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Advances In Bone Marrow Purging And Processing
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Book Synopsis Advances in Bone Marrow Purging and Processing by : Adrian P. Gee
Download or read book Advances in Bone Marrow Purging and Processing written by Adrian P. Gee and published by Wiley-Liss. This book was released on 1994-10-04 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines emerging technology in this field, from both the research and clinical arenas. The book describes approaches for utilizing DNA sense and antisense probes, combinations of elutriators and immunomagnetics as well as refinements in the use of mechanical separation. Contributions from more than 400 investigators address topics such as pharmacological purging, marrow processing, clinical studies and tumor cell detection.
Book Synopsis Advances in Bone Marrow Purging and Processing by : Diana A. Worthington-White
Download or read book Advances in Bone Marrow Purging and Processing written by Diana A. Worthington-White and published by . This book was released on 1992 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the latest research discoveries and current clinical procedures for selectively separating and analyzing subpopulations of cells from bone marrow. Over 400 internationally renowned experts offer contributions on such topics as approaches for using DNA sense and antisense probes, combinations of elutriators and immunomagnetics, expanded cytokines applications, new techniques for the removal of tumor cells from autologous bone marrow and T cells from allogeneic grafts.
Book Synopsis Bone Marrow Processing and Purging by : Adrian P. Gee
Download or read book Bone Marrow Processing and Purging written by Adrian P. Gee and published by CRC Press. This book was released on 2020-11-25 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.
Book Synopsis Bone Marrow Purging and Processing by : Samuel Gross
Download or read book Bone Marrow Purging and Processing written by Samuel Gross and published by . This book was released on 1990 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume assesses research findings as well as the clinical aspects now in use for selectively separating subpopulations of cells from bone marrow. It examines a full range of purging processes including transplantation programs, cryopreservation, cell isolation and cell growth, specificity testing and quality control, as well as the development of alternative sources of stem cells, including peripheral blood and cadaveric marrow. It also presents the conditions necessary to optimize graft toxicity and bone marrow transportation and addresses newer techniques of gene probing/processing as well as mechanisms of genetic alteration including electroporation.
Book Synopsis Recent Advances and Future Directions in Bone Marrow Transplantation by : Sigmund J. Baum
Download or read book Recent Advances and Future Directions in Bone Marrow Transplantation written by Sigmund J. Baum and published by Springer. This book was released on 1988 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Siegmund J. Baum It has become a tradition to commence advocated by Leonard Cole) (3). important meetings of this society with At about the same time, Alpen and reminiscence and nostalgia. Bone marrow Baum (4), using a larger mammal, the dog, transplantation, which has a history of only demonstrated that injecting autologous marrow 30 to 40 years, permits this process, since post irradiation would protect lethally some of the early investigators are still with irradiated animals (see Table). Certainly, us. For example, over the past 15 years, we protection was obtained from the cellular have had three symposia in honor of Egon constituents of the bone marrow. Lorenz. As we all know, the team of Lorenz, We undertook to test on dogs the Uphoff and Congdon was involved in the first hypothesis of Gengozian and Makinodum (5) that successful transplantation of syngeneic and increasing the radiation dose will increase allogeneic bone marrow into irradiated immunologic tolerance for allogeneic implants.
Book Synopsis Purging in Bone Marrow Transplantation by : Subhash Chander Gulati
Download or read book Purging in Bone Marrow Transplantation written by Subhash Chander Gulati and published by . This book was released on 1993 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the rationale for the use of haematopoietic stem cell transplantation after high dose cytotoxic therapy. Gulatis describes methods for ex-vivo elimination (purging) of stem cells, with emphasis on preclinical investigations and how to evaluate the clinical benefit. He also presents methods for eliminating T-cells in patients undergoing allogeneic BMT. Information related to complication of purging haematopoietic stem cell transplantations and unresolved issues that need further study are discussed.
Book Synopsis Processing of Bone Marrow for Transplantation by : Ronald A. Sacher
Download or read book Processing of Bone Marrow for Transplantation written by Ronald A. Sacher and published by . This book was released on 1990 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress in Bone Marrow Transplantation by : Robert Peter Gale
Download or read book Progress in Bone Marrow Transplantation written by Robert Peter Gale and published by . This book was released on 1987 with total page 1056 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in Bone Marrow Transplantation by : Robert Peter Gale
Download or read book Recent Advances in Bone Marrow Transplantation written by Robert Peter Gale and published by . This book was released on 1983 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1990 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Red Cell Transfusion by : Marion E. Reid
Download or read book Red Cell Transfusion written by Marion E. Reid and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative experts in transfusion medicine describe in critical detail the most important procedures for obtaining, selecting, and transfusing red blood cells to patients. The topics covered include such key issues as transfusion problems in the immunocompromised, the complications of autoantibodies, transfusion of infants with hemolytic disease, difficulties arising from solid organ transplantation, stem cell transfusions, and the challenges of massive transfusion. Also discussed are the use, limitations, and alternatives to autogeneic cells; long-term red cell transfusion; the management of adverse reactions to red cell transfusions; and the question of blood group antigens and their association with disease and differential diagnosis. The book offers transfusion specialists fresh insights and information to maximize and extend their current knowledge.
Book Synopsis Bone Marrow Transplantation by : Richard K. Burt
Download or read book Bone Marrow Transplantation written by Richard K. Burt and published by CRC Press. This book was released on 1998-01-01 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is a therapeutic manual designed as a quick, practical guide and reference for house officers, fellows, pharmacists and nurses on the bone marrow transplant unit. Indications, complications, drug doses and approaches to clinical management problems are emphasized. Diseases requiring bone marrow transplants are reviewed along with pati
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 1628 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cell Therapy written by George Morstyn and published by Cambridge University Press. This book was released on 1996-03-29 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.
Book Synopsis Blood Stem Cell Transplantation by : Jane N. Winter
Download or read book Blood Stem Cell Transplantation written by Jane N. Winter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Stem Cell Transplantation conveys the excitement that accompanies the newest developments in hematopoietic stem cell transplantation. Some of the applications that stand to impact this field most significantly are based on recent advances in the biological sciences, as demonstrated by the chapters on gene therapy, on the detection of minimal residual disease using molecular techniques, and on the use of radioimmunoconjugates targeting lymphoma and leukemia-associated antigens. Others are the results of clinical observations - e.g., the association between graft-versus-host- disease (GVHD) and durable remissions that have led to creative clinical experiments such as donor leukocyte infusions (DLI). Attempts to unravel the biological events that underlie the responses seen in patients with relapsed chronic myelogenous leukemia treated with DLI are likely to provide the basis for future refinements in this clinical approach. Hopefully, improved response rates and reduced toxicity will result. The power of the immunologic response in controlling malignant disease is underscored in the chapter on post-transplant immunotherapy. The complex immunologic process that results in clinical GVHD may be dissected and engineered to provide clinical benefits that include, in addition to its antineoplastic effects, the amelioration of its clinical manifestations. Better control of GVHD with less global immunosuppression will facilitate the use of mismatched and unrelated donors. This area of investigation perfectly illustrates the continued interplay between the laboratory and the clinic. The continued cross-fertilization of ideas between immunologists, molecular biologists and clinical investigators is likely to yield important advances in this field for years to come. Possible applications of stem cell transplantation continue to grow with the identification of alternative sources of stem cells and the potential to engineer and/or expand the graft. Although the use of unrelated and mismatched donors continues to increase, the possibilities associated with umbilical cord blood transplantation are legion, especially if stem cells can be expanded ex vivo to provide grafts for full-sized adults. Using techniques in which contaminating malignant cells may be eliminated from autografts through positive selection, autologous transplantation may prove highly effective, especially when coupled with post-transplant immunotherapy. Some of these same methodologies have helped facilitate the use of autologous grafts for transplantation in patients with chronic myelogenous leukemia without allogeneic donors. Advances in the supportive care of transplant patients, including the pretransplant identification of those at risk from pulmonary complications and the use of cytokines to speed engraftment, have reduced morbidity and mortality to such a degree that it is appropriate to consider high-dose therapy and stem cell reconstitution in patients with nonmalignant diseases. The impressive advances that have occurred in transplantation for thalassemia are described by pioneers in their area of investigation. The burgeoning field of transplantation for autoimmune disorders, including its immunobiologic basis and soon-to- be-realized clinical potential, is also summarized. Continued progress in the use of high-dose therapy with stem cell rescue for the treatment of pediatric tumors, which derives in part from improved supportive care, is detailed. The sobering voice of the health care economists underscores the necessary limitations to our seemingly unbridled imagination. Cost- consciousness and financial know-how will need to be reflected in future study designs. Given the seemingly endless applications of our technology, strategies to insure its cost-effectiveness will be necessary. Continued financial support for laboratory investigation and for the clinical experiments they generate will be required if we are to go forward. Blood Stem Cell Transplantation lays the foundation for many of these future advances; it is incumbent upon us all to insure its realization.
Book Synopsis Etiology of Breast and Gynecological Cancers by : C. Marcelo Aldaz
Download or read book Etiology of Breast and Gynecological Cancers written by C. Marcelo Aldaz and published by John Wiley & Sons. This book was released on 1997-03-21 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29–December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including: recent advances in the molecular genetics of hereditary breast and ovarian cancer molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia genotoxicity of environmental agents in human mammary epithelial cells rodent model of reproductive tract leiomyomata estrogens and the genetic control of tumor growth Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.
Book Synopsis Cell Separation Methods and Applications by : Diether Recktenwald
Download or read book Cell Separation Methods and Applications written by Diether Recktenwald and published by CRC Press. This book was released on 1997-11-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Offers complete coverage and assessment of cell separation technologies for analytical and preparative isolations of biological cell populations-demonstrating how to select and devise optimal sorting strategies for applications in biochemistry, immunology, cell and molecular biology, and clinical research. "
