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Animal Models Of Movement Disorders
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Book Synopsis Movement Disorders by : Mark S. LeDoux
Download or read book Movement Disorders written by Mark S. LeDoux and published by Elsevier. This book was released on 2014-10-24 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. - Introduces the scientific foundations for modern movement disorders research - Contributing authors are internationally known experts - Completely revised with 20% new material - Provides a comprehensive discussion of genetics for each type of movement disorder - Covers Parkinson's disease, Huntington's disease, dystonia, tremors, and tics
Book Synopsis Animal Models of Movement Disorders by :
Download or read book Animal Models of Movement Disorders written by and published by . This book was released on 2011-09-09 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Animal Models of Movement Disorders by : Emma L. Lane
Download or read book Animal Models of Movement Disorders written by Emma L. Lane and published by Humana Press. This book was released on 2011-09-15 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.
Book Synopsis Animal Models of Movement Disorders by : Emma L. Lane
Download or read book Animal Models of Movement Disorders written by Emma L. Lane and published by Humana Press. This book was released on 2011-09-08 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume II of this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.
Book Synopsis Animal Models of Neurological Disorders by : Puneet Kumar Bansal
Download or read book Animal Models of Neurological Disorders written by Puneet Kumar Bansal and published by Springer. This book was released on 2018-01-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.
Book Synopsis Animal Models Used in the Study of Movement Disorders by :
Download or read book Animal Models Used in the Study of Movement Disorders written by and published by . This book was released on 2007 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Gene Expression and Behavior in Animal Models of Movement Disorders by : Jill Marie Delfs
Download or read book Gene Expression and Behavior in Animal Models of Movement Disorders written by Jill Marie Delfs and published by . This book was released on 1995 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Motor Activity and Movement Disorders by : Paul Sanberg
Download or read book Motor Activity and Movement Disorders written by Paul Sanberg and published by Springer Science & Business Media. This book was released on 1995-11-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior. Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.
Book Synopsis Genetics of Movement Disorders by : Stefan M. Pulst
Download or read book Genetics of Movement Disorders written by Stefan M. Pulst and published by Elsevier. This book was released on 2002-10-25 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists. - Consistently formatted to present a clinical description of the disorder, followed by an in-depth analysis of the mutation and function of the mutated gene including cellular and animal models - Emphasizes the use of DNA tests for each respective disorder - Provides up-to-date, easily accessible information for clinicians, geneticists, and neuroscientists
Book Synopsis Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials by : Sarat Chandra Yenisetti
Download or read book Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials written by Sarat Chandra Yenisetti and published by BoD – Books on Demand. This book was released on 2023-12-20 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Book Synopsis Rehabilitation in Movement Disorders by : Robert Iansek
Download or read book Rehabilitation in Movement Disorders written by Robert Iansek and published by Cambridge University Press. This book was released on 2013-05-23 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad overview of current rehabilitation approaches, emphasizing the need for interdisciplinary management and focussing on deliverable outcomes.
Book Synopsis Encyclopedia of Movement Disorders by :
Download or read book Encyclopedia of Movement Disorders written by and published by Academic Press. This book was released on 2010-02-26 with total page 1633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists
Book Synopsis Neurodegeneration by : Dennis Dickson
Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin
Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Book Synopsis Movement Disorder Emergencies by : Steven J. Frucht
Download or read book Movement Disorder Emergencies written by Steven J. Frucht and published by Springer Science & Business Media. This book was released on 2008-02-10 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement Disorder Emergencies: Diagnosis and Treatment provides a fresh and unique approach to what is already a high-profile subspecialty area in clinical neurology. The disorders covered in this volume are standard fare in the field but emphasize the urgencies and emergencies that can occur. One of the very attractive features of the field of movement disorders is that diagnosis is often based on unique visible and sometimes audible phenomenological symptoms and signs. Therefore, in this era of highly sophisticated laboratory and radiological diagnostic tools, the diagnosis of many movement disorders is still largely made in the clinic where pattern recognition is key. Crucial to astute clinical diagnosis is broad clinical experience. In short, you have to have seen one to recognize one! Patients with movement disorders nearly always present as outpatients but, as aptly recognized by Drs. Frucht and Fahn, this may include acute manifestations leading to emergency presentations, often in an emergency room setting, where they are very likely to be unrecognized and therefore poorly managed. The authors define an “emergency” movement disorder as one in which failure to promptly diagnose and treat may result in significant morbidity or mortality. However, they also stress the importance of certain “can’t miss” diagnoses such as Wilson’s disease, dopa-responsive dystonia, and Whipple’s disease in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurological damage with tragic consequences.
