Adenosine Triphosphate In Health And Disease

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Adenosine Triphosphate in Health and Disease

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1838802037
Total Pages : 86 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Adenosine Triphosphate in Health and Disease by :

Download or read book Adenosine Triphosphate in Health and Disease written by and published by BoD – Books on Demand. This book was released on 2019-04-24 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.

Adenosine Triphosphate in Health and Disease

Author : Gyula Mozsik
Publisher :
ISBN 13 : 9781838802042
Total Pages : 84 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis Adenosine Triphosphate in Health and Disease by : Gyula Mozsik

Download or read book Adenosine Triphosphate in Health and Disease written by Gyula Mozsik and published by . This book was released on 2019 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.

Extracellular Atp and Adenosine As Regulators of Endothelial Cell Function

Author : Evgenia Gerasimovskaya
Publisher :
ISBN 13 : 9789048134519
Total Pages : 250 pages
Book Rating : 4.1/5 (345 download)

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Book Synopsis Extracellular Atp and Adenosine As Regulators of Endothelial Cell Function by : Evgenia Gerasimovskaya

Download or read book Extracellular Atp and Adenosine As Regulators of Endothelial Cell Function written by Evgenia Gerasimovskaya and published by . This book was released on 2010-11-20 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular ATP and adenosine as regulators of endothelial cell function

Author : Evgenia Gerasimovskaya
Publisher : Springer Science & Business Media
ISBN 13 : 9048134358
Total Pages : 240 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Extracellular ATP and adenosine as regulators of endothelial cell function by : Evgenia Gerasimovskaya

Download or read book Extracellular ATP and adenosine as regulators of endothelial cell function written by Evgenia Gerasimovskaya and published by Springer Science & Business Media. This book was released on 2010-04-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.

Purinergic Signaling in Health and Disease

Author : Eric Boué-Grabot
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Purinergic Signaling in Health and Disease by : Eric Boué-Grabot

Download or read book Purinergic Signaling in Health and Disease written by Eric Boué-Grabot and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenosine 5'-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy "currency." After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia.

Phosphate Metabolism

Author : Shaul Massry
Publisher : Springer Science & Business Media
ISBN 13 : 1461342171
Total Pages : 611 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Phosphate Metabolism by : Shaul Massry

Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

ATP-gated P2X receptors in health and disease

Author : Andrea Nistri
Publisher : Frontiers Media SA
ISBN 13 : 2889194051
Total Pages : 173 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis ATP-gated P2X receptors in health and disease by : Andrea Nistri

Download or read book ATP-gated P2X receptors in health and disease written by Andrea Nistri and published by Frontiers Media SA. This book was released on 2015-01-05 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.

Adenosine Receptors in Health and Disease

Author : Constance N. Wilson
Publisher : Springer Science & Business Media
ISBN 13 : 3540896155
Total Pages : 656 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Adenosine Receptors in Health and Disease by : Constance N. Wilson

Download or read book Adenosine Receptors in Health and Disease written by Constance N. Wilson and published by Springer Science & Business Media. This book was released on 2009-07-28 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Nutrition in Health and Disease

Author : Gyula Mozsik
Publisher : BoD – Books on Demand
ISBN 13 : 1789840074
Total Pages : 246 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Nutrition in Health and Disease by : Gyula Mozsik

Download or read book Nutrition in Health and Disease written by Gyula Mozsik and published by BoD – Books on Demand. This book was released on 2019-10-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with very different aspects of nutrition from different countries (qualities and quantities of food, their absorptions from the gastrointestinal tract, utilization in healthy human beings or in patients with different diseases, food and drug interactions, etc.). However, these different nutritional positions are different in the different countries. The 13 chapters were written by experts from countries in four continents (Asia, Africa, America, and Europe) and generally cover one nutritional problem each; however, if we analyze the results of all the chapters, we can see the most important nutritional problems from all over the world. This detailed analysis offers us an overview of this most urgent nutritional problem.We know that the world's population has increased exponentially in the last few decades (and is still increasing); however, foods and food products have increased more slowly. We have to solve these and other nutritional problems to ensure the health of generations to come.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Biochemistry

Author : David E. Metzler
Publisher : Elsevier
ISBN 13 : 0080924719
Total Pages : 1063 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Biochemistry by : David E. Metzler

Download or read book Biochemistry written by David E. Metzler and published by Elsevier. This book was released on 2003-05-04 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest

The Sinatra Solution

Author : Stephen T. Sinatra
Publisher : Basic Health Publications, Inc.
ISBN 13 : 9781591202165
Total Pages : 276 pages
Book Rating : 4.2/5 (21 download)

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Book Synopsis The Sinatra Solution by : Stephen T. Sinatra

Download or read book The Sinatra Solution written by Stephen T. Sinatra and published by Basic Health Publications, Inc.. This book was released on 2007-10 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.

Adipose Tissue in Health and Disease

Author : Todd Leff
Publisher : John Wiley & Sons
ISBN 13 : 9783527629534
Total Pages : 530 pages
Book Rating : 4.6/5 (295 download)

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Book Synopsis Adipose Tissue in Health and Disease by : Todd Leff

Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Functional Biochemistry in Health and Disease

Author : Eric Newsholme
Publisher : John Wiley & Sons
ISBN 13 : 1119965241
Total Pages : 564 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Functional Biochemistry in Health and Disease by : Eric Newsholme

Download or read book Functional Biochemistry in Health and Disease written by Eric Newsholme and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice. Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding. * Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective. * Clear presentation that minimises the use of jargon. * Each chapter contains boxes on related topics, relevant diagrams and a brief glossary. * Coverage includes athletic performance, apoptosis and the immune system. * Key historical developments are included to show how modern biochemistry has evolved. By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry.

Clinical Mitochondrial Medicine

Author : Patrick F. Chinnery
Publisher : Cambridge University Press
ISBN 13 : 0521132983
Total Pages : 229 pages
Book Rating : 4.5/5 (211 download)

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Book Synopsis Clinical Mitochondrial Medicine by : Patrick F. Chinnery

Download or read book Clinical Mitochondrial Medicine written by Patrick F. Chinnery and published by Cambridge University Press. This book was released on 2018-05-17 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.