A Guide to Sample Size for Animal-based Studies

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119799988
Total Pages : 294 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis A Guide to Sample Size for Animal-based Studies by : Penny S. Reynolds

Download or read book A Guide to Sample Size for Animal-based Studies written by Penny S. Reynolds and published by John Wiley & Sons. This book was released on 2023-08-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Guide to Sample Size for Animal-based Studies Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

A Guide to Sample Size for Animal-based Studies

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 111979997X
Total Pages : 294 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis A Guide to Sample Size for Animal-based Studies by : Penny S. Reynolds

Download or read book A Guide to Sample Size for Animal-based Studies written by Penny S. Reynolds and published by John Wiley & Sons. This book was released on 2023-12-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

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Author :
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Guidance for the Description of Animal Research in Scientific Publications

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Author :
Publisher : National Academies Press
ISBN 13 : 030921954X
Total Pages : 42 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Guidance for the Description of Animal Research in Scientific Publications by : National Research Council

Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

Institutional Animal Care and Use Committee Guidebook

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Author :
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Institutional Animal Care and Use Committee Guidebook by :

Download or read book Institutional Animal Care and Use Committee Guidebook written by and published by . This book was released on 2002 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Power Analysis for the Behavioral Sciences

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Author :
Publisher : Routledge
ISBN 13 : 1134742770
Total Pages : 625 pages
Book Rating : 4.1/5 (347 download)

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Book Synopsis Statistical Power Analysis for the Behavioral Sciences by : Jacob Cohen

Download or read book Statistical Power Analysis for the Behavioral Sciences written by Jacob Cohen and published by Routledge. This book was released on 2013-05-13 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Power Analysis is a nontechnical guide to power analysis in research planning that provides users of applied statistics with the tools they need for more effective analysis. The Second Edition includes: * a chapter covering power analysis in set correlation and multivariate methods; * a chapter considering effect size, psychometric reliability, and the efficacy of "qualifying" dependent variables and; * expanded power and sample size tables for multiple regression/correlation.

The Design of Animal Experiments

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Author :
Publisher : SAGE Publications Limited
ISBN 13 : 9781473974630
Total Pages : 0 pages
Book Rating : 4.9/5 (746 download)

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Book Synopsis The Design of Animal Experiments by : Michael Festing

Download or read book The Design of Animal Experiments written by Michael Festing and published by SAGE Publications Limited. This book was released on 2016-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.

The Design and Statistical Analysis of Animal Experiments

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1107030781
Total Pages : 327 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis The Design and Statistical Analysis of Animal Experiments by : Simon T. Bate

Download or read book The Design and Statistical Analysis of Animal Experiments written by Simon T. Bate and published by Cambridge University Press. This book was released on 2014-03-13 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

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Author :
Publisher : Springer Nature
ISBN 13 : 3030336565
Total Pages : 424 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Good Research Practice in Non-Clinical Pharmacology and Biomedicine by : Anton Bespalov

Download or read book Good Research Practice in Non-Clinical Pharmacology and Biomedicine written by Anton Bespalov and published by Springer Nature. This book was released on 2020-01-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

ANOVA

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Publisher : SAGE
ISBN 13 : 9780803942578
Total Pages : 88 pages
Book Rating : 4.9/5 (425 download)

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Book Synopsis ANOVA by : Ellen R. Girden

Download or read book ANOVA written by Ellen R. Girden and published by SAGE. This book was released on 1992 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on situations in which analysis of variance (ANOVA) involving the repeated measurement of separate groups of individuals is needed, Girden reveals the advantages, disadvantages, and counterbalancing issues of repeated measures situations. Using additive and nonadditive models to guide the analysis in each chapter, the book covers such topics as the rationale for partitioning the sum of squares, detailed analyses to facilitate the interpretation of computer printouts, the rationale for the F ratios in terms of expected means squares, validity assumptions for sphericity or circularity and approximate tests to perform when sphericity is not met.

Step-by-step Programming with Base SAS Software

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Author :
Publisher : SAS Press
ISBN 13 : 9781580257916
Total Pages : 0 pages
Book Rating : 4.2/5 (579 download)

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Book Synopsis Step-by-step Programming with Base SAS Software by :

Download or read book Step-by-step Programming with Base SAS Software written by and published by SAS Press. This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Step-by-Step Programming with Base SAS Software provides conceptual information about Base SAS software along with step-by-step examples that illustrate the concepts. This title is also available online.

Statistical Principles for the Design of Experiments

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Author :
Publisher : Cambridge University Press
ISBN 13 : 113957664X
Total Pages : 587 pages
Book Rating : 4.1/5 (395 download)

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Book Synopsis Statistical Principles for the Design of Experiments by : R. Mead

Download or read book Statistical Principles for the Design of Experiments written by R. Mead and published by Cambridge University Press. This book was released on 2012-09-13 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.

Animal Experimentation: Working Towards a Paradigm Change

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Author :
Publisher : BRILL
ISBN 13 : 9004391193
Total Pages : 749 pages
Book Rating : 4.0/5 (43 download)

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Book Synopsis Animal Experimentation: Working Towards a Paradigm Change by : Kathrin Herrmann

Download or read book Animal Experimentation: Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Encyclopedia of Research Design

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Publisher : SAGE
ISBN 13 : 1412961270
Total Pages : 1779 pages
Book Rating : 4.4/5 (129 download)

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Book Synopsis Encyclopedia of Research Design by : Neil J. Salkind

Download or read book Encyclopedia of Research Design written by Neil J. Salkind and published by SAGE. This book was released on 2010-06-22 with total page 1779 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.

The Theory of the Design of Experiments

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Author :
Publisher : CRC Press
ISBN 13 : 1420035835
Total Pages : 337 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Theory of the Design of Experiments by : D.R. Cox

Download or read book The Theory of the Design of Experiments written by D.R. Cox and published by CRC Press. This book was released on 2000-06-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why study the theory of experiment design? Although it can be useful to know about special designs for specific purposes, experience suggests that a particular design can rarely be used directly. It needs adaptation to accommodate the circumstances of the experiment. Successful designs depend upon adapting general theoretical principles to the spec

Guide for the Care and Use of Laboratory Animals

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Author :
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Cost Analysis and Rate Setting Manual for Animal Resource Facilities

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Author :
Publisher :
ISBN 13 :
Total Pages : 122 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Cost Analysis and Rate Setting Manual for Animal Resource Facilities by : National Institutes of Health (U.S.). Division of Research Resources

Download or read book Cost Analysis and Rate Setting Manual for Animal Resource Facilities written by National Institutes of Health (U.S.). Division of Research Resources and published by . This book was released on 1974 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: