Adenoviruses: Model and Vectors in Virus-Host Interactions

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Publisher : Springer Science & Business Media
ISBN 13 : 366205597X
Total Pages : 453 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Adenoviruses: Model and Vectors in Virus-Host Interactions by : Walter Doerfler

Download or read book Adenoviruses: Model and Vectors in Virus-Host Interactions written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.

Adenoviruses: Model and Vectors in Virus-Host Interactions

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3662055996
Total Pages : 369 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Adenoviruses: Model and Vectors in Virus-Host Interactions by : Walter Doerfler

Download or read book Adenoviruses: Model and Vectors in Virus-Host Interactions written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.

Adenoviruses

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Publisher :
ISBN 13 : 9783662056004
Total Pages : 384 pages
Book Rating : 4.0/5 (56 download)

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Book Synopsis Adenoviruses by : Walter Doerfler

Download or read book Adenoviruses written by Walter Doerfler and published by . This book was released on 2014-01-15 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adenoviruses: Model and Vectors in Virus-Host Interactions

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Author :
Publisher : Springer
ISBN 13 : 9783540068518
Total Pages : 368 pages
Book Rating : 4.0/5 (685 download)

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Book Synopsis Adenoviruses: Model and Vectors in Virus-Host Interactions by : Walter Doerfler

Download or read book Adenoviruses: Model and Vectors in Virus-Host Interactions written by Walter Doerfler and published by Springer. This book was released on 2003-09-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.

Adenovirus Methods and Protocols

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Publisher : Springer Science & Business Media
ISBN 13 : 1597452777
Total Pages : 738 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Adenovirus Methods and Protocols by : William S. M. Wold

Download or read book Adenovirus Methods and Protocols written by William S. M. Wold and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. The protocols presented are written by trendsetting researchers.

Adenoviral Vectors for Gene Therapy

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Author :
Publisher : Academic Press
ISBN 13 : 0128005106
Total Pages : 870 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel

Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Human Adenoviruses: From Villains To Vectors

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Author :
Publisher : World Scientific
ISBN 13 : 9813109815
Total Pages : 416 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Human Adenoviruses: From Villains To Vectors by : Flint S Jane

Download or read book Human Adenoviruses: From Villains To Vectors written by Flint S Jane and published by World Scientific. This book was released on 2016-12-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered. Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.

Adenovirus Methods and Protocols

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Publisher : Springer Science & Business Media
ISBN 13 : 1597451665
Total Pages : 246 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Adenovirus Methods and Protocols by : William S. M. Wold

Download or read book Adenovirus Methods and Protocols written by William S. M. Wold and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.

Virus Host Interactions of Ovine Adenovirus Type 7, a Novel Gene Transfer Vector

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Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (723 download)

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Book Synopsis Virus Host Interactions of Ovine Adenovirus Type 7, a Novel Gene Transfer Vector by : Daniel Kümin

Download or read book Virus Host Interactions of Ovine Adenovirus Type 7, a Novel Gene Transfer Vector written by Daniel Kümin and published by . This book was released on 2003 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adenovirus

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Publisher : Humana
ISBN 13 : 9781493963256
Total Pages : 0 pages
Book Rating : 4.9/5 (632 download)

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Book Synopsis Adenovirus by : Miguel Chillón

Download or read book Adenovirus written by Miguel Chillón and published by Humana. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the development of powerful new tools and high-throughput methods to analyze adenoviral particles and their interactions with host cells, the third edition of Adenovirus Methods and Protocols calls upon experts in the field to convey advances in molecular biology, genomics and proteomics, imaging, and bioinformatics. Beginning with cryo-electron microscopy, atomic force microscopy, and mass spectrometry for a high resolution image and characterization of the virion, this detailed book then continues with capsid modifications and viral-like particles as promising alternatives to classical adenovirus vectors, and the study of adenovirus in host interactions in vitro at the cellular level as well as in vivo in animal models. Finally, the volume concludes with an extensive update of the most efficient protocols to generate, amplify, and/or purify, at small and large scale, standard human Ad5 as well as non-human, chimeric, and helper-dependent adenovirus vectors. Written in the greatly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adenovirus Methods and Protocols, Third Edition serves as an ideal guide for scientists continuing to research this highly valuable viral tool.

Adenovirus and VSV

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Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (429 download)

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Book Synopsis Adenovirus and VSV by : Peter Schache

Download or read book Adenovirus and VSV written by Peter Schache and published by . This book was released on 2009 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Molecular Biology of Adenoviruses I

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Publisher : Springer Science & Business Media
ISBN 13 : 3642694608
Total Pages : 240 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis The Molecular Biology of Adenoviruses I by : W. Doerfler

Download or read book The Molecular Biology of Adenoviruses I written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.

Adeno-Associated Virus (AAV) Vectors in Gene Therapy

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Publisher : Springer Science & Business Media
ISBN 13 : 3642802079
Total Pages : 179 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Adeno-Associated Virus (AAV) Vectors in Gene Therapy by : Kenneth I. Berns

Download or read book Adeno-Associated Virus (AAV) Vectors in Gene Therapy written by Kenneth I. Berns and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).

The Adenoviruses

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Publisher : Springer
ISBN 13 :
Total Pages : 630 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Adenoviruses by : Harold S. Ginsberg

Download or read book The Adenoviruses written by Harold S. Ginsberg and published by Springer. This book was released on 1984-08-31 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .

Viral Gene Techniques

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Author :
Publisher : Elsevier
ISBN 13 : 0080536409
Total Pages : 436 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Viral Gene Techniques by :

Download or read book Viral Gene Techniques written by and published by Elsevier. This book was released on 1995-11-14 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Gene Techniques is a practical laboratory guide to current techniques of molecular biology and genetics. The volume is concerned with methods for the analysis of viral genes and chromosomes: DNA viruses and RNA viruses including HIV are discussed. * Methods presented for ease of use and reasdy adaptation to new systems* Detailed experimental protocols included for:* Viral vectors - construction and use of DNA virus vectors (adenovirus, adeno-associated virus, vaccinia virus, Epstein - Barr virus)* DNA viruses - virus/host interactions, viral chromosomes , transcription regulation (viruses discussed include herpes simplex, hepatitis B, SV40, JC, Epstein-Barr, adenovirus)* Human Immunodeficiency Virus / retroviruses -quantitation of HIV-1 virus stock and RNA, retrovirus reverse transcription / integration, retrovirus-mediated cell fusion, use as cell lineage markers* RNA viruses - RNA virus assembly, analysis of RNA genomes, assays for RNA-binding proteins (viruses discussed include poliovirus, influenza virus, hepatitis delta virus)

Analysis of Adenovirus-host Interactions to Improve Recombinant Adenoviral Vectors for Gene Therapy

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (725 download)

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Book Synopsis Analysis of Adenovirus-host Interactions to Improve Recombinant Adenoviral Vectors for Gene Therapy by : Christina Theresa Rauschhuber

Download or read book Analysis of Adenovirus-host Interactions to Improve Recombinant Adenoviral Vectors for Gene Therapy written by Christina Theresa Rauschhuber and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Adenovirus Fiber and Hexon Proteins in Virus-host Interactions

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Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (237 download)

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Book Synopsis The Role of Adenovirus Fiber and Hexon Proteins in Virus-host Interactions by : Jason G. D. Gall

Download or read book The Role of Adenovirus Fiber and Hexon Proteins in Virus-host Interactions written by Jason G. D. Gall and published by . This book was released on 1998 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: