Animal Lectins Form Function And Clinical Applications

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Animal Lectins: Form, Function and Clinical Applications

Author : G. S. Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 3709110653
Total Pages : 1122 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Animal Lectins: Form, Function and Clinical Applications by : G. S. Gupta

Download or read book Animal Lectins: Form, Function and Clinical Applications written by G. S. Gupta and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided. The recently discovered C-type lectins as well as further novel super-families of this group of molecules are described in detail. Furthermore, the clinical significance of animal lectins in inflammatory diseases, defects of immune defense and autoimmunity are described and their application as drugs and therapeutic targets is discussed. With the increasing interest in lectins in biomedical research and their therapeutic applications, this book on animal lectins and associated proteins is a must have for researchers in the area.

Animal Lectins

Author : G. S. Gupta
Publisher :
ISBN 13 : 9781283849586
Total Pages : 1220 pages
Book Rating : 4.8/5 (495 download)

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Book Synopsis Animal Lectins by : G. S. Gupta

Download or read book Animal Lectins written by G. S. Gupta and published by . This book was released on 2013 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Lectins

Author : A. Pusztai
Publisher : Cambridge University Press
ISBN 13 : 0521328241
Total Pages : 276 pages
Book Rating : 4.5/5 (213 download)

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Book Synopsis Plant Lectins by : A. Pusztai

Download or read book Plant Lectins written by A. Pusztai and published by Cambridge University Press. This book was released on 1991 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume surveys the chemistry, biochemistry, biosynthesis, metabolism and pharmacological properties of lectins. Lectins, which are most commonly found in plants, are widespread natural products with striking biological activities. Their specific ability to recognise and bind to simple or complex saccharides facilitates their role as effective information protein molecules. As agents of cell-to-cell recognition, lectins promote symbiosis between plants and specific nitrogen-fixing soil bacteria. As natural defensive molecules, they can protect plants against predators such as bacteria, fungi and insects. As part of our diet, lectins are powerful exogenous growth factors in the small intestine and influence our health, the digestive function and the bacterial ecology of the alimentary tract. Lectins are also important research tools in preparative biochemistry and cell science.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Lectins

Author : Preetham Elumalai
Publisher : Springer Nature
ISBN 13 : 9811674620
Total Pages : 306 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Lectins by : Preetham Elumalai

Download or read book Lectins written by Preetham Elumalai and published by Springer Nature. This book was released on 2022-03-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the relationship between receptors, carbohydrate moieties, and pathogenic surfaces and lectins’ pathophysiology of immune responses and examines the mechanisms of action of the molecules for the treatment potentials. Increasing evidence has suggested that lectin-carbohydrate interactions perform important roles in various regulations of immune responses, but much remains to be learned about these crucial properties and their interplay with other molecules. In addition, a better understanding of the structural and functional properties of lectin and the activated immune response will be of critical importance for the development of new diagnostic tools and therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the various lectin types from animal and plant as well as microbial or marine lectins, and this wide range of molecular knowledge directs us to various diseases, including infectious diseases and cancer. In presenting state-of-the-art knowledge on the interactions between lectin and its interactions,the book will help to pave the way for the development of novel targets for the prevention and treatment of many disorders.

Handbook of Clinical Nanomedicine

Author : Raj Bawa
Publisher : CRC Press
ISBN 13 : 9814669210
Total Pages : 1686 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Handbook of Clinical Nanomedicine by : Raj Bawa

Download or read book Handbook of Clinical Nanomedicine written by Raj Bawa and published by CRC Press. This book was released on 2016-02-22 with total page 1686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosim

Animal Lectins: Form, Function and Clinical Applications

Author : G. S. Gupta
Publisher : Springer
ISBN 13 : 9783709148372
Total Pages : 0 pages
Book Rating : 4.1/5 (483 download)

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Book Synopsis Animal Lectins: Form, Function and Clinical Applications by : G. S. Gupta

Download or read book Animal Lectins: Form, Function and Clinical Applications written by G. S. Gupta and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided. The recently discovered C-type lectins as well as further novel super-families of this group of molecules are described in detail. Furthermore, the clinical significance of animal lectins in inflammatory diseases, defects of immune defense and autoimmunity are described and their application as drugs and therapeutic targets is discussed. With the increasing interest in lectins in biomedical research and their therapeutic applications, this book on animal lectins and associated proteins is a must have for researchers in the area.

Aquatic Lectins

Author : Preetham Elumalai
Publisher : Springer Nature
ISBN 13 : 9811904324
Total Pages : 389 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Aquatic Lectins by : Preetham Elumalai

Download or read book Aquatic Lectins written by Preetham Elumalai and published by Springer Nature. This book was released on 2022-05-03 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest information on fish lectins from the perspective of inflammation and presents new ideas on the complicated mechanisms of lectin biochemistry and associated interactions. Key features include discussion of mechanisms recently identified to be involving lectin family types, presentation of the latest evidence regarding the molecular approaches in fish lectins, and thorough explanation of the concept of antimicrobial and immunological roles and current understanding of the significance of its disease resistance related studies. Gene expression studies is another important element of the book, and it is proposed that gene editing technology provides gaining attention in the biological role of fish lectin research. Examples of the many lastest molecular approaches, applications and future perspectives in fish lectin specific topics covered in this book include the information right from the basics to the advancements in this area. The book will be a valuable update and resource for both experienced and younger researchers working in the field of lectins and immunology.

Multivalency

Author : Jurriaan Huskens
Publisher : John Wiley & Sons
ISBN 13 : 1119143462
Total Pages : 434 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Multivalency by : Jurriaan Huskens

Download or read book Multivalency written by Jurriaan Huskens and published by John Wiley & Sons. This book was released on 2018-02-05 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.

Phytochemistry, 3-Volume Set

Author : Chukwuebuka Egbuna
Publisher : CRC Press
ISBN 13 : 0429760485
Total Pages : 1806 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Phytochemistry, 3-Volume Set by : Chukwuebuka Egbuna

Download or read book Phytochemistry, 3-Volume Set written by Chukwuebuka Egbuna and published by CRC Press. This book was released on 2022-05-30 with total page 1806 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 3-volume set, Phytochemistry, covers a wide selection of topics in phytochemistry and provides a wealth of information on the fundamentals, new applications, methods and modern analytical techniques, state-of-the-art approaches, and computational techniques. With chapters from professional specialists in their fields from around the world, the volumes deliver a comprehensive coverage of phytochemistry. Phytochemistry is a multidisciplinary field, so this book will appeal to students in both upper-level students, faculty, researchers, and industry professionals in a number of fields, including biological science, biochemistry, pharmacy, food and medicinal chemistry, systematic botany and taxonomy, ethnobotany, conservation biology, plant genetic and metabolomics, evolutionary sciences, and plant pathology.

Galectins in Cancer and Translational Medicine

Author : Armando Bartolazzi
Publisher : MDPI
ISBN 13 : 3038974080
Total Pages : 351 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Galectins in Cancer and Translational Medicine by : Armando Bartolazzi

Download or read book Galectins in Cancer and Translational Medicine written by Armando Bartolazzi and published by MDPI. This book was released on 2018-11-29 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin-glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.

Phytochemistry

Author : Chukwuebuka Egbuna
Publisher : CRC Press
ISBN 13 : 0429760337
Total Pages : 658 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Phytochemistry by : Chukwuebuka Egbuna

Download or read book Phytochemistry written by Chukwuebuka Egbuna and published by CRC Press. This book was released on 2018-12-12 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book in this three-volume set provides comprehensive coverage of a wide range of topics in phytochemistry. With chapters from professional specialists from key institutions around the world, the volume starts with an introduction to phytochemistry and details the fundamentals. Part II discusses the state-of-the-art modern methods and techniques in phytochemical research, while Part III provides an informative overview of computational phytochemistry and its applications. Part IV presents novel research findings in the discovery of drugs that will be effective in the treatment of diseases. The chapters are drawn carefully and integrated sequentially to aid flow, consistency, and continuity.

Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation

Author : Florence E. Roufosse
Publisher : Frontiers Media SA
ISBN 13 : 2889456242
Total Pages : 279 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation by : Florence E. Roufosse

Download or read book Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation written by Florence E. Roufosse and published by Frontiers Media SA. This book was released on 2018-12-06 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.

Sirtuin Biology in Medicine

Author : Kenneth Maiese
Publisher : Academic Press
ISBN 13 : 0128141190
Total Pages : 421 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Sirtuin Biology in Medicine by : Kenneth Maiese

Download or read book Sirtuin Biology in Medicine written by Kenneth Maiese and published by Academic Press. This book was released on 2021-03-04 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. - Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease - Details the basic and clinical role of sirtuins for the development of new clinical treatments - Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Carbohydrate Recognition

Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 0470592079
Total Pages : 448 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Carbohydrate Recognition by : Binghe Wang

Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Targeted Biomarker Quantitation by LC-MS

Author : Naidong Weng
Publisher : John Wiley & Sons
ISBN 13 : 1119413052
Total Pages : 898 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Targeted Biomarker Quantitation by LC-MS by : Naidong Weng

Download or read book Targeted Biomarker Quantitation by LC-MS written by Naidong Weng and published by John Wiley & Sons. This book was released on 2017-07-10 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

Carbohydrates in Drug Design and Discovery

Author : Jesús Jímenez-Barbero
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739390
Total Pages : 336 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Carbohydrates in Drug Design and Discovery by : Jesús Jímenez-Barbero

Download or read book Carbohydrates in Drug Design and Discovery written by Jesús Jímenez-Barbero and published by Royal Society of Chemistry. This book was released on 2015-04-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.