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Agents De Contraste Pour La Detection Quantitative Du Znii Par Irm
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Book Synopsis Agents de contraste pour la détection quantitative du Zn(II) par IRM by : Kyangwi Patrick Malikidogo
Download or read book Agents de contraste pour la détection quantitative du Zn(II) par IRM written by Kyangwi Patrick Malikidogo and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'Imagerie par Résonance Magnétique (IRM) est classiquement utilisée pour l'obtention d'images anatomiques et fonctionnelles. L'émergence de l'imagerie moléculaire, qui cherche à visualiser des modifications biochimiques apparaissant de manière plus précoces que les changements morphologiques, nécessite l'utilisation de sondes spécifiques du processus à détecter. Cela a conduit à la conception de nouveaux agents de contraste IRM « intelligents » à base de Gd(III). La détection du Zn(II) reste un enjeu important du fait de son rôle dans les processus physiologiques et son implication dans diverses pathologies. Un des problèmes majeurs à surmonter est sa quantification. Dans cette perspective, nous avons développé des sondes bimodales variant uniquement par la nature du Ln(III) : Gd(III) pour l'IRM (technique responsive) et 165Er(III) pour la tomographie par émission monophotonique(technique quantitative). Ces sondes sont composées d'un complexe de Ln(III) à base de pyridine relié à un motif DPA (dipicolylamide) ou DPA modifié pour la complexation du Zn(II) via un espaceur.Nous nous sommes d'abord attachés à optimiser la réponse des complexes de Gd(III) au Zn(II). Nous avons augmenté la stabilité thermodynamique des complexes de Ln(III) par ajout d'une fonction carboxylate sur le ligand. Cette famille de complexes répond au Zn(II) en présence de HSA (Albumine sérique humaine) par modification du temps de corrélation rotationnel. Nous avons ensuite réalisé une étude structurale afin de rationaliser les paramètres importants pour optimiser la réponse au Zn(II) en présence de HSA et/ou la sélectivité, en particulier vis-à-vis du Cu(II). Nous avons également développé une famille de molécules répondant à la présence de Zn(II) par variation modeste du nombre d'hydratation q.Finalement nous avons pu valider l'utilisation de l'165Er(III) pour la détection quantitative in vitro de Zn(II).
Book Synopsis 3D Optical flow analysis of a pulsed contrast agent in the bloodstream. Application to virtual angiography and Magnetic Particle Imaging by : Romain Lacroix
Download or read book 3D Optical flow analysis of a pulsed contrast agent in the bloodstream. Application to virtual angiography and Magnetic Particle Imaging written by Romain Lacroix and published by . This book was released on 2015 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: De nos jours, les maladies cardiovasculaires restent un sujet de préoccupation majeur pour la santé et une charge économique importante dans les pays développés. Avec les progrès de la médecine, les systèmes d'imagerie médicale ont permis la détection des pathologies cardiovasculaires à un stade précoce, et la surveillance de leur évolution à travers des outils d'analyse de données avancés. La mesure du débit sanguin, en particulier, est une information précieuse pour le médecin. Aujourd'hui, de nombreuses techniques d'acquisition du flux sanguin ont été développées et appliquées dans les routines cliniques et la recherche médicale. L'une d'entre elles recourt à l'injection d'un produit de contraste dans le sang artériel. La propagation du traceur dans la circulation sanguine et sa modulation spatio-temporelle délivre l'information des motifs du flux sanguin dans des séquences d'images 2D. Cependant, les systèmes d'imagerie de contraste 3D+T n'ont pas encore atteint un stade clinique. Le but de cette thèse est d'apporter un cadre général de l'estimation de flux sanguin pour les futurs systèmes d'imagerie de contraste 3D+T. Une formulation variationnelle du flot optique est présentée, incluant diverses connaissances a priori sur la concentration du produit de contraste, et les propriétés du flux sanguin inspirées de la mécanique des fluides. Par la suite, le potentiel de l'algorithme d'estimation de flot optique est évalué sur de l'angiographie virtuelle par CFD, avec une analyse de l'influence du débit sanguin et des paramètres de l'algorithme. Enfin, une version simplifiée de l'approche de flot optique est testée sur les toutes premières données MPI 3D+T. Dans un premier temps, une expérience de flux in vitro est proposée à l'intérieur d'un fantôme avec une injection de contraste modulé, dans un second temps une analyse du flux sanguin est démontrée sur des données in vivo. Dans son ensemble, cette thèse investigue le sujet original de l'estimation de flux sanguin et l'analyse de ses motifs en 3D. La contribution technique consiste en la création d'un nouvel algorithme de flot optique dédié à de l'information de contraste temporellement résolue dans le système cardiovasculaire. La contribution clinique sous-jacente consiste en un pipeline complet pour l'estimation du flux sanguin, en partant de la procédure d'acquisition par modulation de contraste, jusqu'au calcul du flot optique et à sa validation in silico.
Book Synopsis Redox-Active Therapeutics by : Ines Batinić-Haberle
Download or read book Redox-Active Therapeutics written by Ines Batinić-Haberle and published by Springer. This book was released on 2016-10-13 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.
Book Synopsis Design of Advanced Photocatalytic Materials for Energy and Environmental Applications by : Juan M. Coronado
Download or read book Design of Advanced Photocatalytic Materials for Energy and Environmental Applications written by Juan M. Coronado and published by Springer Science & Business Media. This book was released on 2013-05-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research for the development of more efficient photocatalysts has experienced an almost exponential growth since its popularization in early 1970’s. Despite the advantages of the widely used TiO2, the yield of the conversion of sun power into chemical energy that can be achieved with this material is limited prompting the research and development of a number of structural, morphological and chemical modifications of TiO2 , as well as a number of novel photocatalysts with very different composition. Design of Advanced Photocatalytic Materials for Energy and Environmental Applications provides a systematic account of the current understanding of the relationships between the physicochemical properties of the catalysts and photoactivity. The already long list of photocatalysts phases and their modifications is increasing day by day. By approaching this field from a material sciences angle, an integrated view allows readers to consider the diversity of photocatalysts globally and in connection with other technologies. Design of Advanced Photocatalytic Materials for Energy and Environmental Applications provides a valuable road-map, outlining the common principles lying behind the diversity of materials, but also delimiting the imprecise border between the contrasted results and the most speculative studies. This broad approach makes it ideal for specialist but also for engineers, researchers and students in related fields.
Book Synopsis Liquid Biphasic System by : Pau Loke Show
Download or read book Liquid Biphasic System written by Pau Loke Show and published by Elsevier. This book was released on 2020-11-28 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Downstream bioprocesses have a significant role to play in the creation of a sustainable bio-based economy, enabling the creation of new products and systems from the more sustainable bioprocessing of natural products. Liquid Biphasic System: Fundamentals, Methods, and Applications in Bioseparation Technology explores in detail the fundamental processes and applications of this new separation system, aiding understanding of the basic principles of the technique and offering constructive criticisms on the latest findings. Including coverage of the background, principles, mechanisms, and applications, Liquid Biphasic System addresses how to adapt the technology for the purification of useful compounds with greater cost efficiency and greener processing. It is essential reading for bioprocess engineers, biochemical engineers, biosystem engineers, chemists and microbiologists working in the fields of bioprocessing. Researchers, scientists, and engineers concerned with the selection and evaluation of alternative bioseparation processes will find the book particularly useful. Provides information and examples of advanced separations in a single source Includes detailed descriptions of novel bioseparation systems Covers the latest technologies related to advanced liquid–liquid separation and their applications in various industries
Download or read book Rare Earths written by Jacques Lucas and published by Elsevier. This book was released on 2014-09-09 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-technology and environmental applications of the rare-earth elements (REE) have grown dramatically in diversity and importance over the past four decades. This book provides a scientific understanding of rare earth properties and uses, present and future. It also points the way to efficient recycle of the rare earths in end-of-use products and efficient use of rare earths in new products. Scientists and students will appreciate the book's approach to the availability, structure and properties of rare earths and how they have led to myriad critical uses, present and future. Experts should buy this book to get an integrated picture of production and use (present and future) of rare earths and the science behind this picture. This book will prove valuable to.non-scientists as well in order to get an integrated picture of production and use of rare earths in the 21st Century, and the science behind this picture. Defines the chemical, physical and structural properties of rare earths. Gives the reader a basic understanding of what rare earths can do for us. Describes uses of each rare earth with chemical, physics, and structural explanations for the properties that underlie those uses. Allows the reader to understand how rare earths behave and why they are used in present applications and will be used in future applications. Explains to the reader where and how rare earths are found and produced and how they are best recycled to minimize environmental impact and energy and water consumption.
Book Synopsis Inorganic Membranes: Synthesis, Characterization and Applications by : Reyes Mallada
Download or read book Inorganic Membranes: Synthesis, Characterization and Applications written by Reyes Mallada and published by Elsevier. This book was released on 2008-05-01 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.480 pages Approx.480 pages
Book Synopsis PbZn 2020: 9th International Symposium on Lead and Zinc Processing by : A. Siegmund
Download or read book PbZn 2020: 9th International Symposium on Lead and Zinc Processing written by A. Siegmund and published by Springer Nature. This book was released on 2020-01-24 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established in 1970, the PbZn symposium series is considered the leading international technical forum for the lead and zinc processing industries. The PbZn 2020 volume addresses all aspects of current processing technologies for primary and secondary lead and zinc, as well as emerging technologies for both metals.
Book Synopsis Petrogenesis and Exploration of the Earth’s Interior by : Domenico M. Doronzo
Download or read book Petrogenesis and Exploration of the Earth’s Interior written by Domenico M. Doronzo and published by Springer. This book was released on 2019-02-22 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is based on the best papers accepted for presentation during the 1st Springer Conference of the Arabian Journal of Geosciences (CAJG-1), Tunisia 2018. The book is of interest to all researchers in the fields of Mineralogy, Geochemistry, Petrology and Volcanology. The Earth's interior is a source of heat, which makes our planet unique. This source regulates the formation and evolution of rocks at larger scales, and of minerals and sediments toward smaller scales. In such context, the exploration of georesources (products) has to be related to petrogenesis (processes). This volume offers an overview of the state-of-the-art petrogenesis and exploration in, but not limited to, the Middle East and Mediterranean regions. It gives new insights into processes and products related to the Earth's interior, and associated georesources by international researchers. Main topics include: 1. Petrogenetic processes: geochemistry, geochronology and geophysical approaches 2. Surficial processes: sedimentation and facies analysis 3. Applied mineralogy and tectonics 4. Geological research applied to mineral deposits
Book Synopsis Crown Ethers and Cryptands by : George W Gokel
Download or read book Crown Ethers and Cryptands written by George W Gokel and published by Royal Society of Chemistry. This book was released on 2016-11-08 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crown Ethers and Cryptands introduces the broad and basic principles of crown ether and cryptand chemistry at the advanced undergraduate, graduate and working professional level. The book provides a brief introduction, outlining the history of the field and goes on to cover syntheses, complexation of cations and molecules, complex structures, applications and recent developments. It aims to acquaint readers with the scope and principles of the field, providing a bibliography of reviews and books as reference to further reading and citations of the original literature.
Book Synopsis Principles of Electrical Engineering Materials and Devices by : Safa O. Kasap
Download or read book Principles of Electrical Engineering Materials and Devices written by Safa O. Kasap and published by Irwin Professional Publishing. This book was released on 1997-01-01 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Electrical Engineering Materials and Devices has been developed to bridge the gap between traditional electronic circuits texts and semiconductor texts
Book Synopsis The Molecular Basis of Bacterial Metabolism by : Günter Hauska
Download or read book The Molecular Basis of Bacterial Metabolism written by Günter Hauska and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume contains 17 lectures of the 41 st Mosbach Colloquium of the Gesellschaft fiir Biologische Chemie, held from April 5-7, 1990 on the topic "The Molecular Basis of Bacterial Metabolism". From the beginning it was not the intention of the organizers to present a comprehensive account, but rather to select new, exciting progress on sometimes exotic reactions of specifically bacterial, mainly anaerobic metabolism. Members of our society had contributed to this progress to an extent that greatly stimulated the scientific exchange with international colleagues during the days in Mosbach. The editors hope that this stimulation will be conveyed to the readers of the articles, which reach from the biochemistry of methanogenesis, via anaerobic radical reactions, metal biochemistry in hydrogen and nitrogen metabolism, conversions of light - and redox energy, to the regulation of metabolic adaptation, and the attempts to bioengineer novel pathways for the degradation of xenobiotica. We believe that the book represents a highly progressive field of over lapping disciplines, comprising microbiology and molecular genetics, chemistry of biomimetic interest, and biophysics, and that it gives insight into the impact modern technologies have on microbiological research today. The colloquium was generously supported by the Deutsche Forschungsgemeinschaft, the Paul-Martini-Stiftung, and the Fonds fiir Biologische Chemie. A. Trebst, G. Schafer, and D. Oesterhelt were a great help in preparing the program and we wish to thank them for their advice.
Book Synopsis Modified Clay and Zeolite Nanocomposite Materials by : Mariano Mercurio
Download or read book Modified Clay and Zeolite Nanocomposite Materials written by Mariano Mercurio and published by Elsevier. This book was released on 2018-11-29 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications retraces the most important knowledge gaps that the scientific community is facing, including a drawback of real-world applications. This valuable resource explores the novel applications of this group of nanomaterials that can be suitably surface-modified to obtain properties that can be applied in environmental and pharmaceutical fields. For example, modification with surfactants has given new motivation to the study of these materials by producing an inversion in the ion exchange behavior from cationic to anionic. This strategy has paved the way for new uses highlighted in this timely resource. Explores the combination of both minerals (clay and zeolite) together, with their application in two broad areas of emerging research Explains better utilization and applications for modified clay and zeolite through detailed comparative studies Consolidates information on the modification and tuning of clay and zeolite materials for novelty applications Helps users in the selection of materials, surface features, and other functionalization for diverse applications
Book Synopsis Adsorption and Diffusion by : Hellmut G. Karge
Download or read book Adsorption and Diffusion written by Hellmut G. Karge and published by Springer Science & Business Media. This book was released on 2008-06-17 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Molecular Sieves - Science and Technology" covers, in a comprehensive manner, the science and technology of zeolites and all related microporous and mesoporous materials. The contributions are grouped together topically in such a way that each volume deals with a specific sub-field. Volume 7 treats fundamentals and analyses of adsorption and diffusion in zeolites including single-file diffusion. Various methods of measuring adsorption and diffusion are described and discussed.
Book Synopsis Advanced Intelligent Systems for Sustainable Development (AI2SD’2020) by : Janusz Kacprzyk
Download or read book Advanced Intelligent Systems for Sustainable Development (AI2SD’2020) written by Janusz Kacprzyk and published by Springer Nature. This book was released on 2022-02-10 with total page 1298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book publishes the best papers accepted and presented at the 3rd edition of the International Conference on Advanced Intelligent Systems for Sustainable Development Applied to Agriculture, Energy, Health, Environment, Industry, Education, Economy, and Security (AI2SD’2020). This conference is one of the biggest amalgamations of eminent researchers, students, and delegates from both academia and industry where the collaborators have an interactive access to emerging technology and approaches globally. In this book, readers find the latest ideas addressing technological issues relevant to all areas of the social and human sciences for sustainable development. Due to the nature of the conference with its focus on innovative ideas and developments, the book provides the ideal scientific and brings together very high-quality chapters written by eminent researchers from different disciplines, to discover the most recent developments in scientific research.
Book Synopsis The Deposition of Organic-carbon-rich Sediments by : Nicholas Bennett Harris
Download or read book The Deposition of Organic-carbon-rich Sediments written by Nicholas Bennett Harris and published by SEPM Soc for Sed Geology. This book was released on 2005 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Depositional models for organic-carbon-rich sediments have been the subjects of both great interest and great controversy for many years. These sediments serve as the ultimate source of virtually all oil and gas. They also represent the interface between biological and geological processes and provide critical evidence for the state of the atmosphere and oceans. Yet despite their importance and decades of research, the origin of these sediments remains the source of vigorous disagreement. The twelve papers in this volume represent the cutting edge of research in this topic. They explore the origin of organic-carbon-rich sediments through a variety of techniques, including sedimentology, geochemistry, paleontology and computer modeling. All papers take multidisciplinary approaches to the topic, and together, they demonstrate the complex interconnected processes that trigger the deposition of organic carbon. This book will appeal to geoscientists in many disciplines, including explorers for petroleum who need models for source rock deposition, organic and inorganic geochemists who study processes in water and sediment, sedimentologists who interpret ancient deposition environments, and climatologists and oceanographers who reconstruct the behavior of the ancient atmosphere and oceans.
Book Synopsis Stormwater Infiltration by : Bruce K. Ferguson
Download or read book Stormwater Infiltration written by Bruce K. Ferguson and published by . This book was released on 2017 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Stormwater infiltration is the most complete approach to stormwater management. Only infiltration can simultaneously solve problems of water quality, flood control, streambank erosion, aquifer recharge, and maintenance of downstream base flows and wetland hydroperiods. Stormwater Infiltration is the first book to explain the principles of natural science on which infiltration is based, how to apply infiltration to any region of the country, and what kinds of results can be expected. It brings into one publication the complete range of necessary information on soils, vegetation, infiltration, hydrology, design criteria, site layout, construction process for surface and subsurface basins, porous paving materials, feasibility, maintenance, and performance. It draws more than half a century's actual experiences from all over the United States to place stormwater management in a context of environmental balance and quality for human life."--Provided by publisher.
