Plants with Anti-Diabetes Mellitus Properties

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Author :
Publisher : CRC Press
ISBN 13 : 1482249901
Total Pages : 591 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Plants with Anti-Diabetes Mellitus Properties by : Appian Subramoniam

Download or read book Plants with Anti-Diabetes Mellitus Properties written by Appian Subramoniam and published by CRC Press. This book was released on 2016-04-06 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence and severity of diabetes mellitus is increasing worldwide, presenting a significant burden to society both in economic terms and overall well-being. Fortunately, time-tested anti-diabetes mellitus plant foods exist that are safe and could be effective in addressing this condition when consumed judiciously with a concomitant change in lifestyle. Plants with Anti-Diabetes Mellitus Properties presents an exhaustive compilation of the anti-diabetes mellitus activities of more than 1000 plants occurring worldwide. The author provides a brief botanical description, distribution, pharmacological properties, and phytochemicals, where appropriate. A list of traditional medicinal plants used to treat diabetes, but not tested for anti-diabetic activity, is also given. This unique reference highlights anti-diabetes mellitus plant foods along with a list of the edible parts of plants with anti-diabetes mellitus properties. Anti-diabetes mellitus nutraceuticals are described with guidelines for the development of food supplements and formulations of diets appropriate for diabetic patients. This is a valuable source of information for researchers, students, doctors, diabetic patients, and other individuals wanting to learn more about plant-based treatments for diabetes mellitus.

Traditional Medicines for Modern Times

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Publisher : CRC Press
ISBN 13 : 1420019007
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Traditional Medicines for Modern Times by : Amala Soumyanath

Download or read book Traditional Medicines for Modern Times written by Amala Soumyanath and published by CRC Press. This book was released on 2005-11-02 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing prevalence of diabetes mellitus world-wide is an issue of major socio-economic concern. Scientific interest in plant-derived medicine is steadily rising, yet there is often a wide disparity in the caliber of information available. A detailed compilation of scientific information from across the globe, Traditional Medicines for Modern

Anti-Diabetes Mellitus Plants

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Author :
Publisher : CRC Press
ISBN 13 : 9781498753234
Total Pages : 0 pages
Book Rating : 4.7/5 (532 download)

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Book Synopsis Anti-Diabetes Mellitus Plants by : Appian Subramoniam

Download or read book Anti-Diabetes Mellitus Plants written by Appian Subramoniam and published by CRC Press. This book was released on 2016-08-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence and severity of diabetes mellitus is increasing worldwide, presenting a significant burden to society both in economic terms and overall well-being. There is a growing demand for novel safe and effective medicines due to the limited efficacy and undesirable side effects of current conventional drugs. We now have a great opportunity to develop plant-based therapies for diabetes mellitus with superior efficacy and safety utilizing modern science and technology. Anti-Diabetes Mellitus Plants: Active Principles, Mechanisms of Action and Sustainable Utilization begins with a detailed introduction to diabetes mellitus including current treatments for this disease in conventional medicine. It provides an authoritative overview of available methods for studying the anti-diabetes mellitus activities of plant products. The book highlights the likely therapeutic superiority of scientifically developed combinations of anti-diabetes mellitus phytochemicals and polyherbal formulations. This unique reference covers the development of polyherbal formulations and conventional combination drugs with desired targets of action for diabetes mellitus patients. In this book, more than 300 anti-diabetes phytochemical compounds are extensively covered and updated with their pharmacological properties. It will serve as a valuable source of information for researchers, students, doctors, biotechnologists, diabetic patients, and other individuals wanting to learn more about plant-based treatments for diabetes mellitus.

Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals

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Author :
Publisher : Springer
ISBN 13 : 3319541021
Total Pages : 257 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals by : Bashar Saad

Download or read book Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals written by Bashar Saad and published by Springer. This book was released on 2017-05-11 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current and future trends in anti-diabetic medicinal plants. This unique and comprehensive text is the only current book on the market focusing exclusively on medicinal plants used to combat obesity and diabetes. An introductory chapter focuses on diabetes and obesity and introduces the major causes and main treatments of this increasing epidemic in modern society. Readers are then introduced to medicinal plants, including details on their therapeutic aspects, plus side effects and safety. Following chapters focus on anti-diabetic and anti-obesity medicinal plants, as well as phytogenic natural products in the treatment of each. The text closes by focusing on present and future trends and challenges in these medicinal plants. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals: Safety, Efficacy, and Action Mechanisms is a much-needed and truly original work, finally presenting in one place all the necessary information on medicinal plants used in conjunction with obesity and diabetes prevention.

Herbal Medicine

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Publisher : CRC Press
ISBN 13 : 1439807167
Total Pages : 500 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Herbal Medicine by : Iris F. F. Benzie

Download or read book Herbal Medicine written by Iris F. F. Benzie and published by CRC Press. This book was released on 2011-03-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef

Plant and Human Health, Volume 1

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Author :
Publisher : Springer
ISBN 13 : 3319939971
Total Pages : 805 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Plant and Human Health, Volume 1 by : Munir Ozturk

Download or read book Plant and Human Health, Volume 1 written by Munir Ozturk and published by Springer. This book was released on 2018-10-02 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds, which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, it focuess on the secondary metabolic compounds, which afford protection against diseases. Lastly, Volume 3 discusses the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.

Antioxidant-Antidiabetic Agents and Human Health

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535112155
Total Pages : 384 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Antioxidant-Antidiabetic Agents and Human Health by : Oluwafemi Oguntibeju

Download or read book Antioxidant-Antidiabetic Agents and Human Health written by Oluwafemi Oguntibeju and published by BoD – Books on Demand. This book was released on 2014-02-05 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human system employs the use of endogenous enzymatic as well as non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress. Enzymatic antioxidants and non-enzymatic antioxidants work synergistically with each other, using different mechanisms against different free radicals and stages of oxidative stress. Dietary and lifestyle modifications are seen as the mainstay of treatment and management of chronic diseases such as diabetes mellitus. The major aims of dietary and lifestyle changes are to reduce weight, improve glycaemic control and reduce the risk of coronary heart disease, which accounts for 70- 80% of deaths among those with diabetes. It is also important to note that medicinal plants have been used as medicines since ancient time, and continue to play significant role even in modern medicine in management and treatment of chronic diseases. Impressive numbers of modern therapeutic agents have been developed from plants. Phytochemicals have been isolated and characterised from fruits such as grapes and apples, vegetables such as broccoli and onion, spices such as turmeric, beverages such as green tea and red wine, as well as many other sources. The WHO estimates that approximately 80% of the worlds inhabitants rely on traditional medicine for their primary health care and many medicinal plants have ethno-medical claims of usefulness in the treatment of diabetes and other chronic diseases globally, and have been employed empirically in antidiabetic, antihyperlipidemic, antihypertensive, antinflammatory and antiparasitic remedies. This book examines the role of antioxidant-rich natural products in management and treatment of diabetes and other chronic diseases.

Natural Bio-active Compounds

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Author :
Publisher : Springer Nature
ISBN 13 : 9811372055
Total Pages : 492 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Natural Bio-active Compounds by : Mallappa Kumara Swamy

Download or read book Natural Bio-active Compounds written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2019-09-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

The Genetic Landscape of Diabetes

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (55 download)

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Book Synopsis The Genetic Landscape of Diabetes by : Laura Dean

Download or read book The Genetic Landscape of Diabetes written by Laura Dean and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biotechnology of Anti-diabetic Medicinal Plants

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Author :
Publisher : Springer Nature
ISBN 13 : 9811635293
Total Pages : 482 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biotechnology of Anti-diabetic Medicinal Plants by : Saikat Gantait

Download or read book Biotechnology of Anti-diabetic Medicinal Plants written by Saikat Gantait and published by Springer Nature. This book was released on 2021-11-13 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.

Medicinal Plants

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Publisher : IBDC Publishers
ISBN 13 : 9788181895370
Total Pages : 546 pages
Book Rating : 4.8/5 (953 download)

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Book Synopsis Medicinal Plants by : A. B. Ray

Download or read book Medicinal Plants written by A. B. Ray and published by IBDC Publishers. This book was released on 2010 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antidiabetic Medicinal Plants

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Author :
Publisher : Elsevier
ISBN 13 : 032395720X
Total Pages : 610 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Antidiabetic Medicinal Plants by : M. Naeem

Download or read book Antidiabetic Medicinal Plants written by M. Naeem and published by Elsevier. This book was released on 2023-10-02 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Plants with Antidiabetic Properties: Applications and Opportunities is the first comprehensive reference to present the state of current research as well as those developments that are impacting developments in the use of plants to address diabetic conditions. Presenting multiple perspectives on the plants, their identification, cultivation and application, this book presents the state of the art with an eye toward the future. Herbal drugs and their components with insignificant toxicity and limited or no side effects are valuable therapeutic alternatives in the treatment of diabetes around the world and have been considered a fundamental source of potent antidiabetic drugs. Exploration of plants containing numerous bio-active compounds such as flavonoids, terpenoids, saponins, carotenoids, alkaloids, and glycosides, for their potential antidiabetic properties is increasing as alternative treatments for this globally devastating disease are sought. Presented in 5 parts, the book first provides an overview of those plants with antidiabetic properties, then moves to the agricultural practices for the cultivation and production of those plants. Part Three focuses on the chemical composition and phytochemicals of the plants before then moving into a study of the physiological, biotechnological and molecular approaches to optimizing these plants. The book concludes with insights into current and potential future medical and clinical applications. The book is ideal for those seeking to understand the biology and chemistry of plants with anti-diabetic properties and their effective development and application. Includes insights from laboratory research to field application Presents perspectives from agriculture, biotechnology, molecular biology, pharmaceutical, pharmacological, and clinical trials Highlights the cost-effective and eco-friendly technologies for the sustainable agriculture development of antidiabetic plants

Treating Endocrine and Metabolic Disorders With Herbal Medicines

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Author :
Publisher : IGI Global
ISBN 13 : 1799848094
Total Pages : 489 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Treating Endocrine and Metabolic Disorders With Herbal Medicines by : Hussain, Arif

Download or read book Treating Endocrine and Metabolic Disorders With Herbal Medicines written by Hussain, Arif and published by IGI Global. This book was released on 2020-12-11 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The utilization of herbal medicine to treat endocrine and metabolic disorders has garnered much attention within the past few decades. Specifically, the popularity of using dietary supplements for the management of chronic disorders has drastically increased, with a wide variety of these products available over the counter. They represent an attractive adjuvant to traditional therapy for their lower toxicity and their easy accessibility. The identification of such dietary compounds has prompted researchers to explore the vast array of their beneficial effects. However, despite their widespread use, there is still limited data on the safety and efficacy of the products currently on the market. Current research on the side effects and safe usage of herbal medicines is necessary for providing optimal care and counseling for patients. Treating Endocrine and Metabolic Disorders With Herbal Medicines is a comprehensive reference book focused on spreading awareness on the safety, potential harmful effects, and rational use of herbal medicines. The chapters within explore and provide insight on the effectiveness, versatility, and side effects of various herbal medicines across a range of different diseases and conditions. While highlighting herbal medicine in areas such as diabetes, cancer, infertility, and endocrine disorders, this publication is ideally intended for clinical practitioners, pharmaceutical scientists, doctors, practitioners, stakeholders, researchers, academicians, and students interested in enhancing their knowledge and awareness in the field of complementary medicine.

Antidiabetic Potential of Plants in the Era of Omics

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Author :
Publisher : CRC Press
ISBN 13 : 1000574997
Total Pages : 443 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Antidiabetic Potential of Plants in the Era of Omics by : Deepu Pandita

Download or read book Antidiabetic Potential of Plants in the Era of Omics written by Deepu Pandita and published by CRC Press. This book was released on 2022-12-30 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an informative overview of diabetes mellitus in conjunction with plant-based treatments. It discusses available methods for studying the antidiabetic activities of scientifically developed plant products, mechanisms of action, their therapeutic superiority, and current genome editing research perspectives and biotechnological approaches. The book begins with an introduction to diabetes, giving a brief overview of the history, diagnosis, classification, pathophysiology, and risk factors. It goes on to review traditional uses of plants for diabetes along with ethnobotanical information. The results of scientific studies on the various modes of action of antidiabetic plants are discussed, such as the molecular aspects of active plantbased antidiabetic drug molecules. A section featuring recent biotechnological advancements of antidiabetic plants and plant-based antidiabetic drugs covers advances in molecular breeding and application of molecular markers, biotechnologically engineered transgenic medicinal plants, and advances in genomic editing tools and techniques.

Antidiabetic Plants in India and Herbal Based Antidiabetic Research

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Author :
Publisher : Daya Books
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Antidiabetic Plants in India and Herbal Based Antidiabetic Research by : T. Pullaiah

Download or read book Antidiabetic Plants in India and Herbal Based Antidiabetic Research written by T. Pullaiah and published by Daya Books. This book was released on 2003 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Book Is A Compilation Work And Embodies A Fairly Comprehensive Information Of The Fundamental Aspects Of Diabetes, Herbal Based Antidiabetic Research And Antidiabetic Plants In India. This Book Will Promote Research Aspirations In Botanists And Particularly Beginners In The Area Of Medical Botany, It Also Provides Information To The Pharmacy Students And Researchers In Identifying Antidiabetic Agents From Natural Resource And In Standardizing Herbal Formulations/Crude Drugs. It Provides Information Briefly About The Important Work Done In Antidiabetic Research And A Detailed Account On The Work Done During 1995 To 2002 Encompassing More Than 200 References. This Book Also Provides Brief Information About Diabetes, Especially Pertaining To Niddm; Different Antidiabetic Agents And Management Of Niddm. Information About Animal Models Used In The Screening Of Plant Extracts, Experimental Protocols In Antidiabetic Research Is Also Given In Detail. This Book Also Offers Information About The Antidiabetic Plants Available In Indiua, Brief Description About The Plant, It`S Distribution In India, Flowering Fruiting Season, Vernacular Names, Methods Of Propagation With A Brief Account Of The Herbal Use In Treating Diabetes.

Discovery and Development of Antidiabetic Agents from Natural Products

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Author :
Publisher : Elsevier
ISBN 13 : 0128096926
Total Pages : 332 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Discovery and Development of Antidiabetic Agents from Natural Products by : Goutam Brahmachari

Download or read book Discovery and Development of Antidiabetic Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2016-10-11 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Antidiabetic Medicinal Plants and Herbal Treatments

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Author :
Publisher : CRC Press
ISBN 13 : 1000898105
Total Pages : 517 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Antidiabetic Medicinal Plants and Herbal Treatments by : Azamal Husen

Download or read book Antidiabetic Medicinal Plants and Herbal Treatments written by Azamal Husen and published by CRC Press. This book was released on 2023-07-17 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a chronic condition associated with metabolic disorder. Persons suffering from diabetes have shown accelerated levels of blood sugar which often harms the heart, blood vessels, eyes, kidneys, and nerves. Over the past few decades, the prevalence of diabetes has been progressively increasing. Synthetic drugs are used to treat diabetic patients to help control the disorder, but it is shown that numerous medicinal plants and herbal drugs are widely used in several traditional systems of medicine to prevent and treat diabetes. They are reported to produce beneficial effects in combating diabetes and alleviating diabetes-related complications. These plants contain phtyonutrients and phytoconstituents demonstrating protective or disease preventive properties. In many developing countries, herbal drugs are recommended by traditional practitioners for diabetes treatment because the use of synthetic drugs is not affordable. Key Features: Provides botanical descriptions, distribution, and pharmacological investigations of notable medicinal and herbal plants used to prevent or treat diabetes Discusses phytochemical and polyherbal formulations for the management of diabetes and other related complications Contains reports on antidiabetic plants and their potential uses in drug discovery based on their bioactive molecules This volume in the Exploring Medicinal Plants series provides an overview of natural healing treatments in selected antidiabetic plants. The book presents valuable information to scientists, researchers, and students working with medicinal plants or for those specializing in areas of ethnobotany, natural products, pharmacognosy, and other areas of allied healthcare. It is also useful to pharmaceutical companies, industrialists, and health policy makers.