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Antagonist
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Download or read book The Antagonist written by Lynn Coady and published by Vintage. This book was released on 2013-01-22 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A piercing epistolary novel, The Antagonist explores, with wit and compassion, how the impressions of others shape, pervert, and flummox both our perceptions of ourselves and our very nature. Gordon Rankin Jr., aka “Rank,” thinks of himself as “King Midas in reverse”—and indeed misfortune seems to follow him at every turn. Against his will and his nature, he has long been considered—given his enormous size and strength—a goon and enforcer by his classmates, by his hockey coaches, and, not least, by his “tiny, angry” father. He gamely lives up to their expectations, until a vicious twist of fate forces him to flee underground. Now pushing forty, he discovers that an old, trusted friend from his college days has published a novel that borrows freely from the traumatic events of Rank’s own life. Outraged by this betrayal and feeling cruelly misrepresented, he bashes out his own version of his story in a barrage of e-mails to the novelist that range from funny to furious to heartbreaking. With The Antagonist, Lynn Coady demonstrates all of the gifts that have made her one of Canada’s most respected young writers. Here she gives us an astonishing story of sons and fathers and mothers, of the rewards and betrayals of male friendship, and a large-spirited, hilarious, and exhilarating portrait of a man tearing his life apart in order to put himself back together. This ebook edition includes a Reading Group Guide.
Book Synopsis Opiate Receptors and Antagonists by : Reginald Dean
Download or read book Opiate Receptors and Antagonists written by Reginald Dean and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Book Synopsis Last One at the Party by : Bethany Clift
Download or read book Last One at the Party written by Bethany Clift and published by Hodder & Stoughton. This book was released on 2021-02-04 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'A riotous, black-humoured tonic' Independent 'A masterpiece of modern fiction' Sophie Cousens December 2023. The human race has fought a deadly virus and lost. The only things left from the world before are burning cities and rotting corpses. But in London, one woman is still alive. Although she may be completely unprepared for her new existence, as someone who has spent her life trying to fit in, being alone is surprisingly liberating. Determined to discover if she really is the last survivor on earth, she sets off on an extraordinary adventure, with only an abandoned golden retriever named Lucky for company. Maybe she'll find a better life or maybe she'll die along the way. But whatever happens, the end of everything will be her new beginning. 'Fresh, frank, funny' Elizabeth Kay 'Brilliant. Creepy, witty, laugh-out-loud and shudder-inducing' Harriet Walker 'Harrowing, unflinching and uplifting' Jennifer Saint 'Original, brutal, funny and hugely addictive!' Emma Cooper
Book Synopsis The Handbook of Antagonism by : Joshua W. Miller
Download or read book The Handbook of Antagonism written by Joshua W. Miller and published by Academic Press. This book was released on 2019-02-15 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antagonism as a Personality Trait looks at the theoretical and empirical underpinnings of antagonism, highlighting the consequences of the trait, its role in a number of problem behaviors and psychiatric disorders, and how it exerts itself on externalizing behaviors. Covering the biological and evolutionary roots of antagonism, the book additionally provides clinical insight on assessment strategies while also outlining a number of treatment techniques, including motivational interviewing, cognitive behavioral therapy, interpersonal psychology, and psychodynamic treatment approaches. The book looks at the development of antagonism across childhood and adolescence, discussing the societal consequences of the trait, as well as its role in a number of problem behaviors, such as aggression, violence, crime, and substance use. Provides an overview on the development, assessment and treatment of antagonism Looks at antagonism's role in work, romantic relationships and other domains Outlines self-report and non-self-report assessment approaches Studies the links between antagonism, psychopathy, narcissism and antisocial personality Approaches antagonism from a dimensional trait model Analyzes the role antagonism plays in several prominent psychiatric disorders
Book Synopsis Antagonists in the Church by : Kenneth C. Haugk
Download or read book Antagonists in the Church written by Kenneth C. Haugk and published by . This book was released on 2013 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis We Were the Mulvaneys by : Joyce Carol Oates
Download or read book We Were the Mulvaneys written by Joyce Carol Oates and published by Penguin. This book was released on 1997-09-01 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Oprah Book Club® selection A New York Times Notable Book The Mulvaneys are blessed by all that makes life sweet. But something happens on Valentine’s Day, 1976—an incident that is hushed up in the town and never spoken of in the Mulvaney home—that rends the fabric of their family life...with tragic consequences. Years later, the youngest son attempts to piece together the fragments of the Mulvaneys’ former glory, seeking to uncover and understand the secret violation that brought about the family’s tragic downfall. Profoundly cathartic, this extraordinary novel unfolds as if Oates, in plumbing the darkness of the human spirit, has come upon a source of light at its core. Moving away from the dark tone of her more recent masterpieces, Joyce Carol Oates turns the tale of a family struggling to cope with its fall from grace into a deeply moving and unforgettable account of the vigor of hope and the power of love to prevail over suffering. “It’s the novel closest to my heart....I’m deeply moved that Oprah Winfrey has selected this novel for Oprah’s Book Club, a family novel presented to Oprah’s vast American family.”—Joyce Carol Oates
Book Synopsis The Godspeaker Trilogy by : Karen Miller
Download or read book The Godspeaker Trilogy written by Karen Miller and published by Orbit. This book was released on 2012-11-13 with total page 1375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sold into slavery, Hekat dreams of power. Fate leads her to the warlord Raklion, and she begins turning dreams into reality. For the nameless god of Mijak is with her, and it promises her the world. Far away, the King of Ethrea is dying. His daughter Princess Rhian is ready to rule, but if her enemies have their way the crown of Ethrea will never be worn by a woman. Dexterity Jones is a toymaker. To protect Rhian and his country, he must place his trust in an exile from Mijak. Yet, as Ethrea comes ever closer to civil war, a greater danger awaits. Hekat still desires the world . . . and power is no longer a dream. This omnibus edition of THe Godspeaker Trilogy includes Empress, The Riven Kingdom and The Hammer of God.
Download or read book The Antagonists written by Ernest K Gann and published by . This book was released on 1970 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Writing Irresistible Kidlit by : Mary Kole
Download or read book Writing Irresistible Kidlit written by Mary Kole and published by Penguin. This book was released on 2012-12-04 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Captivate the hearts and minds of young adult readers! Writing for young adult (YA) and middle grade (MG) audiences isn't just "kid's stuff" anymore--it's kidlit! The YA and MG book markets are healthier and more robust than ever, and that means the competition is fiercer, too. In Writing Irresistible Kidlit, literary agent Mary Kole shares her expertise on writing novels for young adult and middle grade readers and teaches you how to: • Recognize the differences between middle grade and young adult audiences and how it impacts your writing. • Tailor your manuscript's tone, length, and content to your readership. • Avoid common mistakes and cliches that are prevalent in YA and MG fiction, in respect to characters, story ideas, plot structure and more. • Develop themes and ideas in your novel that will strike emotional chords. Mary Kole's candid commentary and insightful observations, as well as a collection of book excerpts and personal insights from bestselling authors and editors who specialize in the children's book market, are invaluable tools for your kidlit career. If you want the skills, techniques, and know-how you need to craft memorable stories for teens and tweens, Writing Irresistible Kidlit can give them to you.
Download or read book The Antagonists written by James F. Simon and published by Touchstone Books. This book was released on 1990 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cholecystokinin and Its Antagonists in Pain Management by : Gary McCleane
Download or read book Cholecystokinin and Its Antagonists in Pain Management written by Gary McCleane and published by CRC Press. This book was released on 2006-06-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examine the strong evidence of this unrealized pain management tool Cholecystokinin (CCK), the regulatory peptide hormone found primarily in the gastrointestinal tract that works as a neurotransmitter throughout the nervous system, has been researched for years. CCK antagonists in conjunction with opioids are beginning to be seen as having possible major therapeutic benefits in pain management. Cholecystokinin and Its Antagonists in Pain Management is an extensive examination that gathers the mounting compelling evidence into one comprehensive source. Here researchers, neuroscientists, physicians, and pharmacy professionals are given the research and findings they need to explore the possible applications of CCK antagonists for a variety of illnesses. Cholecystokinin and Its Antagonists in Pain Management extensively describes opioids in pain management, CCK and the body’s uses for the chemical, CCK receptor antagonists, and the evidence that points to its being a possible breakthrough application in pain management. Various animal studies are offered that present a convincing view of what may be the future of chronic pain management, with less side effects and a reduction in analgesic tolerance than when opioids are used alone. Potential uses of CCK antagonists are clearly discussed. The book is comprehensively referenced and provides several tables and graphs to fully illustrate the research findings. Topics in Cholecystokinin and Its Antagonists in Pain Management include: in vivo localization of CCK CCK as a gut and nervous system peptide factors that increase CCK anti-opioid effects CCK receptor antagonists pro-analgesic effect of CCK antagonists CCK antagonists reducing analgesic tolerance to opioids safety of combining opioids and CCK antagonists human clinical application of CCK antagonists Cholecystokinin and Its Antagonists in Pain Management is a crucial source of the latest information and research results on CCK that is certain to be important for neuroscientists, clinicians, and pharmaceutical industry professionals.
Book Synopsis Hormones, Hormone Substitutes, and Hormone Antagonists—Advances in Research and Application: 2012 Edition by :
Download or read book Hormones, Hormone Substitutes, and Hormone Antagonists—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Hormone Substitutes, and Hormone Antagonists—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hormones, Hormone Substitutes, and Horm. The editors have built Hormones, Hormone Substitutes, and Hormone Antagonists—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hormones, Hormone Substitutes, and Horm in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hormones, Hormone Substitutes, and Hormone Antagonists—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists by : Michel Alexander Steiner
Download or read book Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists written by Michel Alexander Steiner and published by Frontiers E-books. This book was released on 2014-11-11 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism’s arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck’s MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as “special topics issue”) comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia.
Book Synopsis Narcotic Antagonists by : National Institute on Drug Abuse. Division of Research
Download or read book Narcotic Antagonists written by National Institute on Drug Abuse. Division of Research and published by . This book was released on 1981 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adenosine A2A Receptor Antagonists by :
Download or read book Adenosine A2A Receptor Antagonists written by and published by Elsevier. This book was released on 2023-09-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson’s disease therapy, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology Updated release includes the latest information on Adenosine A2A Receptor Antagonists
Book Synopsis Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens by : Gene Barnett
Download or read book Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens written by Gene Barnett and published by . This book was released on 1978 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endorphins and Opiate Antagonists in Psychiatric Research by : Nandkumar S. Shah
Download or read book Endorphins and Opiate Antagonists in Psychiatric Research written by Nandkumar S. Shah and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.
