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3d Dna Nanostructure
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Book Synopsis 3D DNA Nanostructure: Methods and Protocols by : Yonggang Ke
Download or read book 3D DNA Nanostructure: Methods and Protocols written by Yonggang Ke and published by Methods in Molecular Biology. This book was released on 2018-11-18 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents a comprehensive technical overview of DNA nanotechnology with an emphasis on 3D DNA nanostructure design and applications. Coverage spans from basic design principles for DNA and RNA nanostructures to their cutting-edge applications in a variety of fields, with the book divided into basic DNA and RNA nanostructure design strategies as well as applications utilizing DNA nanostructures, including but not limited to nanomedicine, bioimaging, biosensing, nanoplasmonics, nanoelectronics, nanofabrication, crystallography, biophysics, and analytical chemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, 3D DNA Nanostructure: Methods and Protocols provides the most up-to-date tutorial style overviews and technical style protocols to benefit researchers in a wide variety of areas.
Book Synopsis 3D DNA Nanostructure by : Yonggang Ke
Download or read book 3D DNA Nanostructure written by Yonggang Ke and published by Humana. This book was released on 2016-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents a comprehensive technical overview of DNA nanotechnology with an emphasis on 3D DNA nanostructure design and applications. Coverage spans from basic design principles for DNA and RNA nanostructures to their cutting-edge applications in a variety of fields, with the book divided into basic DNA and RNA nanostructure design strategies as well as applications utilizing DNA nanostructures, including but not limited to nanomedicine, bioimaging, biosensing, nanoplasmonics, nanoelectronics, nanofabrication, crystallography, biophysics, and analytical chemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, 3D DNA Nanostructure: Methods and Protocols provides the most up-to-date tutorial style overviews and technical style protocols to benefit researchers in a wide variety of areas.
Book Synopsis Structural DNA Nanotechnology by : Nadrian C. Seeman
Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.
Book Synopsis Stabilization of 3D DNA Nanostructures for in Vivo Applications and Developing an Assay to Estimate Stability by : Saswata Banerjee
Download or read book Stabilization of 3D DNA Nanostructures for in Vivo Applications and Developing an Assay to Estimate Stability written by Saswata Banerjee and published by . This book was released on 2018 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though DNA nanostructures (DNs) have become interesting subjects of drug delivery, in vivo imaging and biosensor research, however, for real biological applications, they should be "long circulating" in blood. One of the crucial requirements for DN stability is high salt concentration (like ~5-20 mM Mg2+) that is unavailable in a cell culture medium or in blood. Hence DNs denature promptly when injected into living systems. Another important factor is the presence of nucleases that cause fast degradation of unprotected DNs. The third factor is "opsonization" which is the immune process by which phagocytes target foreign particles introduced into the bloodstream. The primary aim of this thesis is to design strategies that can improve the in vivo stability of DNs, thus improving their pharmacodynamics and biodistribution. Several strategies were investigated to address the three previously mentioned limitations. The first attempt was to study the effect length and conformation of polyethylene glycol (PEG) on DN stability. DNs were also coated with PEG-lipid and human serum albumin (HSA) and their stealth efficiencies were compared. The findings reveal that both PEGylation and albumin coating enhance low salt stability, increase resistance towards nuclease action and reduce uptake of DNs by macrophages. Any protective coating around a DN increases its hydrodynamic radius, which is a crucial parameter influencing their clearance. Keeping this in mind, intrinsically stable DNs that can survive low salt concentration without any polymer coating were built. Several DNA compaction agents and DNA binders were screened to stabilize DNs in low magnesium conditions. Among them arginine, lysine, bis-lysine and hexamine cobalt showed the potential to enhance DN stability. This thesis also presents a sensitive assay, the Proximity Ligation Assay (PLA), for the estimation of DN stability with time. It requires very simple modifications on the DNs and it can yield precise results from a very small amount of sample. The applicability of PLA was successfully tested on several DNs ranging from a simple wireframe tetrahedron to a 3D origami and the protocol to collect in vivo samples, isolate the DNs and measure their stability was developed.
Book Synopsis DNA and RNA Origami by : Julián Valero
Download or read book DNA and RNA Origami written by Julián Valero and published by Springer Nature. This book was released on 2023-05-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume detials diverse methodological approaches on the assembly and applications of DNA origami assemblies. Chapters guide readers through different synthetic and computational methods, isolation and structural characterization of 2D and 3D DNA origami nanoarchitectures, nanophotonics, drug delivery, biophysics, and synthetic biology.Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA and RNA Origami: Methods and Protocols aims to serve as a guideline describing the current state-of-the-art assembly methodologies and applications of DNA origami nanostructures.
Book Synopsis Constructions of 2D-3D Bio-mimetic DNA Nanostructures by : Sibai Xie
Download or read book Constructions of 2D-3D Bio-mimetic DNA Nanostructures written by Sibai Xie and published by . This book was released on 2021 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA nanotechnology as a versatile tool has been growing rapidly in the past three decades, with applications across different disciplines such as drug delivery, imaging, and even computing. Its versatility stems from the programmable nature of DNA and the ability to self-assemble through the A-T and C-G base pairing by hydrogen bonds. These features make DNA nanotechnology the ideal tool for mimicking and studying biological processes that are hard to otherwise model. In this work, the process we focus on is Clathrin-Mediated Endocytosis (CME). CME is one of the major mechanisms for cell entry. This pathway internalizes Influenza A, vesicular stomatitis virus, and many others. Mimicking this process will help us further understand it, and also find ways to utilize it in the field of drug delivery. The process of CME can be described in 3 major steps. The first step is array formation. Clathrin can cluster on cell surface in the form of triskelion, to form small patches of an array. The second step involves the recruitment of adaptor proteins, that transforms the array into three-dimensional lattices to encapsulate the foreign agent. The third step is the transportation of the vehicle inside the cell, along with the disassembly of the vehicle to release the agent. Specifically for each stage, we designed mimicking mechanisms using DNA nano-structures. For the array stage, we designed a three-point-star motif to mimic the triskelion structure, and functionalized it with cholesterol to integrate the array to the cell membrane. Characterization through liquid atomic force microscopy (AFM) showed clear hexagonal pattern, and in vitro cell experiment also showed the integration of the arrays to cell membranes. For the transition stage, we designed a reversible 2D-3D transition mechanism that allowed the 2D arrays to transform into 3D particles with the addition of a particular stimuli, that is a DNA single strand. The transformability and reversibility were confirmed through polyacrylamide gel electrophoresis (PAGE), dynamic light scattering (DLS) and AFM. For the delivery stage, we designed several 3D DNA structures for better drug delivery efficiency, and the designs were also characterized by PAGE and AFM. The successful designs for all three stages led us closer to understanding the structural transformation of clathrin triskelion during CME. The 2D-3D transition mechanism also has the potential to be used in other systems, such as stimuli-controlled drug release and DNA computing using single strand DNA.
Book Synopsis Thermodynamics and Biological Applications of DNA Nanostructures by : Wei, Xixi
Download or read book Thermodynamics and Biological Applications of DNA Nanostructures written by Wei, Xixi and published by . This book was released on 2014 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA nanotechnology is one of the most flourishing interdisciplinary research fields. Through the features of programmability and predictability, DNA nanostructures can be designed to self-assemble into a variety of periodic or aperiodic patterns of different shapes and length scales, and more importantly, they can be used as scaffolds for organizing other nanoparticles, proteins and chemical groups. By leveraging these molecules, DNA nanostructures can be used to direct the organization of complex bio-inspired materials that may serve as smart drug delivery systems and in vitro or in vivo bio-molecular computing and diagnostic devices. In this dissertation I describe a systematic study of the thermodynamic properties of complex DNA nanostructures, including 2D and 3D DNA origami, in order to understand their assembly, stability and functionality and inform future design endeavors. It is conceivable that a more thorough understanding of DNA self-assembly can be used to guide the structural design process and optimize the conditions for assembly, manipulation, and functionalization, thus benefiting both upstream design and downstream applications. As a biocompatible nanoscale motif, the successful integration, stabilization and separation of DNA nanostructures from cells/cell lysate suggests its potential to serve as a diagnostic platform at the cellular level. Here, DNA origami was used to capture and identify multiple T cell receptor mRNA species from single cells within a mixed cell population. This demonstrates the potential of DNA nanostructure as an ideal nano scale tool for biological applications.
Download or read book DNA Nanotechnology written by Chunhai Fan and published by Springer Nature. This book was released on 2020-09-07 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials" is available open access under a CC BY 4.0 License via link.springer.com.
Book Synopsis Design Tools for Reinforced 3D DNA Nanostructures by : Oriol Corcoll Andreu
Download or read book Design Tools for Reinforced 3D DNA Nanostructures written by Oriol Corcoll Andreu and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this document we present an algorithm which takes a structure and a path for the scaffold as input and reinforces its long edges with a bipyramid-like structure. Also we give a tool to visualise the original structure, its reinforced version and the modified path for the scaffold.
Book Synopsis DNA Nanostructures as a Printing Press for DNA-polymer Hybrid Materials by : Sean Laxton
Download or read book DNA Nanostructures as a Printing Press for DNA-polymer Hybrid Materials written by Sean Laxton and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Block copolymers have widespread use in areas such as luminescence, photovoltaics, electronics, optics, shape memory, self healing, stimuli-responsiveness, photonics, and drug delivery due to their predictable, ordered nanostructures. However, block copolymer materials are usually restricted to highly symmetric spherical, cylindrical, lamellar, and vesicular morphologies, resulting from the non-covalent interactions that direct their assembly. Recent interest, inspired by natural systems, has emerged to break the symmetry in polymer self-assembly to achieve materials with new and unusual functional properties. To break the symmetry of polymer assembly, patchy particles, Janus particles, multicompartment particles, and lithography have been employed. Although these methods of polymer assembly have improved the range of polymer architectures, they have limited control of the compartmentalization and orientation of the binding sites on the particle surface. In contrast, DNA nanotechnology harnesses Watson-Crick-Franklin base pairing to create highly specific and programmable assemblies at the nanoscale. Therefore, transferring a pattern of DNA strands from a DNA nanostructure onto polymer particles ("printing") combines the materials properties of polymers with the high structural control of DNA nanotechnology. In this thesis, advances to make new DNA polymer hybrid materials are employed-with an emphasis of printing DNA patterns on polymer particle surfaces. First, the use of DNA cubes as a 2D printing press, placing DNA strands with controlled sequence, valency, and patterns on the surface of block copolymer micelles and spherical nucleic acids will be investigated. Second, using sequence-defined polymers, a polymer particle that can be assembled inside a DNA cube with a 3D DNA pattern attached will be examined. Again, these printed strands have controlled DNA sequence, valency, and pattern on the surface. Furthermore, these 3D cube printed particles can have polymers attached, with click chemistry, to the surface to change particle properties. All these cube printing methods are modular; changing the polymer composition of the DNA printed particles can further give assemblies with given polymer types at a given position, further tuning the material properties. Lastly, spherical nucleic acids will be used as a nanoreactor to incorporate hydrophobic drug-polymer conjugates for controlled drug release. These materials will be useful for drug delivery and building blocks for asymmetric polymer patterning. Overall, these DNA-polymer materials can be used to make new hierarchical and functional materials through their programmable assembly"--
Book Synopsis DNA Nanostructures as Platforms for Chemical Transformations by : Tuan Trinh
Download or read book DNA Nanostructures as Platforms for Chemical Transformations written by Tuan Trinh and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "DNA is an exceptional material for bottom-up assembly of nanostructures with arbitrary shapes and high level of complexity due to its programmability, predictability and biocompatibility. Variety of well-defined DNA nanostructures ranging from a few nanometers to microns can be constructed with unparalleled precision and control. Beyond the self-assembly perspective, chemists have discovered that DNA can provide an excellent template for chemical reactions with high selectivity because it can significantly increase the local concentration of appended reactants. This thesis aims to explore the possibility of using minimalist DNA nanostructures as templates for chemical transformations to generate unique DNA-hybrid materials. First, the use of DNA micelle as a new reaction platform to enable DNA functionalization with highly hydrophobic molecules in aqueous media is investigated. The hydrophobic core of the DNA micelle can act as a reaction auxiliary that facilitates the conjugation of complementary DNA strands to hydrophobic units. Due to the sequence-controlled properties of each component used for DNA micelles assembly, reactivity can be easily tuned and studied. Second, the use of DNA nanostructures for templating reactions is expanded further to two-dimensional (2D) chemical transfer of DNA strand patterns, from a multi-arm DNA junction to a small molecule. This “printing” approach is highly modular, and it allows the resulting branched DNA-small molecule can be controlled precisely in terms of DNA sequences, valency and directionalities (5’-3’). Finally, a three-dimensional (3D) DNA “printing” method using minimal DNA cages to well-defined polymeric materials is presented. The organization of DNA strands on these scaffolds creates DNA strand patterns that can be efficiently transferred to a crosslinked polymer core inside the cage with precise control over the number, directionality, geometry and sequence anisotropy of DNA strands. The resulting DNA-imprinted polymer nanoparticles can be programmed to assemble into asymmetric higher order structures using DNA hybridization. These unique DNA-hybrid molecules can find numerous potential applications. The work presented in chapter 2 opens an opportunity to synthesize a variety of DNA hybrid materials with hydrophobic molecules, which are useful in DNA and small molecule therapeutic delivery, diagnostics, nanopore formation and self-assembly. Branched DNA-imprinted small molecules demonstrated in chapter 3 can be useful in the field of DNA nanotechnology as building blocks for wireframe DNA nanostructures, branching staple strands in DNA origami and tunable templates for material organization. The DNA-imprinted polymeric particles in chapter 4 can serve as precisely-defined “multi-arm junctions” to create highly complex structures in a predictable manner. They can also be useful in applications such as drug delivery, barcoded diagnostic or building blocks for non-centrosymmetric polymer patterning. Overall, the approaches introduced in this thesis can be used to make functional DNA-hybrid structures, with an emphasis on simplifying synthetic efforts while retaining structural complexity"--
Book Synopsis 3D Printing Technology in Nanomedicine by : Nabeel Ahmad
Download or read book 3D Printing Technology in Nanomedicine written by Nabeel Ahmad and published by Elsevier. This book was released on 2019-03-30 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms Develops the concept of integrating different technologies along the hierarchical structure of biological systems
Book Synopsis Bottom-up Construction of Complex Metal Nanoparticle Structures with DNA as a Chaperone by : Xin Luo
Download or read book Bottom-up Construction of Complex Metal Nanoparticle Structures with DNA as a Chaperone written by Xin Luo and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nanoscale metal structures has been an essential topic in modern nanotechnology due to their wide range of applications in catalysis, sensing, diagnosis, medicine and optics. Plasmonic metal nanostructures have attracted particular attention, as their light-focusing property can be efficiently tuned by changing their spatial structure. Traditionally, top-down lithography approaches have been the main tool to implement precise metal nanostructure designs, which, however, has shown drawbacks such as low throughput, high cost and low resolution when reaching the sub-5 nm scale. Over the past two decades, the field of DNA nanotechnology has enabled the fabrication of increasingly complex one-, two- and three-dimensional nanostructures with unprecedented specificity, programmability, and sub-nanometer precision. These DNA structures have been demonstrated to be an ideal chaperone for the bottom-up self-assembly of metal nanostructures, pushing the boundaries of plasmonic nanophotonics design and fabrication. This thesis targets a few challenges in constructing complex metal nanostructures with DNA as a template. First, to access hierarchical assembly in 3D, nanoparticles must be functionalized with anisotropic valency-controlled DNA strands. We developed a simple one-step method to encode 3D DNA strand patterns to gold nanoparticles with a controlled number of unique DNA strands in a predesigned spatial arrangement, through encapsulating the gold nanoparticle into a predesigned DNA minimal nanocage. The encapsulated gold nanoparticle, as a building block, inherits the 3D anisotropic molecular information from the DNA nanocage with enhanced structural stability, which allows its hierarchical self-assembly into complex metal architectures. Second, we developed an Assemble, Grow and Lift-Off (AGLO) strategy to construct robust standalone gold nanostructures with pre-designed customizable shapes in solution, using only a simple 2D DNA origami sheet as a transient template. AuNP seeds were assembled on DNA origami template in a predesigned shape, grown to merge into robust gold structures, and lifted-off to regenerate and recycle the DNA origami template. Finally, we discovered a Contact-dependent Localized Electrochemical Ripening (CLER) mechanism with DNA-templated metal growth, which, for the first time, systematically explains the heterogenous silver deposition phenomenon. The mechanism can be manipulated to synthesize deterministic asymmetric metal structures with core-shell NPs of pre-designed arrangements in a one-pot system, which demonstrates promising applications in surface-enhanced Raman spectroscopy. Overall, the work presented in this thesis not only pushes DNA-templated metal structures forward by demonstrating practical strategies to increase the 3D metal structure complexity and robustness, but also offers valuable fundamental insights in metal growth mechanisms. This knowledge provides guidelines for the future design and construction of DNA-templated metal structures. More importantly, the new mechanisms discovered contribute to the fundamental understanding of the metal nanoparticle synthesis process"--
Book Synopsis Nucleic Acid-Based Nanomaterials by : Yunfeng Lin
Download or read book Nucleic Acid-Based Nanomaterials written by Yunfeng Lin and published by John Wiley & Sons. This book was released on 2024-04-24 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acid-Based Nanomaterials Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies Nucleic acids, the biomolecules that carry most of nature’s critical genetic information, are an omnipresent component of life on earth. Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more. Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials. Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications. Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries. The result is an essential contribution to materials science in a variety of life-saving contexts. Nucleic Acid-Based Nanomaterials readers will also find: Application-oriented structure that grounds general concepts in their specific instantiations Detailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and more A rigorous yet accessible approach suitable for both academia and industry Nucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.
Book Synopsis DNA Nanotechnology for Cell Research by : Zhou Nie
Download or read book DNA Nanotechnology for Cell Research written by Zhou Nie and published by John Wiley & Sons. This book was released on 2024-02-20 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Nanotechnology for Cell Research Comprehensive coverage of DNA nanotechnology with a focus on its biomedical applications in disease diagnosis, gene therapy, and drug delivery Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery. The text is divided into four parts. Part I surveys the progress of functional DNA nanotechnology tools for cellular recognition. Part II illustrates the use of DNA-based biochemical sensors to monitor and image intracellular molecules and processes. Part III examines the use of DNA to regulate biological functions of individual cells. Part IV elucidates the use of DNA nanotechnology for cell-targeted medical applications. Sample topics covered in DNA Nanotechnology for Cell Research include: Selections and applications of functional nucleic acid toolkits, including DNA/RNA aptamers, DNAzymes, and riboswitches, for cellular recognition, metabolite detection, and liquid biopsy. Developing intelligent DNA nanodevices implemented in living cells for amplified cell imaging, smart intracellular sensing, and in cellulo programmable biocomputing. Harnessing dynamic DNA nanotechnology for non-genetic cell membrane engineering, receptor signaling reprogramming, and cellular behavior regulation. Construction of biocompatible nucleic acid nanostructures as precisely controlled vehicles for drug delivery, immunotherapy, and tissue engineering. Providing an up-to-date tutorial style overview along with a highly valuable in-depth perspective, DNA Nanotechnology for Cell Research is an essential resource for the entire DNA-based nanotechnology community, including analytical chemists, biochemists, materials scientists, and bioengineers.
Book Synopsis Self-assembling Biomaterials by : Helena S. Azevedo
Download or read book Self-assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials
Book Synopsis DNA Nanotechnology by : Giampaolo Zuccheri
Download or read book DNA Nanotechnology written by Giampaolo Zuccheri and published by Humana Press. This book was released on 2018-06-21 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated methods that detail new DNA nanotechnology techniques. Chapters focus on DNA origami nanostructures for arranging matter in the nanoscale or on their manipulation with the aid of other technologies, on procedures for making nucleic acids nanostructures of different kinds, and methods to simulate complex nanostructures or to use them in biosensing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Nanotechnology: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
