Advances In Cancer Signal Transduction And Therapy

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Advances in Cancer Signal Transduction and Therapy

Author : Manoj K. Pandey
Publisher : Bentham Science Publishers
ISBN 13 : 981145809X
Total Pages : 207 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Advances in Cancer Signal Transduction and Therapy by : Manoj K. Pandey

Download or read book Advances in Cancer Signal Transduction and Therapy written by Manoj K. Pandey and published by Bentham Science Publishers. This book was released on 2020-10-05 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration. Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threonine kinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge about these signaling components is highly desirable for researchers involved in developing therapies against cancer. Signal Transduction Research for Cancer Therapy covers advancements in research on the signaling pathways in the human body, especially in some types of cancers, such as breast cancer, pancreatic cancer and colon cancer. Key features of this volume include 8 focused topical reviews on signaling pathways in a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (both receptor mediated and non receptor mediated pathways). This volume is essential reading for researchers in pharmaceutical R&D and postgraduate research programs in pharmacology and allied disciplines. Clinicians involved in oncology will also benefit from the information provided in the chapters. [Series Intro] This series provides scientists and clinicians with updated clinical information about signal transduction that will be valuable in their pursuit to investigate, develop, and apply novel agents to prevent or treat life-threatening diseases such as cancer. Contributions to the series will focus on methods that also enhance the quality of life for patients.

Advances in Cancer Signal Transduction and Therapy

Author : Manoj K. Pandey
Publisher : Bentham Science Publishers
ISBN 13 : 9789811458101
Total Pages : 206 pages
Book Rating : 4.4/5 (581 download)

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Book Synopsis Advances in Cancer Signal Transduction and Therapy by : Manoj K. Pandey

Download or read book Advances in Cancer Signal Transduction and Therapy written by Manoj K. Pandey and published by Bentham Science Publishers. This book was released on 2020-10-05 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canceris driven by numerous genetic and epigenetic changes occurring at the cellular level.These changes drive normal cells to proliferate and escape processes thatusually regulate their survival and migration. Many of these alterations areoften associated with signaling pathways which regulate cell growth anddivision, cell death, survival, invasion and metastasis, and angiogenesis.Almost all cancer cells show high expression of signaling components includinggrowth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threoninekinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge aboutthese signaling components is highly desirable for researchers involved indeveloping therapies against cancer.Signal TransductionResearch for Cancer Therapy covers advancements in research on the signalingpathways in the human body, especially in some types of cancers, such asbreast cancer, pancreatic cancer and colon cancer. Keyfeatures of this volume include 8 focused topical reviews on signaling pathwaysin a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (bothreceptor mediated and non receptor mediated pathways). Thisvolume is essential reading for researchers in pharmaceutical R&D andpostgraduate research programs in pharmacology and allied disciplines.Clinicians involved in oncology will also benefit from the information providedin the chapters.

Signaling Pathways in Cancer Pathogenesis and Therapy

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1461412161
Total Pages : 152 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Signaling Pathways in Cancer Pathogenesis and Therapy by : David A. Frank

Download or read book Signaling Pathways in Cancer Pathogenesis and Therapy written by David A. Frank and published by Springer Science & Business Media. This book was released on 2011-11-12 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

Cancer Therapeutic Targets

Author : John L. Marshall
Publisher : Springer
ISBN 13 : 9781441907165
Total Pages : 0 pages
Book Rating : 4.9/5 (71 download)

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Book Synopsis Cancer Therapeutic Targets by : John L. Marshall

Download or read book Cancer Therapeutic Targets written by John L. Marshall and published by Springer. This book was released on 2017-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.

Signal Transduction in Cancer

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 0306481588
Total Pages : 358 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Signal Transduction in Cancer by : David A. Frank

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
ISBN 13 : 1588297144
Total Pages : 726 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Transforming Growth Factor-Beta in Cancer Therapy, Volume I by : Sonia B. Jakowlew

Download or read book Transforming Growth Factor-Beta in Cancer Therapy, Volume I written by Sonia B. Jakowlew and published by Springer Science & Business Media. This book was released on 2008-02-28 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
ISBN 13 : 1597452920
Total Pages : 726 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Transforming Growth Factor-Beta in Cancer Therapy, Volume I by : Sonia B. Jakowlew

Download or read book Transforming Growth Factor-Beta in Cancer Therapy, Volume I written by Sonia B. Jakowlew and published by Springer Science & Business Media. This book was released on 2010-01-01 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Advances in Cancer Therapy

Author : Hala Gali-Muhtasib
Publisher : BoD – Books on Demand
ISBN 13 : 9533077034
Total Pages : 582 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Advances in Cancer Therapy by : Hala Gali-Muhtasib

Download or read book Advances in Cancer Therapy written by Hala Gali-Muhtasib and published by BoD – Books on Demand. This book was released on 2011-11-21 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Advances in Cancer Therapy" is a new addition to the Intech collection of books and aims at providing scientists and clinicians with a comprehensive overview of the state of current knowledge and latest research findings in the area of cancer therapy. For this purpose research articles, clinical investigations and review papers that are thought to improve the readers' understanding of cancer therapy developments and/or to keep them up to date with the most recent advances in this field have been included in this book. With cancer being one of the most serious diseases of our times, I am confident that this book will meet the patients', physicians' and researchers' needs.

Advances in Cancer Research

Author :
Publisher : Academic Press
ISBN 13 : 9780080562407
Total Pages : 223 pages
Book Rating : 4.5/5 (624 download)

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Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1992-02-24 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research

Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
ISBN 13 : 1597452939
Total Pages : 785 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Transforming Growth Factor-Beta in Cancer Therapy, Volume II by : Sonia B. Jakowlew

Download or read book Transforming Growth Factor-Beta in Cancer Therapy, Volume II written by Sonia B. Jakowlew and published by Springer Science & Business Media. This book was released on 2010-01-01 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Molecular Targeting and Signal Transduction

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078471
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Molecular Targeting and Signal Transduction by : Rakesh Kumar

Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Signaling Pathways in Cancer Pathogenesis and Therapy

Author :
Publisher : Springer
ISBN 13 : 9781461412175
Total Pages : 158 pages
Book Rating : 4.4/5 (121 download)

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Book Synopsis Signaling Pathways in Cancer Pathogenesis and Therapy by :

Download or read book Signaling Pathways in Cancer Pathogenesis and Therapy written by and published by Springer. This book was released on 2011-11-13 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EGFR Signaling Networks in Cancer Therapy

Author : John D. Haley
Publisher : Springer Science & Business Media
ISBN 13 : 1597453560
Total Pages : 393 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis EGFR Signaling Networks in Cancer Therapy by : John D. Haley

Download or read book EGFR Signaling Networks in Cancer Therapy written by John D. Haley and published by Springer Science & Business Media. This book was released on 2009-03-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Targeted Interference with Signal Transduction Events

Author : B. Groner
Publisher : Springer Science & Business Media
ISBN 13 : 3540312099
Total Pages : 192 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Targeted Interference with Signal Transduction Events by : B. Groner

Download or read book Targeted Interference with Signal Transduction Events written by B. Groner and published by Springer Science & Business Media. This book was released on 2007-08-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?

Signal Transduction and Human Disease

Author : Toren Finkel
Publisher : John Wiley & Sons
ISBN 13 : 0471448370
Total Pages : 490 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Signal Transduction and Human Disease by : Toren Finkel

Download or read book Signal Transduction and Human Disease written by Toren Finkel and published by John Wiley & Sons. This book was released on 2003-07-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Precision Cancer Therapies, Volume 1

Author : Owen A. O'Connor
Publisher : John Wiley & Sons
ISBN 13 : 1119819946
Total Pages : 516 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Precision Cancer Therapies, Volume 1 by : Owen A. O'Connor

Download or read book Precision Cancer Therapies, Volume 1 written by Owen A. O'Connor and published by John Wiley & Sons. This book was released on 2023-03-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies A thorough compilation of the many scientific breakthroughs in the ongoing development of precision cancer therapies related to lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.

Prostate Cancer

Author : Richard G. Pestell
Publisher : Springer Science & Business Media
ISBN 13 : 1603270795
Total Pages : 462 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Prostate Cancer by : Richard G. Pestell

Download or read book Prostate Cancer written by Richard G. Pestell and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. The authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer and into future, novel treatment strategies.