Aids Vaccine Development

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The Search for an AIDS Vaccine

Author : Christine Grady
Publisher : Indiana University Press
ISBN 13 : 9780253112729
Total Pages : 220 pages
Book Rating : 4.1/5 (127 download)

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Book Synopsis The Search for an AIDS Vaccine by : Christine Grady

Download or read book The Search for an AIDS Vaccine written by Christine Grady and published by Indiana University Press. This book was released on 1995-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book is a balanced and comprehensive treatment of an important social issue. It is accessible to the general reader and belongs in public as well as academic libraries." -- Religious Studies Review "Painstaking analysis of the knotty ethical problems involved in human-subjects research, and a well-thought-out proposal for a community approach to conducting field trials for an HIV vaccine.... Highly recommended for medical ethicists and anyone concerned about the AIDS epidemic and how HIV research is conducted."Â -- Kirkus Reviews "... a carefully reasoned account of how research for and trial of a preventive vaccine differ from the methods used to discover a therapy."Â -- Booklist "I highly recommend reading this book which I would attest to be a thrilling, ethically challenging, and informative descent into the allopathic solution." -- Ryan Hosken, Bastyr University Library Newsletter "As the scientific effort to produce an efficacious vaccine continues, [Grady's] work provides an ethical compass that will guide us well, regardless of where phase III HIV vaccine trials ultimately occur." -- Journal of the American Medical Association "Highly recommended... " -- AIDS Book Review Journal "A remarkable treatment of a most difficult and complex subject... Grady's book is of special merit because it is simple, readable, and understandable, while conveying in-depth perceptions that are critical to the reader. A useful and essential reference work for those who would engage in the initiative to bring about a resolution of a mighty human health problem." -- Maurice R. Hilleman, Ph.D., D.Sc., Director, Merck Institute for Therapeutic Research "Dr. Grady's important study captures the complexity of the search for an AIDS vaccine with startling clarity. Her insights into the full range of forces that shape our national response to AIDS vaccine development should read like signposts to vaccinologists, AIDS community activists, and most importantly, the Public Health Service. An impressive contribution." -- Derek Hodel, Gay Men's Health Crisis "This book is recommended to medical ethicists, those involved in non-HIV vaccine trials, and all persons involved in HIV vaccine trials, including investigators, sponsors, study subjects and communities at risk." -- Journal of Health Politics, Policy and Law The creation of a vaccine now seems the best hope for controlling AIDS. Yet developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Essential reading for everyone interested in ethics and the conduct of HIV vaccine research.

HIV Vaccines and Cure

Author : Linqi Zhang
Publisher : Springer
ISBN 13 : 981130484X
Total Pages : 326 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis HIV Vaccines and Cure by : Linqi Zhang

Download or read book HIV Vaccines and Cure written by Linqi Zhang and published by Springer. This book was released on 2018-07-20 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

Vaccine: The Controversial Story of Medicine's Greatest Lifesaver

Author : Arthur Allen
Publisher : W. W. Norton & Company
ISBN 13 : 1324036354
Total Pages : 542 pages
Book Rating : 4.3/5 (24 download)

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Book Synopsis Vaccine: The Controversial Story of Medicine's Greatest Lifesaver by : Arthur Allen

Download or read book Vaccine: The Controversial Story of Medicine's Greatest Lifesaver written by Arthur Allen and published by W. W. Norton & Company. This book was released on 2008-05-17 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A timely, fair-minded and crisply written account."—New York Times Book Review Vaccine juxtaposes the stories of brilliant scientists with the industry's struggle to produce safe, effective, and profitable vaccines. It focuses on the role of military and medical authority in the introduction of vaccines and looks at why some parents have resisted this authority. Political and social intrigue have often accompanied vaccination—from the divisive introduction of smallpox inoculation in colonial Boston to the 9,000 lawsuits recently filed by parents convinced that vaccines caused their children's autism. With narrative grace and investigative journalism, Arthur Allen reveals a history illuminated by hope and shrouded by controversy, and he sheds new light on changing notions of health, risk, and the common good.

Priorities for the National Vaccine Plan

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309156203
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Priorities for the National Vaccine Plan by : Institute of Medicine

Download or read book Priorities for the National Vaccine Plan written by Institute of Medicine and published by National Academies Press. This book was released on 2010-05-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccination is a fundamental component of preventive medicine and public health. The use of vaccines to prevent infectious diseases has resulted in dramatic decreases in disease, disability, and death in the United States and around the world. The current political, economic, and social environment presents both opportunities for and challenges to strengthening the U.S. system for developing, manufacturing, regulating, distributing, funding, and administering safe and effective vaccines for all people. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. The book makes recommendations about priority actions in the update to the National Vaccine Plan that are intended to achieve the objectives of disease prevention and enhancement of vaccine safety. It is centered on the plan's five goals in the areas of vaccine development, safety, communication, supply and use, and global health.

The River

Author : Edward Hooper
Publisher : Back Bay
ISBN 13 : 9780316371377
Total Pages : 1118 pages
Book Rating : 4.3/5 (713 download)

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Book Synopsis The River by : Edward Hooper

Download or read book The River written by Edward Hooper and published by Back Bay. This book was released on 2000 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: A British medical journalist offers a meticulously researched look at HIV and its potential source, discussing the history of this lethal epidemic, analyzing a number of theories concerning its origins, and investigating current scientific inquiries into HIV, AIDS, and the search for a cure. Reprint. 15,000 first printing.

History of Vaccine Development

Author : Stanley A. Plotkin
Publisher : Springer Science & Business Media
ISBN 13 : 1441913394
Total Pages : 352 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis History of Vaccine Development by : Stanley A. Plotkin

Download or read book History of Vaccine Development written by Stanley A. Plotkin and published by Springer Science & Business Media. This book was released on 2011-05-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology, the concept of a science ranging from the study of immunology to the development and distribution of vaccines, was a word invented by Jonas Salk. This book covers the history of the methodological progress in vaccine development and to the social and ethical issues raised by vaccination. Chapters include "Jenner and the Vaccination against Smallpox," "Viral Vaccines," and "Ethical and Social Aspects of vaccines." Contributing authors include pioneers in the field, such as Samuel L. Katz and Hilary Koprowski. This history of vaccines is relatively short and many of its protagonists are still alive. This book was written by some of the chief actors in the drama whose subject matter is the conquest of epidemic disease.

Experimental Animal Models of Human Diseases

Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
ISBN 13 : 1789231647
Total Pages : 410 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Experimental Animal Models of Human Diseases by : Bartholomew Ibeh

Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

The Social Impact of AIDS in the United States

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309046289
Total Pages : 337 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Social Impact of AIDS in the United States by : National Research Council

Download or read book The Social Impact of AIDS in the United States written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Europe's "Black Death" contributed to the rise of nation states, mercantile economies, and even the Reformation. Will the AIDS epidemic have similar dramatic effects on the social and political landscape of the twenty-first century? This readable volume looks at the impact of AIDS since its emergence and suggests its effects in the next decade, when a million or more Americans will likely die of the disease. The Social Impact of AIDS in the United States addresses some of the most sensitive and controversial issues in the public debate over AIDS. This landmark book explores how AIDS has affected fundamental policies and practices in our major institutions, examining: How America's major religious organizations have dealt with sometimes conflicting values: the imperative of care for the sick versus traditional views of homosexuality and drug use. Hotly debated public health measures, such as HIV antibody testing and screening, tracing of sexual contacts, and quarantine. The potential risk of HIV infection to and from health care workers. How AIDS activists have brought about major change in the way new drugs are brought to the marketplace. The impact of AIDS on community-based organizations, from volunteers caring for individuals to the highly political ACT-UP organization. Coping with HIV infection in prisons. Two case studies shed light on HIV and the family relationship. One reports on some efforts to gain legal recognition for nonmarital relationships, and the other examines foster care programs for newborns with the HIV virus. A case study of New York City details how selected institutions interact to give what may be a picture of AIDS in the future. This clear and comprehensive presentation will be of interest to anyone concerned about AIDS and its impact on the country: health professionals, sociologists, psychologists, advocates for at-risk populations, and interested individuals.

Shots in the Dark

Author : Jon Cohen
Publisher : W. W. Norton & Company
ISBN 13 : 9780393322255
Total Pages : 468 pages
Book Rating : 4.3/5 (222 download)

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Book Synopsis Shots in the Dark by : Jon Cohen

Download or read book Shots in the Dark written by Jon Cohen and published by W. W. Norton & Company. This book was released on 2001 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1984 it was announced that an AIDS vaccine would be ready for testing in two years. More than 15 years later only one vaccine has made it to a field trial. This text explains the reasons for this slow progress.

Novel Technologies for Vaccine Development

Author : Igor S Lukashevich
Publisher : Springer
ISBN 13 : 3709118182
Total Pages : 393 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Novel Technologies for Vaccine Development by : Igor S Lukashevich

Download or read book Novel Technologies for Vaccine Development written by Igor S Lukashevich and published by Springer. This book was released on 2014-11-13 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

AIDS Vaccine Research

Author : Flossie Wong-Staal
Publisher : CRC Press
ISBN 13 : 9781135560867
Total Pages : 352 pages
Book Rating : 4.5/5 (68 download)

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Book Synopsis AIDS Vaccine Research by : Flossie Wong-Staal

Download or read book AIDS Vaccine Research written by Flossie Wong-Staal and published by CRC Press. This book was released on 2002-02-22 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference describes the latest advances in the development and design of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV infection for the construction of molecular and therapeutic strategies to reduce the progression and transmission of AIDS. With contributions by universally recognized authorities in the field, AIDS Vaccine Research discusses major obstacles in the identification of a preventive vaccine the role of innate immunity in management of HIV infection the impact of highly active antiretroviral therapy (HAART) on AIDS research the creation of an effective mucosal DNA vaccine the effect of the AIDS epidemic on developing countries Offering nearly 2000 contemporary references to facilitate further study, AIDS Vaccine Research is a timely manual suitable for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate students in these disciplines.

Making Markets for Vaccines

Author : Owen Barder
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Making Markets for Vaccines by : Owen Barder

Download or read book Making Markets for Vaccines written by Owen Barder and published by . This book was released on 2005 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: A legacy of our generation -- Ch. 1. We need to invest more in vaccines -- Ch. 2. Promoting private investment in vaccine development -- Ch. 3. A market not a prize -- Ch. 4. Design choices -- Ch. 5. $3 billion per disease -- Ch. 6. Meeting industry requirements -- Ch. 7. How sponsors can do it.

A Media Handbook for HIV Vaccine Trials for Africa

Author : Yinka Adeyemi
Publisher : World Health Organization
ISBN 13 :
Total Pages : 52 pages
Book Rating : 4.:/5 (8 download)

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Book Synopsis A Media Handbook for HIV Vaccine Trials for Africa by : Yinka Adeyemi

Download or read book A Media Handbook for HIV Vaccine Trials for Africa written by Yinka Adeyemi and published by World Health Organization. This book was released on 2001 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Good Participatory Practice

Author :
Publisher : World Health Organization
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Good Participatory Practice by :

Download or read book Good Participatory Practice written by and published by World Health Organization. This book was released on 2007 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: These Good Participatory Practice guidelines aim to provide systematic guidance on the roles and responsibilities of entities funding and conducting biomedical HIV prevention trials towards participants and their communities. Such entities include investigators, research staff, pharmaceutical industry sponsors, foundations, government-supported research networks, non-governmental research sponsors, and all others involved in designing, financing, and executing clinical trials research.

HIV

Author : Frederic Bushman
Publisher : Cold Spring Harbor Perspective
ISBN 13 : 9781936113408
Total Pages : 0 pages
Book Rating : 4.1/5 (134 download)

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Book Synopsis HIV by : Frederic Bushman

Download or read book HIV written by Frederic Bushman and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic biology of the HIV virus provides a model for a more general understanding of retroviruses, and the worldwide epidemic of AIDS makes research into the disease process and potential therapies among the most critical in biomedical science. This book explores work on the molecular biology of HIV, host-virus interactions, host immune responses, HIV transmission, and more.

The CAPRISA Clinical Trials: HIV Treatment and Prevention

Author : Quarraisha Abdool Karim
Publisher : Springer
ISBN 13 : 9783319837567
Total Pages : 243 pages
Book Rating : 4.8/5 (375 download)

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Book Synopsis The CAPRISA Clinical Trials: HIV Treatment and Prevention by : Quarraisha Abdool Karim

Download or read book The CAPRISA Clinical Trials: HIV Treatment and Prevention written by Quarraisha Abdool Karim and published by Springer. This book was released on 2018-04-29 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA’s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.