Advanced Chemical Biology

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Advanced Chemical Biology

Author : Howard C. Hang
Publisher : John Wiley & Sons
ISBN 13 : 352734733X
Total Pages : 806 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Advanced Chemical Biology by : Howard C. Hang

Download or read book Advanced Chemical Biology written by Howard C. Hang and published by John Wiley & Sons. This book was released on 2023-04-03 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Chemical Biology The modern approach to teaching chemical biology Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like: DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. With a Foreword by Nobel Laureate Carolyn Bertozzi.

The Chemical Biology of Plant Biostimulants

Author : Danny Geelen
Publisher : John Wiley & Sons
ISBN 13 : 1119357195
Total Pages : 323 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis The Chemical Biology of Plant Biostimulants by : Danny Geelen

Download or read book The Chemical Biology of Plant Biostimulants written by Danny Geelen and published by John Wiley & Sons. This book was released on 2020-04-06 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to the chemical biology of plant biostimulants This book brings together different aspects of biostimulants, providing an overview of the variety of materials exploited as biostimulants, their biological activity, and agricultural applications. As different groups of biostimulants display different bioactivity and specificity, advances in biostimulant research is illustrated by different examples of biostimulants, such as humic substance, seaweed extracts, and substances with hormone-like activities. The book also reports on methods used to screen for new biostimulant compounds by exploring natural sources. Combining the expertise of internationally-renowned scientists and entrepreneurs in the area of biostimulants and biofertilisers, The Chemical Biology of Plant Biostimulants offers in-depth chapters that look at: agricultural functions and action mechanisms of plant biostimulants (PBs); plant biostimulants from seaweed; seaweed carbohydrates; and the possible role for electron shuttling capacity in elicitation of PB activity of humic substances on plant growth enhancement. The subject of auxins is covered next, followed closely by a chapter on plant biostimulants in vermicomposts. Other topics include: exploring natural resources for biostimulants; the impact of biostimulants on whole plant and cellular levels; the impact of PBs on molecular level; and the use of use of plant metabolites to mitigate stress effects in crops. Provides an insightful introduction to the subject of biostimulants Discusses biostimulant modes of actions Covers microbial biostimulatory activities and biostimulant application strategies Offers unique and varied perspectives on the subject by a team of international contributors Features summaries of publications on biostimulants and biostimulant activity The Chemical Biology of Plant Biostimulants will appeal to a wide range of readers, including scientists and agricultural practitioners looking for more knowledge about the development and application of biostimulants.

Essentials of Chemical Biology

Author : Andrew D. Miller
Publisher : John Wiley & Sons
ISBN 13 : 1118687833
Total Pages : 620 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Essentials of Chemical Biology by : Andrew D. Miller

Download or read book Essentials of Chemical Biology written by Andrew D. Miller and published by John Wiley & Sons. This book was released on 2013-05-03 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.

Introduction to Bioorganic Chemistry and Chemical Biology

Author : David Van Vranken
Publisher : Garland Science
ISBN 13 : 1135054827
Total Pages : 504 pages
Book Rating : 4.1/5 (35 download)

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Book Synopsis Introduction to Bioorganic Chemistry and Chemical Biology by : David Van Vranken

Download or read book Introduction to Bioorganic Chemistry and Chemical Biology written by David Van Vranken and published by Garland Science. This book was released on 2018-10-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Current Protocols in Chemical Biology

Author : Adam P. Arkin
Publisher : Wiley-Blackwell
ISBN 13 : 9780470559260
Total Pages : 0 pages
Book Rating : 4.5/5 (592 download)

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Book Synopsis Current Protocols in Chemical Biology by : Adam P. Arkin

Download or read book Current Protocols in Chemical Biology written by Adam P. Arkin and published by Wiley-Blackwell. This book was released on 2009-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chemical Biology of Nucleic Acids

Author : Günter Mayer
Publisher : John Wiley & Sons
ISBN 13 : 1119957265
Total Pages : 595 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis The Chemical Biology of Nucleic Acids by : Günter Mayer

Download or read book The Chemical Biology of Nucleic Acids written by Günter Mayer and published by John Wiley & Sons. This book was released on 2011-06-17 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

The Chemical Biology of Human Vitamins

Author : Christopher Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014642
Total Pages : 462 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis The Chemical Biology of Human Vitamins by : Christopher Walsh

Download or read book The Chemical Biology of Human Vitamins written by Christopher Walsh and published by Royal Society of Chemistry. This book was released on 2019 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a thorough chemocentric view on the key small molecules of life, the human vitamins and their active coenzyme forms.

Protein Degradation with New Chemical Modalities

Author : Hilmar Weinmann
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160772
Total Pages : 382 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Protein Degradation with New Chemical Modalities by : Hilmar Weinmann

Download or read book Protein Degradation with New Chemical Modalities written by Hilmar Weinmann and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Chemistry and Chemical Biology

Author : Roman Joswik
Publisher : CRC Press
ISBN 13 : 1482246619
Total Pages : 303 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Chemistry and Chemical Biology by : Roman Joswik

Download or read book Chemistry and Chemical Biology written by Roman Joswik and published by CRC Press. This book was released on 2014-09-19 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important volume highlights the latest developments and trends in chemistry, biochemistry, and biology. It presents the developments of advanced materials and respective tools to characterize and predict the material properties and behavior. The book provides original, theoretical, and important experimental results that use non-routine method

Biotherapeutics

Author : Lyn Jones
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737150
Total Pages : 331 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Biotherapeutics by : Lyn Jones

Download or read book Biotherapeutics written by Lyn Jones and published by Royal Society of Chemistry. This book was released on 2013-09-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text highlights recent developments from these disciplines that have delivered drugs, clinical candidates or significantly advanced biotherapeutic approaches. Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area, by explaining and describing the chemical biology technologies that underpin specific therapeutic advances and demonstrating the unique value of molecular design and understanding. Covering topics such as selective protein modification, immunopharmacotherapy, chemically programmed vaccinations, nanobodies and antibodies, this book provides essential reading for medicinal and pharmaceutical chemists working in both industry and academia.

Chemical Biology of Natural Products

Author : David J. Newman
Publisher : CRC Press
ISBN 13 : 1351643282
Total Pages : 650 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Chemical Biology of Natural Products by : David J. Newman

Download or read book Chemical Biology of Natural Products written by David J. Newman and published by CRC Press. This book was released on 2017-09-22 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Chemical Biology

Author : Natanya Civjan
Publisher : John Wiley & Sons
ISBN 13 : 1118434501
Total Pages : 657 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Chemical Biology by : Natanya Civjan

Download or read book Chemical Biology written by Natanya Civjan and published by John Wiley & Sons. This book was released on 2012-08-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Nucleic Acids in Chemistry and Biology

Author : G Michael Blackburn
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625771
Total Pages : 503 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Fluorine in Medicinal Chemistry and Chemical Biology

Author : Iwao Ojima
Publisher : John Wiley & Sons
ISBN 13 : 9780470744086
Total Pages : 640 pages
Book Rating : 4.7/5 (44 download)

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Book Synopsis Fluorine in Medicinal Chemistry and Chemical Biology by : Iwao Ojima

Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Industrialization of Biology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309316553
Total Pages : 158 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Industrialization of Biology by : National Research Council

Download or read book Industrialization of Biology written by National Research Council and published by National Academies Press. This book was released on 2015-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.

Chemical Biology of the Genome

Author : Siddhartha Roy
Publisher : Academic Press
ISBN 13 : 0128176458
Total Pages : 352 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chemical Biology of the Genome by : Siddhartha Roy

Download or read book Chemical Biology of the Genome written by Siddhartha Roy and published by Academic Press. This book was released on 2021-05-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. - Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts - Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics - Highlights innovative pathways and molecular targets for new disease study and drug discovery

Materials in Biology and Medicine

Author : Sunggyu Lee
Publisher : CRC Press
ISBN 13 : 1439881707
Total Pages : 253 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Materials in Biology and Medicine by : Sunggyu Lee

Download or read book Materials in Biology and Medicine written by Sunggyu Lee and published by CRC Press. This book was released on 2012-03-21 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the interdisciplinary field of materials science and engineering is relatively new, remarkable developments in materials have emerged for biological and medical applications, from biocompatible polymers in medical devices to the use of carbon nanotubes as drug delivery vehicles. Exploring these materials and applications, Materials in Biology