Alteration Of Excitation Contraction Coupling In The Failing Human Hurt

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Alterations of Excitation-Contraction Coupling in the Failing Human Heart

Author : Gerd Hasenfuss
Publisher : Springer Science & Business Media
ISBN 13 : 3642486703
Total Pages : 318 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Alterations of Excitation-Contraction Coupling in the Failing Human Heart by : Gerd Hasenfuss

Download or read book Alterations of Excitation-Contraction Coupling in the Failing Human Heart written by Gerd Hasenfuss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium. In 1987 basic mechanisms and clinical implications of then new insights into cardiac energetics was followed by a comprehensive review of inotropic stimulation and myocardial energetics in 1989. Here, we undertook a re-evaluation of the principles of inotropic stimulation and of its potential therapeutic value, based on new observa tions from experiments with human myocardium. In 1992 the risk due to myocardial phenotype change as a consequence of adaptation in heart failure was published. Here, alterations of subcellular structures and functions as a consequence of chronic heart failure, summarized as phenotype change, could be described as an essential characteristic of the failing human myocardium. This topic was discussed in greater depth in the volume "Cellular and Molecular Alterations in the Failing Human Heart", considering both the sarcolemma and the phosphodiesterases, as well as excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function.

Cellular and Molecular Alterations in the Failing Human Heart

Author : Hansjörg Just
Publisher : Springer Science & Business Media
ISBN 13 : 3642724744
Total Pages : 345 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Cellular and Molecular Alterations in the Failing Human Heart by : Hansjörg Just

Download or read book Cellular and Molecular Alterations in the Failing Human Heart written by Hansjörg Just and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors.

Calcium and Heart Failure: From Bench to Bedside

Author : Elisabetta Cerbai
Publisher : Frontiers Media SA
ISBN 13 : 2889765547
Total Pages : 148 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Calcium and Heart Failure: From Bench to Bedside by : Elisabetta Cerbai

Download or read book Calcium and Heart Failure: From Bench to Bedside written by Elisabetta Cerbai and published by Frontiers Media SA. This book was released on 2022-07-12 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiovascular Signaling in Health and Disease

Author : Narasimham L. Parinandi
Publisher : Springer Nature
ISBN 13 : 3031083091
Total Pages : 535 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Cardiovascular Signaling in Health and Disease by : Narasimham L. Parinandi

Download or read book Cardiovascular Signaling in Health and Disease written by Narasimham L. Parinandi and published by Springer Nature. This book was released on 2022-09-21 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.

Molecular Defects in Cardiovascular Disease

Author : Naranjan S. Dhalla
Publisher : Springer Science & Business Media
ISBN 13 : 1441971300
Total Pages : 381 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Molecular Defects in Cardiovascular Disease by : Naranjan S. Dhalla

Download or read book Molecular Defects in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2011-08-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Molecular Approaches to Heart Failure Therapy

Author : G. Hasenfuss
Publisher : Springer Science & Business Media
ISBN 13 : 3642577105
Total Pages : 382 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Molecular Approaches to Heart Failure Therapy by : G. Hasenfuss

Download or read book Molecular Approaches to Heart Failure Therapy written by G. Hasenfuss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: G. HASENFUSS, E. MARBAN Heart failure embodies the central irony of modern medicine. As we have become increasingly adept at treating the major proximate causes of death in Western society, we have effectively converted acute illness into chronic malady. The last twenty years have witnessed a revolution in the treatment of acute coronary syndromes, myocardial infarction in particular. Patients who reach the hospital now have every expectation of leaving alive, but not necessarily well. Our ability to blunt the edge of ischemic insults has en gendered new problems: a new cohort of patients whose hearts function well enough to enable short-term survival, but at the cost of decreased ex ercise tolerance, dyspnea and increased long-term mortality. The irony is compounded by our increasingly sophisticated pharmacopeia for the treat ment of heart failure, which, by slowing the progression of ventricular dys function, has created a chronic illness. The fact of its chronicity makes heart failure no less deadly. In symptomatic patients, mortality exceeds 5-10% per year even with the best contemporary therapy. Not all heart failure is ischemic, of course, but the final common phenotype is eerily concordant regardless of the proximate cause. No wonder, then, that heart failure is the leading cause of hospitalization in America and in Western Europe and that the prevalence of the disease continues to rise. Drugs have indeed revolutionized heart failure therapy, ACE inhibitors and beta-adrenergic blockers having the most outstanding records to date.

Excitation-Contraction Coupling and Cardiac Contractile Force

Author : Donald Bers
Publisher : Springer Science & Business Media
ISBN 13 : 940100658X
Total Pages : 468 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Excitation-Contraction Coupling and Cardiac Contractile Force by : Donald Bers

Download or read book Excitation-Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Cardiology E-Book

Author : Michael H. Crawford
Publisher : Elsevier Health Sciences
ISBN 13 : 0723436444
Total Pages : 2214 pages
Book Rating : 4.7/5 (234 download)

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Book Synopsis Cardiology E-Book by : Michael H. Crawford

Download or read book Cardiology E-Book written by Michael H. Crawford and published by Elsevier Health Sciences. This book was released on 2009-09-18 with total page 2214 pages. Available in PDF, EPUB and Kindle. Book excerpt: With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.

Diastolic Relaxation of the Heart

Author : Beverly H. Lorell
Publisher : Springer Science & Business Media
ISBN 13 : 1461525942
Total Pages : 342 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Diastolic Relaxation of the Heart by : Beverly H. Lorell

Download or read book Diastolic Relaxation of the Heart written by Beverly H. Lorell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease. This brand new Second Edition, based on a recent meeting, includes such topics as: molecular biology of relaxation; consequences of altered gene expression; impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); diastolic dysfunction in the diseased human heart. Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function.

Pathobiology of Human Disease

Author :
Publisher : Elsevier
ISBN 13 : 0123864577
Total Pages : 4376 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Pathobiology of Human Disease by :

Download or read book Pathobiology of Human Disease written by and published by Elsevier. This book was released on 2014-08-01 with total page 4376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human - Organ Systems - Molecular Pathology/Basic Mechanisms of Diseases - Animal Models/Other Model Systems - Experimental Pathology - Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. - Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting - Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images - Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Oxford Textbook of Heart Failure

Author : Andrew L. Clark
Publisher : Oxford University Press
ISBN 13 : 0191078832
Total Pages : 936 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Textbook of Heart Failure by : Andrew L. Clark

Download or read book Oxford Textbook of Heart Failure written by Andrew L. Clark and published by Oxford University Press. This book was released on 2022-05-20 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.

Heart Physiology and Pathophysiology

Author : Yoshihisa Kurachi
Publisher : Elsevier
ISBN 13 : 0080533884
Total Pages : 1286 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Heart Physiology and Pathophysiology by : Yoshihisa Kurachi

Download or read book Heart Physiology and Pathophysiology written by Yoshihisa Kurachi and published by Elsevier. This book was released on 2000-10-09 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

Heart Hypertrophy and Failure

Author : Naranjan S. Dhalla
Publisher : Springer Science & Business Media
ISBN 13 : 146131237X
Total Pages : 549 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Heart Hypertrophy and Failure by : Naranjan S. Dhalla

Download or read book Heart Hypertrophy and Failure written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system in health and disease. The papers presented describe fundamental mechanisms underlying changes in the cellular machinery during the development of cardiac hypertrophy and heart failure. Audience: Students, scientists, clinical and experimental cardiologists who seek to understand and manage the perplexing problems of hypertrophy and heart failure.

The Right Heart

Author : Sean P. Gaine
Publisher : Springer
ISBN 13 : 1447123980
Total Pages : 326 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis The Right Heart by : Sean P. Gaine

Download or read book The Right Heart written by Sean P. Gaine and published by Springer. This book was released on 2014-05-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heart and lung are intricately linked. When the heart is affected by disease, the lungs will often show some related pathological or clinical conditions and vice versa. Pulmonary heart disease is by definition a condition when the lungs cause the heart to fail. The left ventricle in combination with the other structures in the “left heart” pumps blood throughout the body. The right ventricle (and structures of the “right heart”) pumps blood to the lungs where it is oxygenated and returned to the left heart for distribution. In normal circumstances, the right heart pumps blood into the lungs without any resistance. The lungs usually have minimal pressure and the right heart easily pumps blood through. However when there is lung disease present, like emphysema, chronic obstructive lung disease (COPD) or pulmonary hypertension- the small blood vessels become very stiff and rigid. The right ventricle is no longer able to push blood into the lungs and eventually fails. This is known as pulmonary heart disease. Pulmonary heart disease is also known as right heart failure or cor pulmonale. The chief cause of right heart failure is the increase in blood pressure in the lungs (pulmonary artery).

Nanodomain Regulation of Muscle Physiology and Alterations in Disease

Author : Niall Macquaide
Publisher : Frontiers Media SA
ISBN 13 : 2832510264
Total Pages : 202 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Nanodomain Regulation of Muscle Physiology and Alterations in Disease by : Niall Macquaide

Download or read book Nanodomain Regulation of Muscle Physiology and Alterations in Disease written by Niall Macquaide and published by Frontiers Media SA. This book was released on 2023-01-03 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Heart Failure

Author : Marc Semigran
Publisher : CRC Press
ISBN 13 : 1420077015
Total Pages : 488 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heart Failure by : Marc Semigran

Download or read book Heart Failure written by Marc Semigran and published by CRC Press. This book was released on 2012-12-07 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient's cardiac impairment.New topics in this edit

Congestive Heart Failure

Author : Jeffrey D. Hosenpud
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781762855
Total Pages : 1487 pages
Book Rating : 4.7/5 (817 download)

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Book Synopsis Congestive Heart Failure by : Jeffrey D. Hosenpud

Download or read book Congestive Heart Failure written by Jeffrey D. Hosenpud and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized leaders in the field, Congestive Heart Failure, Third Edition is a comprehensive, state-of-the-art reference on all basic and clinical aspects of heart failure. Coverage includes an entire section on pharmacologic therapy and a twenty-chapter section on clinical approaches to acute and chronic heart failure. This edition has new chapters on impact and treatment of comorbidities, prevention of sudden cardiac death, rationale for use of anticoagulants, ultrafiltration, use of mechanical devices, and gene and cell therapy. Readers will find up-to-date information on genetics, surgical therapies, ventricular synchronization, defibrillator therapy, mechanical approaches to atrial fibrillation, left ventricular assist devices, ventricular support and ventricular remodeling surgery, and myocardial regeneration/cell transplantation.