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Application Of Pd Catalyzed Alkylation
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Book Synopsis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis by : Montserrat Diéguez
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Book Synopsis Application of Pd Catalyzed Alkylation by : Pasha Moeenuddin Khan
Download or read book Application of Pd Catalyzed Alkylation written by Pasha Moeenuddin Khan and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Palladium is probably the most useful metal in organic syntheses. It has shown great utility in various reactions such as C-C, C-N, C-O bond formation under mild conditions. The presence of abundant amount of palladium-chemistry related literature in the form of books, reviews emphasizes the growing importance of these reagents. Nowadays organopalladium chemistry is being used in various fields such as new methodology development, natural product synthesis, synthesis of polymers. Regio- and stereoselectivity is another facet of Pd catalyzed methodologies which has been extensively utilized in the last decade to obtain enantiopure compounds. The main emphasis of this work is to utilize Pd catalyzed allylic alkylation to synthesize new heterocycles including furans, isoxazolines and new cyclopentane amino-acid analogs in an enantioselective manner. The stereochemical outcome of these reactions is influenced by desymmetrization catalyzed by hydrolytic enzymes namely lipases. Chapter 1 reviews the recent advances in the field of palladium catalyzed synthesis of bicyclic furan analogs and provides a mechanistic explanation for these processes. Chapter 2 describes synthesis of new optically pure isoxazoline-2-oxide and furan analogs using Pd(0) catalyzed intramolecular cyclizations. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99 % ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereoselective nature of the palladium catalyzed transformations. Chapter 3 describes Pd(0) catalyzed allylic alkylation of allylic esters using various 1°, 2° nitroalkanes. This reaction resulted in the formation of nitro substituted aldehydes and ketones via an isomerization-alkylation step. The effect of various solvents, catalyst-ligand systems and bases was also studied. The presence of versatile nitro group in these compounds which can be easily converted to a ketone, reduced to amine or transformed into carboxyl group, imines, hydroxylamines, makes them an attractive starting material for various other synthetic compounds. Chapter 4 describes the chemoenzymatic synthesis of L-carbafuranomycin and related cyclopentane amino acids analogs. The synthesis utilizes the hydrolytic enzymes to induce enantioselectivity in the whole process. Out of all the peptidomimetics and related compounds, unnatural amino acids such as bicyclic and carbocyclic amino acids are of valuable interest as they have provided new building blocks for large number of potential drug candidates. The work presented here provides a more general and efficient route to these class of unnatural amino acids.
Book Synopsis Applications of Palladium-catalyzed Enantioselective Decarboxylative Alkylation in Natural Products Total Synthesis by : Ryan Michael McFadden
Download or read book Applications of Palladium-catalyzed Enantioselective Decarboxylative Alkylation in Natural Products Total Synthesis written by Ryan Michael McFadden and published by . This book was released on 2008 with total page 1148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Palladium Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Unstabilized Enolates by : Jiayi Xu
Download or read book Palladium Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Unstabilized Enolates written by Jiayi Xu and published by . This book was released on 2008 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Palladium Catalyzed Asymmetric Allylic Alkylation (AAA) by : Daniel Edward Patterson
Download or read book The Palladium Catalyzed Asymmetric Allylic Alkylation (AAA) written by Daniel Edward Patterson and published by . This book was released on 2000 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expanding the Scope of the Palladium-catalyzed Asymmetric Allylic Alkylation Reaction and Applications Towards Alkaloid Syntheses by : Megan Brennan
Download or read book Expanding the Scope of the Palladium-catalyzed Asymmetric Allylic Alkylation Reaction and Applications Towards Alkaloid Syntheses written by Megan Brennan and published by . This book was released on 2008 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Palladium-catalyzed Asymmetric Allylic Alkylation by : Nathan Bruce Bennett
Download or read book Palladium-catalyzed Asymmetric Allylic Alkylation written by Nathan Bruce Bennett and published by . This book was released on 2013 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: The asymmetric construction of quaternary stereocenters is a topic of great interest in the organic chemistry community given their prevalence in natural products and biologically active molecules. Over the last decade, the Stoltz group has pursued the synthesis of this challenging motif via a palladium-catalyzed allylic alkylation using chiral phosphinooxazoline (PHOX) ligands. Recent results indicate that the alkylation of lactams and imides consistently proceeds with enantioselectivities substantially higher than any other substrate class previously examined in this system. This observation prompted exploration of the characteristics that distinguish these molecules as superior alkylation substrates, resulting in newfound insights and marked improvements in the allylic alkylation of carbocyclic compounds.
Book Synopsis Applications of Transition Metal Catalysis in Drug Discovery and Development by : Matthew L. Crawley
Download or read book Applications of Transition Metal Catalysis in Drug Discovery and Development written by Matthew L. Crawley and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
Book Synopsis Strategies for the Stereoselective Synthesis of Carbon Quaternary Centers Via Transition Metal-catalyzed Alkylation of Enolate Compounds by : Corey Michael Reeves
Download or read book Strategies for the Stereoselective Synthesis of Carbon Quaternary Centers Via Transition Metal-catalyzed Alkylation of Enolate Compounds written by Corey Michael Reeves and published by . This book was released on 2015 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notwithstanding advances in modern chemical methods, the selective installation of sterically encumbered carbon stereocenters, in particular all-carbon quaternary centers, remains an unsolved problem in organic chemistry. The prevalence of all-carbon quaternary centers in biologically active natural products and pharmaceutical compounds provides a strong impetus to address current limitations in the state of the art of their generation. This thesis presents four related projects, all of which share in the goal of constructing highly-congested carbon centers in a stereoselective manner, and in the use of transition-metal catalyzed alkylation as a means to address that goal. The first research described is an extension of allylic alkylation methodology previously developed in the Stoltz group to small, strained rings. This research constitutes the first transition metal-catalyzed enantioselective alpha-alkylation of cyclobutanones. Under Pd-catalysis, this chemistry affords all - carbon alpha-quaternary cyclobutanones in good to excellent yields and enantioselectivities. Next is described our development of a (trimethylsilyl)ethyl beta-ketoester class of enolate precursors, and their application in palladium-catalyzed asymmetric allylic alkylation to yield a variety of alpha-quaternary ketones and lactams. Independent coupling partner synthesis engenders enhanced allyl substrate scope relative to allyl beta-ketoester substrates; highly functionalized alpha-quaternary ketones generated by the union of our fluoride-triggered beta-ketoesters and sensitive allylic alkylation coupling partners serve to demonstrate the utility of this method for complex fragment coupling. Lastly, our development of an Ir-catalyzed asymmetric allylic alkylation of cyclic beta-ketoesters to afford highly congested, vicinal stereocenters comprised of tertiary and all-carbon quaternary centers with outstanding regio-, diastereo-, and enantiocontrol is detailed. Implementation of a subsequent Pd-catalyzed alkylation affords dialkylated products with pinpoint stereochemical control of both chiral centers. The chemistry is then extended to include acyclic bega-ketoesters and similar levels of selective and functional group tolerance are observed. Critical to the successful development of this method was the employment of iridium catalysis in concert with N-aryl-phosphoramidite ligands.
Book Synopsis Application of Chiral Bis(phosphine) Monosulfide Ligands to Pd-catalyzed Asymmetric Allylic Alkylation by : Jeremy Clinton Wilt
Download or read book Application of Chiral Bis(phosphine) Monosulfide Ligands to Pd-catalyzed Asymmetric Allylic Alkylation written by Jeremy Clinton Wilt and published by . This book was released on 2005 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Organopalladium Chemistry for Organic Synthesis by : Ei-ichi Negishi
Download or read book Handbook of Organopalladium Chemistry for Organic Synthesis written by Ei-ichi Negishi and published by John Wiley & Sons. This book was released on 2003-11-24 with total page 1697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Book Synopsis Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis by : Uli Kazmaier
Download or read book Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis written by Uli Kazmaier and published by Springer Science & Business Media. This book was released on 2011-10-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giovanni Poli, Guillaume Prestat, Frédéric Liron, Claire Kammerer-Pentier: Selectivity in Palladium Catalyzed Allylic Substitution.- Jonatan Kleimark and Per-Ola Norrby: Computational Insights into Palladium-mediated Allylic Substitution Reactions.- Ludovic Milhau, Patrick J. Guiry: Palladium-catalyzed enantioselective allylic substitution.- Wen-Bo Liu, Ji-Bao Xia, Shu-Li You: Iridium-Catalyzed Asymmetric Allylic Substitutions.- Christina Moberg: Molybdenum- and Tungsten-Catalyzed Enantioselective Allylic Substitutions.- Jean-Baptiste Langlois, Alexandre Alexakis: Copper-catalyzed enantioselective allylic substitution.- Jeanne-Marie Begouin, Johannes E. M. N. Klein, Daniel Weickmann, B. Plietker: Allylic Substitutions Catalyzed by Miscellaneous Metals.- Barry M. Trost, Matthew L. Crawley: Enantioselective Allylic Substitutions in Natural Product Synthesis.
Book Synopsis Palladium Catalyzed Allylic Alkylation by : Thomas Robert Verhoeven
Download or read book Palladium Catalyzed Allylic Alkylation written by Thomas Robert Verhoeven and published by . This book was released on 1979 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Palladacycles written by Anant Kapdi and published by Elsevier. This book was released on 2019-06-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists.
Book Synopsis Applications of Palladum [sic] Catalyzed Asymmetric Allylic Alkylation by : Jennifer Ann Vance
Download or read book Applications of Palladum [sic] Catalyzed Asymmetric Allylic Alkylation written by Jennifer Ann Vance and published by . This book was released on 2005 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanistic Investigations Into the Palladium-catalyzed Decarboxylative Allylic Alkylation of Ketone Enolates Using the PHOX Ligand Architecture by : Nathaniel Haynes Sherden
Download or read book Mechanistic Investigations Into the Palladium-catalyzed Decarboxylative Allylic Alkylation of Ketone Enolates Using the PHOX Ligand Architecture written by Nathaniel Haynes Sherden and published by . This book was released on 2011 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladium-catalyzed asymmetric allylic alkylation has become a large and important field for chemical synthesis. Many methodologies in this field offer mild conditions under which challenging and important molecular features can be reliably synthesized, including chiral all-carbon quaternary stereocenters. As a result, palladium- catalyzed asymmetric allylic alkylation has found significant use in total synthesis, and growing use in industry. While the general process of palladium-catalyzed asymmetric allylic alkylation has been studied for decades, there have been a number of recent modifications and developments, such as asymmetric versions of decarboxylative allylic alkylation procedures that are not yet well understood. The development of future implementations and improvements to palladium-catalyzed asymmetric allylic alkylation and related methodologies is expected to be facilitated by a better understanding of these more recent developments, and thus further mechanistic investigation is warranted. Reported herein is a set of investigations into the palladium-catalyzed decarboxylative asymmetric allylic alkylation of ketone enolates using the PHOX ligand architecture. By monitoring the reaction via 31P NMR, a series of previously unidentified key intermediates is discovered. Two representatives of these key intermediates are isolated and characterized. The solution behavior of these species under reaction-like conditions is studied along with a few novel and related complexes. The role of these intermediates and their impact on the behavior of the reaction and product formation is discussed. Previously confounding experimentally observed behavior for this methodology is rationalized via the properties elucidated for these discovered intermediates.
Book Synopsis Oxidation of C-H Bonds by : Wenjun Lu
Download or read book Oxidation of C-H Bonds written by Wenjun Lu and published by John Wiley & Sons. This book was released on 2017-02-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: A combination of oxidation methods and C‒H bond functionalization, this book emphasizes mechanistic understanding and critical analysis of synthetic reactions to offer a guide or manual for practicing chemists. • Combines oxidation methods and C‒H bond functionalization, two of the most important aspects of organic synthesis • Deals with C‒H bonds, an area of dynamic and continuous research across chemistry and catalysis • Helps readers understand the fundamental and applied differences among various oxidation methods and reactions • Covers mechanistic details, conditions, oxidation reagents, and practical aspects of different reactions
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