Adaptive Designs

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Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Author : Gernot Wassmer
Publisher : Springer
ISBN 13 : 3319325620
Total Pages : 310 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Group Sequential and Confirmatory Adaptive Designs in Clinical Trials by : Gernot Wassmer

Download or read book Group Sequential and Confirmatory Adaptive Designs in Clinical Trials written by Gernot Wassmer and published by Springer. This book was released on 2016-07-04 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application. The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.

Randomised Response-Adaptive Designs in Clinical Trials

Author : Anthony C Atkinson
Publisher : CRC Press
ISBN 13 : 1584886935
Total Pages : 341 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Randomised Response-Adaptive Designs in Clinical Trials by : Anthony C Atkinson

Download or read book Randomised Response-Adaptive Designs in Clinical Trials written by Anthony C Atkinson and published by CRC Press. This book was released on 2013-12-26 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

Adaptive Design Methods in Clinical Trials

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 1439839883
Total Pages : 368 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Adaptive Design Methods in Clinical Trials by : Shein-Chung Chow

Download or read book Adaptive Design Methods in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2011-12-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

Author : Annpey Pong
Publisher : CRC Press
ISBN 13 : 9781439810170
Total Pages : 496 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Handbook of Adaptive Designs in Pharmaceutical and Clinical Development by : Annpey Pong

Download or read book Handbook of Adaptive Designs in Pharmaceutical and Clinical Development written by Annpey Pong and published by CRC Press. This book was released on 2016-04-19 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip

Adaptive Web Design

Author : Aaron Gustafson
Publisher : New Riders
ISBN 13 : 0134216202
Total Pages : 385 pages
Book Rating : 4.1/5 (342 download)

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Book Synopsis Adaptive Web Design by : Aaron Gustafson

Download or read book Adaptive Web Design written by Aaron Gustafson and published by New Riders. This book was released on 2015-11-21 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building an elegant, functional website requires more than just knowing how to code. In Adaptive Web Design, Second Edition, you’ll learn how to use progressive enhancement to build websites that work anywhere, won’t break, are accessible by anyone—on any device—and are designed to work well into the future. This new edition of Adaptive Web Design frames even more of the web design process in the lens of progressive enhancement. You will learn how content strategy, UX, HTML, CSS, responsive web design, JavaScript, server-side programming, and performance optimization all come together in the service of users on whatever device they happen to use to access the web. Understanding progressive enhancement will make you a better web professional, whether you’re a content strategist, information architect, UX designer, visual designer, front-end developer, back-end developer, or project manager. It will enable you to visualize experience as a continuum and craft interfaces that are capable of reaching more users while simultaneously costing less money to develop. When you’ve mastered the tenets and concepts of this book, you will see the web in a whole new way and gain web design superpowers that will make you invaluable to your employer, clients, and the web as a whole. Visit http://adaptivewebdesign.info to learn more.

Adaptive Survey Design

Author : Barry Schouten
Publisher : CRC Press
ISBN 13 : 1498767885
Total Pages : 267 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Adaptive Survey Design by : Barry Schouten

Download or read book Adaptive Survey Design written by Barry Schouten and published by CRC Press. This book was released on 2017-07-28 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive survey designs (ASDs) provide a framework for data-driven tailoring of data collection procedures to different sample members, often for cost and bias reduction. People vary in how likely they are to respond and in how they respond. This variation leads to opportunities to selectively deploy design features in order to control both nonresponse and measurement errors. ASD aims at the optimal matching of design features and the characteristics of respondents given the survey budget. Such a goal is sensible, but ASD requires investment in more advanced technical systems and management infrastructure and asks for the collection of relevant auxiliary data. So what are current best practices in ASD? And is ASD worthwhile when the same auxiliary data are employed in the estimation afterwards? In this book, the authors provide answers to these questions, and much more.

Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio

Author : Mark Chang
Publisher : John Wiley & Sons
ISBN 13 : 0470438568
Total Pages : 284 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio by : Mark Chang

Download or read book Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio written by Mark Chang and published by John Wiley & Sons. This book was released on 2010-06-15 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations, Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio: Covers both classical and adaptive clinical trial designs, monitoring, and analyses Explains various classical and adaptive designs including groupsequential, sample-size reestimation, dropping-loser, biomarker-adaptive, and response-adaptive randomization designs Includes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examples Emphasizes applications, yet covers key mathematical formulations Introduces readers to additional toolkits in ExpDesign Studio that help in designing, monitoring, and analyzing trials, such as the adaptive monitor, graphical calculator, the probability calculator, the confidence interval calculator, and more Presents comprehensive technique notes for sample-size calculation methods, grouped by the number of arms, the trial endpoint, and the analysis basis Written with practitioners in mind, this is an ideal self-study guide for not only statisticians, but also scientists, researchers, and professionals in the pharmaceutical industry, contract research organizations (CROs), and regulatory bodies. It's also a go-to reference for biostatisticians, pharmacokinetic specialists, and principal investigators involved in clinical trials. ERRATUM Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio By Mark Chang The license for the ExpDesign Studio software on the CD included with this book is good for one-year after installation of the software. Prior to the expiration of this period, the software will generate a reminder about renewal for the license. The user should contact CTriSoft International (the owners of ExpDesign Studio) at www.CTriSoft.net or by email at [email protected], about renewal for the license. This should have been made clear in the first printing of this book. We apologize for this error.

Climate-Resilient Infrastructure

Author : Committee on Adaptation to a Changing Climate
Publisher :
ISBN 13 : 9781523125821
Total Pages : pages
Book Rating : 4.1/5 (258 download)

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Book Synopsis Climate-Resilient Infrastructure by : Committee on Adaptation to a Changing Climate

Download or read book Climate-Resilient Infrastructure written by Committee on Adaptation to a Changing Climate and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Prepared by the Committee on Adaptation to a Changing Climate of ASCE Civil infrastructure systems traditionally have been designed for appropriate functionality, durability, and safety for climate and weather extremes during their full-service lives; however, climate scientists inform us that the extremes of climate and weather have altered from historical values in ways difficult to predict or project. Climate-Resilient Infrastructure: Adaptive Design and Risk Management, MOP 140, provides guidance for and contributes to the developing or enhancing of methods for infrastructure analysis and design in a world in which risk profiles are changing and can be projected with varying degrees of uncertainty requiring a new design philosophy to meet this challenge. The underlying approaches in this manual of practice (MOP) are based on probabilistic methods for quantitative risk analysis, and the design framework provided focuses on identifying and analyzing low-regret, adaptive strategies to make a project more resilient. Beginning with an overview of the driving forces and hazards associated with a changing climate, subsequent chapters in MOP 140 provide observational methods, illustrative examples, and case studies; estimation of extreme events particularly related to precipitation with guidance on monitoring and measuring methods; flood design criteria and the development of project design flood elevations; computational methods of determining flood loads; adaptive design and adaptive risk management in the context of life-cycle engineering and economics; and climate resilience technologies. MOP 140 will be of interest to engineers, researchers, planners, and other stakeholders charged with adaptive design decisions to achieve infrastructure resilience targets while minimizing life-cycle costs in a changing climate

Clinical Trial Design

Author : Guosheng Yin
Publisher : John Wiley & Sons
ISBN 13 : 1118183320
Total Pages : 368 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Clinical Trial Design by : Guosheng Yin

Download or read book Clinical Trial Design written by Guosheng Yin and published by John Wiley & Sons. This book was released on 2013-06-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Adaptive Control Design and Analysis

Author : Gang Tao
Publisher : John Wiley & Sons
ISBN 13 : 9780471274520
Total Pages : 652 pages
Book Rating : 4.2/5 (745 download)

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Book Synopsis Adaptive Control Design and Analysis by : Gang Tao

Download or read book Adaptive Control Design and Analysis written by Gang Tao and published by John Wiley & Sons. This book was released on 2003-07-09 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: A systematic and unified presentation of the fundamentals of adaptive control theory in both continuous time and discrete time Today, adaptive control theory has grown to be a rigorous and mature discipline. As the advantages of adaptive systems for developing advanced applications grow apparent, adaptive control is becoming more popular in many fields of engineering and science. Using a simple, balanced, and harmonious style, this book provides a convenient introduction to the subject and improves one's understanding of adaptive control theory. Adaptive Control Design and Analysis features: Introduction to systems and control Stability, operator norms, and signal convergence Adaptive parameter estimation State feedback adaptive control designs Parametrization of state observers for adaptive control Unified continuous and discrete-time adaptive control L1+a robustness theory for adaptive systems Direct and indirect adaptive control designs Benchmark comparison study of adaptive control designs Multivariate adaptive control Nonlinear adaptive control Adaptive compensation of actuator nonlinearities End-of-chapter discussion, problems, and advanced topics As either a textbook or reference, this self-contained tutorial of adaptive control design and analysis is ideal for practicing engineers, researchers, and graduate students alike.

Bayesian Adaptive Methods for Clinical Trials

Author : Scott M. Berry
Publisher : CRC Press
ISBN 13 : 1439825513
Total Pages : 316 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bayesian Adaptive Methods for Clinical Trials by : Scott M. Berry

Download or read book Bayesian Adaptive Methods for Clinical Trials written by Scott M. Berry and published by CRC Press. This book was released on 2010-07-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti

Adaptive Design Methods in Clinical Trials

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 158488777X
Total Pages : 296 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Adaptive Design Methods in Clinical Trials by : Shein-Chung Chow

Download or read book Adaptive Design Methods in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2006-11-16 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures

Adaptive Designs for Sequential Treatment Allocation

Author : Alessandro Baldi Antognini
Publisher : CRC Press
ISBN 13 : 1466505761
Total Pages : 210 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Adaptive Designs for Sequential Treatment Allocation by : Alessandro Baldi Antognini

Download or read book Adaptive Designs for Sequential Treatment Allocation written by Alessandro Baldi Antognini and published by CRC Press. This book was released on 2015-04-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way. The authors first introduce the terminology and statistical models most commonly used in comparative experiments. They then illustrate biased coin and urn designs that only take into account past treatment allocations as well as designs that use past data, such as sequential maximum likelihood and various types of doubly adaptive designs. The book also covers multipurpose adaptive experiments involving utilitarian choices and ethical issues. It ends with adaptive methods that include covariates in the design. The appendices present basic tools of optimal design theory and address Bayesian adaptive designs. This book helps readers fully understand the theoretical properties behind various adaptive designs. Readers are then equipped to choose the best design for their experiment.

Adaptive Design Theory and Implementation Using SAS and R

Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1482256606
Total Pages : 689 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Adaptive Design Theory and Implementation Using SAS and R by : Mark Chang

Download or read book Adaptive Design Theory and Implementation Using SAS and R written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the

Introductory Adaptive Trial Designs

Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1498717470
Total Pages : 226 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Introductory Adaptive Trial Designs by : Mark Chang

Download or read book Introductory Adaptive Trial Designs written by Mark Chang and published by CRC Press. This book was released on 2015-05-21 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the Essentials to Start Using Adaptive Designs in No TimeCompared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time. Introductory Adaptive Trial Designs: A Practical Guide with R motivates newcomers to quickly and easily grasp the essence of adaptive desig

Adaptive Code

Author : Gary McLean Hall
Publisher : Microsoft Press
ISBN 13 : 1509302611
Total Pages : 854 pages
Book Rating : 4.5/5 (93 download)

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Book Synopsis Adaptive Code by : Gary McLean Hall

Download or read book Adaptive Code written by Gary McLean Hall and published by Microsoft Press. This book was released on 2017-04-18 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Write code that can adapt to changes. By applying this book’s principles, you can create code that accommodates new requirements and unforeseen scenarios without significant rewrites. Gary McLean Hall describes Agile best practices, principles, and patterns for designing and writing code that can evolve more quickly and easily, with fewer errors, because it doesn’t impede change. Now revised, updated, and expanded, Adaptive Code, Second Edition adds indispensable practical insights on Kanban, dependency inversion, and creating reusable abstractions. Drawing on over a decade of Agile consulting and development experience, McLean Hall has updated his best-seller with deeper coverage of unit testing, refactoring, pure dependency injection, and more. Master powerful new ways to: • Write code that enables and complements Scrum, Kanban, or any other Agile framework • Develop code that can survive major changes in requirements • Plan for adaptability by using dependencies, layering, interfaces, and design patterns • Perform unit testing and refactoring in tandem, gaining more value from both • Use the “golden master” technique to make legacy code adaptive • Build SOLID code with single-responsibility, open/closed, and Liskov substitution principles • Create smaller interfaces to support more-diverse client and architectural needs • Leverage dependency injection best practices to improve code adaptability • Apply dependency inversion with the Stairway pattern, and avoid related anti-patterns About You This book is for programmers of all skill levels seeking more-practical insight into design patterns, SOLID principles, unit testing, refactoring, and related topics. Most readers will have programmed in C#, Java, C++, or similar object-oriented languages, and will be familiar with core procedural programming techniques.

The Adaptive Design of the Human Psyche

Author : Malcolm Owen Slavin
Publisher : Guilford Press
ISBN 13 : 9780898627954
Total Pages : 360 pages
Book Rating : 4.6/5 (279 download)

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Book Synopsis The Adaptive Design of the Human Psyche by : Malcolm Owen Slavin

Download or read book The Adaptive Design of the Human Psyche written by Malcolm Owen Slavin and published by Guilford Press. This book was released on 1992-09-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing one of the most fundamental issues in any examination of human experience, this important new work connects evolutionary biological concepts to modern psychoanalytic theory and the clinical encounter. Synthesizing their years of experience in the practice of psychotherapy and psychoanalysis, the authors provide a comparative psychoanalytic map of current theoretical controversies and a new way of deconstructing the hidden assumptions that underlie Freudian, Ego Psychological, Kleinian, Object Relational, Self Psychological, and Interpersonal theories. In so doing, they provide a new vantage point from which to integrate competing models into a larger picture that more fully embraces the many facets of human nature. Moreover, they offer clinicians a new framework with which to understand and respond to the inevitable paradoxes and conflicts that arise in the therapeutic relationship.