Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
A Detailed Chronological Record Of Project 523 And The Discovery And Development Of Qinghaosu Artemisinin
Download A Detailed Chronological Record Of Project 523 And The Discovery And Development Of Qinghaosu Artemisinin full books in PDF, epub, and Kindle. Read online A Detailed Chronological Record Of Project 523 And The Discovery And Development Of Qinghaosu Artemisinin ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu (Artemisinin) by : Zhang Jianfang
Download or read book A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu (Artemisinin) written by Zhang Jianfang and published by Strategic Book Publishing. This book was released on 2013 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an account of a project in China carried out in secrecy from the Chinese people and the Western World during the tumultuous years of the Cultural Revolution. Project 523, as it was called, resulted in one of the most significant advances in the treatment of malaria since the discovery and first use of quinine over 300 years ago. The origin of the project was a request from the North Vietnamese Government to Mao Zedong in China, for assistance in managing chloroquine drug-resistant malaria affecting their military forces during the Vietnam-American war. Initially the project was directed by the Chinese military medical research authorities, but it became so large that civilian scientists were called upon to help. Ultimately, to accomplish this task, over 60 institutions and more than 500 scientists and other personnel scattered throughout mainland China became involved. This achievement is all the more remarkable because it was accomplished during the Cultural Revolution using obsolete equipment, and at a time when all regular research was halted, scientists were harassed and denigrated, and academic and intellectual activity was discouraged or even forbidden. The drug discovered - artemisinin from the plant Qinghao (Artemisia annua L) - is now the most widely used treatment for malaria in the world.
Book Synopsis Science-Based Innovation by : A. Styhre
Download or read book Science-Based Innovation written by A. Styhre and published by Springer. This book was released on 2008-02-27 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge management has become a well-known term, but science-based innovation remains relatively unexploited. Bridging the gap between knowledge management theory and studies of science of technology, such as in the pharmaceutical industry and biotechnology firms, this book provides a timely insight into the innovation of the knowledge economy.
Book Synopsis World Malaria Report 2014 by : World Health Organization
Download or read book World Malaria Report 2014 written by World Health Organization and published by World Health Organization. This book was released on 2015-07-07 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World malaria report 2014 summarizes information received from 97 malaria endemic countries and other sources and updates the analyses presented in 2013. It assesses global and regional malaria trends highlights progress made towards global targets and describes opportunities and challenges in controlling and eliminating the disease. Most of the data presented in this report are for 2013.
Book Synopsis Guidelines for the Treatment of Malaria by : World Health Organization
Download or read book Guidelines for the Treatment of Malaria written by World Health Organization and published by World Health Organization. This book was released on 2010 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.
Book Synopsis Artemisinin-Based and Other Antimalarials by : Guoqiao Li
Download or read book Artemisinin-Based and Other Antimalarials written by Guoqiao Li and published by Academic Press. This book was released on 2017-11-28 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. - Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria - Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development - Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery
Book Synopsis Successful Drug Discovery, Volume 5 by : Janos Fischer
Download or read book Successful Drug Discovery, Volume 5 written by Janos Fischer and published by John Wiley & Sons. This book was released on 2021-02-12 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drugs discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the books nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: - Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references - Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.
Book Synopsis Antibiotics and Antimicrobial Resistance Genes in the Environment by : Muhammad Zaffar Hashmi
Download or read book Antibiotics and Antimicrobial Resistance Genes in the Environment written by Muhammad Zaffar Hashmi and published by Elsevier. This book was released on 2019-11-22 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics and Antimicrobial Resistance Genes (AMR) in the Environment summarizes and updates information on antibiotic producing organisms and their resistance and entry routes in soil, air, water and sediment. As antibiotic use continues to rise in healthcare, their fate, bioavailability and biomonitoring, and impacts on environment and public health are becoming increasingly important. The book addresses the impact of antibiotics and AMR to environment and public health and risk assessment. Moreover, it focused on the metagenomics and molecular techniques for the detection of antibiotics and antimicrobial genes. Lastly, it introduces management strategies, such as treatment technologies for managing antibiotics and AMR/ARGs-impacted environment, and bioremediation approaches. - Summarizes and updates information on antibiotics and AMR/ARGs production and its fate and transport in the environment - Includes phytoremediation and bioremediation technologies for environmental management - Provides analysis of risk assessment of antibiotic resistance genes to help understand the environmental and socioeconomic impacts of antibiotics and AMR/ARGs
Book Synopsis Tu Youyou And The Discovery Of Artemisinin: 2015 Nobel Laureate In Physiology Or Medicine by : Yi Rao
Download or read book Tu Youyou And The Discovery Of Artemisinin: 2015 Nobel Laureate In Physiology Or Medicine written by Yi Rao and published by World Scientific. This book was released on 2016-09-28 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nobel laureate Tu Youyou won the 2015 prize for Medicine/Physiology for the discovery of artemisinin, a drug therapy for malaria that has saved millions across the globe.This book traces the path of discovery beginning with Chairman Mao's 1964 instruction to Chinese researchers to find a cure for malaria, a disease that plagued the military and civilians alike in endemic regions. It chronicles the years of painstaking research to find effective anti-malarial drugs, and how an entry in a collection of traditional Chinese medicine prescriptions gave Tu Youyou the clue which led her to successfully extract artemisinin from the plant, Artemisia annua.Gathering together information from a variety of sources including first-hand accounts, this book describes the contributions of the many organisations, scientists, doctors and countless others who played a part in the process of discovery and clinical testing. It also provides insights into the challenges of carrying out such an extensive research project with limited resources during the upheavals of the Cultural Revolution. An inspirational read for young scientists.Includes the translation of Professor Tu Youyou's 2015 Nobel Lecture.
Download or read book Upshift written by Ben Ramalingam and published by Flatiron Books. This book was released on 2023-02-07 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over two decades’ experience both observing and interpreting how people channel disaster into opportunity in the most extreme circumstances and environments on Earth, Ben Ramalingam has a unique vantage point from which to identify the key principles that can enable anyone to use stress as an opportunity for change. In Upshift, Ramalingam distils this expertise into an insightful, powerful, and engaging book that will show you how to reframe your set responses to stress and pressure and instead use them to harness the potential they hold not just for improving your work, your relationships, and your mindset, but for transforming them. Upshift takes readers on an epic journey from early humans’ survival of the Ice Age to present times in our inescapable, pernicious and ever-shifting digital landscape. You will hear remarkable stories from a vast range of upshifters—all of whom carved new routes around perceived barriers using their powers to upshift. Underlying stories of how city commuters navigate train cancellations to how astronauts deal with life-threatening incidents, is one key message: We all have the power to innovate, whether or not we identify ourselves as creative or extraordinary. Maybe you’re the challenger, who thrives by constructively disrupting the status quo like Greta Thunberg. Or perhaps you find yourself constantly tweaking, prodding, breaking, rebuilding, and improving like crafters such as the team that revolutionized space travel called the NASA Pirates. Do you love introducing people whose combined efforts will lead to greater achievements? You might be a connector, like master networker Ariana Huffington. In a runaway world that is an engine for perpetual crisis, Upshift is not only an essential toolkit for survival, it is a roadmap for positive, and potentially life-changing transformation and influence. You don’t have to shut down – you can upshift.
Book Synopsis Approaching Complex Diseases by : Mariano Bizzarri
Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Book Synopsis Understanding Drugs Markets by : Carine Baxerres
Download or read book Understanding Drugs Markets written by Carine Baxerres and published by Routledge. This book was released on 2021-07-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on anthropology, historical sociology and social-epidemiology, this multidisciplinary book investigates how pharmaceuticals are produced, distributed, prescribed, (and) consumed, and regulated in order to construct a comprehensive understanding of the issues that drive (medicine) pharmaceutical markets in the Global South today. Based on primary research conducted in Benin and Ghana, and additional data collected in Cambodia and the Ivory Coast, this volume uses artemisinin-based combination therapies (ACTs) against malaria as a central case study. It highlights the influence of the countries colonial and post-colonial history on their models for state regulation, production, and distribution, explores the determining role transnational actors as well as industries from the North but also and increasingly from the South play in influencing local pharmaceutical markets and looks at the behaviour of health care professionals and individuals. Stepping back, the authors then unpick the pharmaceuticalization process and the multiple regulations at stake by looking at the workings of, and linkages between, (biomedical health) pharmaceutical systems, (representatives of companies) industries, actors in private distribution, and consumer practices. Providing a thorough comparative analysis of the advantages and disadvantages of different pharmaceutical systems, it is an important contribution to the literature on pharmaceutalization and the governance of medication. It is of interest to students, researchers and policy-makers interested in medical anthropology, the sociology of health and illness, global health, healthcare management and pharmacy.
Book Synopsis Tropical Diseases in China by : Xiao-Nong Zhou
Download or read book Tropical Diseases in China written by Xiao-Nong Zhou and published by Springer Nature. This book was released on 2022-12-02 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the changing patterns of schistosomiasis transmission in China at different stages. Arduous efforts have been made in the last 7 decades to control and eliminate schistosomiasis in China using various control strategies, such as snail control to reduce the intensity of the disease transmission, morbidity control to reduce disease prevalence, and integrated control strategies to block the disease transmission, supported by governments at different levels. This book also presents the scientific progresses which technically support the control and surveillance of schistosomiasis in the field. It summarizes the working mechanism and control strategies of multi-sectoral collaboration to promote the national control programme leading to schistosomiasis elimination eventually.
Book Synopsis Research Methods and Applications in Chemical and Biological Engineering by : Ali Pourhashemi
Download or read book Research Methods and Applications in Chemical and Biological Engineering written by Ali Pourhashemi and published by CRC Press. This book was released on 2019-07-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research-oriented book presents up-to-date experimental methods currently used in research for many branches of chemical and biological engineering. The book surveys essential ideas and research methodologies, concentrating on experiments used in applications rather than on the fine points of rigorous mathematics. Examples of important applications are reviewed in sufficient detail to provide the reader with a critical understanding of context and research methodology. The volume presents a broad spectrum of chapters in the various branches of chemical and biological engineering that demonstrate key developments in these rapidly changing fields. Chapters explore the design, development, operation, monitoring, control, and optimization of chemical, physical and biological processes. Case studies are included in some chapters, building a real-world connection.
Book Synopsis Chinese Medicine in East Africa by : Elisabeth Hsu
Download or read book Chinese Medicine in East Africa written by Elisabeth Hsu and published by Berghahn Books. This book was released on 2022-07-08 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on fieldwork conducted between 2001-2008 in urban East Africa, this book explores who the patients, practitioners and paraprofessionals doing Chinese medicine were in this early period of renewed China-Africa relations. Rather than taking recourse to the ‘placebo effect’, the author explains through the spatialities and materialities of the medical procedures provided why - apart from purchasing the Chinese antimalarial called Artemisinin - locals would try out their ‘alternatively modern’ formulas for treating a wide range of post-colonial disorders and seek their sexual enhancement medicines.
Book Synopsis Application of Natural Products in SARS-CoV-2 by : Kamal Niaz
Download or read book Application of Natural Products in SARS-CoV-2 written by Kamal Niaz and published by Elsevier. This book was released on 2022-10-20 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Application of Natural Products in SARS-CoV-2 examines the potential for natural products to treat COVID-19, bringing together the most recent research. SARS-CoV-2 is a novel disease H54 that is still being researched despite being globally prevalent. There are still few proven treatments, so repurposing existing drugs and treatments is essential. While there have been many articles published on the subject, this book is the first to bring together data and research on the topic. It includes information about molecular mechanism, dosage and safety profiles, and an essential resource for all scientists and researchers working to combat SARS-CoV-2. - Collates known data and research on COVID-19 and natural products in a single and easy to find place - Includes information about molecular mechanism, dosage and safety profiles - Provides information from a diverse group of academics and industrial scientists
Book Synopsis Applied Physical Chemistry with Multidisciplinary Approaches by : A. K. Haghi
Download or read book Applied Physical Chemistry with Multidisciplinary Approaches written by A. K. Haghi and published by CRC Press. This book was released on 2018-05-03 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting illustrative case studies, highlighting technological applications, and explaining theoretical and foundational concepts, this book is an important reference source on the key concepts for modern technologies and optimization of new processes in physical chemistry. This volume combines up-to-date research findings and relevant theoretical frameworks on applied chemistry, materials, and chemical engineering. This new volume presents an up-to-date review of modern materials and chemistry concepts, issues, and recent advances in the field. Distinguished scientists and engineers from key institutions worldwide have contributed chapters that provide a deep analysis of their particular subjects. At the same time, each topic is framed within the context of a broader more multidisciplinary approach, demonstrating its relationship and interconnectedness to other areas. The premise of this book, therefore, is to offer both a comprehensive understanding of applied science and engineering as a whole and a thorough knowledge of individual subjects. This approach appropriately conveys the basic fundamentals, state-of-the-art technology, and applications of the involved disciplines, and further encourages scientific collaboration among researchers. This volume emphasizes the intersection of chemistry, math, physics, and the resulting applications across many disciplines of science and explores applied physical chemistry principles in specific areas, including the life chemistry, environmental sciences, geosciences, and materials sciences. The applications from these multidisciplinary fields illustrate methods that can be used to model physical processes, design new products and find solutions to challenging problems.
Book Synopsis Guidelines for the Treatment of Malaria. Third Edition by : World Health Organization
Download or read book Guidelines for the Treatment of Malaria. Third Edition written by World Health Organization and published by World Health Organization. This book was released on 2015-08-13 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.
