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A Digital Twin Of The Human Colon For The Design And Optimisation Of Colon Targeted Drug Delivery Systems
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Book Synopsis A Digital Twin of the Human Colon for the Design and Optimisation of Colon-targeted Drug Delivery Systems by : Michael Schûtt
Download or read book A Digital Twin of the Human Colon for the Design and Optimisation of Colon-targeted Drug Delivery Systems written by Michael Schûtt and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This note is part of Quality testing.
Book Synopsis Advanced Drug Delivery Systems for Colonic Disorders by : Harish Dureja
Download or read book Advanced Drug Delivery Systems for Colonic Disorders written by Harish Dureja and published by Elsevier. This book was released on 2023-11-04 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems for Colonic Disorders present the current state of the art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters are written in a way that allows the audience to not only become familiar with the most recent advancement in the field, but to better understand them by referring to various illustrations, figures, and informative tables. The contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the current status of clinical trials in the area. Advanced Drug Delivery Systems for Colonic Disorders is the perfect resources for researchers in pharma, biomaterials, and nutrition to familiarize themselves with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications. - Covers recent perspectives and challenges towards the treatment of colonic disorders - Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disorders - Discusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer
Book Synopsis Design and Development of Colon Targeted Drug Delivery System by : Mukesh R. Patel
Download or read book Design and Development of Colon Targeted Drug Delivery System written by Mukesh R. Patel and published by LAP Lambert Academic Publishing. This book was released on 2012-06 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn s diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co
Book Synopsis Design and Evaluation of Colon Specific Drug Delivery System by : Nirav Patel
Download or read book Design and Evaluation of Colon Specific Drug Delivery System written by Nirav Patel and published by LAP Lambert Academic Publishing. This book was released on 2011 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn s diseases, ulcerative colitis, irritable bowl syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. Targeted drug delivery to the colon would therefore, ensure direct treatment at the disease site and, consequently, lower dosing and reducing systemic side effects. The most critical challenge in such drug delivery approach is to preserve the formulation during its passage through the stomach and about first six meters of small intestine. In the present investigations, two drugs mesalamine and budesonide was selected for ulcerative colitis in colon. An attempt was made to prepare formulations which could not release the drug into stomach for up to 2 h. which is residence time for it, also it could not release the drug into small intestine up to 3 h. which is residence time for it and could release the drug up to 24 h to 3 days which is residence time for colon. These attempts formulate the colon targeted controlled release dosage form for ulcerative colitis.
Book Synopsis Oral Colon-Specific Drug Delivery by : David R. Friend
Download or read book Oral Colon-Specific Drug Delivery written by David R. Friend and published by CRC Press. This book was released on 1992-07-27 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon.
Book Synopsis Innovative Drug Delivery Systems for Colon Targeting by : Youness Karrout
Download or read book Innovative Drug Delivery Systems for Colon Targeting written by Youness Karrout and published by . This book was released on 2008 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Development of Novel Colon Targeted Drug Delivery Systems by : Zuzana Hlaskova
Download or read book The Development of Novel Colon Targeted Drug Delivery Systems written by Zuzana Hlaskova and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design of Drug Delivery Systems for the Colon by : Janine Lesley Bragger
Download or read book The Design of Drug Delivery Systems for the Colon written by Janine Lesley Bragger and published by . This book was released on 1995 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Biorelevant Dynamic Model of Human Proximal Colon by : Konstantinos Stamatopoulos
Download or read book Development of a Biorelevant Dynamic Model of Human Proximal Colon written by Konstantinos Stamatopoulos and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enzymatically Triggered Polymeric Drug Delivery Systems for Colon Targeting by : Youcef Benzine
Download or read book Enzymatically Triggered Polymeric Drug Delivery Systems for Colon Targeting written by Youcef Benzine and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammatory bowel diseases (IBD) today affects close to 200,000 people in France. They are characterized by the inflammation of the wall of a part of the digestive tract. They usually include Ulcerative Colitis and Crohn's disease. Both are chronic diseases that involve inflammation of the colonic mucosa. The main difference between Crohn's disease and Ulcerative Colitis is the location and nature of inflammation. Crohn's disease can affect any part of the GIT from mouth to anus but in most cases attacks the terminal ileum. In contrast, Ulcerative Colitis is restricted to the colon and the rectum. An ideal dosage form should effectively protect the drug in the stomach and small intestine and subsequently release the drug in the colon in a targeted and controlled manner. The objective of this work was to develop new drug delivery systems containing a polysaccharide (pectin, guar gum, inulin ...), which are degradable by the colonic bacteria and a hydrophobic thermoplastic polymer (ethylcellulose, polyurethane, polyvinyl acetate ...), which will reduce the hydrophilicity of the polysaccharide. The technique used for the preparation of these dosage forms is hot-melt extrusion. It is a continuous and free solvent process that allows the manufacturing of a dosage form called "extrudate" by forcing the soften material through an orifice. It has been demonstrated that extrudates based on polyvinyl acetate/polyurethane and inulin can minimize the release of a model active substance in the upper part of GIT due to the hydrophobic properties of polyvinyl acetate. Indeed, these extrudates uptake low amount of water and lose low dry mass upon exposure to media simulating the stomach and the small intestine. However, once in contact with the colonic flora, these systems show a considerable loss of mass due to the degradation of inulin by enzymes secreted by colonic bacteria. In another study, hot melt extrudates based on ethylcellulose blended with different types of polysaccharides (guar gum, inulin, corn starch, maltodextrin, pectin and chitosan) were studied for the development of controlled drug delivery systems. Anhydrous theophylline and diprophylline have been used as model drugs. This study was useful to set the extrusion parameters: temperature 100 °C; screw speed 30 rpm; feed rate 3 cc/min; 30 % dibutyl sebacate as a plasticizer. Importantly, hot melt extrudates based on ethylcellulose:guar gum blends offer an interesting potential as controlled drug delivery systems: They can be prepared at temperatures of about 100 °C, provide broad spectra of drug release patterns (in particular about constant drug release rates). Finally, hot melt extrudates remained stable after 1 year storage at ambient conditions.
Book Synopsis Development of Anti-EpCAM Targeted Drug Delivery Systems for Treatment of Colon Cancer by : 侯宗緯
Download or read book Development of Anti-EpCAM Targeted Drug Delivery Systems for Treatment of Colon Cancer written by 侯宗緯 and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Swellable Core Tablet by : Chirag Patel
Download or read book Swellable Core Tablet written by Chirag Patel and published by LAP Lambert Academic Publishing. This book was released on 2014-02 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel drug delivery systems (NDDS) have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Delivery of drugs directly to targeted sites of action provides several advantages over non-specific delivery of drugs. Oral colon targeted drug delivery system is one of that NDDS which directly deliver a drug in to the colon for local treatment of a variety of colonic diseases as well as systemic absorption of proteins and peptides. The Metronidazole is the drug of choice in the treatment of the diseases like Amoebiasis, Giardiasis, Trichomonosis and Bacterial Vaginosis. The aim of the present research was to design, development and optimization of swellable rupturable system taking account of local action of the Metronidazole drug in the lower gastrointestinal tract to kill the bacteria in the disease conditions like Amoebiasis, Giardiasis and Trichomonosis.
Book Synopsis Colon Targeted Drug Delivery of Aecelofenac Microcapsules by : Muhammad Farooq
Download or read book Colon Targeted Drug Delivery of Aecelofenac Microcapsules written by Muhammad Farooq and published by LAP Lambert Academic Publishing. This book was released on 2015-08-21 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colonic drug delivery system has achieved great significance in the treatment of local diseases of colon. Microcapsules are particularly appealing for the development of controlled or targeted release dosage forms. They play significant role as drug delivery systems aiming at enhanced bio availability of conventional drugs and minimizing side effects. The formulated microcapsules provide the pH dependent targeted release which proved that microcapsules are excellent candidate for site specific colon drug delivery.
Book Synopsis Colon Targeted Drug Delivery Systems by : Anil K. Philip
Download or read book Colon Targeted Drug Delivery Systems written by Anil K. Philip and published by . This book was released on 2010 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Exploring the Advancements and Future Directions of Digital Twins in Healthcare 6.0 by : Dubey, Archi
Download or read book Exploring the Advancements and Future Directions of Digital Twins in Healthcare 6.0 written by Dubey, Archi and published by IGI Global. This book was released on 2024-07-18 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The healthcare industry is increasingly complex, demanding personalized treatments and efficient operational processes. Traditional research methods need help to keep pace with these demands, often leading to inefficiencies and suboptimal outcomes. Integrating digital twin technology presents a promising solution to these challenges, offering a virtual platform for modeling and simulating complex healthcare scenarios. However, the full potential of digital twins still needs to be explored mainly due to a lack of comprehensive guidance and practical insights for researchers and practitioners. Exploring the Advancements and Future Directions of Digital Twins in Healthcare 6.0 is not just a theoretical exploration. It is a practical guide that bridges the gap between theory and practice, offering real-world case studies, best practices, and insights into personalized medicine, real-time patient monitoring, and healthcare process optimization. By equipping you with the knowledge and tools needed to effectively integrate digital twins into your healthcare research and operations, this book is a valuable resource for researchers, academicians, medical practitioners, scientists, and students.
Book Synopsis Excipient Applications in Formulation Design and Drug Delivery by : Ajit S Narang
Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.
Book Synopsis Artificial Intelligence in Drug Discovery by : Nathan Brown
Download or read book Artificial Intelligence in Drug Discovery written by Nathan Brown and published by Royal Society of Chemistry. This book was released on 2020-11-04 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
