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Amp Activated Protein Kinase And Nitric Oxide Synthase Phosphorylation In Kidney And Endothelium
Download Amp Activated Protein Kinase And Nitric Oxide Synthase Phosphorylation In Kidney And Endothelium full books in PDF, epub, and Kindle. Read online Amp Activated Protein Kinase And Nitric Oxide Synthase Phosphorylation In Kidney And Endothelium ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Book Synopsis AMP-Activated Protein Kinase Signalling by : Dietbert Neumann
Download or read book AMP-Activated Protein Kinase Signalling written by Dietbert Neumann and published by MDPI. This book was released on 2019-03-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.
Author :American Diabetes Association Publisher :American Diabetes Association ISBN 13 :9781580400190 Total Pages :0 pages Book Rating :4.4/5 (1 download)
Book Synopsis Handbook of Exercise in Diabetes by : American Diabetes Association
Download or read book Handbook of Exercise in Diabetes written by American Diabetes Association and published by American Diabetes Association. This book was released on 2003-06-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive resource contains the latest data on the effects of exercise on blood glucose and metabolism, prevention of type 2, treatment plans, and medication adjustment, as well as exercise’s effects on conditions such as retinopathy, nephropathy, and neuropathy. Highlights special patient groups.
Book Synopsis O-GlcNAcylation: Expanding the Frontiers by : Tarik Issad
Download or read book O-GlcNAcylation: Expanding the Frontiers written by Tarik Issad and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pediatric Hypertension by : Joseph Flynn
Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Book Synopsis Comprehensive Hypertension E-Book by : Gregory Y. H. Lip
Download or read book Comprehensive Hypertension E-Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.
Book Synopsis The Diabetic Kidney by : Pedro Cortes
Download or read book The Diabetic Kidney written by Pedro Cortes and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.
Book Synopsis Aging, Globalization and Inequality by : Jan Baars
Download or read book Aging, Globalization and Inequality written by Jan Baars and published by Routledge. This book was released on 2016-11-03 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a major reassessment of work in the field of critical gerontology, providing a comprehensive survey of issues by a team of contributors drawn from Europe and North America. The book focuses on the variety of ways in which age and ageing are socially constructed, and the extent to which growing old is being transformed through processes associated with globalisation. The collection offers a range of alternative views and visions about the nature of social ageing, making a major contribution to theory-building within the discipline of gerontology. The different sections of the book give an overview of the key issues and concerns underlying the development of critical gerontology. These include: first, the impact of globalisation and of multinational organizations and agencies on the lives of older people; second, the factors contributing to the "social construction" of later life; and third, issues associated with diversity and inequality in old age, arising through the effects of cumulative advantage and disadvantage over the life course. These different themes are analysed using a variety of theoretical perspectives drawn from sociology, social policy, political science, and social anthropology. "Aging, Globalization and Inequality" brings together key contributors to critical perspectives on aging and is unique in the range of themes and concerns covered in a single volume. The study moves forward an important area of debate in studies of aging, and thus provides the basis for a new type of critical gerontology relevant to the twenty-first century.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Endothelial Barrier Function by : Sarah Y. Yuan
Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Biota Publishing. This book was released on 2011-02-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Author :Evgenia Gerasimovskaya Publisher :Springer Science & Business Media ISBN 13 :9048134358 Total Pages :240 pages Book Rating :4.0/5 (481 download)
Book Synopsis Extracellular ATP and adenosine as regulators of endothelial cell function by : Evgenia Gerasimovskaya
Download or read book Extracellular ATP and adenosine as regulators of endothelial cell function written by Evgenia Gerasimovskaya and published by Springer Science & Business Media. This book was released on 2010-04-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Book Synopsis Regulation of Endothelial Nitric Oxide Synthase by Intracellular Calcium and Phosphorylation by : Jacqueline M. Cale
Download or read book Regulation of Endothelial Nitric Oxide Synthase by Intracellular Calcium and Phosphorylation written by Jacqueline M. Cale and published by . This book was released on 2005 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu
Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Book Synopsis Basic and Clinical Understanding of Microcirculation by : Kaneez Fatima Shad
Download or read book Basic and Clinical Understanding of Microcirculation written by Kaneez Fatima Shad and published by BoD – Books on Demand. This book was released on 2020-07-22 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microcirculation is key to providing enough nutrition and oxygen from head to toe. This is possible only through an extensive network of blood vessels spread around the body. Effect of microcirculation abnormalities stretch beyond one’s comprehension. The effects could be felt at any age, from the foetal life to the adulthood. The chapters present in this book describe how these abnormalities could lead to diseases such as atherosclerosis, thrombosis, diabetes, hypertension. Disorders of microcirculation could be related to the structural and/or functional damage to the inner lining of the blood vessels. Early identification of these disorders could benefit many ailments including cardiovascular and cerebrovascular diseases such as heart attack and stroke.
Book Synopsis The Vascular Endothelium I by : Salvador Moncada
Download or read book The Vascular Endothelium I written by Salvador Moncada and published by Springer Science & Business Media. This book was released on 2006-12-22 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Book Synopsis Signaling Mechanisms of Oxygen and Nitrogen Free Radicals by : Igor B. Afanas'ev
Download or read book Signaling Mechanisms of Oxygen and Nitrogen Free Radicals written by Igor B. Afanas'ev and published by CRC Press. This book was released on 2009-06-18 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regu
