A Toxicologist's Guide to Clinical Pathology in Animals

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Author :
Publisher : Springer
ISBN 13 : 3319158538
Total Pages : 165 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis A Toxicologist's Guide to Clinical Pathology in Animals by : John E. Whalan

Download or read book A Toxicologist's Guide to Clinical Pathology in Animals written by John E. Whalan and published by Springer. This book was released on 2015-03-25 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.

Animal Hematotoxicology

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Publisher : CRC Press
ISBN 13 : 1420080105
Total Pages : 222 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Hematotoxicology by : G.O. Evans

Download or read book Animal Hematotoxicology written by G.O. Evans and published by CRC Press. This book was released on 2008-07-25 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types - erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics fo

A Comprehensive Guide to Toxicology in Preclinical Drug Development

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Author :
Publisher : Academic Press
ISBN 13 : 0123878160
Total Pages : 903 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-10-18 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. - Chapters written by world-renowned contributors who are experts in their fields - Includes the latest research in preclinical drug testing and international guidelines - Covers preclinical toxicology in small molecules and biologics in one single source

Guide for the Care and Use of Laboratory Animals

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Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

A Comprehensive Guide to Toxicology in Preclinical Drug Development

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Author :
Publisher : Academic Press
ISBN 13 : 0123878152
Total Pages : 904 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-11-02 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --

Bone Tumors in Domestic Animals

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Publisher : Springer Nature
ISBN 13 : 3030902102
Total Pages : 206 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Bone Tumors in Domestic Animals by : Leonardo Leonardi

Download or read book Bone Tumors in Domestic Animals written by Leonardo Leonardi and published by Springer Nature. This book was released on 2022-01-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comparatively examines the etiopathogenetic, clinical-pathological, diagnostic and therapeutic strategies of the main bone tumors of domestic animals. The book also includes a description of the most significant aspects of macroscopic, microscopic, immunohistochemical, instrumental, diagnostic imaging and molecular biology aspects of spontaneous bone tumors in Veterinary Medicine, with also interspecies comparative aspects, including the human one. Last but not least, the book provides an overview of the new diagnostic and therapeutic frontiers related to the approach to animal bone tumors. The book serves as essential reading for professionals, researchers and students who work or want to tackle three paths in the field of comparative veterinary bone oncology.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

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Author :
Publisher : Elsevier
ISBN 13 : 0323984622
Total Pages : 1074 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy - Includes the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Pathology for Toxicologists

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Publisher : John Wiley & Sons
ISBN 13 : 1118755308
Total Pages : 214 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Pathology for Toxicologists by : Elizabeth McInnes

Download or read book Pathology for Toxicologists written by Elizabeth McInnes and published by John Wiley & Sons. This book was released on 2017-03-24 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary

Haschek and Rousseaux's Handbook of Toxicologic Pathology

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Publisher : Academic Press
ISBN 13 : 0124157653
Total Pages : 3055 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Haschek and Rousseaux's Handbook of Toxicologic Pathology by : Wanda M Haschek

Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology written by Wanda M Haschek and published by Academic Press. This book was released on 2013-05-01 with total page 3055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. - Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Animal Abuse and Unlawful Killing

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Publisher : Elsevier Health Sciences
ISBN 13 : 070203729X
Total Pages : 121 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Animal Abuse and Unlawful Killing by : Ranald Munro

Download or read book Animal Abuse and Unlawful Killing written by Ranald Munro and published by Elsevier Health Sciences. This book was released on 2008-07-04 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides veterinarians and lawyers through the diverse and complex fields of alleged cruelty to, and unlawful killing of, companion animals, farm livestock and wildlife. It draws together current knowledge on how to approach, investigate and report forensic cases. - Covers all aspects of the forensic post-mortem including cause and time of death - Features the fundamentals of abuse and neglect - Allows rapid access to descriptions of different types of injuries and gives essential guidance on their interpretation - Backed by practical standard operative procedures from world experts to ensure proper and professional case management - High quality, specially selected photographs, a clear writing style and concise presentation informs and encourages the reader towards soundly-based conclusions

Fundamental Neuropathology for Pathologists and Toxicologists

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470227338
Total Pages : 661 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Fundamental Neuropathology for Pathologists and Toxicologists by : Brad Bolon

Download or read book Fundamental Neuropathology for Pathologists and Toxicologists written by Brad Bolon and published by John Wiley & Sons. This book was released on 2011-10-04 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Small Animal Toxicology Essentials

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Publisher : John Wiley & Sons
ISBN 13 : 081381538X
Total Pages : 355 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Small Animal Toxicology Essentials by : Robert H. Poppenga

Download or read book Small Animal Toxicology Essentials written by Robert H. Poppenga and published by John Wiley & Sons. This book was released on 2011-05-31 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a ready reference for the initial triage, collection of diagnostic samples, and management of a poisoning case, Small Animal Toxicology Essentials focuses on the most common poisons encountered by companion animals. From prevention to evaluation, monitoring, and treatment, the book is a guide for veterinary technicians to differentiate between significant and insignificant exposures and effectively manage animal poisonings. Emphasizing clinical signs, differential diagnoses, and case management, the book begins with the principles of veterinary toxicology, such as terminology, history-taking, and decontamination. The second half of the book is devoted to specific toxicants, including plants, metals, drugs, and household poisons. A companion website at www.wiley.com/go/poppenga provides review questions in Word and color images available for download into PowerPoint. Small Animal Toxicology Essentials is a useful resource for veterinary technicians, especially those with a interest in emergency and critical care, and veterinary technician students, as well as practicing veterinarians looking for an introduction to toxicology.

The Clinical Chemistry of Laboratory Animals

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Publisher : CRC Press
ISBN 13 : 142009114X
Total Pages : 1162 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Clinical Chemistry of Laboratory Animals by : David M. Kurtz

Download or read book The Clinical Chemistry of Laboratory Animals written by David M. Kurtz and published by CRC Press. This book was released on 2017-10-18 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.

Clinical Veterinary Toxicology - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323058345
Total Pages : 495 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Clinical Veterinary Toxicology - E-Book by : Konnie Plumlee

Download or read book Clinical Veterinary Toxicology - E-Book written by Konnie Plumlee and published by Elsevier Health Sciences. This book was released on 2003-12-10 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated. Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons. - Most comprehensive toxicology book available - Written in a user-friendly style that makes it easy to master the content - Covers poisonings in both large and small domestic animals - The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information - The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs - The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment - The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information

Veterinary Clinical Pathology

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Publisher :
ISBN 13 :
Total Pages : 1076 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Veterinary Clinical Pathology by :

Download or read book Veterinary Clinical Pathology written by and published by . This book was released on 2008 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal Clinical Chemistry

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Author :
Publisher : CRC Press
ISBN 13 : 1420080121
Total Pages : 360 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Clinical Chemistry by : G.O. Evans

Download or read book Animal Clinical Chemistry written by G.O. Evans and published by CRC Press. This book was released on 2009-04-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: 10+ Years of Updates Since First EditionNewcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Editio

Veterinary Clinical Pathology

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Publisher : John Wiley & Sons
ISBN 13 : 1118710649
Total Pages : 419 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Veterinary Clinical Pathology by : Marion L. Jackson

Download or read book Veterinary Clinical Pathology written by Marion L. Jackson and published by John Wiley & Sons. This book was released on 2013-03-18 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique among current literature as a rich source of clinical case material, this book can be used by veterinary students as a reader-friendly introduction to the subject and as the primary textbook in clinical pathology coursework. With its multitude of cases and images, the book is also a useful resource for faculty members to enhance instruction. Veterinary Clinical Pathology: An Introduction aims to provide the veterinary student with a clear, concise overview of basic mechanisms without being overwhelming. Clinical cases enhance the learning experience. Having evolved from the reading assignments for veterinary medical courses in clinical pathology, this text aids in providing students with a sound knowledge base with which to work. Reader-friendly textbook Features innovative case-based approach Provides clear and concise overview of basic mechanisms Practical text for veterinary students, instructors and clinicians alike Students, instructors, and veterinary clinicians seeking a concise, practical handbook will find Veterinary Clinical Pathology: An Introduction invaluable.