Advances in Hepatobiliary and Pancreatic Diseases Special Clinical Topics

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Publisher : Springer
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advances in Hepatobiliary and Pancreatic Diseases Special Clinical Topics by : G. Dobrilla

Download or read book Advances in Hepatobiliary and Pancreatic Diseases Special Clinical Topics written by G. Dobrilla and published by Springer. This book was released on 1995-11-30 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first section deals with the rational clinical and laboratory approach to liver disease patients and mainly with the therapeutic aspects of chronic hepatitis, cirrhosis of the liver, liver cancer and portal hypertension. The second section is devoted to bile duct treatment with overviews of the non-surgical treatment of gallstones, the endoscopic therapy of biliary stenosis and the role of the sphincter of Oddi in biliopancreatic disease.

Advances in Inflammatory Bowel Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387503
Total Pages : 340 pages
Book Rating : 4.3/5 (875 download)

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Book Synopsis Advances in Inflammatory Bowel Diseases by : P. Rutgeerts

Download or read book Advances in Inflammatory Bowel Diseases written by P. Rutgeerts and published by Springer Science & Business Media. This book was released on 1998-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy.

Hepatobiliary Diseases: Cholestasis and Gallstone

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387701
Total Pages : 202 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Hepatobiliary Diseases: Cholestasis and Gallstone by : M. Acalovschi

Download or read book Hepatobiliary Diseases: Cholestasis and Gallstone written by M. Acalovschi and published by Springer Science & Business Media. This book was released on 2001-03-31 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecular basis of cholestatic disorders as well as of gallstone disease is increasingly recognized. This has resulted in improved diagnosis, for instance in hereditary forms of intrahepatic cholestasis, and advances in treatment, for example in primary biliary cirrhosis and other chronic cholestatic disorders. This book, the proceedings of a Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000, brings together contributions from scientists and clinicians to highlight the most recent advances in molecular biology, pathophysiology, diagnosis and therapy of diseases of the hepatobiliary system. World experts cover a broad spectrum of topics from genetic studies to endoscopy and from medical treatment to liver transplantation.

Bile Acids in Hepatobiliary Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387558
Total Pages : 366 pages
Book Rating : 4.3/5 (875 download)

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Book Synopsis Bile Acids in Hepatobiliary Disease by : T.C. Northfield

Download or read book Bile Acids in Hepatobiliary Disease written by T.C. Northfield and published by Springer Science & Business Media. This book was released on 2000-02-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease', which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.

Clinical Challenges in Inflammatory Bowel Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387336
Total Pages : 270 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Clinical Challenges in Inflammatory Bowel Diseases by : M. Campieri

Download or read book Clinical Challenges in Inflammatory Bowel Diseases written by M. Campieri and published by Springer Science & Business Media. This book was released on 1998-01-31 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most symposia on chronic inflammatory bowel disease during the last few years have focused on new aspects of aetiology and pathophysiology. However, based on such new aspects, changes in diagnosis and treatment have been developed over the last few years and some others are currently under investigation. This book, the proceedings of Falk Symposium 97, `Clinical Challenges in Inflammatory Bowel Diseases - Diagnosis, Prognosis and Treatment', held in Lugano, Switzerland, 18-19 April 1997, summarizes these changes and new developments, discusses their value and defines further new approaches. The topics include primary diagnosis, definition of different patient groups, special problems of these patients in daily life and very new therapeutic principles. This volume opens new possibilities of diagnosis and treatment of inflammatory bowel disease to physicians and provides stimulation for further development.

Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice

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Publisher : Springer Science & Business Media
ISBN 13 : 9781402028472
Total Pages : 314 pages
Book Rating : 4.0/5 (284 download)

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Book Synopsis Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice by : B. Vucelic

Download or read book Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice written by B. Vucelic and published by Springer Science & Business Media. This book was released on 2004-12-09 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amount of information on the pathogenesis of inflammatory bowel disease is growing rapidly. This is reflected by a continuous increase in the number of papers presented at international GI meetings. To make things more difficult for practicing physicians, there is also a large number of new clinical trials being published which require periodical critical reviews and recommendations. Faced with these issues, the scientific commitee of the Falk Symposium No. 140 decided to take a different approach and to apply a novel format that is reflected in the title of the Symposium: "Translation from basic research to clinical practice". This book contains the proceedings of that Symposium, held in Dubrovnik, Croatia, on May 7–8, 2004. The sections are designed so that they start with the information from basic sciences on different aspects of these complex diseases and further lead to their clinical implications. Special attention is paid to the mechanisms of actions of established drugs. The last two sections are clinically oriented and focus on the most difficult aspects of both Crohn's disease and ulcerative colitis. This format provides state-of-the-art chapters by leading experts in the field and at the same time up-to-date information on the clinical application of the new knowledge.

Malignant Liver Tumours: Basic Concepts and Clinical Management

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387794
Total Pages : 242 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Malignant Liver Tumours: Basic Concepts and Clinical Management by : F. Berr

Download or read book Malignant Liver Tumours: Basic Concepts and Clinical Management written by F. Berr and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.

Immunosuppression in Inflammatory Bowel Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387671
Total Pages : 288 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Immunosuppression in Inflammatory Bowel Diseases by : K. Fellermann

Download or read book Immunosuppression in Inflammatory Bowel Diseases written by K. Fellermann and published by Springer Science & Business Media. This book was released on 2001-06-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aetiology of the chronic inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is still enigmatic. The therapeutic approach has therefore traditionally focused on anti-inflammatory principles, including corticosteroids and aminosalicylates. Since a significant proportion of patients is steroid-dependent or refractory and because of the problematic side-effects of long-term systemic steroids, active immunosuppression has gained acceptance in the field. The classical immunosuppressants azathioprine and 6-mercaptopurine have long been evidence-based in IBD, but underused. Recently, methotrexate and cyclosporine have also been proven to be effective in certain situations. Newer drugs like tacrolimus, mycophenolate and others may be similarly useful but their potential is still unclear. Finally, the immune modifiers including IL-10 and TNF-antibodies have been successfully subjected to controlled trials. Other experimental drugs discussed in this book are on the horizon. This volume is the Proceedings of Falk Symposium 119 held in Freiburg-im-Breisgau, Germany, October 3-4, 2000, and covers systematically the field of immunosuppression in inflammatory bowel diseases. It is hoped that it will further the prudent use of these drugs in the proper clinical situations by increasing our understanding of both the mechanisms of action and the clinical benefit to the patient.

Immunological Diseases of Liver and Gut

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387923
Total Pages : 338 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Immunological Diseases of Liver and Gut by : M. Lukás

Download or read book Immunological Diseases of Liver and Gut written by M. Lukás and published by Springer Science & Business Media. This book was released on 2004-06-30 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Symposium No. 135 held in Prague, Czech Republic, on September 12-13, 2003, and is dedicated to the important issue of immunological aspects of diseases of the liver and gut. Without any doubt, immunological pathways are among the most important and universal factors in the pathogenesis of all diseases. Their importance is also constantly increasing, because these principles have been adopted in clinical practice for both diagnostic and therapeutic procedures. Chapters by prominent experts will stimulate new ideas and set the scene for productive discussion on this topic.

Cholestatic Liver Diseases: Therapeutic Options and Perspectives

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387930
Total Pages : 424 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Cholestatic Liver Diseases: Therapeutic Options and Perspectives by : U. Leuschner

Download or read book Cholestatic Liver Diseases: Therapeutic Options and Perspectives written by U. Leuschner and published by Springer Science & Business Media. This book was released on 2004-06-30 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decade, knowledge about cholestatic liver disease and concomitant diseases, such as ulcerative colitis, cholangio- and hepatocellular carcinoma, pancreas and colon cancer, has increased considerably. Studies on ursodeoxycholic acid treatment alone or in combination with immunosuppressive compounds and their positive effects on biliary liver disease as well as on so-called overlap syndromes or intestinal tumors are published in increasing numbers, and stimulate discussion on whether or not ursodeoxycholic acid is able to improve the general condition and/or life expectancy of patients. On the other hand, genetics, aetiological and pathogenetic aspects are still difficult to comprehend, but are the absolute prerequisite for the development of better treatment options. This book is the proceedings of Falk Symposium No. 136 (Part I of the XII Falk Liver Week, held in Freiburg, Germany, on October 15-16, 2003), and contains stimulating, exciting and controversial papers on clinical and also basic research at the highest scientific level.

Prevention of Progression in Chronic Liver Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387961
Total Pages : 140 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Prevention of Progression in Chronic Liver Disease by : N. Hiyashi

Download or read book Prevention of Progression in Chronic Liver Disease written by N. Hiyashi and published by Springer Science & Business Media. This book was released on 2004-07-21 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In several liver diseases, the underlying cause cannot always be eliminated, i.e. the progression of liver disease cannot be prevented. This is particularly true for non-responders to the treatment of chronic hepatitis C (HCV). It is relevant for more than 40% of patients with HCV genotype 1 and up to 20% of patients with genotype 2 or 3. Several approaches are now underway to prevent or ameliorate mechanisms of disease progression. In Asia, and particularly in Japan, Glycyrrhizine-SNMC has been widely used for this purpose. At present, SNMC is under clinical evaluation in Europe. This book, the proceedings of the Falk Workshop on 'Prevention of Progression in Chronic Liver Disease - An Update on SNMC (Stronger Neo-Minophagen C)' (Part IV of the XII Falk Liver Week, in honour of Hans Popper's 100th birthday) held in Freiburg, Germany, on 22 October 2003, is devoted to the understanding of basic mechanisms of fibrogenesis, the state of the art of non-invasive markers of disease progression that may substitute liver biopsy in the future, and of other predictive parameters indicating disease progression, in particular the development of hepatocellular carcinoma. All these problems are particularly relevant for chronic hepatitis C. A better characterization of so-called non-responders for the treatments available is crucial for the development of new strategies preventing or postponing disease progression. Such strategies should influence fibrogenesis and, thus, cirrhosis formation as well as the development of life threatening complications of liver cirrhosis, including hepatocellular carcinoma. In this volume, the available information on SNMC as an approach to prevent progression of chronic liver disease is discussed by several internationally renowned authors who report on the mechanisms of liver fibrogenesis and fibrolysis, on non-invasive markers of disease progression, and on hepatocellular carcinoma as one of the major complications of liver cirrhosis nowadays. Finally, experts from Japan report on their knowledge and experience concerning the drug SNMC/Glycyrrhizine in the prevention of cirrhosis and HCC, and first study results from Europe are presented.

Medical Imaging in Gastroenterology and Hepatology

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387749
Total Pages : 262 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Medical Imaging in Gastroenterology and Hepatology by : F. Hagenmüller

Download or read book Medical Imaging in Gastroenterology and Hepatology written by F. Hagenmüller and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the proceedings of Falk Symposium 124, `Medical Imaging in Gastroenterology and Hepatology' (Progress in Gastroenterology and Hepatology Part I), held in Hannover, Germany, on September 28-29, 2001, aims to demonstrate the newest developments in the various imaging techniques for diagnosis and therapy, coupled with overviews by renowned international experts. In this book, up-to-date technologies in medical imaging and image documentation as well as the most modern transmission techniques should bridge the gap between futuristic research and everyday clinical practice.

Autoimmune Diseases in Pediatric Gastroenterology

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387787
Total Pages : 304 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Autoimmune Diseases in Pediatric Gastroenterology by : Faruk Hadziselimovic

Download or read book Autoimmune Diseases in Pediatric Gastroenterology written by Faruk Hadziselimovic and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Symposium No. 127 on `Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response. Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules. Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC. In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response. Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.

VI International Symposium on Inflammatory Bowel Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387732
Total Pages : 266 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis VI International Symposium on Inflammatory Bowel Diseases by : D. Rachmilewitz

Download or read book VI International Symposium on Inflammatory Bowel Diseases written by D. Rachmilewitz and published by Springer Science & Business Media. This book was released on 2002-06-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the proceedings of Falk Symposium No. 123, VI International Symposium on Inflammatory Bowel Diseases, held in Istanbul, Turkey, on September 3-5, 2001, focuses on the issues and controversies pertinent to IBD in the 21st century. The achievements in medical, surgical, and in the basic sciences in the last twenty years since the first Jerusalem IBD Symposium are summarized in detail. Controversies with respect to the medical treatment of inflammatory bowel diseases are discussed. One section deals with surgical issues such as laparoscopic surgery in inflammatory bowel diseases, ileo-anal pouches and the surgical treatment of Crohn's disease. The last section is devoted to the biological treatment of IBD and to the needs both in medical science and in the clinic.

Intestinal Mucosa and Its Diseases - Pathophysiology and Clinics

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387541
Total Pages : 542 pages
Book Rating : 4.3/5 (875 download)

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Book Synopsis Intestinal Mucosa and Its Diseases - Pathophysiology and Clinics by : W. Domschke

Download or read book Intestinal Mucosa and Its Diseases - Pathophysiology and Clinics written by W. Domschke and published by Springer Science & Business Media. This book was released on 1999-07-31 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings of Falk Symposium 110 on `Intestinal Mucosa and its Diseases - Pathophysiology and Clinics' held at Titisee/Black Forest, Germany, 16-17 October 1998, comprehensively review salient clinical as well as scientific aspects - pending or settled - of the main intestinal diseases. In particular, chapters deal with infectious and neuroendocrine diarrhoeas, coeliac sprue, allergic enteropathy, intestinal lymphomas, colorectal carcinomas, and chronic inflammatory bowel diseases, in terms of clinical presentation as well as underlying mechanisms. This book therefore aims to bridge the gaps between basic science and clinics for the eventual treatment of patients afflicted with these diseases.

Innovative Concepts in Inflammatory Bowel Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387497
Total Pages : 388 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Innovative Concepts in Inflammatory Bowel Disease by : J. Emmrich

Download or read book Innovative Concepts in Inflammatory Bowel Disease written by J. Emmrich and published by Springer Science & Business Media. This book was released on 1999-01-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammatory bowel diseases represent an important medical problem, since they have a devastating impact on the quality of life and require longstanding medical care. Many medical disciplines are involved in tackling the immensely complex studies on pathogenesis, clinical expression and treatment possibilities. This book, the proceedings of the Falk Symposium 105 on `Innovative Concepts in Inflammatory Bowel Diseases', held in Rostock, Germany, on April 30 - May 2, 1998, brought together experts from different fields of science to allow a unified view on clinical and basic research. The main themes of the meeting were genetics, animal models, immunology, epithelial cells, endotoxin, diagnostic procedures, malignancy, medical therapies, and surgery. In each section of the book experts present state-of-the-art reviews with the very latest developments in the respective research areas followed by chapters on different aspects of inflammatory bowel diseases. They provide suggestions concerning future research and clinical management of patients with inflammatory bowel diseases.

Biology of Bile Acids in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792387688
Total Pages : 364 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Biology of Bile Acids in Health and Disease by : G.P. van Berge Henegouwen

Download or read book Biology of Bile Acids in Health and Disease written by G.P. van Berge Henegouwen and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning in 1970, the International Bile Acid Meeting has taken place every two years and each time new progress in our understanding of the complex role of bile acids in many metabolic processes of the liver and the intestine has been revealed by a selected group of leading scientists from all over the world. Although originally mainly physiological data on bile acid synthesis and transport were emphasized, and later on also the therapeutic benefit of bile acids in gallstone disease and cholestasis was discovered, we have come now to the molecular biology and genetic era with major discoveries in transport defects and related diseases. This book is the proceedings of Falk Symposium No. 120, held in The Hague, The Netherlands, on October 12-13, 2000 - the 16th International Bile Acid Meeting. One of the main discoveries recently has been the identification of nuclear receptors for bile acids, which gives them a much broader perspective than previously anticipated. It even suggests that bile acids can regulate their biosynthesis and enterohepatic circulation transcriptionally. It will therefore not be surprising that this topic, together with the molecular regulation of cholesterol 7alpha-hydroxylase and cholesterol homeostasis, has a dominant place in these proceedings. Another important topic is the progress in our molecular understanding of hepatic (both at the basolateral and canalicular sites), cholangiocytic and intestinal bile acid transport processes. Further insights into genetic defects causing cholestasis or intestinal malabsorption in animal models and in human diseases are also discussed by a number of well-known authors. Finally the last section deals with new findings on the role of bile acid therapy in cholestatic syndromes or chemoprevention and with the potential benefit of bile acid inhibitors. All contributors provide an update on the most recent developments in their field.