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Download or read book Antisense Technology Part B written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0080496717
Total Pages : 683 pages
Book Rating : 4.0/5 (84 download)
Download or read book Antisense Technology, Part B: Applications written by and published by Elsevier. This book was released on 1999-11-10 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.
Author : Stanley T. Crooke
Publisher : CRC Press
ISBN 13 : 9780849347054
Total Pages : 620 pages
Book Rating : 4.3/5 (47 download)
Download or read book Antisense Research and Applications written by Stanley T. Crooke and published by CRC Press. This book was released on 1993-05-27 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Author :
Publisher : Elsevier
ISBN 13 : 0080496709
Total Pages : 614 pages
Book Rating : 4.0/5 (84 download)
Download or read book Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies written by and published by Elsevier. This book was released on 1999-11-01 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author : Michael L. Johnson
Publisher : Academic Press
ISBN 13 : 0123812682
Total Pages : 409 pages
Book Rating : 4.1/5 (238 download)
Download or read book Biothermodynamics written by Michael L. Johnson and published by Academic Press. This book was released on 2011 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last several years there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.
Author :
Publisher : Academic Press
ISBN 13 : 9780080956961
Total Pages : 350 pages
Book Rating : 4.9/5 (569 download)
Download or read book Chemokines written by and published by Academic Press. This book was released on 2009-05-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of chemokines, the proteins that control the migration of cells, and their receptors, is critical to the study of causes and therapies for a wide range of human diseases and infections, including certain types of cancer, inflammatory diseases, HIV, and malaria. This volume, focusing on chemokine structure and function, as well as signaling, and its companion volume (Methods in Enzymology volume 461, focusing on chemokines as potential targets for disease intervention) provide a comprehensive overview and time-tested protocols in this field, making it an essential reference for researchers in the area. Along with its companion volume, provides a comprehensive overview of chemokine methods, specifically as related to potential disease therapy Gathers tried, tested, and trusted methods and techniques from top players in chemokine research Provides an essential reference for researchers in the field
Author : Chris Voigt
Publisher : Academic Press
ISBN 13 : 0123851211
Total Pages : 550 pages
Book Rating : 4.1/5 (238 download)
Download or read book Synthetic Biology, Part B written by Chris Voigt and published by Academic Press. This book was released on 2011-07-15 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology encompasses a variety of different approaches, methodologies and disciplines, and many different definitions exist. This Volume of Methods in Enzymology has been split into 2 Parts and covers topics such as Measuring and Engineering Central Dogma Processes, Mathematical and Computational Methods and Next-Generation DNA Assembly and Manipulation. Encompasses a variety of different approaches, methodologies and disciplines Split into 2 parts and covers topics such as measuring and engineering central dogma processes, mathematical and computational methods and next-generation DNA assembly and manipulation
Author :
Publisher : Academic Press
ISBN 13 : 0080962807
Total Pages : 711 pages
Book Rating : 4.0/5 (89 download)
Download or read book Computer Methods Part B written by and published by Academic Press. This book was released on 2009-11-05 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed. This volume, along with previous and forthcoming Computer Methods volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as applied to biomedical research. Presents step-by-step computer methods and discusses the techniques in detail to enable their implementation in solving a wide range of problems Informs biomedical researchers of the modern data analysis methods that have developed alongside computer hardware Presents methods at the "nuts and bolts" level to identify and resolve a problem and analyze what the results mean
Author :
Publisher : Academic Press
ISBN 13 : 9780080923505
Total Pages : 450 pages
Book Rating : 4.9/5 (235 download)
Download or read book Mitochondrial Function, Part B written by and published by Academic Press. This book was released on 2009-05-05 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second of two new volumes covering mitochondria, methods developed to assess the number and function of nuclear-encoded proteins in the mitochondrion are presented. Chapters focus on the regulation of mitochondrial function and mitochondrial diseases, with a section emphasizing the mitochondrial defects associated with type 2 diabetes. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. With more than 450 volumes published, each volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. New methods focusing on the examination of normal and abnormal mitochondrial function are presented in an easy-to-follow format by the researchers who developed them Along with a companion volume covering topics including mitochondrial electron transport chain complexes and reactive oxygen species, provides a comprehensive overview of modern techniques in the study of mitochondrial malfunction Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Author : Roya Khosravi-Far
Publisher : Elsevier
ISBN 13 : 9780080888132
Total Pages : 504 pages
Book Rating : 4.8/5 (881 download)
Download or read book Programmed Cell Death written by Roya Khosravi-Far and published by Elsevier. This book was released on 2008-07-29 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer’s disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.
Author : Amy Rosenzweig
Publisher : Academic Press
ISBN 13 : 0123869064
Total Pages : 360 pages
Book Rating : 4.1/5 (238 download)
Download or read book Methods in Methane Metabolism, Part B written by Amy Rosenzweig and published by Academic Press. This book was released on 2011-03-17 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Produced by microbes on a large scale, methane is an important alternative fuel as well as a potent greenhouse gas. This volume focuses on microbial methane metabolism, which is central to the global carbon cycle. Both methanotrophy and methanogenesis are covered in detail. Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems, and field measurements. The state of the art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field. Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems and field measurements. The state-of-the-art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field.
Author :
Publisher : Academic Press
ISBN 13 : 9780080921662
Total Pages : 464 pages
Book Rating : 4.9/5 (216 download)
Download or read book Angiogenesis: In Vivo Systems written by and published by Academic Press. This book was released on 2009-02-12 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition * Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics
Author :
Publisher : Academic Press
ISBN 13 : 0123972647
Total Pages : 392 pages
Book Rating : 4.1/5 (239 download)
Download or read book Protein Engineering for Therapeutics written by and published by Academic Press. This book was released on 2012-01-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds Chapters provide an invaluable resource for academics, researchers and students alike Iinternational board of authors This volume is split into sections that cover subjects such as peptides, and scaffolds
Author : Daniel Klionsky
Publisher : Academic Press
ISBN 13 : 0080923259
Total Pages : 571 pages
Book Rating : 4.0/5 (89 download)
Download or read book Autophagy in Mammalian Systems, Part B written by Daniel Klionsky and published by Academic Press. This book was released on 2009-03-05 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the companion volume to Daniel Klionsky’s Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi (aspergillus, podospora, magnaporthe). Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, “Autophagy: From phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors, that will publish in Autophagy. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning in the cell is called autophagy – literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 (autophagy-related gene 1) in yeast. (To date, 30 additional yeast genes have been identified.) These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth.
Author :
Publisher : Academic Press
ISBN 13 : 9780080570075
Total Pages : 616 pages
Book Rating : 4.5/5 (7 download)
Download or read book Small GTPases in Disease written by and published by Academic Press. This book was released on 2008-04-01 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volume 1 onward.
Author :
Publisher : Academic Press
ISBN 13 : 9780123849922
Total Pages : 456 pages
Book Rating : 4.8/5 (499 download)
Download or read book Cryo-EM Part B: 3-D Reconstruction written by and published by Academic Press. This book was released on 2010-09-30 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. * Includes time-tested core methods and new innovations applicable to any researcher * Methods included are useful to both established researchers and newcomers to the field * Relevant background and reference information given for procedures can be used as a guide
Author :
Publisher : Academic Press
ISBN 13 : 9780123864901
Total Pages : 576 pages
Book Rating : 4.8/5 (649 download)
Download or read book Research on Nitrification and Related Processes written by and published by Academic Press. This book was released on 2011-06-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global nitrogen cycle is the one most impacted by mankind. The past decade has changed our view on many aspects of the microbial biogeochemical cycles, including the global nitrogen cycle, which is mainly due to tremendous advances in methods, techniques and approaches. Many novel processes and the molecular inventory and organisms that facilitate them have been discovered only within the last 5 to 10 years, and the process is in progress. Research on Nitrification and Related Processes, Part B provides state-of-the-art updates on methods and protocols dealing with the detection, isolation and characterization of macromolecules and their hosting organisms that facilitate nitrification and related processes in the nitrogen cycle as well as the challenges of doing so in very diverse environments. Provides state-of-the-art update on methods and protocols Deals with the detection, isolation and characterization of macromolecules and their hosting organisms Deals with the challenges of very diverse environments
