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Author : Amnah Alyaqoub
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)
Download or read book A Structure/function Analysis of Runx Transcription Factor Complex Interactions written by Amnah Alyaqoub and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yoram Groner
Publisher : Springer
ISBN 13 : 9811032335
Total Pages : 518 pages
Book Rating : 4.8/5 (11 download)
Download or read book RUNX Proteins in Development and Cancer written by Yoram Groner and published by Springer. This book was released on 2017-03-15 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
Author : David S. Latchman
Publisher : Academic Press
ISBN 13 : 0080531261
Total Pages : 391 pages
Book Rating : 4.0/5 (85 download)
Download or read book Eukaryotic Transcription Factors written by David S. Latchman and published by Academic Press. This book was released on 2003-11-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo
Author : Timothy R. Hughes
Publisher : Springer Science & Business Media
ISBN 13 : 904819069X
Total Pages : 310 pages
Book Rating : 4.0/5 (481 download)
Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Author : Pierre Martinez
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (799 download)
Download or read book Computational Analysis of Transcription Factor Cooperation and Protein-protein Interaction Structural Features written by Pierre Martinez and published by . This book was released on 2011 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent completion of the 1000 genomes project [44] has opened a new era in comparative biology and has paved the way to more accurate insights in the relationship between genotype and phenotype. Recently published large-scale maps of pair-wise Protein-Protein Interactions (PPI), transcription factor-target interactions (TFTI), three-dimensional structure of Protein complexes and other complementary datasets allow for a detailed understanding of the molecular mechanisms at the basis of protein function. From a theoretical point of view, efficient integration of all these available data will allow for an enriched knowledge of the genotype-phenotype relation [178]. In our study we explore different aspects of PPIs and TFTIs, focusing for PPI particularly on the analysis of their three-dimensional structure, and for TFTIs on over-represented distances between DNA-binding targets and the mapping of this information on com¬plementary data. -- In the analysis of structural properties of PPI, we have focused on properties of backbone hydrogen bonds and their importance in different types of interactions. The wrapping of backbone hydrogen bonds (BHBs) by hydrophobic carboxyl groups has been shown to correlate with protein stability and the number of interactions a given protein family is involved in. We analyzed the behaviour of BHBs in transient and obligate heterodimeric interactions and found interesting differences in the two datasets, suggesting that poorly wrapped BHBs are important for the stability of obligate interactions, while they tend to allow easier conformational changes necessary to transient protein-protein recognition. For the TFTI analysis, our efforts focused on enhancing the knowledge of protein-protein interactions regarding gene regulation in human and mouse.
Author : Thomas Lee Hunsaker
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.:/5 (5 download)
Download or read book Structure/function Analysis of the Neural-specific Basic Helix-loop-helix Transcription Factor Mash1 written by Thomas Lee Hunsaker and published by . This book was released on 2001 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Monique Bastidas
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (927 download)
Download or read book Structural and Functional Characterization of the Transcription Factor Pdx1 and Its Interactions with DNA and Proteins written by Monique Bastidas and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeobox proteins are vital DNA-binding transcription factors that control the spatial and temporal expression of cells and tissue during early development. These proteins are necessary for other biological processes, including the activation of genes. The DNA-binding homeodomain motif of homeobox proteins bind sequence specifically to double stranded DNA containing the core binding site (5 ́-TAAT-3 ́), achieving high specificity in vivo. Our current understanding of the mechanism by which these transcription factors recognize their cognate sites is not clear. Moreover, the homeodomain motif is often a small domain within a larger polypeptide chain tethered to intrinsically disordered domains at one or both termini. Intrinsically disordered proteins (IDPs) play a vital role in maintaining cellular functions. The homeobox transcription factor, Pdx1 is an IDP, important for maintaining proper function of the pancreas and [beta]-cells by recognizing A-box elements (TA-rich sequences containing a 5 ́-TAAT-3 ́core site). The overarching goal of this dissertation was to further the understanding of the mechanism by which homeobox proteins recognize their target sites and bind with high specificity, as well as illuminate the structural and functional role of the disordered C-terminus of Pdx1. Using isothermal titration calorimetry (ITC), it was shown that the homeodomain (HD) of Pdx1 exhibited varying binding affinities for promoter-derived (islet amyloid polypeptide (IAPP) and insulin) and consensus-derived DNA sequences indicating nucleotide sequence discrimination in the flanking regions. The calorimetric data demonstrated that Pdx1 preferentially bound sequence specific insulin elements containing a pentameric DNA sequence (5 ́-CTAAT-3 ́) rather than IAPP elements encompassing a 5 ́-TTAAT-3 ́sequence. Furthermore, binding studies of the HD with a panel of consensus-derived mutants demonstrate a slight preference for an insulin-like 5 ́-CTAAT-3 ́sequence over an IAPP-like 5 ́-TTAAT-3 ́sequence based on a combination of a tighter binding constant and a more favorable binding enthalpy. Molecular dynamics simulations further showed a strictly conserved arginine has preference for the pentanucleotide sequence 5 ́-CTAAT-3 ́rather than 5 ́-TTAAT-3 ́, due to a more electronegative binding pocket. To determine the residue(s) involved in sequence specificity upstream from the core site and understand the role of residues in the C-terminus in DNA-binding, a slightly longer homeomdomain construct (HDx) was studied using nuclear magnetic resonance (NMR) and ITC. The construct was much more stable than the HD construct, which was likely a result of the increased stability of helix 3 as evidenced in the NMR data. Using ITC, the binding affinities of HDx to a panel of DNA were in the low nanomolar range and tighter than the HD affinities to the same panel of sequences. In an attempt to identify the residues responsible for imparting specificity upstream from the core site, a mutational analysis with HDx was carried out. Neither mutations resulted in decreased specificity; however, one mutation contributed slightly to the binding enthalpy. Many folded proteins contain regions that are random coil in structure or form transient secondary structures, which are important for cell signaling, molecular recognition, and transcription. The non-homeodomain regions of Pdx1, which make up a large portion of the protein, are predicted to be disordered based on the amino acid sequence. However, there is no concrete evidence to suggest whether the non-homeodomain regions of Pdx1 are truly unstructured or whether they adopt residual structure. The NMR data of the Pdx1 C-terminus shows that this region adopts random coil structure in solution. Biologically, the plasticity of the intrinsically disordered regions is utilized as a probe to weakly associate with multiple binding partners. One such partner for Pdx1 is SPOP, which is involved in mediating the interaction between an ubiquitin ligase complex and its substrate. Calorimetric data and NMR demonstrated a direct binding interaction and identification of the SPOP binding regions of Pdx1 by NMR.
Author : Magnus Wolf-Watz
Publisher :
ISBN 13 : 9789172830844
Total Pages : 38 pages
Book Rating : 4.8/5 (38 download)
Download or read book Structure-function Relationships of the Human Runx1 Transcription Factor written by Magnus Wolf-Watz and published by . This book was released on 2001 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cali Matheny
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (326 download)
Download or read book The Expression, Regulation, and Structure/function Analysis of the Transcription Factor NGFI-A written by Cali Matheny and published by . This book was released on 1995 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jacqueline M. Matthews
Publisher : Springer Science & Business Media
ISBN 13 : 1461432294
Total Pages : 184 pages
Book Rating : 4.4/5 (614 download)
Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author : Rajesh V. Thakker
Publisher : Academic Press
ISBN 13 : 0128041986
Total Pages : 880 pages
Book Rating : 4.1/5 (28 download)
Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Author : R. Curtis Bird
Publisher : Elsevier
ISBN 13 : 0080537812
Total Pages : 317 pages
Book Rating : 4.0/5 (85 download)
Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird and published by Elsevier. This book was released on 1996-11-28 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author : Eric H. Davidson
Publisher : Elsevier
ISBN 13 : 0080525598
Total Pages : 274 pages
Book Rating : 4.0/5 (85 download)
Download or read book Genomic Regulatory Systems written by Eric H. Davidson and published by Elsevier. This book was released on 2001-01-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Author : Isabelle S. Peter
Publisher : Academic Press
ISBN 13 : 0124047467
Total Pages : 461 pages
Book Rating : 4.1/5 (24 download)
Download or read book Genomic Control Process written by Isabelle S. Peter and published by Academic Press. This book was released on 2015-01-21 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Author : Francis H. Glorieux
Publisher : Academic Press
ISBN 13 : 0123820405
Total Pages : 885 pages
Book Rating : 4.1/5 (238 download)
Download or read book Pediatric Bone written by Francis H. Glorieux and published by Academic Press. This book was released on 2011-09-28 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric osteology, a medical specialty that has come of age, has contributed to the understanding of adult bone diseases as well. This second edition reference updates the 2003 edition with more emphasis on management as well as new and revised contributions. Thirty chapters present basic information regarding bone development, tools and techniques for evaluation (including a new chapter on radiographic imaging), and the specifics of various diseases. The three editors are affiliated as follows: Francis H. Glorieux (McGill U., Canada), John M. Pettifor (Chir Hani Baragwanath Hospital, South Africa), and Harald Juppner (Harvard Medical School, US). Academic Press is an imprint of Elsevier. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).
