : Wilfried M.A. Niessen

Download or read book Liquid Chromatography-Mass Spectrometry written by Wilfried M.A. Niessen and published by CRC Press. This book was released on 2006-08-09 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and

Liquid Chromatography

Author : Wilfried M.A. Niessen
Publisher : CRC Press
ISBN 13 : 9780824719364
Total Pages : 654 pages
Book Rating : 4.7/5 (193 download)

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Book Synopsis Liquid Chromatography by : Wilfried M.A. Niessen

Download or read book Liquid Chromatography written by Wilfried M.A. Niessen and published by CRC Press. This book was released on 1998-09-01 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprehensively relates developments, principles, and applications of combined liquid chromatography-mass spectrometry and other techniques such as capillary electrophoresis and supercritical fluid chromatography combined with mass spectrometry. It covers historical developments, currently important interfaces and technologies, and LC-MS applications in environmental analysis, pharmaceuticals and bioanalysis, and additional fields. It offers in-depth coverage of interfaces and technologies currently important in the laboratory, especially electrospray and APCI, contains an expanded applications section, and provides over 2200 references, tables, equations, and drawings.

Liquid Chromatography - Mass Spectrometry

Author : Robert E. Ardrey
Publisher : John Wiley & Sons
ISBN 13 : 0470862173
Total Pages : 296 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Liquid Chromatography - Mass Spectrometry by : Robert E. Ardrey

Download or read book Liquid Chromatography - Mass Spectrometry written by Robert E. Ardrey and published by John Wiley & Sons. This book was released on 2003-07-25 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique. * First book to concentrate on principles of LC-MS * Explains principles of mass spectrometry and chromatography before moving on to LC-MS * Describes instrumental aspects of LC-MS * Discusses current applications of LC-MS and shows benefits of using this technique in practice

High-Resolution Mass Spectroscopy for Phytochemical Analysis

Author : Sreeraj Gopi
Publisher : CRC Press
ISBN 13 : 1000353613
Total Pages : 240 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis High-Resolution Mass Spectroscopy for Phytochemical Analysis by : Sreeraj Gopi

Download or read book High-Resolution Mass Spectroscopy for Phytochemical Analysis written by Sreeraj Gopi and published by CRC Press. This book was released on 2021-09-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume provides a bird’s-eye view of the properties, utilization, and importance of high resolution mass spectrometry (HRMS) for phytochemical analysis. The book discusses the new and state-of-the-art technologies related to HRMS in phytochemical analysis for the food industry in a comprehensive manner. Phytochemical characterization of plants is important in the food and nutraceutical industries and is also necessary in the procedures followed for drug development, toxicology determination, forensic studies, origin verification, quality assurance, etc. Easy determination of active compounds and isolation as well as purification of the same from natural matrices are required, and the possibilities and advantages of HRMS pave the way for improved analysis patterns in phytochemistry. This book is unique in that its sole consideration is on the importance of HRMS in the field of phytochemical analysis. Along with an overview of basic instrumental information, the volume provides a detailed account of data processing and dereplication strategies. Technologies such as bioanalytical techniques and bioassays are considered also to provide support for the functions of the instruments used. In addition, a case study is presented to depict the complete phytochemical characterization of a matrix by HRMS. The book covers processing and computational techniques, dereplication, hyphenation, high-resolution bioassays, bioanalytical screening/purification techniques, applications of gas chromatography–high-resolution mass spectrometry, and more. Key features: Covers the fundamental instrumentation and techniques Discusses HRMS-based phytochemical research details Focuses strictly on the phytochemical considerations High-Resolution Mass Spectroscopy for Phytochemical Analysis: State-of-the-Art Applications and Techniques will be a valuable reference guide and resource for researchers, faculty and students in related fields, as well as those in the phytochemical industries.

Liquid Chromatography-mass Spectrometry

Author : Mark A. Brown
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (62 download)

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Book Synopsis Liquid Chromatography-mass Spectrometry by : Mark A. Brown

Download or read book Liquid Chromatography-mass Spectrometry written by Mark A. Brown and published by . This book was released on 1990 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analyzing Biomolecular Interactions by Mass Spectrometry

Author : Jeroen Kool
Publisher : John Wiley & Sons
ISBN 13 : 3527334645
Total Pages : 402 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Analyzing Biomolecular Interactions by Mass Spectrometry by : Jeroen Kool

Download or read book Analyzing Biomolecular Interactions by Mass Spectrometry written by Jeroen Kool and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

Applications of Liquid Chromatography/mass Spectrometry in Studies of Drug Metabolism

Author : J. Maltas
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Applications of Liquid Chromatography/mass Spectrometry in Studies of Drug Metabolism by : J. Maltas

Download or read book Applications of Liquid Chromatography/mass Spectrometry in Studies of Drug Metabolism written by J. Maltas and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liquid Chromatography

Author : Salvatore Fanali
Publisher : Elsevier
ISBN 13 : 0128093447
Total Pages : 840 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Liquid Chromatography by : Salvatore Fanali

Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. - Emphasizes the integration of chromatographic methods and sample preparation - Explains how liquid chromatography is used in different industrial sectors - Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) - Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making

Principles and Practice of Bioanalysis

Author : Richard F. Venn
Publisher : CRC Press
ISBN 13 : 9780748408429
Total Pages : 392 pages
Book Rating : 4.4/5 (84 download)

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Book Synopsis Principles and Practice of Bioanalysis by : Richard F. Venn

Download or read book Principles and Practice of Bioanalysis written by Richard F. Venn and published by CRC Press. This book was released on 2000-06-22 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Bioanalysis provides a guide to the methods available and the techniques currently used in this field. It provides up to the minute information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The authors writes in an informal and didactic style, offering a logical path through the problems of small molecule (bio)analysis and enables readers to choose appropriate methods of analysis for their needs. Principles and Practice of Bioanalysis provides an overview of analytical methods for analytical scientists within the pharmaceutical industry, research and development, the agrochemical industry, and scientists in the health service, biology and biochemistry. It also gives postgraduate students a useful reference for their research methods.

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography

Author : Steven H.Y. Wong
Publisher : Routledge
ISBN 13 : 135140847X
Total Pages : 521 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography by : Steven H.Y. Wong

Download or read book Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography written by Steven H.Y. Wong and published by Routledge. This book was released on 2017-09-19 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.

Liquid Chromatography--mass Spectrometry

Author : Wilfried M. A. Niessen
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Liquid Chromatography--mass Spectrometry by : Wilfried M. A. Niessen

Download or read book Liquid Chromatography--mass Spectrometry written by Wilfried M. A. Niessen and published by Marcel Dekker. This book was released on 1992 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bioanalysis of Pharmaceuticals

Author : Steen Honoré Hansen
Publisher : John Wiley & Sons
ISBN 13 : 1118716825
Total Pages : 332 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Bioanalysis of Pharmaceuticals by : Steen Honoré Hansen

Download or read book Bioanalysis of Pharmaceuticals written by Steen Honoré Hansen and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.

Liquid Chromatography/mass Spectrometry

Author : Mark A. Brown
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Liquid Chromatography/mass Spectrometry by : Mark A. Brown

Download or read book Liquid Chromatography/mass Spectrometry written by Mark A. Brown and published by . This book was released on 1990 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the versatility of liquid chromatography/mass spectrometry and describes the LC/MS instruments now available or under development. Among the topics covered is a discussion of the applications of LC/MS to the analysis of agricultural chemicals and their metabolites, including polar pesticide metabolites and conjugates. Annotation copyrighted by Book News, Inc., Portland, OR