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A Comparative Study Of A Pathogenic Versus A Nonpathogenic Naegleria Species
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Book Synopsis A Comparative Study of a Pathogenic Versus a Nonpathogenic Naegleria Species by : Melissa Jamerson
Download or read book A Comparative Study of a Pathogenic Versus a Nonpathogenic Naegleria Species written by Melissa Jamerson and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Naegleria fowleri (N. fowleri) and Naegleria lovaniensis (N. lovaniensis) are closely related amebae found in the environment. N. fowleri causes Primary Amebic Meningoencephalitis (PAM), a fatal disease of the central nervous system, while N. lovaniensis is nonpathogenic. N. fowleri infection occurs when amebae enter the nasal passages, and migrate to the brain. The molecular mechanisms involved in the pathogenesis of PAM are not well-defined. Therefore, the purpose of this study was to define phenotypic characteristics that may be functionally linked to the pathogenicity associated with N. fowleri. Studies revealed that N. fowleri has a faster growth rate and is more resistant to complement-mediated lysis when compared to N. lovaniensis. Additionally, contact-independent cytotoxicity was observed only for N. fowleri. The ability to invade tissues can be a characteristic that distinguishes pathogens from nonpathogens. Therefore, adhesion to extracellular matrix components (ECM), laminin-1, fibronectin, and collagen I, was assessed. N. fowleri exhibited a higher level of adhesion to ECM components and was shown to invade tri-dimensional ECM scaffolds (matrigel and collagen I) to a greater extent than N. lovaniensis. Scanning electron microscopy revealed that N. fowleri attached on ECM substrata exhibited a spread-out appearance that included the presence of focal adhesion-like structures. Attachment of N. fowleri to ECM components was decreased significantly when amebae were pretreated with trypsin, suggesting a role for a surface protein in this process. Pretreatment of N. fowleri amebae with periodate, a sugar oxidant, led to a decrease in attachment to laminin-1 and fibronectin suggesting that the surface component contained a sugar moiety. Western immunoblotting revealed two integrin-like proteins for both species. However, one with a molecular mass of approximately 70 kDa, was detected at a higher level for N. fowleri. Confocal microscopy indicated that the integrin-like proteins co-localized to the focal adhesion-like structures. An anti-integrin antibody decreased adhesion of N. fowleri to ECM components. Zymographic analysis demonstrated differential expression of proteases occurs when N. fowleri and N. lovaniensis invade ECM components using an in vitro invasion assay. These results indicate a distinction in adhesion to, and invasion of, extracellular matrix proteins between N. fowleri and N. lovaniensis.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :030949382X Total Pages :291 pages Book Rating :4.3/5 (94 download)
Book Synopsis Management of Legionella in Water Systems by : National Academies of Sciences, Engineering, and Medicine
Download or read book Management of Legionella in Water Systems written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-02-20 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionnaires' disease, a pneumonia caused by the Legionella bacterium, is the leading cause of reported waterborne disease outbreaks in the United States. Legionella occur naturally in water from many different environmental sources, but grow rapidly in the warm, stagnant conditions that can be found in engineered water systems such as cooling towers, building plumbing, and hot tubs. Humans are primarily exposed to Legionella through inhalation of contaminated aerosols into the respiratory system. Legionnaires' disease can be fatal, with between 3 and 33 percent of Legionella infections leading to death, and studies show the incidence of Legionnaires' disease in the United States increased five-fold from 2000 to 2017. Management of Legionella in Water Systems reviews the state of science on Legionella contamination of water systems, specifically the ecology and diagnosis. This report explores the process of transmission via water systems, quantification, prevention and control, and policy and training issues that affect the incidence of Legionnaires' disease. It also analyzes existing knowledge gaps and recommends research priorities moving forward.
Download or read book Bad Bug Book written by Mark Walderhaug and published by Createspace Independent Publishing Platform. This book was released on 2014-01-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bad Bug Book 2nd Edition, released in 2012, provides current information about the major known agents that cause foodborne illness.Each chapter in this book is about a pathogen—a bacterium, virus, or parasite—or a natural toxin that can contaminate food and cause illness. The book contains scientific and technical information about the major pathogens that cause these kinds of illnesses.A separate “consumer box” in each chapter provides non-technical information, in everyday language. The boxes describe plainly what can make you sick and, more important, how to prevent it.The information provided in this handbook is abbreviated and general in nature, and is intended for practical use. It is not intended to be a comprehensive scientific or clinical reference.The Bad Bug Book is published by the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA), U.S. Department of Health and Human Services.
Book Synopsis Microbiology of Waterborne Diseases by :
Download or read book Microbiology of Waterborne Diseases written by and published by Academic Press. This book was released on 2013-11-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
Download or read book Acanthamoeba written by Naveed Ahmed Khan and published by Caister Academic Press Limited. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully up-to-date book covers all aspects of Acanthamoeba biology. Following the success of the first edition, the author has extensively revised and expanded the text to produce a new volume that includes all the latest research and information on every aspect of this organism. There is a particular emphasis on the Acanthamoeba genome sequence and the novel insights gained from the application of molecular methods to Acanthamoeba developmental/cellular biology, in terms of metabolism and morphogenesis, classification, ecology and role in the ecosystem, host-pathogen interactions, virulence factors and immunological basis of pathogenesis, clinical manifestation, diagnosis, treatment, new target development, and drug resistance and its interactions with other microbes in the environment. The book will be an essential reference text for parasitologists, microbiologists, immunologists, and physicians in the field of basic and medical microbiology, as well as an invaluable reference for new and experienced researchers who wish to better understand this organism.
Book Synopsis Free-Living Amebas by : A. Julio Martinez
Download or read book Free-Living Amebas written by A. Julio Martinez and published by CRC Press. This book was released on 2019-08-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book places greater emphasis on the practical problems of epidemiology, prevention, diagnosis, and pathological aspects of the two principle types of free-living amoebic infection: the acute disease produced by Naegleria fowleri and the chronic, subacute and opportunistic form, produced by acanthamoeba spp.
Book Synopsis Guidelines for Drinking-water Quality by : World Health Organization
Download or read book Guidelines for Drinking-water Quality written by World Health Organization and published by World Health Organization. This book was released on 1993 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the methods used in the surveillance of drinking water quality in the light of the special problems of small-community supplies, particularly in developing countries, and outlines the strategies necessary to ensure that surveillance is effective.
Book Synopsis Indicators for Waterborne Pathogens by : National Research Council
Download or read book Indicators for Waterborne Pathogens written by National Research Council and published by National Academies Press. This book was released on 2004-06-19 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent and forecasted advances in microbiology, molecular biology, and analytical chemistry have made it timely to reassess the current paradigm of relying predominantly or exclusively on traditional bacterial indicators for all types of waterborne pathogens. Nonetheless, indicator approaches will still be required for the foreseeable future because it is not practical or feasible to monitor for the complete spectrum of microorganisms that may occur in water, and many known pathogens are difficult to detect directly and reliably in water samples. This comprehensive report recommends the development and use of a "tool box" approach by the U.S Environmental Protection Agency and others for assessing microbial water quality in which available indicator organisms (and/or pathogens in some cases) and detection method(s) are matched to the requirements of a particular application. The report further recommends the use of a phased, three-level monitoring framework to support the selection of indicators and indicator approaches.Â
Book Synopsis Paniker's Textbook of Medical Parasitology by : C. K. Jayaram Paniker
Download or read book Paniker's Textbook of Medical Parasitology written by C. K. Jayaram Paniker and published by JP Medical Ltd. This book was released on 2017-09-14 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this textbook is a complete guide to parasitology for undergraduate medical students. Divided into 23 chapters, each topic has been thoroughly updated and expanded to cover the most recent advances and latest knowledge in the field. The book begins with an overview of parasitology, then discusses numerous different types of parasite, concluding with a chapter on diagnosis methods. Many chapters have been rewritten and the eighth edition of the book features many new tables, flow charts and photographs. Each chapter concludes with a ‘key points’ box to assist with revision. Key points Eighth edition providing undergraduates with a complete guide to parasitology Fully revised text with many new topics, tables and photographs Each chapter concludes with ‘key points’ box to assist revision Previous edition (9789350905340) published in 2013
Book Synopsis Pathogenic Naegleria by : Flora Mae Wellings
Download or read book Pathogenic Naegleria written by Flora Mae Wellings and published by . This book was released on 1979 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Pangenome written by Hervé Tettelin and published by Springer Nature. This book was released on 2020-04-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Book Synopsis Human Parasitology by : Burton J. Bogitsh
Download or read book Human Parasitology written by Burton J. Bogitsh and published by Elsevier. This book was released on 2005-04-07 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Parasitology emphasizes the medical aspects of the topic, while incorporating functional morphology, physiology, biochemistry, and immunology to enhance appreciation of the diverse implications of parasitism. Bridging the gap between classical clinical parasitology texts and traditional encyclopaedic treatises, Human Parasitology appeals to students interested not only in the medical aspects of Parasitology but also to those who require a solid foundation in the biology of parasites. Updated and expanded reference section New chapter on Immunology Additional SEM and TEM micrographs Professionally drawn life cycle illustrations Addition of “Host Immune Response section for each organism
Book Synopsis Index-catalogue of Medical and Veterinary Zoology by :
Download or read book Index-catalogue of Medical and Veterinary Zoology written by and published by . This book was released on 1980 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microbial Zoonoses and Sapronoses by : Zdenek Hubálek
Download or read book Microbial Zoonoses and Sapronoses written by Zdenek Hubálek and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of art in the field of microbial zoonoses and sapronoses. It could be used as a textbook or manual in microbiology and medical zoology for students of human and veterinary medicine, including Ph.D. students, and for biomedicine scientists and medical practitioners and specialists as well. Surprisingly, severe zoonoses and sapronoses still appear that are either entirely new (e.g., SARS), newly recognized (Lyme borreliosis), resurging (West Nile fever in Europe), increasing in incidence (campylobacterosis), spatially expanding (West Nile fever in the Americas), with a changing range of hosts and/or vectors, with changing clinical manifestations or acquiring antibiotic resistance. The collective term for those diseases is (re)emerging infections, and most of them represent zoonoses and sapronoses (the rest are anthroponoses). The number of known zoonotic and sapronotic pathogens of humans is continually growing − over 800 today. In the introductory part, short characteristics are given of infectious and epidemic process, including the role of environmental factors, possibilities of their epidemiological surveillance, and control. Much emphasis is laid on ecological aspects of these diseases (haematophagous vectors and their life history; vertebrate hosts of zoonoses; habitats of the agents and their geographic distribution; natural focality of diseases). Particular zoonoses and sapronoses are then characterized in the following brief paragraphs: source of human infection; animal disease; transmission mode; human disease; epidemiology; diagnostics; therapy; geographic distribution.
Book Synopsis Rickettsial Diseases by : Didier Raoult
Download or read book Rickettsial Diseases written by Didier Raoult and published by CRC Press. This book was released on 2007-04-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho
Book Synopsis Pathogenic Mycobacteria in Water by : Steve Pedley
Download or read book Pathogenic Mycobacteria in Water written by Steve Pedley and published by IWA Publishing. This book was released on 2004-08-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental mycobacteria can be found in diverse environments around the world and most appear to exhibit a saprophytic lifestyle. However, some have the ability to infect animals, birds and humans, and have evolved mechanisms by which they can invade and grow within host cells: the pathogenic environmental mycobacteria (PEM). Although the diseases caused by these organisms have been known for many years, it is only recently that the potential significance of PEM as a waterborne pathogen has been appreciated. Pathogenic Mycobacteria in Water describes the current knowledge of the distribution of PEM in water and other parts of the environment. The routes of transmission that lead to human infection are discussed and there is a detailed analysis of the most significant disease symptoms that can follow infection. Many species of PEM are difficult to isolate in culture and so detection and identification rely upon the use modern techniques such as those based on selective nucleic acid amplification (PCR). The classical and modern methods of analysis are described. The book concludes with a discussion of the issues surrounding the control of PEM in drinking-water and the assessment and management of risks. Pathogenic Mycobacteria in Water has been developed from an expert workshop convened by the World Health Organization and the US Environmental Protection Agency. Contents Natural ecology and survival in water of mycobacteria of potential public health significance Environmental sources of Mycobacterium avium linked to routes of exposure Biology of waterborne pathogenic mycobacteria Analytical methods for the detection of waterborne and environmental pathogenic mycobacteria The Mycobacterium avium subspecies paratuberculosis problem and its relation to the causation of Crohn disease Disseminated infection, cervical adenitis and other MAC infections Skin, Bone, and Soft Tissue Infections Pulmonary infection in non-HIV infected individuals Disease resulting from contaminated equipment and invasive procedures Control, Treatment and Disinfection of Mycobacterium avium Complex in Drinking Water Approaches to risk management in priority settings
Download or read book Soil Protists written by Stefan Geisen and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2015-10-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protists are by far the most diverse and abundant eukaryotes in soils. Nevertheless, very little is known about individual representatives, the diversity and community composition and ecological functioning of these important organisms. For instance, soil protists are commonly lumped into a single functional unit, i.e. bacterivores. This work tackles missing knowledge gaps on soil protists and common misconceptions using multi-methodological approaches including cultivation, microcosm experiments and environmental sequencing. In a first part, several new species and genera of amoeboid protists are described showing their immense unknown diversity. In the second part, the enormous complexity of soil protists communities is highlighted using cultivation- and sequence-based approaches. In the third part, the present of diverse mycophagous and nematophagous protists are shown in functional studies on cultivated taxa and their environmental importance supported by sequence-based approaches. This work is just a start for a promising future of soil Protistology that is likely to find other important roles of these diverse organisms.
