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Aluminum Neurotoxicity
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Book Synopsis Neurotoxicity of Aluminum by : Qiao Niu
Download or read book Neurotoxicity of Aluminum written by Qiao Niu and published by Springer. This book was released on 2018-10-12 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity.
Book Synopsis Neurotoxicity of Aluminum by : Qiao Niu
Download or read book Neurotoxicity of Aluminum written by Qiao Niu and published by Springer Nature. This book was released on 2023-07-08 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid beta—the pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment. The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.
Book Synopsis Aluminum Neurotoxicity by : Leopold Liss
Download or read book Aluminum Neurotoxicity written by Leopold Liss and published by . This book was released on 1980 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotoxicity of Aluminum by : Qiao Niu
Download or read book Neurotoxicity of Aluminum written by Qiao Niu and published by . This book was released on 2018 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book reviews the scientific literature and the authors' own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer's disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum's complex speciation chemistry in relation to biology, and details aluminum's mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal's debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity"--Publisher's description.
Book Synopsis Aluminum Neurotoxicity by : Ankica Jelenković
Download or read book Aluminum Neurotoxicity written by Ankica Jelenković and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aluminum is the third most abundant element in the Earth's crust. In many of the previous experimental, epidemiological, pathohistological, biochemical and other research studies, aluminum, accumulated from the environment has been recognized as a very harmful substance to the human body. Aluminum intake usually happens unintentionally due to the fact that people know little about its prevalence in water, factory-processed foods, medicines, cosmetics, etc. When accumulated in human organs, it can cause severe damage, and even lead to chronic neurodegenerative diseases. Both oxidative and nitrosative stress can be the leading cause or contribute to its toxic effects in humans and animals. All of this is supported by the fact that mitochondrial dysfunction is the earliest stage of aluminum neurotoxicity. When oxidative damage occurs under the effects of free radicals, together with the decreased antioxidant protection due to the decreased production of the chemical energy molecule (adenosine triphosphate) as well as reducing equivalents (both in and out of mitochondria) then the conditions for the occurrence of a vicious circle in aluminum neurotoxicity are created. Aluminum also significantly interferes with the main steps of the synaptic neurotransmission, which may lead to the progression of neuropathies. The glutamate-glutamine pathway and numerous neurotransmitter transporters are affected as well. Oxidative stress and the disruption of neurotransmission do not only exist when adult individuals are exposed to this neurotoxin, but also in individuals prenatally exposed to it as well, and these are expressed after birth. Numerous research studies, both in animals and humans, ex vivo and in vitro, quite clearly showed that aluminum can be associated with chronic neurodegenerative diseases. Additionally, there is a positive correlation between the exposure to aluminum and the pathophysiology of Alzheimer's, Parkinson's, Huntington's disease, amyotrophic lateral sclerosis, and so on. One of the possible mechanisms for the generation/development of these diseases could be the disturbed homeostasis of essential metals and the appearance of unfolded or misfolded proteins that are mostly specific for a particular disease. In those research studies, the influence of aluminum on the generation of beta-amyloid, alpha synuclein, etc. was satisfactorily examined. It is very difficult, however, to suppress aluminum neurotoxicity, as well as development and progression of the diseases caused by or associated with aluminum. This is the result of some complex mechanisms through which aluminum causes its deleterious effects, and which are also responsible for the existence of multiple targets for aluminum. It is, therefore, necessary to know how these mechanisms induce the damage, in order to be able to prevent or treat the damage once it occurs. A large number of substances, including active components in traditional medicine, medical drugs and substances which are used only experimentally, have been examined so far. The results of studies conducted so far are inconclusive and they require further research. According to all the aforementioned findings, it may be concluded that well-planned, prospective and randomized clinical trials are necessary in order to use any of these substances in humans.
Book Synopsis Biochemical Mechanisms of Aluminium Induced Neurological Disorders by : Touqeer Ahmed
Download or read book Biochemical Mechanisms of Aluminium Induced Neurological Disorders written by Touqeer Ahmed and published by Bentham Science Publishers. This book was released on 2021-12-13 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.
Book Synopsis Studies on Aluminum Neurotoxicity by : Sung-Woo Cho
Download or read book Studies on Aluminum Neurotoxicity written by Sung-Woo Cho and published by . This book was released on 1988 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aluminum Neurotoxicity by : Umberto De Boni
Download or read book Aluminum Neurotoxicity written by Umberto De Boni and published by . This book was released on 1975 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mineral and Metal Neurotoxicology by : Masayuki Yasui
Download or read book Mineral and Metal Neurotoxicology written by Masayuki Yasui and published by CRC Press. This book was released on 1996-09-26 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trace minerals and metals such as zinc, copper, and magnesium are accepted as a "natural" part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues
Book Synopsis In Vitro Study of Mechanisms Involved in Aluminum Neurotoxicity and Alzheimer's Disease by : Arezoo Campbell
Download or read book In Vitro Study of Mechanisms Involved in Aluminum Neurotoxicity and Alzheimer's Disease written by Arezoo Campbell and published by . This book was released on 1999 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals by : Canada. Health Canada
Download or read book Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals written by Canada. Health Canada and published by . This book was released on 1997 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aluminum Neurotoxicity by : Masashi Tsunoda
Download or read book Aluminum Neurotoxicity written by Masashi Tsunoda and published by . This book was released on 1998 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotoxicity of Aluminum by : G. P. Cooper
Download or read book Neurotoxicity of Aluminum written by G. P. Cooper and published by . This book was released on 1981 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals by : Canada. Health Canada
Download or read book Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals written by Canada. Health Canada and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes proceedings and discussions, and includes contributed papers, from a workshop held to investigate the feasibility of a study of the chronic neurotoxicity of aluminium administered in drinking water of animals. Such a study could be used to establish a health-based guideline for human exposure to aluminium in drinking water. The papers addressed the following issues: problems involved in the assessment of the human health effects of aluminium in drinking water; the importance of aluminium speciation and substances that affect speciation; the appropriateness of an animal study in human risk assessment; the best animal model and the appropriate end-points to be measured; aluminium absorption, accumulation site and pathway, and effects of age on accumulation of aluminium in animals; and methods for avoiding contamination from aluminium during an animal study.
Book Synopsis Adverse Effects of Pertussis and Rubella Vaccines by : Institute of Medicine
Download or read book Adverse Effects of Pertussis and Rubella Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 1991-01-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura. The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.
Book Synopsis Environmental Neurotoxicology by : National Research Council
Download or read book Environmental Neurotoxicology written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Book Synopsis Mechanisms Underlying Aluminum Neurotoxicity Related to 14-3-3ζ Protein by :
Download or read book Mechanisms Underlying Aluminum Neurotoxicity Related to 14-3-3ζ Protein written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
