Advancing Functional Assessment With Flow Sensitive Magnetic Resonance Imaging

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Advancing Functional Assessment with Flow-sensitive Magnetic Resonance Imaging

Author : Grant Steven Roberts (Ph.D.)
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Advancing Functional Assessment with Flow-sensitive Magnetic Resonance Imaging by : Grant Steven Roberts (Ph.D.)

Download or read book Advancing Functional Assessment with Flow-sensitive Magnetic Resonance Imaging written by Grant Steven Roberts (Ph.D.) and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase-contrast magnetic resonance imaging (PC-MRI) is a non-invasive imaging method capable of quantifying time-resolved hemodynamics. This dissertation aims to develop novel acquisition methods and post-processing tools for the robust assessment of intracranial and aortic hemodynamics using PC-MRI and to study their relationship with aging and neurodegeneration. The associations between cerebrovascular health, arterial stiffness, aging, and neurodegeneration are poorly understood. 4D flow MRI is a noninvasive, quantitative imaging technique well-suited for the comprehensive assessment of cerebrovascular anatomy and function. However, its use in large-scale studies and clinical translation requires automation and robustness to accurately visualize and quantify hemodynamic parameters of interest. Currently, no adequate freely-available analysis tools exist and commercial post-processing packages are targeted toward cardiac applications. Here, I develop and validate a method to improve 4D flow MRI streamlines for generating 'virtual injections', enabling visualization of complex blood flow patterns in the brain. In addition, I introduce and validate an automated tool designed for simplified, robust, and reproducible cranial 4D flow MRI analysis, reducing post-processing times and interobserver variability. This tool is subsequently used to establish normative intracranial hemodynamics in one of the largest 4D flow studies to date from 759 older adults. Blood flow rates and pulsatility indices are tabulated in all major intracranial vessels and show a strong age dependency. This tool is also used to assess the relationship between cerebrovascular hemodynamics and white matter microstructure in cognitively unimpaired and Alzheimer's disease subjects. We find that white matter integrity is reduced in Alzheimer's disease and that white matter microstructure correlates with cerebral blood flow and pulsatility in cognitively unimpaired subjects. Furthermore, aortic stiffening, caused by aging or cardiovascular disease, can propagate harmful pulsatility into the cerebral microvasculature. PC-MRI methods have been developed to probe aortic stiffness by measuring pulse wave velocity (PWV), however, temporal resolution and breath-holds are methodological limitations, particularly in older adults. A free-breathing, radial, 2D-PC sequence with advanced image reconstruction is introduced to overcome these limitations and is validated in a custom-manufactured aortic phantom. Obtained PWVs are repeatable and comparable to standard breath-hold sequences. The image acquisition is further advanced by using a simultaneous multislice acquisition and reconstruction methodology to acquire two PC slices simultaneously which reduces scan time, improves physiological consistency, and maintains image quality. Together, these novel post-processing and acquisition techniques provide a means to quantitatively and comprehensively assess both intracranial and aortic vascular health. Using these techniques, a strong relationship between aging, aortic stiffness, cerebral blood flow and pulsatility, and white matter integrity was observed in older adults. These methods and results will help elucidate the pathophysiological contributions of vascular health in the context of aging and neurodegeneration.

Advancing Functional Assessment with Flow-sensitive Magnetic Resonance Imaging

Author : Grant Steven Roberts (Ph.D.)
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Advancing Functional Assessment with Flow-sensitive Magnetic Resonance Imaging by : Grant Steven Roberts (Ph.D.)

Functional Magnetic Resonance Imaging

Author : Rakesh Sharma
Publisher : BoD – Books on Demand
ISBN 13 : 9535105418
Total Pages : 228 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Functional Magnetic Resonance Imaging by : Rakesh Sharma

Download or read book Functional Magnetic Resonance Imaging written by Rakesh Sharma and published by BoD – Books on Demand. This book was released on 2012-05-09 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Functional Magnetic Resonance Imaging - Advanced Neuroimaging Applications" is a concise book on applied methods of fMRI used in assessment of cognitive functions in brain and neuropsychological evaluation using motor-sensory activities, language, orthographic disabilities in children. The book will serve the purpose of applied neuropsychological evaluation methods in neuropsychological research projects, as well as relatively experienced psychologists and neuroscientists. Chapters are arranged in the order of basic concepts of fMRI and physiological basis of fMRI after event-related stimulus in first two chapters followed by new concepts of fMRI applied in constraint-induced movement therapy; reliability analysis; refractory SMA epilepsy; consciousness states; rule-guided behavioral analysis; orthographic frequency neighbor analysis for phonological activation; and quantitative multimodal spectroscopic fMRI to evaluate different neuropsychological states.

Handbook of MRI Pulse Sequences

Author : Matt A. Bernstein
Publisher : Elsevier
ISBN 13 : 0080533124
Total Pages : 1041 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Handbook of MRI Pulse Sequences by : Matt A. Bernstein

Download or read book Handbook of MRI Pulse Sequences written by Matt A. Bernstein and published by Elsevier. This book was released on 2004-09-21 with total page 1041 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is among the most important medical imaging techniques available today. There is an installed base of approximately 15,000 MRI scanners worldwide. Each of these scanners is capable of running many different "pulse sequences", which are governed by physics and engineering principles, and implemented by software programs that control the MRI hardware. To utilize an MRI scanner to the fullest extent, a conceptual understanding of its pulse sequences is crucial. Handbook of MRI Pulse Sequences offers a complete guide that can help the scientists, engineers, clinicians, and technologists in the field of MRI understand and better employ their scanner. Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI Provides self-contained sections for individual techniques Can be used as a quick reference guide or as a resource for deeper study Includes both non-mathematical and mathematical descriptions Contains numerous figures, tables, references, and worked example problems

Translational Research in Traumatic Brain Injury

Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Essentials of Functional MRI

Author : Patrick W Stroman
Publisher :
ISBN 13 : 9781032873824
Total Pages : 0 pages
Book Rating : 4.8/5 (738 download)

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Book Synopsis Essentials of Functional MRI by : Patrick W Stroman

Download or read book Essentials of Functional MRI written by Patrick W Stroman and published by . This book was released on 2024-12-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Functional MRI is explained from the basic theory underlying magnetic resonance imaging. This includes how it can be used to detect dynamic variations in neural activity to become "functional" MRI, and how fMRI can be used for a variety of applications. The reader will gain an understanding of how fMRI is currently used, its limitations, and how it is still developing. This is achieved by explaining the core concepts and building on them to explain how fMRI data are acquired and what physiological information they provide. These ideas are the key to understanding how the data are analyzed to detect physiological changes that are related to neural activity. With an understanding of the basic underlying concepts, the way that fMRI is used, and its limitations, are much easier to understand. This 2nd edition includes explanations of new advances in MRI techniques and fMRI data analysis methods, and updated examples of applications of fMRI, including current or future clinical applications. This book is intended for students, researchers, and clinicians, who want to understand the theory and practice of fMRI in sufficient detail to use it for neuroscience research, clinical research, and for clinical practice.

Advanced MR Neuroimaging

Author : Ioannis Tsougos
Publisher : CRC Press
ISBN 13 : 1351216538
Total Pages : 239 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Advanced MR Neuroimaging by : Ioannis Tsougos

Download or read book Advanced MR Neuroimaging written by Ioannis Tsougos and published by CRC Press. This book was released on 2017-12-04 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, some of the greatest achievements in the field of neuroimaging have been related to remarkable advances in magnetic resonance techniques, including diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. Such techniques have provided valuable insights into tissue microstructure, microvasculature, metabolism and brain connectivity. Previously available mostly in research environments, these techniques are now becoming part of everyday clinical practice in a plethora of clinical MR systems. Nevertheless, despite growing interest and wider acceptance, there remains a lack of a comprehensive body of knowledge on the subject, exploring the intrinsic complexity and physical difficulty of the techniques. This book focuses on the basic principles and theories of diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. It also explores their clinical applications and places emphasis on the associated artifacts and pitfalls with a comprehensive and didactic approach. This book aims to bridge the gap between research applications and clinical practice. It will serve as an educational manual for neuroimaging researchers and radiologists, neurologists, neurosurgeons, and physicists with an interest in advanced MR techniques. It will also be a useful reference text for experienced clinical scientists who wish to optimize their multi-parametric imaging approach.

Advancing Ultra-high Field MRI Functional and Structural Applications

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Advancing Ultra-high Field MRI Functional and Structural Applications by :

Download or read book Advancing Ultra-high Field MRI Functional and Structural Applications written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) has shown to be a valuable tool for studying the human brain, allowing in-vivo visualization of structures and anatomy in great detail, especially at Ultra-High field strengths (≥ 7T). MRI is not limited by anatomical and structural information. It can study the brain’s anatomy, functionality, connectivity (functional and structural), and chemical metabolism. Functional MRI (fMRI), for instance, enables the investigation of brain function mechanisms in-vivo with a non-invasive advantage compared to other tools. The present thesis focuses on advanced MRI techniques for ultra-high field strength (≥ 7T), specifically for neuroscience applications. Combined with the higher field strength, these techniques provide better imaging quality and precise brain activity measurement. For example, high-quality anatomical T1 weighted images are essential for several MRI applications, notably, to serve as an anatomical reference in fMRI and gray matter segmentation. Unfortunately, increased field strength also induces non-uniformities in the transmit field (B1+) that can compromise image contrast non-uniformly. One of the goals of the present thesis was to investigate new strategies to overcome this issue. Regarding the functional brain investigation, the gradient-echo (GRE) is the typical method of choice for fMRI applications. Despite its high sensitivity to deoxyhemoglobin variations and widespread availability, the gradient-echo (GRE) BOLD signal is predominantly driven by the large draining vessels resulting in a limited spatial specificity, especially for 7T or higher field strength applications in which the BOLD sensitivity (susceptibility effect) is higher compared to lower static field scanners. In this context, we investigated an alternative fMRI method called vascular space occupancy (VASO) that promises higher spatial specificity than the typical GRE BOLD. To achieve the aim of this thesis, we used four approaches (chapters 2-5).

Quantitative Magnetic Resonance Imaging

Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Cerebral Blood Flow

Author :
Publisher : Elsevier
ISBN 13 : 0080861601
Total Pages : 447 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Cerebral Blood Flow by :

Download or read book Cerebral Blood Flow written by and published by Elsevier. This book was released on 1972-01-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.

fMRI Neurofeedback

Author : Michelle Hampson
Publisher : Academic Press
ISBN 13 : 0128224363
Total Pages : 366 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis fMRI Neurofeedback by : Michelle Hampson

Download or read book fMRI Neurofeedback written by Michelle Hampson and published by Academic Press. This book was released on 2021-10-09 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: fMRI Neurofeedback provides a perspective on how the field of functional magnetic resonance imaging (fMRI) neurofeedback has evolved, an introduction to state-of-the-art methods used for fMRI neurofeedback, a review of published neuroscientific and clinical applications, and a discussion of relevant ethical considerations. It gives a view of the ongoing research challenges throughout and provides guidance for researchers new to the field on the practical implementation and design of fMRI neurofeedback protocols. This book is designed to be accessible to all scientists and clinicians interested in conducting fMRI neurofeedback research, addressing the variety of different knowledge gaps that readers may have given their varied backgrounds and avoiding field-specific jargon. The book, therefore, will be suitable for engineers, computer scientists, neuroscientists, psychologists, and physicians working in fMRI neurofeedback. Provides a reference on fMRI neurofeedback covering history, methods, mechanisms, clinical applications, and basic research, as well as ethical considerations Offers contributions from international experts—leading research groups are represented, including from Europe, Japan, Israel, and the United States Includes coverage of data analytic methods, study design, neuroscience mechanisms, and clinical considerations Presents a perspective on future translational development

Advanced Machine Vision Paradigms for Medical Image Analysis

Author : Tapan K. Gandhi
Publisher : Academic Press
ISBN 13 : 0128192968
Total Pages : 308 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advanced Machine Vision Paradigms for Medical Image Analysis by : Tapan K. Gandhi

Download or read book Advanced Machine Vision Paradigms for Medical Image Analysis written by Tapan K. Gandhi and published by Academic Press. This book was released on 2020-08-11 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer vision and machine intelligence paradigms are prominent in the domain of medical image applications, including computer assisted diagnosis, image guided radiation therapy, landmark detection, imaging genomics, and brain connectomics. Medical image analysis and understanding are daunting tasks owing to the massive influx of multi-modal medical image data generated during routine clinal practice. Advanced computer vision and machine intelligence approaches have been employed in recent years in the field of image processing and computer vision. However, due to the unstructured nature of medical imaging data and the volume of data produced during routine clinical processes, the applicability of these meta-heuristic algorithms remains to be investigated. Advanced Machine Vision Paradigms for Medical Image Analysis presents an overview of how medical imaging data can be analyzed to provide better diagnosis and treatment of disease. Computer vision techniques can explore texture, shape, contour and prior knowledge along with contextual information, from image sequence and 3D/4D information which helps with better human understanding. Many powerful tools have been developed through image segmentation, machine learning, pattern classification, tracking, and reconstruction to surface much needed quantitative information not easily available through the analysis of trained human specialists. The aim of the book is for medical imaging professionals to acquire and interpret the data, and for computer vision professionals to learn how to provide enhanced medical information by using computer vision techniques. The ultimate objective is to benefit patients without adding to already high healthcare costs. Explores major emerging trends in technology which are supporting the current advancement of medical image analysis with the help of computational intelligence Highlights the advancement of conventional approaches in the field of medical image processing Investigates novel techniques and reviews the state-of-the-art in the areas of machine learning, computer vision, soft computing techniques, as well as their applications in medical image analysis

Advanced Image Processing in Magnetic Resonance Imaging

Author : Luigi Landini
Publisher : CRC Press
ISBN 13 : 1420028669
Total Pages : 632 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Advanced Image Processing in Magnetic Resonance Imaging by : Luigi Landini

Download or read book Advanced Image Processing in Magnetic Resonance Imaging written by Luigi Landini and published by CRC Press. This book was released on 2018-10-03 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popularity of magnetic resonance (MR) imaging in medicine is no mystery: it is non-invasive, it produces high quality structural and functional image data, and it is very versatile and flexible. Research into MR technology is advancing at a blistering pace, and modern engineers must keep up with the latest developments. This is only possible with a firm grounding in the basic principles of MR, and Advanced Image Processing in Magnetic Resonance Imaging solidly integrates this foundational knowledge with the latest advances in the field. Beginning with the basics of signal and image generation and reconstruction, the book covers in detail the signal processing techniques and algorithms, filtering techniques for MR images, quantitative analysis including image registration and integration of EEG and MEG techniques with MR, and MR spectroscopy techniques. The final section of the book explores functional MRI (fMRI) in detail, discussing fundamentals and advanced exploratory data analysis, Bayesian inference, and nonlinear analysis. Many of the results presented in the book are derived from the contributors' own work, imparting highly practical experience through experimental and numerical methods. Contributed by international experts at the forefront of the field, Advanced Image Processing in Magnetic Resonance Imaging is an indispensable guide for anyone interested in further advancing the technology and capabilities of MR imaging.

Advanced Cardiac Imaging

Author : Koen Nieman
Publisher : Elsevier
ISBN 13 : 1782422943
Total Pages : 804 pages
Book Rating : 4.7/5 (824 download)

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Book Synopsis Advanced Cardiac Imaging by : Koen Nieman

Download or read book Advanced Cardiac Imaging written by Koen Nieman and published by Elsevier. This book was released on 2015-07-16 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease. Presents a thorough overview of cardiac imaging technology Addresses specific applications for a number of cardiac diseases and how they can improve diagnoses and treatment protocols Includes technological developments in cardiac imaging and imaging applications in a clinical setting

Advanced Imaging in Coronary Artery Disease

Author : Ernst E. van der Wall
Publisher : Springer Science & Business Media
ISBN 13 : 9400708661
Total Pages : 470 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Advanced Imaging in Coronary Artery Disease by : Ernst E. van der Wall

Download or read book Advanced Imaging in Coronary Artery Disease written by Ernst E. van der Wall and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advanced Imaging in Coronary Artery Disease, the role of several imaging techniques in diagnosing atherosclerosis, assessment of myocardial ischemia, myocardial viability, and heart failure are broadly discussed. The issues derived from cardiac PET are presented in relation to the conventional techniques, such as echocardiography, SPECT and MRI. In addition, newer imaging techniques such as intracoronary ultrasound, electron beam computed tomography, and Raman spectroscopy are given wide attention. The effects of drug treatment, such as anti-ischemic and lipid-lowering drugs, are also evaluated. This book will assist clinical cardiologists, nuclear medicine physicians, fellows in cardiology and nuclear medicine, radiochemists, basic research fellows, and technicians, in understanding the new advances in clinical cardiac PET.

Advanced Signal Processing

Author : Stergios Stergiopoulos
Publisher : CRC Press
ISBN 13 : 1351834932
Total Pages : 839 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Advanced Signal Processing by : Stergios Stergiopoulos

Download or read book Advanced Signal Processing written by Stergios Stergiopoulos and published by CRC Press. This book was released on 2017-09-29 with total page 839 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the Applicability, Benefits, and Potential of New Technologies As advances in algorithms and computer technology have bolstered the digital signal processing capabilities of real-time sonar, radar, and non-invasive medical diagnostics systems, cutting-edge military and defense research has established conceptual similarities in these areas. Now civilian enterprises can use government innovations to facilitate optimal functionality of complex real-time systems. Advanced Signal Processing details a cost-efficient generic processing structure that exploits these commonalities to benefit commercial applications. Learn from a Renowned Defense Scientist, Researcher, and Innovator The author preserves the mathematical focus and key information from the first edition that provided invaluable coverage of topics including adaptive systems, advanced beamformers, and volume visualization methods in medicine. Integrating the best features of non-linear and conventional algorithms and explaining their application in PC-based architectures, this text contains new data on: Advances in biometrics, image segmentation, registration, and fusion techniques for 3D/4D ultrasound, CT, and MRI Fully digital 3D/ (4D: 3D+time) ultrasound system technology, computing architecture requirements, and relevant implementation issues State-of-the-art non-invasive medical procedures, non-destructive 3D tomography imaging and biometrics, and monitoring of vital signs Cardiac motion correction in multi-slice X-ray CT imaging Space-time adaptive processing and detection of targets interference-intense backgrounds comprised of clutter and jamming With its detailed explanation of adaptive, synthetic-aperture, and fusion-processing schemes with near-instantaneous convergence in 2-D and 3-D sensors (including planar, circular, cylindrical, and spherical arrays), the quality and illustration of this text’s concepts and techniques will make it a favored reference.

Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN

Author : Alfonso Nieto-Castanon
Publisher : Hilbert Press
ISBN 13 : 0578644002
Total Pages : 108 pages
Book Rating : 4.5/5 (786 download)

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Book Synopsis Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN by : Alfonso Nieto-Castanon

Download or read book Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN written by Alfonso Nieto-Castanon and published by Hilbert Press. This book was released on 2020-01-31 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes methods for processing and analyzing functional connectivity Magnetic Resonance Imaging (fcMRI) data using the CONN toolbox, a popular freely-available functional connectivity analysis software. Content description [excerpt from introduction] The first section (fMRI minimal preprocessing pipeline) describes standard and advanced preprocessing steps in fcMRI. These steps are aimed at correcting or minimizing the influence of well-known factors affecting the quality of functional and anatomical MRI data, including effects arising from subject motion within the scanner, temporal and spatial image distortions due to the sequential nature of the scanning acquisition protocol, and inhomogeneities in the scanner magnetic field, as well as anatomical differences among subjects. Even after these conventional preprocessing steps, the measured blood-oxygen-level-dependent (BOLD) signal often still contains a considerable amount of noise from a combination of physiological effects, outliers, and residual subject-motion factors. If unaccounted for, these factors would introduce very strong and noticeable biases in all functional connectivity measures. The second section (fMRI denoising pipeline) describes standard and advanced denoising procedures in CONN that are used to characterize and remove the effect of these residual non-neural noise sources. Functional connectivity Magnetic Resonance Imaging studies attempt to quantify the level of functional integration across different brain areas. The third section (functional connectivity measures) describes a representative set of functional connectivity measures available in CONN, each focusing on different indicators of functional integration, including seed-based connectivity measures, ROI-to-ROI measures, graph theoretical approaches, network-based measures, and dynamic connectivity measures. Second-level analyses allow researchers to make inferences about properties of groups or populations, by generalizing from the observations of only a subset of subjects in a study. The fourth section (General Linear Model) describes the mathematics behind the General Linear Model (GLM), the approach used in CONN for all second-level analyses of functional connectivity measures. The description includes GLM model definition, parameter estimation, and hypothesis testing framework, as well as several practical examples and general guidelines aimed at helping researchers use this method to answer their specific research questions. The last section (cluster-level inferences) details several approaches implemented in CONN that allow researchers to make meaningful inferences from their second-level analysis results while providing appropriate family-wise error control (FWEC), whether in the context of voxel-based measures, such as when studying properties of seed-based maps across multiple subjects, or in the context of ROI-to-ROI measures, such as when studying properties of ROI-to-ROI connectivity matrices across multiple subjects.