Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889633284
Total Pages : 116 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer by : Athanassios Argiris

Download or read book Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer written by Athanassios Argiris and published by Frontiers Media SA. This book was released on 2020-01-22 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Head and Neck Cancer

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Author :
Publisher : Demos Medical Publishing
ISBN 13 : 1617050717
Total Pages : 186 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Head and Neck Cancer by : Dwight E. Heron, MD, MBA, FACRO, FACR

Download or read book Head and Neck Cancer written by Dwight E. Heron, MD, MBA, FACRO, FACR and published by Demos Medical Publishing. This book was released on 2011-08-29 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Radiation Medicine Rounds examines the latest advances in the use of radiation medicine in treatment of head and neck cancer. Head and neck cancer treatment has undergone major change over the course of the past few years and Head and Neck Cancer addresses current best practices in the light of the most recent evidence. Head and Neck Cancer addresses a wide range of topics under the broad heading of head and neck oncology. In the initial section, the authors address therapeutic approaches with chapters on current and future treatments. Coverage is extensive and includes articles on IMRT, combined modality treatments, the use of targeted agents in conjunction with chemotherapy, the use of transoral robotic surgery followed by postoperative radiation therapy, and the use of particle therapy. The second section addresses issues of health services and covers palliative care, how to assess toxicity in patients, and issues of interpreting and integrating classic study data into treatment decisions. The third section examines the factors influencing clinical decisions ranging including biomarkers and image guidance. . Radiation Medicine Rounds features : In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Each issue edited by an authority in that subject area Each issue focused on a single major topic in Radiation Medicine, providing coverage of advances in radiation science, radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcome studies Series Description: Radiation Medicine Rounds is a review series providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There will be an emphasis throughout on multidisciplinary approaches to the specialty, as well as an emphasis on quality and outcomes analysis. The goal is to provide authoritative, thorough assessment of a wide range of "hot topics" and emerging new data for the entire specialty of radiation medicine.

Cancers of the Head and Neck

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461320291
Total Pages : 286 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Cancers of the Head and Neck by : Charlotte Jacobs

Download or read book Cancers of the Head and Neck written by Charlotte Jacobs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancers of the head and neck are among the most morbid of cancers. Convention al surgery and/or radiation therapy have a high cure rate for patients with early stage disease. However, despite optimal treatment with surgery and radiotherapy, patients with nodal spread or extensive local disease have a low cure rate. Even if a cancer is cured, a patient is often left with long-term debilities from the treatment and/or cancer. The major causes for decreased survival in patients with advanced head and neck cancer include local recurrence, distant metastases, and second primaries. All of these need to be addressed if one is to improve upon the curability of advanced disease. There are several new techniques, surgical and radiotherapeutic, designed to improve local control. Brachytherapy, or interstitial implantation, delivers a high dose of localized radiation with minimal normal tissue injury. This technique as discussed by Goffinet, may be even more efficacious when combined with hyperthermia. New, creative methods of radiation therapy delivery, such as the use of multiple fractions per day, as discussed by Parsons and Million, are also contributing to long-term local control. Laser therapy, discussed by Ossoff and Nemeroff, provides another tool for treatment of local disease.

Critical Issues in Head and Neck Oncology

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Publisher : Springer Nature
ISBN 13 : 3031231759
Total Pages : 361 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Critical Issues in Head and Neck Oncology by : Jan B. Vermorken

Download or read book Critical Issues in Head and Neck Oncology written by Jan B. Vermorken and published by Springer Nature. This book was released on 2023-03-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Head and Neck Cancer

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441994645
Total Pages : 700 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Head and Neck Cancer by : Jacques Bernier

Download or read book Head and Neck Cancer written by Jacques Bernier and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

Squamous Cell Head and Neck Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1592599389
Total Pages : 357 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Squamous Cell Head and Neck Cancer by : David J. Adelstein

Download or read book Squamous Cell Head and Neck Cancer written by David J. Adelstein and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.

Surgical Palliative Care

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Publisher : Oxford University Press, USA
ISBN 13 : 0190858362
Total Pages : 385 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Surgical Palliative Care by : Anne C. Mosenthal

Download or read book Surgical Palliative Care written by Anne C. Mosenthal and published by Oxford University Press, USA. This book was released on 2019-11-12 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palliative care has become increasingly important across the spectrum of healthcare, and with it, the need for education and training of a broad range of medical practitioners not previously associated with this field of care. Part of the Integrating Palliative Care series, this volume on surgical palliative care guides readers through the core palliative skills and knowledge needed to deliver high value care for patients with life-limiting, critical, and terminal illness under surgical care. Chapters explore the historical, philosophical, and spiritual principles of surgical palliative care, and follow the progression of the seriously ill surgical patient's journey from the pre-operative encounter, to the invasive procedure, to the post-operative setting, and on to survivorship. An overview of the future of surgical palliative care education and research rounds out the text. Surgical Palliative Care is an ideal resource for surgeons, surgical nurses, intensivists, and other practitioners who wish to learn more about integrating palliative care into the surgical field.

Anterior Skull Base Tumors

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318066702
Total Pages : 266 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Anterior Skull Base Tumors by : P. Nicolai

Download or read book Anterior Skull Base Tumors written by P. Nicolai and published by Karger Medical and Scientific Publishers. This book was released on 2020-07-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, interest in the management of anterior skull base tumors has been fostered by the introduction and subsequent rapid expansion of indications of transnasal endoscopic techniques. In parallel, extraordinary progress has been made in all the other disciplines which are involved in the complex process of managing anterior skull base tumors, leading to substantial improvements in diagnosis and treatment. The anterior skull base can be involved in a large variety of tumors of a varying nature and histology, which in the majority of cases originate from adjacent anatomic sites. In fact, primary lesions of the anterior skull base mainly include osteoma and other tumors originating from bone and cartilage. Tumors involving the anterior skull base have their origin prevalently in the sinonasal tract, but lesions developing on the intracranial site, such as meningiomas, may also extend caudally to encroach upon this area. All these lesions are rare, which means that the pertinent literature does not include prospective studies or treatment guidelines based on a high level of evidence. In view of the extreme histological variability of lesions involving the anterior skull base, much emphasis has been placed on addressing the different nuances of treatment in relation to histology, especially for malignant tumors. The chapters focusing on surgery provide divergent views on selection criteria for a specific surgical technique, which is the aim of this publication.

Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323809316
Total Pages : 193 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Glenn J. Hanna

Download or read book Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Glenn J. Hanna and published by Elsevier Health Sciences. This book was released on 2021-09-09 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include: Radiologic Evaluation of the Head and Neck Cancer Patient, Robotic and Endoscopic Approaches to Head and Neck Surgery, Cancer of the Oral Cavity and Lip, Cancer of the Oropharynx and the Association with Human Papillomavirus, Cancer of the Larynx and Hypopharynx, Cancer of the Nasal Cavity and Paranasal Sinuses, Cancer of the Nasopharynx and the Association with Epstein-Barr Virus, Salivary Glands Cancers, Thyroid and Parathyroid Cancers, Cutaneous Malignancies of the Head and Neck, Managing Recurrent and Metastatic Head and Neck Cancer, and Immunotherapy for Head and Neck Cancer. Provides in-depth, clinical reviews on head and neck cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Head and Neck Cancer Recurrence

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Author :
Publisher : Thieme
ISBN 13 : 3132579998
Total Pages : 716 pages
Book Rating : 4.1/5 (325 download)

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Book Synopsis Head and Neck Cancer Recurrence by : Hisham M. Mehanna

Download or read book Head and Neck Cancer Recurrence written by Hisham M. Mehanna and published by Thieme. This book was released on 2021-04-14 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function. Special features: Brings together all the current evidence and expertise on the epidemiology, risk factors, clinical and imaging evaluation, and management of recurrent head and neck cancer tumors Includes both curative and palliative approaches, and discusses surgical, radiotherapeutic, and chemotherapeutic strategic options Contains substantial contributions by specialists in speech and language therapy, palliative care, psychology, epidemiology, and clinical cancer nursing to provide a holistic, multidisciplinary approach to the management of recurrence of head and neck cancers Brings the decision-making process to life with illustrative case studies that contain patient histories, clinical findings, treatment planning, and documented results The combination of the most recent clinical advances with the latest thinking in the field makes this book an essential resource for all head and neck surgeons, clinical oncologists, radiation oncologists, nurse practitioners, allied health professionals and senior trainees working to improve patient management and outcomes in this challenging arena.

Cases in Head and Neck Cancer

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Author :
Publisher : Plural Publishing
ISBN 13 : 1944883193
Total Pages : 305 pages
Book Rating : 4.9/5 (448 download)

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Book Synopsis Cases in Head and Neck Cancer by : Bari Hoffman Ruddy

Download or read book Cases in Head and Neck Cancer written by Bari Hoffman Ruddy and published by Plural Publishing. This book was released on 2016-05-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cases in Head and Neck Cancer: A Multidisciplinary Approach encompasses rich material and resources that demonstrate the complex interface between the diagnostic and clinical information necessary to successfully manage patients with head and neck cancer. This must-read book contains cases written by leading experts in the field that cover a wide variety of head and neck cancers (i.e., tongue base, tonsil, laryngeal, HPV related, etc.) and treatment options, including minimally invasive surgery such as robotic surgery and combined modality treatment protocols. Specifically, this text addresses comprehensive cases from initial evaluation, diagnosis, imaging, and other physiological tests to multidisciplinary treatment management (surgery, chemotherapy, and radiation therapy). Additionally, approaches for the management of toxicities or morbidities of cancer treatment are presented, as well as care plans, discharge plans, and caregiver burden and survivorship issues. Moreover, material on health literacy, humanistic care, and improving communication with assistive technology has been included. Written by clinicians specializing in speech-language pathology, otolaryngology, medical and radiation oncology, pathology, nurse case management, radiology, dietics, among other fields, this collection of authors provides one of the most complete presentations of the inner workings of the multidisciplinary care team. The adult cases of head and neck cancer reviewed in this text exemplify current practice issues surrounding HPV, minimally invasive robotic surgery and combined modality treatments. Each author threads introductory comments throughout the cases illustrating the critical role of the speech-language pathologist, in particular, and how all clinicians must address coping with survivorship and caregiver burden issues. Cases in Head and Neck Cancer intends to teach future medical practitioners how to approach the complexities associated with head and neck cancer. Its vast number of images and videos allow for experiential driven classroom activities. This text will be an invaluable resource for the education of speech-language pathologists, medical students, nurse care managers, dieticians, and any person involved in a head and neck cancer team.

Head and Neck Cancer Recurrence

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Author :
Publisher : Thieme
ISBN 13 : 3131645717
Total Pages : 716 pages
Book Rating : 4.1/5 (316 download)

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Book Synopsis Head and Neck Cancer Recurrence by : Hisham M. Mehanna

Download or read book Head and Neck Cancer Recurrence written by Hisham M. Mehanna and published by Thieme. This book was released on 2012-12-12 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function. Special features: Brings together all the current evidence and expertise on the epidemiology, risk factors, clinical and imaging evaluation, and management of recurrent head and neck cancer tumors Includes both curative and palliative approaches, and discusses surgical, radiotherapeutic, and chemotherapeutic strategic options Contains substantial contributions by specialists in speech and language therapy, palliative care, psychology, epidemiology, and clinical cancer nursing to provide a holistic, multidisciplinary approach to the management of recurrence of head and neck cancers Brings the decision-making process to life with illustrative case studies that contain patient histories, clinical findings, treatment planning, and documented results The combination of the most recent clinical advances with the latest thinking in the field makes this book an essential resource for all head and neck surgeons, clinical oncologists, radiation oncologists, nurse practitioners, allied health professionals and senior trainees working to improve patient management and outcomes in this challenging arena.

Head and Neck Cancer

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Author :
Publisher : Springer
ISBN 13 : 3319276018
Total Pages : 877 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Head and Neck Cancer by : Jacques Bernier

Download or read book Head and Neck Cancer written by Jacques Bernier and published by Springer. This book was released on 2016-08-22 with total page 877 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Carcinomas of the Head and Neck

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461314992
Total Pages : 290 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Carcinomas of the Head and Neck by : Charlotte Jacobs

Download or read book Carcinomas of the Head and Neck written by Charlotte Jacobs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome.

Improving the Therapeutic Ratio in Head and Neck Cancer

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Author :
Publisher : Academic Press
ISBN 13 : 0128178698
Total Pages : 376 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Improving the Therapeutic Ratio in Head and Neck Cancer by :

Download or read book Improving the Therapeutic Ratio in Head and Neck Cancer written by and published by Academic Press. This book was released on 2019-10-04 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Carcinomas of the Head and Neck

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Author :
Publisher :
ISBN 13 : 9781461315001
Total Pages : 308 pages
Book Rating : 4.3/5 (15 download)

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Book Synopsis Carcinomas of the Head and Neck by : Charlotte Jacobs

Download or read book Carcinomas of the Head and Neck written by Charlotte Jacobs and published by . This book was released on 1990-07-31 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Management of Oral Cancers

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Author :
Publisher : Springer Nature
ISBN 13 : 981156499X
Total Pages : 277 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Management of Oral Cancers by : Sudhir Bahadur

Download or read book Management of Oral Cancers written by Sudhir Bahadur and published by Springer Nature. This book was released on 2020-09-08 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor biology varies at different subsites in the oral cavity, and therefore carcinoma of the gingivo-buccal sulcus (also known as Indian cancer) behaves differently from carcinoma of the tongue. Oral cancer is very often diagnosed at an advanced stage with neck metastasis, and most cases have a guarded prognosis. Loco-regional recurrences are frequent and morbidity following treatment is considerable. However, results have improved in recent years, particularly in early and certain advanced stages, due to better imaging and case selection, improved surgical techniques, including those for reconstructive surgery, a multidisciplinary team approach and a better understanding of tumor biology and prognostic factors. This book comprehensively and systematically reviews all these aspects of diagnostic and therapeutic advances in oral cancer, particularly discussing early detection, epidemiology, chemoprevention and current research. Written by specialists who are active leaders in basic sciences or clinical fields, the chapters address individual and collective issues in managing patients with oral cancer, and provide insights into various treatment approaches. The authors share their knowledge and experience and provide extensive literature sources to encourage clinicians to be flexible, innovative and help them make the best, educated decisions for individual patients.