Anatomy And Plasticity In Large Scale Brain Models

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Anatomy and Plasticity in Large-Scale Brain Models

Author : Markus Butz
Publisher : Frontiers Media SA
ISBN 13 : 2889450651
Total Pages : 175 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Anatomy and Plasticity in Large-Scale Brain Models by : Markus Butz

Download or read book Anatomy and Plasticity in Large-Scale Brain Models written by Markus Butz and published by Frontiers Media SA. This book was released on 2017-01-05 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)—an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.

Anatomy and Plasticity in Large-Scale Brain Models

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Anatomy and Plasticity in Large-Scale Brain Models by :

Download or read book Anatomy and Plasticity in Large-Scale Brain Models written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)--an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.Supercomputing facilities are becoming increasingly available for simulating activity dynamics in large-scale neuronal networks. On today's most advanced supercomputers, networks with up to a billion of neurons can be readily simulated. However, building biologically realistic, full-scale brain models requires more than just a huge number of neurons. In addition to network size, the detailed local and global anatomy of neuronal connections is of crucial importance. Moreover, anatomical connectivity is not fixed, but can rewire throughout life (structural plasticity)--an aspect that is missing in most current network models, in which plasticity is confined to changes in synaptic strength (synaptic plasticity). The papers in this Ebook, which may broadly be divided into three themes, aim to bring together high-performance computing with recent experimental and computational research in neuroanatomy. In the first theme (fiber connectivity), new methods are described for measuring and data-basing microscopic and macroscopic connectivity. In the second theme (structural plasticity), novel models are introduced that incorporate morphological plasticity and rewiring of anatomical connections. In the third theme (large-scale simulations), simulations of large-scale neuronal networks are presented with an emphasis on anatomical detail and plasticity mechanisms. Together, the articles in this Ebook make the reader aware of the methods and models by which large-scale brain networks running on supercomputers can be extended to include anatomical detail and plasticity.

Mutable Brain

Author : Jon H. Kaas
Publisher : CRC Press
ISBN 13 : 1482284138
Total Pages : 462 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Mutable Brain by : Jon H. Kaas

Download or read book Mutable Brain written by Jon H. Kaas and published by CRC Press. This book was released on 2001-09-13 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extremely labile nature of the nervous system has proved an intriguing area of research for over thirty years. From the earliest stages of neuronal growth during development, both the morphology and strength of neuronal connections within the central nervous system are shaped and modified by experience. While connections between neurons that ar

Neural Plasticity

Author : Peter R. Huttenlocher
Publisher : Harvard University Press
ISBN 13 : 0674038932
Total Pages : 285 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis Neural Plasticity by : Peter R. Huttenlocher

Download or read book Neural Plasticity written by Peter R. Huttenlocher and published by Harvard University Press. This book was released on 2009-07-01 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural plasticity--the brain's ability to change in response to normal developmental processes, experience, and injury--is a critically important phenomenon for both neuroscience and psychology. Increasing evidence about the extent of plasticity--long past the supposedly critical first three years--has recently emerged. Neural Plasticity offers the first succinct and lucid integration of this research and its implications. Pointing out the negative and the positive consequences of plasticity, Peter Huttenlocher describes plasticity in children and adults (in normal aging and in response to trauma), in sensory systems, the motor cortex, higher cortical functions, and language development, proceeding system by system, and paying particular attention to the cerebral cortex. One of the book's strengths is its range of references, not only to studies on human subjects but to the experimental study of animal models as well. This book will be a unique contribution to research and to the literature on clinical neuroscience.

The Plastic Brain

Author : Rommy von Bernhardi
Publisher : Springer
ISBN 13 : 3319628178
Total Pages : 281 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis The Plastic Brain by : Rommy von Bernhardi

Download or read book The Plastic Brain written by Rommy von Bernhardi and published by Springer. This book was released on 2017-10-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the many factors that can influence brain plasticity throughout the lifespan. Addresses perinatal plasticity, functional state plasticity, injury-induced plasticity, and stressor-induced plasticity. Because it looks at so many aspects of the field, this volume will serve as a great resource for students as well as researchers interested in expanding their knowledge. The volume comes out as an integrated view based in the expertise of Ibero American neuroscientists working in the field.

Neuronal Plasticity: Building a Bridge from the Laboratory to the Clinic

Author : Jordan Grafman
Publisher : Springer Science & Business Media
ISBN 13 : 3642598978
Total Pages : 298 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Neuronal Plasticity: Building a Bridge from the Laboratory to the Clinic by : Jordan Grafman

Download or read book Neuronal Plasticity: Building a Bridge from the Laboratory to the Clinic written by Jordan Grafman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last twenty years there has been an explosive growth in our understanding of the molecular, cellular, and anatomical changes that occur in the days and weeks following brain injury. It is now clear that training and exposure to certain environments can modify and shape neuronal plasticity in lower animals and humans. In humans, in particular, there are new ways of charting neuronal plasticity at the ensemble or regional level using functional neuroimaging techniques such as positron emission tomography and functional magnetic resonance imaging. Thus, the time seems right for transporting the laboratory results to the clinic so that experimental findings can be tested in the "field". This volume provides some impetus to moving the field of cognitive neuroscience a little further in its efforts to improve the lives of patients who have suffered a debilitating brain injury.

The Rewiring Brain

Author : Arjen van Ooyen
Publisher : Academic Press
ISBN 13 : 0128038721
Total Pages : 586 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Rewiring Brain by : Arjen van Ooyen

Download or read book The Rewiring Brain written by Arjen van Ooyen and published by Academic Press. This book was released on 2017-06-23 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity pattern, with plasticity merely arising from changes in the strength of existing synapses (synaptic plasticity). In The Rewiring Brain, the editors bring together for the first time contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology. Starting with an experimental background on structural plasticity in the adult brain, the book covers computational studies on homeostatic structural plasticity, the impact of structural plasticity on cognition and cortical connectivity, the interaction between synaptic and structural plasticity, neurogenesis-related structural plasticity, and structural plasticity in neurological disorders. Structural plasticity adds a whole new dimension to brain plasticity, and The Rewiring Brain shows how computational approaches may help to gain a better understanding of the full adaptive potential of the adult brain. The book is written for both computational and experimental neuroscientists. Reviews the current state of knowledge of structural plasticity in the adult brain Gives a comprehensive overview of computational studies on structural plasticity Provides insights into the potential driving forces of structural plasticity and the functional implications of structural plasticity for learning and memory Serves as inspiration for developing novel treatment strategies for stimulating functional repair after brain damage

Brain Plasticity and Behavior

Author : Bryan Kolb
Publisher : Psychology Press
ISBN 13 : 113478421X
Total Pages : 226 pages
Book Rating : 4.1/5 (347 download)

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Book Synopsis Brain Plasticity and Behavior by : Bryan Kolb

Download or read book Brain Plasticity and Behavior written by Bryan Kolb and published by Psychology Press. This book was released on 2013-06-17 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are few books devoted to the topic of brain plasticity and behavior. Most previous works that cover topics related to brain plasticity do not include extensive discussions of behavior. The first to try to address the relationship between recovery from brain damage and changes in the brain that might support the recovery, this volume includes studies of humans as well as laboratory species, particularly rats. The subject matter identifies a consistent correlation between specific changes in the brain and behavioral recovery, as well as various factors such as sex and experience that influence this correlation in consistent ways. Evolving from a series of lectures given as the McEachran Lectures at the University of Alberta, this volume originally began as a summary of the lectures, but has expanded to include more background literature, allowing the reader to see the author's biases, assumptions, and hunches in a broader perspective. In writing this volume, the author had two goals in mind: * to initiate senior undergraduates or graduate psychology, biology, neuroscience or other interested students to the issues and questions regarding the nature of brain plasticity, and * to provide a monograph in the form of an extended summary of the work the author and his colleagues have done on brain plasticity and recovery of function.

Human Brain Anatomy in Computerized Images

Author : Hanna Damasio M.D.
Publisher : Oxford University Press
ISBN 13 : 0198037058
Total Pages : 560 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Human Brain Anatomy in Computerized Images by : Hanna Damasio M.D.

Download or read book Human Brain Anatomy in Computerized Images written by Hanna Damasio M.D. and published by Oxford University Press. This book was released on 2005-03-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: By using non-invasive tomographic scans, modern neuroimaging technologies are revealing the structure of the human brain in unprecedented detail. This spectacular progress, however, poses a critical problem for neuroscientists and for practitioners of brain-related professions: how to find their way in the current tomographic images so as to identify a particular brain site, be it normal or damaged by disease? Prepared by a leading expert in advanced brain-imaging techniques, this unique atlas is a guide to the localization of brain structures that illustrates the wide range of neuroanatomical variation. It is based on the analysis of 29 normal human brains obtained from three-dimensional reconstructions of magnetic resonance scans of living persons. The Second Edition of this atlas offers entirely new images, all from new brain specimens.

Neural Models of Plasticity

Author : John H. Byrne
Publisher : Academic Press
ISBN 13 : 148321687X
Total Pages : 457 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Neural Models of Plasticity by : John H. Byrne

Download or read book Neural Models of Plasticity written by John H. Byrne and published by Academic Press. This book was released on 2013-10-22 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Models of Plasticity: Experimental and Theoretical Approaches is an outgrowth of a conference that was held at Woods Hole, Massachusetts, in the spring of 1987. The purpose of that conference was to review recent developments in both areas and to foster communication between those researchers pursuing theoretical approaches and those pursuing more empirical approaches. Contributions have been solicited from individuals who represent both ends of the spectrum of approaches as well as those using a combination of the two. These indicate that our knowledge of the plastic capabilities of the nervous system is accelerating rapidly due to rapid advances in the understanding of basic subcellular and molecular mechanisms of plasticity, and because of the computational capabilities and plastic properties that emerge from neural networks and assemblies. The book contains 19 chapters and opens with a study on the role of the neuromodulator in associative learning of the marine mollusk Hermissend. Subsequent chapters examine topics such as learning and memory in Aplysia; the Hebb rule for synaptic plasticity; olfactory processing and associative memory in the mollusk Limax maximus; simulation of a classically conditioned response; and the neural substrates of memory, focusing on the role of the hippocampus.

Changing Brains

Author :
Publisher : Elsevier
ISBN 13 : 0444633340
Total Pages : 493 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Changing Brains by :

Download or read book Changing Brains written by and published by Elsevier. This book was released on 2013-12-03 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Brain Research focuses on the applying brain plasticity to advance and recover human ability. The volume starts off discussing brain plasticity in the young, adults and old brains with follow on discussions regarding the type of neuroscience-based training that is on offer in impaired child populations as well as discussing the therapeutics involved in adults. Applying brain Plasticity and advances and recover human ability

Plasticity in the Adult Brain: From Genes to Neurotherapy

Author : M.A. Hofman
Publisher : Elsevier
ISBN 13 : 008049773X
Total Pages : 497 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Plasticity in the Adult Brain: From Genes to Neurotherapy by : M.A. Hofman

Download or read book Plasticity in the Adult Brain: From Genes to Neurotherapy written by M.A. Hofman and published by Elsevier. This book was released on 2002-10-23 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.

Development and Plasticity of the Brain

Author : Raymond D. Lund
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Development and Plasticity of the Brain by : Raymond D. Lund

Download or read book Development and Plasticity of the Brain written by Raymond D. Lund and published by Oxford University Press, USA. This book was released on 1978 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A welcome newcomer to the meager ranks of developmental texts ... Either as a text ... or as an introduction to the developmental and plasticity literature ... it represents a valuable and most appreciated addition." --Development Psychobiology

Neuroanatomy of Human Brain Development

Author : Hao Huang
Publisher : Frontiers Media SA
ISBN 13 : 2889451208
Total Pages : 223 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Neuroanatomy of Human Brain Development by : Hao Huang

Download or read book Neuroanatomy of Human Brain Development written by Hao Huang and published by Frontiers Media SA. This book was released on 2017-03-07 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain is extraordinary complex and yet its origin is a simple tubular structure. Rapid and dramatic structural growth takes place during the fetal and perinatal period. By the time of birth, a repertoire of major cortical, subcortical and white matter structures resembling the adult pattern has emerged, however there are continued maturational changes of the gray matter and white matter throughout childhood and adolescence and into adulthood. The maturation of neuronal structures provides the neuroanatomical basis for the acquisition and refinement of cognitive functions during postnatal development. Histological imaging has been traditionally dominant in understanding neuroanatomy of early brain development and still plays an unparalleled role in this field. Modern magnetic resonance imaging (MRI) techniques including diffusion MRI, as noninvasive tools readily applied to in vivo brains, have become an important complementary approach in revealing the detailed brain anatomy, including the structural connectivity between brain regions. In this research topic, we presented the most recent investigations on understanding the neuroanatomy and connectivity of human brain development using both histology and MRI. Modern advances in mapping normal developmental brain anatomy and connectivity should elucidate many neurodevelopmental disorders, ranging from rare congenital malformations to common disorders such as autism and attention deficit hyperactivity disorder (ADHD), which is a prerequisite for better diagnosis and treatment of these currently poorly understood diseases.

Quantitative analysis of neuroanatomy

Author : Julian M L Budd
Publisher : Frontiers Media SA
ISBN 13 : 2889197964
Total Pages : 246 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Quantitative analysis of neuroanatomy by : Julian M L Budd

Download or read book Quantitative analysis of neuroanatomy written by Julian M L Budd and published by Frontiers Media SA. This book was released on 2016-03-22 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.

An Exploration of the Role of Cellular Neuroplasticity in Large Scale Models of Biological Neural Networks

Author : Steven W. Skorheim
Publisher :
ISBN 13 : 9781321088502
Total Pages : 162 pages
Book Rating : 4.0/5 (885 download)

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Book Synopsis An Exploration of the Role of Cellular Neuroplasticity in Large Scale Models of Biological Neural Networks by : Steven W. Skorheim

Download or read book An Exploration of the Role of Cellular Neuroplasticity in Large Scale Models of Biological Neural Networks written by Steven W. Skorheim and published by . This book was released on 2014 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together these models set the stage for a model network that can learn through input driven processes in a waking state then explore the consolidation of memory in a sleeping state. This will allow us to explore in greater detail how plasticity on the level of a single cell contributes to learning and stability on the level of the whole brain.

Vital Models

Author :
Publisher : Academic Press
ISBN 13 : 0128125586
Total Pages : 248 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Vital Models by :

Download or read book Vital Models written by and published by Academic Press. This book was released on 2017-08-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of models has been important to the historical and contemporary study of the human brain, yet very little study by social scientists has been dedicated to how the brain sciences develop and use models to better understand what brains are and how they work, including the complex entanglements between brains, bodies and their environments. Vital Models: The Making and Use of Models in the Brain Sciences explores the history and use of brain models from clinical psychiatry to psychopharmacology and cybernetics, as well as developments in digital brain modeling, simulation, imaging and connectomics. This timely volume helps both scientists and students better understand the variety, strengths, weaknesses and applicability of models in neuroscience. Presents a timely update on the topic of brain research and modeling techniques Contains sections from true authorities in the field